IL98881A - Esters of 2-amino-6-alkoxyl-9-(beta-d-arabinofuranosyl)-9h-purine derivatives their preparation and immunomodulating compositions containing them - Google Patents

Esters of 2-amino-6-alkoxyl-9-(beta-d-arabinofuranosyl)-9h-purine derivatives their preparation and immunomodulating compositions containing them

Info

Publication number
IL98881A
IL98881A IL9888191A IL9888191A IL98881A IL 98881 A IL98881 A IL 98881A IL 9888191 A IL9888191 A IL 9888191A IL 9888191 A IL9888191 A IL 9888191A IL 98881 A IL98881 A IL 98881A
Authority
IL
Israel
Prior art keywords
amino
purine
mmol
methoxy
arabinofuranosyl
Prior art date
Application number
IL9888191A
Other languages
English (en)
Other versions
IL98881A0 (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IL98881A0 publication Critical patent/IL98881A0/xx
Publication of IL98881A publication Critical patent/IL98881A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Earth Drilling (AREA)
  • Stereophonic System (AREA)
IL9888191A 1990-07-19 1991-07-18 Esters of 2-amino-6-alkoxyl-9-(beta-d-arabinofuranosyl)-9h-purine derivatives their preparation and immunomodulating compositions containing them IL98881A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909015914A GB9015914D0 (en) 1990-07-19 1990-07-19 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
IL98881A0 IL98881A0 (en) 1992-07-15
IL98881A true IL98881A (en) 1996-01-19

Family

ID=10679359

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9888191A IL98881A (en) 1990-07-19 1991-07-18 Esters of 2-amino-6-alkoxyl-9-(beta-d-arabinofuranosyl)-9h-purine derivatives their preparation and immunomodulating compositions containing them

Country Status (23)

