IL98133A - 2-alkyl-1, 2, 3, 4, 4a, 10b-hexahydro-6-(sulfonamidophenyl)-benzo-(c)-1, 6-naphthyridine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

2-alkyl-1, 2, 3, 4, 4a, 10b-hexahydro-6-(sulfonamidophenyl)-benzo-(c)-1, 6-naphthyridine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number
IL98133A
IL98133A IL9813391A IL9813391A IL98133A IL 98133 A IL98133 A IL 98133A IL 9813391 A IL9813391 A IL 9813391A IL 9813391 A IL9813391 A IL 9813391A IL 98133 A IL98133 A IL 98133A
Authority
IL
Israel
Prior art keywords
compounds
denotes
alkyl
salts
methyl
Prior art date
Application number
IL9813391A
Other languages
English (en)
Other versions
IL98133A0 (en
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of IL98133A0 publication Critical patent/IL98133A0/xx
Publication of IL98133A publication Critical patent/IL98133A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Heat Treatment Of Steel (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL9813391A 1990-05-16 1991-05-14 2-alkyl-1, 2, 3, 4, 4a, 10b-hexahydro-6-(sulfonamidophenyl)-benzo-(c)-1, 6-naphthyridine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same IL98133A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH165890 1990-05-16

Publications (2)

Publication Number Publication Date
IL98133A0 IL98133A0 (en) 1992-06-21
IL98133A true IL98133A (en) 1994-11-11

Family

ID=4215610

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9813391A IL98133A (en) 1990-05-16 1991-05-14 2-alkyl-1, 2, 3, 4, 4a, 10b-hexahydro-6-(sulfonamidophenyl)-benzo-(c)-1, 6-naphthyridine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same

Country Status (23)

Country Link
US (1) US5346904A (fr)
EP (1) EP0528922B1 (fr)
JP (1) JP3238397B2 (fr)
CN (1) CN1027507C (fr)
AT (1) ATE181330T1 (fr)
AU (1) AU651592B2 (fr)
CA (1) CA2082923C (fr)
CS (1) CS144791A3 (fr)
DE (3) DE4191109A1 (fr)
DK (1) DK0528922T3 (fr)
ES (1) ES2134777T3 (fr)
FI (1) FI925005A (fr)
GR (1) GR3031098T3 (fr)
HU (2) HUT62895A (fr)
IE (1) IE911625A1 (fr)
IL (1) IL98133A (fr)
MY (1) MY105344A (fr)
NO (1) NO924414L (fr)
NZ (1) NZ238141A (fr)
PT (1) PT97680B (fr)
WO (1) WO1991017991A1 (fr)
YU (1) YU85691A (fr)
ZA (1) ZA913627B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0612247A1 (fr) * 1991-11-15 1994-08-31 Byk Gulden Lomberg Chemische Fabrik GmbH Utilisation de composes de sulfonyle
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
EA001551B1 (ru) * 1996-11-11 2001-04-23 Бык Гюльден Ломберг Хемише Фабрик Гмбх Бензонафтиридины в качестве бронхиальных терапевтических средств
AU6825898A (en) * 1997-03-07 1998-09-29 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel tetrazoles
AU8106598A (en) * 1997-06-03 1998-12-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine
EP0997462B1 (fr) 1997-06-30 2004-12-22 Nippon Kayaku Kabushiki Kaisha Nouveaux derives de naphthyridine ou leurs sels
CA2381802C (fr) 1999-08-21 2010-12-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Combinaison synergique de roflumilast et de salmeterol
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EA200501548A1 (ru) 2003-04-01 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. Ингибиторы фосфодиэстераз при бесплодии
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2170930B3 (fr) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US8196556B2 (en) * 2009-09-17 2012-06-12 Delphi Technologies, Inc. Apparatus and method for setting mechanical lash in a valve-deactivating hydraulic lash adjuster
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
DK2681236T3 (en) 2011-03-01 2018-04-16 Synergy Pharmaceuticals Inc PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS
EP2958577A2 (fr) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Agonistes du recepteur de la guanylate cyclase pour l'utilisation dans l'irrigation du colon
WO2014151206A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
CA2905435A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
EP3004138B1 (fr) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Agonistes ultra-purs de guanylate cyclase c, leur procédé de production et d'utilisation
AU2014305843B2 (en) 2013-08-09 2019-08-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899494A (en) * 1970-05-13 1975-08-12 Sandoz Ltd Substituted 6-phenyl benzo-naphthyridines
US4087530A (en) * 1974-02-05 1978-05-02 Sandoz Ltd. Substituted 6-phenyl-octahydrobenzo [c] [1,6] naphthyridines
DK136189B (da) * 1974-02-05 1977-08-29 Sandoz Ag Analogifremgangsmåde til fremstilling af benzo(c)(1,6)naphthyridinderivater eller syreadditionssalte deraf.
EP0247971A3 (fr) * 1986-05-29 1990-01-17 Sandoz Ag Compositions pharmaceutiques contenant de la cis-6-(4-acétanilido)-8,9-diméthoxy-2-méthyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphtyridine et son utilisation

Also Published As

Publication number Publication date
US5346904A (en) 1994-09-13
JP3238397B2 (ja) 2001-12-10
IE911625A1 (en) 1991-11-20
CA2082923A1 (fr) 1991-11-17
ATE181330T1 (de) 1999-07-15
EP0528922B1 (fr) 1999-06-16
NO924414D0 (no) 1992-11-16
FI925005A0 (fi) 1992-11-05
HUT62895A (en) 1993-06-28
AU651592B2 (en) 1994-07-28
CS144791A3 (en) 1992-03-18
DE59109135D1 (de) 1999-07-22
NO924414L (no) 1992-11-16
MY105344A (en) 1994-09-30
JPH05507081A (ja) 1993-10-14
CA2082923C (fr) 2001-12-18
ES2134777T3 (es) 1999-10-16
GR3031098T3 (en) 1999-12-31
WO1991017991A1 (fr) 1991-11-28
FI925005A (fi) 1992-11-05
ZA913627B (en) 1992-01-29
EP0528922A1 (fr) 1993-03-03
DK0528922T3 (da) 1999-11-22
DE4191109D2 (en) 1993-04-01
AU7870191A (en) 1991-12-10
NZ238141A (en) 1993-07-27
IL98133A0 (en) 1992-06-21
PT97680B (pt) 1998-09-30
YU85691A (sh) 1994-06-24
PT97680A (pt) 1992-02-28
CN1027507C (zh) 1995-01-25
DE4191109A1 (fr) 1993-04-01
HU9203557D0 (en) 1993-03-29
CN1056691A (zh) 1991-12-04

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