IL97814A - New inhibitors of alpha-monosidase and fucozirase, their preparation and pharmaceutical preparations containing them - Google Patents

New inhibitors of alpha-monosidase and fucozirase, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL97814A
IL97814A IL9781491A IL9781491A IL97814A IL 97814 A IL97814 A IL 97814A IL 9781491 A IL9781491 A IL 9781491A IL 9781491 A IL9781491 A IL 9781491A IL 97814 A IL97814 A IL 97814A
Authority
IL
Israel
Prior art keywords
group
compound
formula
optionally substituted
alkyl
Prior art date
Application number
IL9781491A
Other languages
English (en)
Hebrew (he)
Other versions
IL97814A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL97814A0 publication Critical patent/IL97814A0/xx
Publication of IL97814A publication Critical patent/IL97814A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
IL9781491A 1990-04-12 1991-04-10 New inhibitors of alpha-monosidase and fucozirase, their preparation and pharmaceutical preparations containing them IL97814A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50887590A 1990-04-12 1990-04-12

Publications (2)

Publication Number Publication Date
IL97814A0 IL97814A0 (en) 1992-06-21
IL97814A true IL97814A (en) 1995-08-31

Family

ID=24024437

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9781491A IL97814A (en) 1990-04-12 1991-04-10 New inhibitors of alpha-monosidase and fucozirase, their preparation and pharmaceutical preparations containing them

Country Status (19)

Country Link
EP (1) EP0451834B1 (xx)
JP (1) JP2955057B2 (xx)
KR (1) KR100197382B1 (xx)
CN (1) CN1033638C (xx)
AT (1) ATE140692T1 (xx)
AU (1) AU646855B2 (xx)
CA (1) CA2040058C (xx)
DE (1) DE69121000T2 (xx)
DK (1) DK0451834T3 (xx)
ES (1) ES2092520T3 (xx)
FI (1) FI109200B (xx)
GR (1) GR3020934T3 (xx)
HU (1) HU213396B (xx)
IE (1) IE75195B1 (xx)
IL (1) IL97814A (xx)
NO (1) NO175856C (xx)
NZ (1) NZ237734A (xx)
PT (1) PT97339B (xx)
ZA (1) ZA912588B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773239A (en) * 1993-10-19 1998-06-30 Mount Sinai Hospital Corporation. Mannosidase inhibitors, process for their preparation and their use as therapeutic agents
US5650413A (en) * 1995-06-07 1997-07-22 Glycodesign Inc. Derivatives of swainsonine, processes for their preparation and their use as therapeutic agents
AU736668B2 (en) * 1996-10-01 2001-08-02 Glycodesign Inc. Novel 3, 5, and/or 6 substituted analogues of swainsonine, processes for their preparation and their use as therapeutic agents
CA2286766A1 (en) 1997-04-15 1998-10-22 Glycodesign Inc. Alkaloid halide salts of swainsonine and methods of use
EP1023290A1 (en) * 1997-10-24 2000-08-02 Glycodesign Inc. Synthesis of swainsonine salts
JP6170675B2 (ja) * 2010-01-28 2017-07-26 ラプトール ファーマシューティカルズ インコーポレイテッド 受容体関連タンパク質（ｒａｐ）ペプチド−フコシダーゼ阻害薬複合体による肝障害処置のための方法
CN101870992A (zh) * 2010-06-21 2010-10-27 天津科技大学 利用基因工程菌耦合发酵合成gdp-岩藻糖的方法
CN102286608B (zh) * 2011-06-08 2014-06-25 郑州安图生物工程股份有限公司 衣原体诊断方法和试剂盒

Also Published As

Publication number Publication date
AU646855B2 (en) 1994-03-10
CN1055732A (zh) 1991-10-30
EP0451834A2 (en) 1991-10-16
FI911751A (fi) 1991-10-13
HUT60994A (en) 1992-11-30
ZA912588B (en) 1992-01-29
DE69121000T2 (de) 1996-12-19
EP0451834B1 (en) 1996-07-24
NO911419L (no) 1991-10-14
NO175856C (no) 1994-12-21
IL97814A0 (en) 1992-06-21
HU911196D0 (en) 1991-10-28
IE911229A1 (en) 1991-10-23
ATE140692T1 (de) 1996-08-15
ES2092520T3 (es) 1996-12-01
GR3020934T3 (en) 1996-12-31
NZ237734A (en) 1993-05-26
FI911751A0 (fi) 1991-04-11
PT97339B (pt) 1998-08-31
HU213396B (en) 1997-06-30
CA2040058A1 (en) 1991-10-13
NO911419D0 (no) 1991-04-11
JPH04234834A (ja) 1992-08-24
IE75195B1 (en) 1997-08-27
CN1033638C (zh) 1996-12-25
DK0451834T3 (da) 1996-08-26
AU7416491A (en) 1991-10-17
FI109200B (fi) 2002-06-14
PT97339A (pt) 1992-01-31
KR100197382B1 (ko) 1999-06-15
KR910018341A (ko) 1991-11-30
JP2955057B2 (ja) 1999-10-04
NO175856B (xx) 1994-09-12
DE69121000D1 (de) 1996-08-29
CA2040058C (en) 2001-10-23
EP0451834A3 (en) 1993-10-20

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Legal Events

Date Code Title Description
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees