IN164615B - - Google Patents

Info

Publication number
IN164615B
IN164615B IN652/CAL/85A IN652CA1985A IN164615B IN 164615 B IN164615 B IN 164615B IN 652CA1985 A IN652CA1985 A IN 652CA1985A IN 164615 B IN164615 B IN 164615B
Authority
IN
India
Prior art keywords
substituents
chem
compounds
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
IN652/CAL/85A
Other languages
English (en)
Inventor
Edward S Neiss
John T Suh
John R Regan
Jeffrey N Barton
Jerry W Skiles
Paul Menard
James J Mencel
Original Assignee
Usv Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/649,797 external-priority patent/US4746676A/en
Priority claimed from US06/752,695 external-priority patent/US4749698A/en
Application filed by Usv Pharma Corp filed Critical Usv Pharma Corp
Publication of IN164615B publication Critical patent/IN164615B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
IN652/CAL/85A 1984-09-12 1985-09-16 IN164615B (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/649,797 US4746676A (en) 1984-09-12 1984-09-12 Carboxyalkyl dipeptide compounds
US06/752,695 US4749698A (en) 1985-07-08 1985-07-08 Antihypertensive derivatives

Publications (1)

Publication Number Publication Date
IN164615B true IN164615B (fr) 1989-04-22

Family

ID=27095707

Family Applications (1)

Application Number Title Priority Date Filing Date
IN652/CAL/85A IN164615B (fr) 1984-09-12 1985-09-16

Country Status (13)

Country Link
EP (1) EP0175266B1 (fr)
KR (1) KR860002464A (fr)
AT (1) ATE135711T1 (fr)
AU (1) AU578489B2 (fr)
CA (1) CA1288893C (fr)
DE (1) DE3588094T2 (fr)
DK (1) DK412985A (fr)
ES (1) ES8609364A1 (fr)
FI (1) FI89716C (fr)
IL (1) IL76345A (fr)
IN (1) IN164615B (fr)
NO (1) NO169442C (fr)
NZ (1) NZ213432A (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
EP0765341A4 (fr) * 1994-06-16 1998-09-16 Smithkline Beecham Corp Cyclisation dirigee par matrice
DE60027749T3 (de) † 1999-10-14 2012-01-19 Curis, Inc. Vermittler von "hedgehog" übermittelnden bahnen, dazugehörige zusammenetzungen und verwendungen
ATE471589T1 (de) 2000-09-21 2010-07-15 Abb Schweiz Ag Konfiguration eines leitsystems einer elektrischen schaltanlage
WO2007078990A2 (fr) 2005-12-23 2007-07-12 Zealand Pharma A/S Composés modifiés mimétiques de la lysine
DK2468724T3 (en) * 2006-12-21 2016-02-22 Zealand Pharma As Synthesis of pyrrolidine compounds
CN110709096B (zh) 2017-05-05 2023-10-31 泽兰德制药公司 细胞间隙连接通讯调节剂及其在糖尿病性眼病治疗中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
GR75019B (fr) * 1980-09-17 1984-07-12 Univ Miami
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
FR2501399B1 (fr) * 1981-03-03 1987-06-19 France Etat Dispositif d'affichage de messages graphiques transmis par des systemes de videotex
EP0080822A1 (fr) * 1981-11-27 1983-06-08 Beecham Group Plc Peptides issus de prolinol, à activité anti-hypertensive
EP0088350B1 (fr) * 1982-03-08 1985-02-20 Schering Corporation Carboxyalkyl dipeptides, leur procédé de préparation et leurs compositions pharmaceutiques les contenant
ZA832762B (en) * 1982-04-30 1983-12-28 Squibb & Sons Inc Substituted 4-phenoxy prolines
IL69136A0 (en) * 1982-07-19 1983-10-31 Squibb & Sons Inc Substituted peptide compounds
US4623729A (en) * 1982-07-22 1986-11-18 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
FI841052A (fi) * 1983-03-16 1984-09-17 Usv Pharma Corp Foereningar foer behandling av blodtryckssjukdomar.
ZA843899B (en) * 1983-05-23 1984-12-24 Usv Pharma Corp Compounds for treating hypertension

Also Published As

Publication number Publication date
IL76345A (en) 1988-12-30
DE3588094D1 (de) 1996-04-25
DK412985D0 (da) 1985-09-11
FI853494L (fi) 1986-03-13
EP0175266A2 (fr) 1986-03-26
NO853551L (no) 1986-03-13
ES546866A0 (es) 1986-07-16
IL76345A0 (en) 1986-01-31
ATE135711T1 (de) 1996-04-15
DK412985A (da) 1986-03-13
FI853494A0 (fi) 1985-09-12
AU4733185A (en) 1986-03-20
KR860002464A (ko) 1986-04-26
AU578489B2 (en) 1988-10-27
DE3588094T2 (de) 1996-08-22
NO169442C (no) 1992-06-24
NZ213432A (en) 1988-11-29
NO169442B (no) 1992-03-16
ES8609364A1 (es) 1986-07-16
FI89716C (fi) 1993-11-10
FI89716B (fi) 1993-07-30
CA1288893C (fr) 1991-09-10
EP0175266A3 (en) 1988-08-03
EP0175266B1 (fr) 1996-03-20

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