IN2012DN02227A - - Google Patents

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Publication number
IN2012DN02227A
IN2012DN02227A IN2227DEN2012A IN2012DN02227A IN 2012DN02227 A IN2012DN02227 A IN 2012DN02227A IN 2227DEN2012 A IN2227DEN2012 A IN 2227DEN2012A IN 2012DN02227 A IN2012DN02227 A IN 2012DN02227A
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IN
India
Prior art keywords
identified
clade
karis
ketol
yeast
Prior art date
Application number
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English (en)
Inventor
Vasantha Nagarajan
Brian James Paul
Wonchul Suh
Jean-Francois Tomb
Rick W Ye
Original Assignee
Butamax Tm Advanced Biofuels
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Butamax Tm Advanced Biofuels filed Critical Butamax Tm Advanced Biofuels
Publication of IN2012DN02227A publication Critical patent/IN2012DN02227A/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/16Butanols
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01008Glycerol-3-phosphate dehydrogenase (NAD+) (1.1.1.8)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01086Ketol-acid reductoisomerase (1.1.1.86)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/01Carboxy-lyases (4.1.1)
    • C12Y401/01001Pyruvate decarboxylase (4.1.1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/01Carboxy-lyases (4.1.1)
    • C12Y401/01072Branched-chain-2-oxoacid decarboxylase (4.1.1.72)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/02Aldehyde-lyases (4.1.2)
    • C12Y401/02009Phosphoketolase (4.1.2.9)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y402/00Carbon-oxygen lyases (4.2)
    • C12Y402/01Hydro-lyases (4.2.1)
    • C12Y402/01009Dihydroxy-acid dehydratase (4.2.1.9), i.e. acetohydroxyacid dehydratase
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02EREDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00Technologies for the production of fuel of non-fossil origin
    • Y02E50/10Biofuels, e.g. bio-diesel
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/52Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IN2227DEN2012 2009-09-29 2010-09-29 IN2012DN02227A (show.php)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24684409P 2009-09-29 2009-09-29
PCT/US2010/050724 WO2011041415A1 (en) 2009-09-29 2010-09-29 Fermentive production of isobutanol using highly effective ketol-acid reductoisomerase enzymes

Publications (1)

Publication Number Publication Date
IN2012DN02227A true IN2012DN02227A (show.php) 2015-08-21

Family

ID=43242464

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2227DEN2012 IN2012DN02227A (show.php) 2009-09-29 2010-09-29

Country Status (10)

Country Link
US (2) US20110244536A1 (show.php)
EP (1) EP2483411A1 (show.php)
JP (1) JP5805094B2 (show.php)
CN (1) CN102666866A (show.php)
AU (1) AU2010300642B2 (show.php)
BR (1) BR112012007168A2 (show.php)
CA (1) CA2775892A1 (show.php)
IN (1) IN2012DN02227A (show.php)
WO (1) WO2011041415A1 (show.php)
ZA (1) ZA201202054B (show.php)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8945899B2 (en) 2007-12-20 2015-02-03 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase using NADH
US9303225B2 (en) 2005-10-26 2016-04-05 Butamax Advanced Biofuels Llc Method for the production of isobutanol by recombinant yeast
BRPI0808600A2 (pt) 2007-04-18 2018-12-26 Du Pont "método para a conversão de acetolactato em dihidroxi-isovalerato, método para a produção de isobutanol, célula hospedeira recombinante e método para a identificação e isolameno de uma construção genética"
US8188250B2 (en) 2008-04-28 2012-05-29 Butamax(Tm) Advanced Biofuels Llc Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
BRPI0909989A2 (pt) * 2008-06-05 2021-06-22 Butamax Advanced Biofuels Llc célula de levedura recombinante e método para a produção de um produto
WO2010037111A1 (en) 2008-09-29 2010-04-01 Butamax™ Advanced Biofuels LLC INCREASED HETEROLOGOUS Fe-S ENZYME ACTIIVTY IN YEAST
EP2337851B1 (en) * 2008-09-29 2014-08-13 Butamax Advanced Biofuels Llc IDENTIFICATION AND USE OF BACTERIAL Ý2Fe-2S¨DIHYDROXY-ACID DEHYDRATASES
US9260708B2 (en) * 2009-09-29 2016-02-16 Butamax Advanced Biofuels Llc Yeast production host cells
BR112012016042A2 (pt) * 2009-12-29 2020-09-15 Butamax Advanced Biofuels Llc "celula hospedeira microbiana recombinante, metodo para a produção de isobutanol, método para a produção de 2-butanol e método para a produção de 14-butanol
MX357290B (es) 2010-02-17 2018-07-04 Butamax Tm Advanced Biofuels Mejoramiento de la actividad de proteínas que requieren centros fe-s.
US9249420B2 (en) * 2010-05-31 2016-02-02 Vib Vzw Isobutanol production using yeasts with modified transporter expression
KR20130027551A (ko) 2010-06-17 2013-03-15 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 부탄올 생산을 위한 효모 생산 배양물
US8871488B2 (en) 2010-06-18 2014-10-28 Butamax Advanced Biofuels Llc Recombinant host cells comprising phosphoketolases
US9012190B2 (en) 2011-06-15 2015-04-21 Butamax Advanced Biofuels Llc Use of thiamine and nicotine adenine dinucleotide for butanol production
US9040263B2 (en) 2010-07-28 2015-05-26 Butamax Advanced Biofuels Llc Production of alcohol esters and in situ product removal during alcohol fermentation
CN103119172B (zh) 2010-06-18 2016-05-11 布特马斯先进生物燃料有限责任公司 在提取发酵中用于醇移除的来源于油的提取溶剂
CN105950525A (zh) 2010-09-07 2016-09-21 布特马斯先进生物燃料有限责任公司 整合编码催化丙酮酸至乙酰乳酸的转化的多肽的多核苷酸
US8759044B2 (en) 2011-03-23 2014-06-24 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
US8765425B2 (en) 2011-03-23 2014-07-01 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
KR20140092759A (ko) 2011-03-24 2014-07-24 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 숙주 세포 및 아이소부탄올의 제조 방법
AU2012249389A1 (en) 2011-04-29 2013-11-14 Danisco Us Inc. Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, HMG-CoA synthase and HMG-CoA reductase enzymatic activities
BR112013032319A2 (pt) 2011-06-17 2016-12-20 Butamax Advanced Biofuels Llc métodos da geração de coprodutos de destilação, coprodutos de destilação, método para atenuar o impacto de contaminantes de fermentação, método para a redução da contaminação por micotoxinas, método para a redução da variabilidade do teor de lipídeos, método para aumento do teor de triglicerídeos, método de produção de um coproduto de destilação para o combustível e método de produção de um coproduto destilação para o biodiesel
JP6093764B2 (ja) 2011-07-28 2017-03-08 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー ケトイソ吉草酸デカルボキシラーゼ酵素およびその使用方法
EP2788096A2 (en) 2011-12-09 2014-10-15 Butamax Advanced Biofuels LLC Process to remove product alcohols from fermentation broth
CN104321436A (zh) 2011-12-30 2015-01-28 布特马斯先进生物燃料有限责任公司 醇类的发酵生产
MX2014011355A (es) 2012-03-23 2014-12-05 Butamax Advanced Biofuels Llc Complementacion con acetato de medio para butanologenos.
KR20150014953A (ko) 2012-05-11 2015-02-09 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 케톨-산 리덕토아이소머라아제 효소 및 사용 방법
US20140024064A1 (en) 2012-07-23 2014-01-23 Butamax(Tm) Advanced Biofuels Llc Processes and systems for the production of fermentative alcohols
AU2013305714A1 (en) 2012-08-22 2015-02-05 Butamax Advanced Biofuels Llc Production of fermentation products
EP2895612A1 (en) 2012-09-12 2015-07-22 Butamax Advanced Biofuels LLC Processes and systems for the production of fermentation products
WO2014047421A1 (en) * 2012-09-21 2014-03-27 Butamax(Tm) Advanced Biofuels Llc Production of renewable hydrocarbon compositions
CA2886157A1 (en) 2012-09-26 2014-04-03 Butamax Advanced Biofuels Llc Polypeptides with ketol-acid reductoisomerase activity
AU2013323396B2 (en) 2012-09-28 2017-04-20 Butamax Advanced Biofuels Llc Production of fermentation products
US9273330B2 (en) 2012-10-03 2016-03-01 Butamax Advanced Biofuels Llc Butanol tolerance in microorganisms
BR112015008077A2 (pt) 2012-10-11 2017-12-05 Butamax Advanced Biofuels Llc métodos para a produção de um produto de fermentação
US9650624B2 (en) 2012-12-28 2017-05-16 Butamax Advanced Biofuels Llc DHAD variants for butanol production
WO2014105840A1 (en) 2012-12-31 2014-07-03 Butamax Advanced Biofuels Llc Fermentative production of alcohols
WO2014159309A1 (en) 2013-03-12 2014-10-02 Butamax Advanced Biofuels Llc Processes and systems for the production of alcohols
CA2905912A1 (en) 2013-03-14 2014-10-02 E. I. Du Pont De Nemours And Company Glycerol 3- phosphate dehydrogenase for butanol production
US10006033B2 (en) * 2013-03-14 2018-06-26 The Regents Of The University Of California Recombinant microorganisms having a methanol elongation cycle (MEC)
WO2014151190A1 (en) 2013-03-15 2014-09-25 Butamax Advanced Biofuels Llc Dhad variants and methods of screening
WO2014151645A1 (en) 2013-03-15 2014-09-25 Butamax Advanced Biofuels Llc Process for maximizing biomass growth and butanol yield by feedback control
WO2014144728A1 (en) 2013-03-15 2014-09-18 Butamax Advanced Biofuels Llc Method for production of butanol using extractive fermentation
WO2014144643A1 (en) 2013-03-15 2014-09-18 Butamax Advanced Biofuels Llc Method for producing butanol using extractive fermentation
WO2014144210A2 (en) 2013-03-15 2014-09-18 Butamax Advanced Biofuels Llc Competitive growth and/or production advantage for butanologen microorganism
WO2015002913A1 (en) 2013-07-03 2015-01-08 Butamax Advanced Biofuels Llc Partial adaptation for butanol production
WO2016025425A1 (en) 2014-08-11 2016-02-18 Butamax Advanced Biofuels Llc Yeast preparations and methods of making the same
US11680280B2 (en) 2018-01-09 2023-06-20 Lygos, Inc. Recombinant host cells and methods for the production of isobutyric acid

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
FR2696190B1 (fr) * 1992-09-25 1994-12-09 Agronomique Inst Nat Rech Acide nucléique codant pour une alpha-acétolactate synthase et ses applications.
FR2829363B1 (fr) * 2001-09-10 2005-11-04 Aventis Cropscience Sa Utilisations d'inhibiteurs de l'acetohydroxyacide isomeroreductase pour le traitement des maladies fongiques des cultures
JP5804666B2 (ja) 2005-04-12 2015-11-04 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company バイオマスの処理および利用における別の供給流れの集中
US8945899B2 (en) 2007-12-20 2015-02-03 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase using NADH
BRPI0619325B8 (pt) * 2005-10-26 2020-11-17 Butamax Advanced Biofuels Llc célula hospedeira microbiana recombinante e método para produção de isobutanol
BRPI0808600A2 (pt) * 2007-04-18 2018-12-26 Du Pont "método para a conversão de acetolactato em dihidroxi-isovalerato, método para a produção de isobutanol, célula hospedeira recombinante e método para a identificação e isolameno de uma construção genética"
EP2677028B1 (en) 2007-12-20 2016-03-09 Butamax (TM) Advanced Biofuels LLC Ketol-acid reductoisomerase using NADH
US8372612B2 (en) * 2007-12-21 2013-02-12 Butamax(Tm) Advanced Biofuels Llc Production of four carbon alcohols using improved strain
US8518678B2 (en) * 2007-12-21 2013-08-27 Butamax(Tm) Advanced Biofuels Llc Strain comprising increased expression of a CFA coding region for butanol production
CA2990939A1 (en) * 2007-12-23 2009-07-09 Gevo, Inc. Yeast organism producing isobutanol at a high yield
US8188250B2 (en) 2008-04-28 2012-05-29 Butamax(Tm) Advanced Biofuels Llc Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
BRPI0909989A2 (pt) 2008-06-05 2021-06-22 Butamax Advanced Biofuels Llc célula de levedura recombinante e método para a produção de um produto
WO2010037111A1 (en) 2008-09-29 2010-04-01 Butamax™ Advanced Biofuels LLC INCREASED HETEROLOGOUS Fe-S ENZYME ACTIIVTY IN YEAST
WO2010037105A1 (en) * 2008-09-29 2010-04-01 Butamax™ Advanced Biofuels LLC Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria
EP2337869B1 (en) 2008-09-29 2015-08-19 Butamax Advanced Biofuels Llc Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria
EP2342330A1 (en) 2008-09-29 2011-07-13 Butamax Advanced Biofuels Llc Enhanced iron-sulfur cluster formation for increased dihydroxy-acid dehydratase activity in lactic acid bacteria
EP2337851B1 (en) 2008-09-29 2014-08-13 Butamax Advanced Biofuels Llc IDENTIFICATION AND USE OF BACTERIAL Ý2Fe-2S¨DIHYDROXY-ACID DEHYDRATASES
CA2737112A1 (en) 2008-10-27 2010-06-03 Butamax Advanced Biofuels Llc Carbon pathway optimized production hosts for the production of isobutanol
US8465964B2 (en) 2008-11-13 2013-06-18 Butamax (TM) Advanced Biofules LLC Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis
EP2957322B1 (en) 2014-06-18 2019-11-20 Fotona d.o.o. Laser treatment head and laser system

Also Published As

Publication number Publication date
CN102666866A (zh) 2012-09-12
US20160319307A1 (en) 2016-11-03
BR112012007168A2 (pt) 2019-09-24
CA2775892A1 (en) 2011-04-07
AU2010300642B2 (en) 2015-05-14
ZA201202054B (en) 2014-05-28
AU2010300642A1 (en) 2012-04-05
WO2011041415A1 (en) 2011-04-07
JP2013505740A (ja) 2013-02-21
EP2483411A1 (en) 2012-08-08
US20110244536A1 (en) 2011-10-06
JP5805094B2 (ja) 2015-11-04

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