IL98968A - Pharmaceutical compositions of phenylphthalane derivatives for the treatment of cerebrovascular disorders - Google Patents
Pharmaceutical compositions of phenylphthalane derivatives for the treatment of cerebrovascular disordersInfo
- Publication number
- IL98968A IL98968A IL9896891A IL9896891A IL98968A IL 98968 A IL98968 A IL 98968A IL 9896891 A IL9896891 A IL 9896891A IL 9896891 A IL9896891 A IL 9896891A IL 98968 A IL98968 A IL 98968A
- Authority
- IL
- Israel
- Prior art keywords
- treatment
- citalopram
- medicament
- cerebral
- dementia
- Prior art date
Links
- 208000026106 cerebrovascular disease Diseases 0.000 title claims abstract description 16
- 239000008194 pharmaceutical composition Substances 0.000 title description 3
- 150000003839 salts Chemical class 0.000 claims abstract description 13
- 239000002253 acid Substances 0.000 claims abstract description 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 4
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 3
- 150000002367 halogens Chemical class 0.000 claims abstract description 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 3
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 claims description 45
- 229960001653 citalopram Drugs 0.000 claims description 44
- 239000003814 drug Substances 0.000 claims description 32
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- 208000005314 Multi-Infarct Dementia Diseases 0.000 claims description 5
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 claims description 3
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- 206010008111 Cerebral haemorrhage Diseases 0.000 claims description 3
- 206010008132 Cerebral thrombosis Diseases 0.000 claims description 3
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- UYNVMODNBIQBMV-UHFFFAOYSA-N 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol Chemical compound C1CC(CC=2C=CC=CC=2)CCN1C(C)C(O)C1=CC=C(O)C=C1 UYNVMODNBIQBMV-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK213290A DK213290D0 (da) | 1990-09-06 | 1990-09-06 | Treatment of cerebrovascular disorders |
| SG165594A SG165594G (en) | 1990-09-06 | 1994-11-16 | 1-[3-(dimethylamino)propyl]-1-phenylphthalenes for the treatment of cerebrovascular disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL98968A0 IL98968A0 (en) | 1992-07-15 |
| IL98968A true IL98968A (en) | 1996-06-18 |
Family
ID=26066379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9896891A IL98968A (en) | 1990-09-06 | 1991-07-25 | Pharmaceutical compositions of phenylphthalane derivatives for the treatment of cerebrovascular disorders |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0474580B1 (de) |
| JP (1) | JPH085787B2 (de) |
| KR (1) | KR970002246B1 (de) |
| AT (1) | ATE112166T1 (de) |
| AU (1) | AU644204B2 (de) |
| CA (1) | CA2049368C (de) |
| DE (1) | DE69104314T2 (de) |
| DK (2) | DK213290D0 (de) |
| HK (1) | HK21595A (de) |
| IE (1) | IE72160B1 (de) |
| IL (1) | IL98968A (de) |
| NZ (1) | NZ239437A (de) |
| SG (1) | SG165594G (de) |
| ZA (1) | ZA916187B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA001728B1 (ru) * | 1997-07-08 | 2001-08-27 | Х.Лундбекк А/С | Способ получения циталопрама |
| JP4674339B2 (ja) * | 1998-08-07 | 2011-04-20 | 三菱化学株式会社 | 脳損傷の予防・治療剤 |
| EA002977B1 (ru) * | 1998-10-20 | 2002-12-26 | Х.Лундбекк А/С | Способ получения циталопрама |
| ATE236145T1 (de) | 1998-12-23 | 2003-04-15 | Lundbeck & Co As H | Verfahren zur herstellung von 5-cyanophthalid |