Country Link
US (3) US5492897A (ja)
EP (1) EP0539479B1 (ja)
JP (1) JP2873086B2 (ja)
KR (1) KR100187326B1 (ja)
AT (1) ATE151637T1 (ja)
CA (1) CA2087543C (ja)
CY (1) CY2165B1 (ja)
DE (1) DE69125715T2 (ja)
DK (1) DK0539479T3 (ja)
ES (1) ES2103311T3 (ja)
GB (1) GB9015914D0 (ja)
GR (1) GR3023776T3 (ja)
HU (2) HUT62911A (ja)
IE (1) IE912513A1 (ja)
IL (1) IL98881A (ja)
MC (1) MC2289A1 (ja)
MY (1) MY111871A (ja)
NZ (1) NZ239025A (ja)
PT (1) PT98371B (ja)
RU (1) RU2114860C1 (ja)
TW (1) TW208655B (ja)
WO (1) WO1992001456A1 (ja)
ZA (1) ZA915656B (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds
AU6771198A (en) * 1997-03-24 1998-10-20 Glaxo Group Limited Method for treating b-cell tumors with ara-g nucleoside derivatives
ES2284256T3 (es) * 1998-07-02 2007-11-01 Kyowa Hakko Kogyo Co., Ltd. Medicamentos para la diabetes.
US6753322B2 (en) * 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
DE60234376D1 (de) * 2001-11-27 2009-12-24 Anadys Pharmaceuticals Inc 3-beta-d-ribofuranosylthiazolo(4,5-delta)pyridimin-nucleoside und ihre verwendung
AU2003261354A1 (en) * 2002-08-02 2004-02-23 The Regents Of The University Of California New uses for inhibitors of inosine monophosphate dehydrogenase
CA2537450C (en) * 2003-09-05 2012-04-17 Anadys Pharmaceuticals, Inc. Administration of tlr7 ligands and prodrugs thereof for treatment of infection by hepatitis c virus
GB0321613D0 (en) * 2003-09-15 2003-10-15 Drug Discovery Lab As Compounds
EP1804838A2 (en) * 2004-09-15 2007-07-11 Drug Discovery Laboratory AS Drug conjugates of long chain fatty acid or ester moieties as protein binding prodrugs
US20090082304A1 (en) * 2004-11-12 2009-03-26 Northwestern University Methods of Treating Hematological Malignancies with Nucleoside Analog Drugs
TWI407956B (zh) * 2004-12-17 2013-09-11 Anadys Pharmaceuticals Inc ３，５-二取代和３，５，７-三取代-３Ｈ-唑并及３Ｈ-噻唑并〔４，５-ｄ〕嘧啶-２-酮化合物及其前藥
US20060189543A1 (en) * 2005-02-23 2006-08-24 Rosenbloom Richard A Compositions and methods for the treatment of leukemia
EP1973920B1 (en) 2005-11-21 2010-07-21 Anadys Pharmaceuticals, Inc. Process for the preparation of 5-amino-3h-thiazolo [4,5-d] pyrimidin-2-one
ATE496924T1 (de) * 2006-06-22 2011-02-15 Anadys Pharmaceuticals Inc Prodrugs von 5-amino-3-(3'-deoxy-beta-d- ribofuranosyl)-thiazolä4,5-düpyrimidin-2,7-dion
DE602007012881D1 (en) 2006-07-18 2011-04-14 Anadys Pharmaceuticals Inc Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen
CN101768197A (zh) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 一种奈拉滨的制备方法
US9351989B2 (en) 2010-12-29 2016-05-31 Inhibitex, Inc. Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
WO2018230479A1 (ja) * 2017-06-13 2018-12-20 大原薬品工業株式会社 ヌクレオシド系抗がん剤又は抗ウィルス剤の５'位シリルエーテル誘導体
JP2024503755A (ja) * 2020-12-30 2024-01-26 サウザン・ユニバーシティ・オブ・サイエンス・アンド・テクノロジー ウイルス感染症治療用ヌクレオシド系化合物及びその用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2152486A1 (de) * 1970-11-20 1972-06-29 Akad Wissenschaften Ddr Verfahren zur Herstellung von 5'-Desoxy-5'-fluor-6-methyl-mercaptopurinribosid
US3872084A (en) * 1972-10-10 1975-03-18 Syntex Inc Purine nucleoside 3,5-cyclicphosphate compounds
US4081534A (en) * 1973-09-11 1978-03-28 Burroughs Wellcome Co. Amino purine nucleosides as autoimmune suppressant agents
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
JPS61233696A (ja) * 1985-04-08 1986-10-17 Kanegafuchi Chem Ind Co Ltd ７−ヒドロキシグアニン誘導体及びその製造方法並びにそれを有効成分とする抗腫瘍剤
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
CA1317291C (en) * 1987-12-14 1993-05-04 Naeem Botros Hanna Antitumor 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and related compounds
US5352669A (en) * 1990-03-13 1994-10-04 The Of The United States Of America As Represented By The Department Of Health And Human Services O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds

Also Published As

Publication number Publication date
US5821236A (en) 1998-10-13
MY111871A (en) 2001-02-28
JP2873086B2 (ja) 1999-03-24
DK0539479T3 (da) 1997-08-25
IE912513A1 (en) 1992-01-29
IL98881A0 (en) 1992-07-15
EP0539479A1 (en) 1993-05-05
TW208655B (ja) 1993-07-01
GR3023776T3 (en) 1997-09-30
AU8196091A (en) 1992-02-18
PT98371A (pt) 1992-06-30
US5492897A (en) 1996-02-20
ZA915656B (en) 1993-03-31
AU641533B2 (en) 1993-09-23
ES2103311T3 (es) 1997-09-16
EP0539479B1 (en) 1997-04-16
NZ239025A (en) 1993-08-26
HUT62911A (en) 1993-06-28
CA2087543A1 (en) 1992-01-20
DE69125715T2 (de) 1997-08-07
CY2165B1 (en) 2002-08-23
JPH05508649A (ja) 1993-12-02
US5747472A (en) 1998-05-05
DE69125715D1 (de) 1997-05-22
WO1992001456A1 (en) 1992-02-06
PT98371B (pt) 1999-01-29
MC2289A1 (fr) 1993-07-14
RU2114860C1 (ru) 1998-07-10
KR100187326B1 (ko) 1999-05-01
HU9300115D0 (en) 1993-04-28
ATE151637T1 (de) 1997-05-15
CA2087543C (en) 1998-08-25
GB9015914D0 (en) 1990-09-05

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