IL99759A - Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them - Google Patents

Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL99759A
IL99759A IL99759A IL9975991A IL99759A IL 99759 A IL99759 A IL 99759A IL 99759 A IL99759 A IL 99759A IL 9975991 A IL9975991 A IL 9975991A IL 99759 A IL99759 A IL 99759A
Authority
IL
Israel
Prior art keywords
aminoindan
propargyl
mono
preparation
pharmaceutical compositions
Prior art date
Application number
IL99759A
Other languages
English (en)
Other versions
IL99759A0 (en
Inventor
Sterling Jeff
Levy Ruth
Veinberg Alex
Goldenberg Willy
Finberg John
Youdim Musa
Gutman Arieh
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IL99759A priority Critical patent/IL99759A/xx
Priority to IL11281991A priority patent/IL112819A/en
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of IL99759A0 publication Critical patent/IL99759A0/xx
Priority to AU26063/92A priority patent/AU649565B2/en
Priority to ZA927570A priority patent/ZA927570B/xx
Priority to FI924458A priority patent/FI113262B/fi
Priority to NZ244616A priority patent/NZ244616A/en
Priority to CA002079968A priority patent/CA2079968C/en
Priority to HU9203162A priority patent/HU217589B/hu
Priority to CN92113070A priority patent/CN1038928C/zh
Priority to DK92402821.0T priority patent/DK0538134T3/da
Priority to ES92402821T priority patent/ES2101063T3/es
Priority to AT92402821T priority patent/ATE149999T1/de
Priority to EP92402821A priority patent/EP0538134B1/en
Priority to JP27731492A priority patent/JP3247165B2/ja
Priority to DE69218101T priority patent/DE69218101T2/de
Priority to US08/310,480 priority patent/US5486541A/en
Priority to GR970401207T priority patent/GR3023556T3/el
Publication of IL99759A publication Critical patent/IL99759A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL99759A 1991-10-16 1991-10-16 Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them IL99759A (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IL99759A IL99759A (en) 1991-10-16 1991-10-16 Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them
IL11281991A IL112819A (en) 1991-10-16 1991-10-16 Fluorinated 1-aminoindan compounds and a process for their preparation
AU26063/92A AU649565B2 (en) 1991-10-16 1992-09-30 Mono-fluorinated derivatives of N-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase
ZA927570A ZA927570B (en) 1991-10-16 1992-10-01 Mono-fluorinated derivatives of N-propagyl-1-aminoindan and their use as inhibitors of monoamine oxidase.
FI924458A FI113262B (fi) 1991-10-16 1992-10-02 Menetelmä N-propargyyli-1-aminoindaanin fluorattujen johdannaisten valmistamiseksi
NZ244616A NZ244616A (en) 1991-10-16 1992-10-05 Mono-fluorinated derivatives of n-propargyl-1-aminoindan, preparation and pharmaceutical compositions thereof
CA002079968A CA2079968C (en) 1991-10-16 1992-10-06 Mono-fluorinated derivatives of n-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase
HU9203162A HU217589B (hu) 1991-10-16 1992-10-06 N-propargil-1-amino-indán monofluorszármazékai és ezeket tartalmazó gyógyászati készítmények, valamint eljárás a vegyületek és a gyógyászati készítmények előállítására
CN92113070A CN1038928C (zh) 1991-10-16 1992-10-14 制备单氟化的n－炔丙基－1－氨基茚满衍生物的方法
DK92402821.0T DK0538134T3 (da) 1991-10-16 1992-10-15 Monofluorerede derivater af N-propargyl-1-aminoindan og deres anvendelse som inhibitorer for monoaminoxidase
DE69218101T DE69218101T2 (de) 1991-10-16 1992-10-15 Monofluorierte Derivate von N-Propargyl-1-Aminoindan und deren Verwendung als Monoamino-Oxidaseinhibitoren
ES92402821T ES2101063T3 (es) 1991-10-16 1992-10-15 Derivados monofluorados de n-propargil-1-amino-indano y su utilizacion como inhibidores de la monoamin-oxidasa.
AT92402821T ATE149999T1 (de) 1991-10-16 1992-10-15 Monofluorierte derivate von n-propargyl-1- aminoindan und deren verwendung als monoamino- oxidaseinhibitoren
EP92402821A EP0538134B1 (en) 1991-10-16 1992-10-15 Mono-fluorinated derivatives of N-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase
JP27731492A JP3247165B2 (ja) 1991-10-16 1992-10-15 Ｎ−プロパルギル−１−アミノインダンのモノ−弗素化誘導体、これを有効成分とする薬剤およびその製造方法
US08/310,480 US5486541A (en) 1991-10-16 1994-09-22 Monofluorinated derivatives of N-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase
GR970401207T GR3023556T3 (en) 1991-10-16 1997-05-26 Mono-fluorinated derivatives of N-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL99759A IL99759A (en) 1991-10-16 1991-10-16 Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
IL99759A0 IL99759A0 (en) 1992-08-18
IL99759A true IL99759A (en) 1997-06-10

Family

ID=11062970

Family Applications (2)

Application Number Title Priority Date Filing Date
IL99759A IL99759A (en) 1991-10-16 1991-10-16 Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them
IL11281991A IL112819A (en) 1991-10-16 1991-10-16 Fluorinated 1-aminoindan compounds and a process for their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL11281991A IL112819A (en) 1991-10-16 1991-10-16 Fluorinated 1-aminoindan compounds and a process for their preparation

Country Status (16)

Country Link
US (1) US5486541A (zh)
EP (1) EP0538134B1 (zh)
JP (1) JP3247165B2 (zh)
CN (1) CN1038928C (zh)
AT (1) ATE149999T1 (zh)
AU (1) AU649565B2 (zh)
CA (1) CA2079968C (zh)
DE (1) DE69218101T2 (zh)
DK (1) DK0538134T3 (zh)
ES (1) ES2101063T3 (zh)
FI (1) FI113262B (zh)
GR (1) GR3023556T3 (zh)
HU (1) HU217589B (zh)
IL (2) IL99759A (zh)
NZ (1) NZ244616A (zh)
ZA (1) ZA927570B (zh)

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* Cited by examiner, † Cited by third party
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US5744500A (en) * 1990-01-03 1998-04-28 Teva Pharmaceutical Industries, Ltd. Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof
DK0712387T3 (da) * 1993-08-06 2000-05-29 Upjohn Co 2-Aminoindaner som selektive dopamin-D3-ligander
IL111240A (en) * 1993-10-18 2001-10-31 Teva Pharma Salts of r(+) - enantiomers of n- propargyl-1-aminoindan and pharmaceutical compositions comprising them
US5877218A (en) 1994-01-10 1999-03-02 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
JP4782252B2 (ja) * 1994-01-10 2011-09-28 テバ ファーマシューティカル インダストリーズ リミテッド １−アミノインダン及びこれらの組成物
IL115357A (en) * 1995-09-20 2000-01-31 Teva Pharma Stable compositions containing N-propargyl-1-aminoindan and polyhydric alcohols
IL118836A (en) * 1996-07-11 2001-01-11 Teva Pharma Pharmaceutical compositions comprising s-(-)-n-propargyl-1-aminoindan
US6211235B1 (en) 1996-11-22 2001-04-03 Elan Pharmaceuticals, Inc. Compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6191166B1 (en) 1997-11-21 2001-02-20 Elan Pharmaceuticals, Inc. Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis
EP1535902B1 (en) 1996-12-18 2007-11-07 Teva Pharmaceutical Industries, Ltd. Aminoindan derivatives
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
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US6569851B1 (en) * 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) * 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
IL149308A0 (en) 1999-10-27 2002-11-10 Teva Pharma Use of 1-aminoindan derivatives for treatment of manic disorders
US6949575B2 (en) 2000-05-04 2005-09-27 Pfizer Inc. Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives
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US6956129B2 (en) * 2001-02-16 2005-10-18 Bayer Aktiengesellschaft Polyhalogen-substituted cinnamic acids and cinnamic acid derivatives and a process for the preparation of polyhalogen-substituted cinnamic acids and cinnamic acid derivatives
US20040010038A1 (en) * 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
WO2004045515A2 (en) * 2002-11-15 2004-06-03 Teva Pharmaceutical Industries, Ltd. Use of rasagiline with or without riluzole to treat amyotrophic lateral sclerosis
US20050192265A1 (en) * 2003-03-20 2005-09-01 Thompson Richard C. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
US20080090915A1 (en) * 2003-11-25 2008-04-17 Technion Research And Development Foundation Ltd. Method for preventing or attenuating anthracycline-induced cardiotoxicity
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US8097608B2 (en) 2003-11-25 2012-01-17 Technion Research And Development Foundation Ltd. Methods for treatment of cardiovascular disorders and diseases
AU2005269416B2 (en) * 2004-07-26 2011-07-28 Teva Pharmaceutical Industries, Ltd. Pharmaceutical dosage forms including rasagiline
US20060025446A1 (en) * 2004-07-27 2006-02-02 Jeffrey Sterling Propargyl nitroxides and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders
PL1848415T3 (pl) * 2005-02-17 2013-10-31 Teva Pharma Terapia kombinowana obejmująca octan glatirameru oraz rasagilinę do leczenia stwardnienia rozsianego
US20100167983A1 (en) * 2007-10-22 2010-07-01 Teva Pharmaceutical Industries, Ltd. Combination therapy with glatiramer acetate and rasagiline for the treatment of multiple sclerosis
BRPI0608209A2 (pt) 2005-02-23 2010-11-09 Teva Pharma mistura de partìculas, composição sólida, método para tratamento de um paciente com mal de parkinson, processo para preparação de uma composição, e, composição farmacêutica sólida
AU2006252540B2 (en) * 2005-06-02 2011-12-01 Jenrin Discovery MAO-B inhibitors useful for treating obesity
US8263655B2 (en) * 2005-10-06 2012-09-11 Technion Research And Development Foundation Ltd Methods for treatment of renal failure
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US7572834B1 (en) 2005-12-06 2009-08-11 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations and processes for their preparation
EP1956904B1 (en) 2005-12-09 2017-04-12 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Low-dose ladostigil for the treatment of mild cognitive impairment
AU2007217349B9 (en) 2006-02-21 2013-06-27 Teva Pharmaceutical Industries, Ltd. Use of rasagiline for the treatment of Multiple System Atrophy
TW200744576A (en) 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
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EP1892233A1 (de) * 2006-08-18 2008-02-27 Ratiopharm GmbH Neue Salze des Wirkstoffs Rasagilin
EP2101570B1 (en) * 2006-12-14 2013-02-13 Teva Pharmaceutical Industries, Ltd. Tannate salt of rasagiline
ZA200903903B (en) * 2006-12-14 2010-08-25 Teva Pharma Crystalline solid rasagiline base
EP1987816A1 (de) * 2007-04-30 2008-11-05 Ratiopharm GmbH Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff
US20090062400A1 (en) * 2007-09-05 2009-03-05 Laurence Oron Method of treating glaucoma using rasagiline
US8188149B2 (en) * 2007-09-17 2012-05-29 Teva Pharmaceutical Industries, Ltd. Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss
EP2053033A1 (en) * 2007-10-26 2009-04-29 Bayer Schering Pharma AG Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system or of tumors
AU2009204454B2 (en) * 2008-01-11 2015-02-05 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations, their preparation and use
EP2285214B1 (en) * 2008-06-10 2012-05-16 Teva Pharmaceutical Industries Ltd. Rasagiline soft gelatin capsules
NZ589445A (en) * 2008-06-13 2013-06-28 Teva Pharma Rasagiline for parkinson's disease modification
EP2299993A4 (en) * 2008-06-19 2014-08-20 Teva Pharma PROCESS FOR PURIFYING THE BASE OF RASAGILINE
NZ589547A (en) * 2008-06-19 2013-03-28 Teva Pharma Dried rasagiline base having a water content less than 0.5 % by weight
WO2010072409A1 (en) * 2008-12-22 2010-07-01 Krka, D. D., Novo Mesto Process for preparation of ivabradine
US20100189788A1 (en) * 2009-01-23 2010-07-29 Teva Pharmaceutical Industries, Ltd. Delayed release rasagiline base formulation
US8946482B2 (en) 2009-07-09 2015-02-03 Ratiopharm Gmbh Salts of rasagiline and pharmaceutical preparations thereof
EP2515891A4 (en) * 2009-12-22 2013-06-05 Teva Pharma 3-keto-N-propargyl-1-aminoindan
PL2531181T3 (pl) 2010-02-03 2019-09-30 Pharma Two B Ltd. Preparaty rasagiliny o przedłużonym uwalnianiu i ich zastosowanie
EP2598136A4 (en) 2010-07-27 2015-03-25 Teva Pharma DISPERSIONS OF RASAGILINE CITRATE
AU2011282720B2 (en) 2010-07-27 2016-12-22 Teva Pharmaceutical Industries Ltd. Use of rasagiline for the treatment of olfactory dysfunction
BR112014008555A2 (pt) 2011-10-10 2017-04-18 Teva Pharma r(+)-n-formil-propargil-aminoindano
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Also Published As

Publication number Publication date
FI924458A0 (fi) 1992-10-02
DE69218101T2 (de) 1997-09-25
CA2079968A1 (en) 1993-04-17
NZ244616A (en) 1995-04-27
IL112819A (en) 2001-11-25
EP0538134A3 (en) 1993-06-16
HUT67218A (en) 1995-03-28
JP3247165B2 (ja) 2002-01-15
FI113262B (fi) 2004-03-31
IL99759A0 (en) 1992-08-18
DE69218101D1 (de) 1997-04-17
US5486541A (en) 1996-01-23
GR3023556T3 (en) 1997-08-29
HU217589B (hu) 2000-02-28
CN1038928C (zh) 1998-07-01
FI924458A (fi) 1993-04-17
ZA927570B (en) 1993-04-14
JPH05262701A (ja) 1993-10-12
DK0538134T3 (da) 1997-04-01
EP0538134A2 (en) 1993-04-21
AU649565B2 (en) 1994-05-26
CA2079968C (en) 2004-12-21
AU2606392A (en) 1993-04-22
ATE149999T1 (de) 1997-03-15
ES2101063T3 (es) 1997-07-01
CN1073427A (zh) 1993-06-23
EP0538134B1 (en) 1997-03-12
HU9203162D0 (en) 1992-12-28

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