| JP3798940B2 (ja) | 1999-04-14 | 2006-07-19 | ハー・ルンドベック・アクチエゼルスカベット | シタロプラムの製造方法 |
| ITMI991581A1 (it) * | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| AR021155A1 (es) | 1999-07-08 | 2002-06-12 | Lundbeck & Co As H | Tratamiento de desordenes neuroticos |
| GB2357762B (en) | 2000-03-13 | 2002-01-30 | Lundbeck & Co As H | Crystalline base of citalopram |
| BG64901B1 (bg) * | 2000-05-29 | 2006-08-31 | H. Lundbeck A/S | Метод за получаване на циталопрам |
| IL144816A (en) * | 2000-08-18 | 2005-09-25 | Lundbeck & Co As H | Method for the preparation of citalopram |
| HK1048812B (zh) * | 2000-12-22 | 2007-06-01 | H‧隆德贝克有限公司 | 制备纯西酞普兰的方法 |
| BG65515B1 (bg) * | 2002-07-26 | 2008-10-31 | H. Lundbeck A/S | Метод за получаване на 5-цианофталид |
| PL1691811T3 (pl) | 2003-12-11 | 2014-12-31 | Sunovion Pharmaceuticals Inc | Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji |
| TW200812993A (en) * | 2006-05-02 | 2008-03-16 | Lundbeck & Co As H | New uses of escitalopram |
| EP2008653A1 (de) * | 2007-06-28 | 2008-12-31 | Charité-Universitätsmedizin Berlin | Serotonerge Verbindungen zur Behandlung neuronaler Krankheiten |
| DE102007051090A1 (de) | 2007-06-28 | 2009-01-08 | Charité - Universitätsmedizin Berlin | SSRI zur Behandlung neuronaler Krankheiten |
| CN104005415B (zh) * | 2014-02-18 | 2015-12-02 | 中铁十六局集团北京轨道交通工程建设有限公司 | 微风化花岗岩中地下连续墙的高效成槽施工方法 |
| CN106871753B (zh) * | 2017-01-04 | 2018-10-16 | 中铁隧道集团有限公司 | 一种用于提高水平岩层隧道成型的装药方法 |
-
1990
- 1990-09-06 DK DK213290A patent/DK213290D0/da not_active Application Discontinuation
-
1991
- 1991-07-25 IL IL9896891A patent/IL98968A/en not_active IP Right Cessation
- 1991-07-30 IE IE268291A patent/IE72160B1/en not_active IP Right Cessation
- 1991-08-06 ZA ZA916187A patent/ZA916187B/xx unknown
- 1991-08-16 CA CA002049368A patent/CA2049368C/en not_active Expired - Lifetime
- 1991-08-16 NZ NZ239437A patent/NZ239437A/en not_active IP Right Cessation
- 1991-08-16 AT AT91610063T patent/ATE112166T1/de not_active IP Right Cessation
- 1991-08-16 DK DK91610063.9T patent/DK0474580T3/da active
- 1991-08-16 DE DE69104314T patent/DE69104314T2/de not_active Expired - Lifetime
- 1991-08-16 EP EP91610063A patent/EP0474580B1/de not_active Expired - Lifetime
- 1991-08-19 KR KR1019910014255A patent/KR970002246B1/ko not_active Expired - Fee Related
- 1991-08-20 AU AU82594/91A patent/AU644204B2/en not_active Ceased
- 1991-09-04 JP JP3224192A patent/JPH085787B2/ja not_active Expired - Fee Related
-
1994
- 1994-11-16 SG SG165594A patent/SG165594G/en unknown
-
1995
- 1995-02-16 HK HK21595A patent/HK21595A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA916187B (en) | 1992-04-29 |
| SG165594G (en) | 1995-05-12 |
| IE72160B1 (en) | 1997-03-26 |
| KR920005983A (ko) | 1992-04-27 |
| ATE112166T1 (de) | 1994-10-15 |
| EP0474580A2 (de) | 1992-03-11 |
| DE69104314D1 (de) | 1994-11-03 |
| EP0474580A3 (en) | 1992-06-03 |
| AU644204B2 (en) | 1993-12-02 |
| AU8259491A (en) | 1992-03-12 |
| DE69104314T2 (de) | 1995-02-16 |
| KR970002246B1 (ko) | 1997-02-26 |
| JPH04244024A (ja) | 1992-09-01 |
| CA2049368C (en) | 2001-10-23 |
| NZ239437A (en) | 1997-02-24 |
| DK0474580T3 (da) | 1995-04-03 |
| EP0474580B1 (de) | 1994-09-28 |
| CA2049368A1 (en) | 1992-03-07 |
| IE912682A1 (en) | 1992-03-11 |
| IL98968A0 (en) | 1992-07-15 |
| HK21595A (en) | 1995-02-24 |
| JPH085787B2 (ja) | 1996-01-24 |
| DK213290D0 (da) | 1990-09-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |