IL97344A - Synergistic preparations containing B-lactam antibiotics and cationic oligopeptides for the treatment of inflammation - Google Patents

Synergistic preparations containing B-lactam antibiotics and cationic oligopeptides for the treatment of inflammation

Info

Publication number
IL97344A
IL97344A IL9734491A IL9734491A IL97344A IL 97344 A IL97344 A IL 97344A IL 9734491 A IL9734491 A IL 9734491A IL 9734491 A IL9734491 A IL 9734491A IL 97344 A IL97344 A IL 97344A
Authority
IL
Israel
Prior art keywords
lys
leu
ala
tyr
gly
Prior art date
Application number
IL9734491A
Other languages
English (en)
Hebrew (he)
Other versions
IL97344A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL97344A0 publication Critical patent/IL97344A0/xx
Publication of IL97344A publication Critical patent/IL97344A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
IL9734491A 1990-02-23 1991-02-24 Synergistic preparations containing B-lactam antibiotics and cationic oligopeptides for the treatment of inflammation IL97344A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48402090A 1990-02-23 1990-02-23
US65532191A 1991-02-19 1991-02-19
OA59988A OA10059A (en) 1990-02-23 1991-04-12 Compositions and methods for treating infections caused by organisms sensitive to beta-lactam antibiotics

Publications (2)

Publication Number Publication Date
IL97344A0 IL97344A0 (en) 1992-05-25
IL97344A true IL97344A (en) 1995-12-31

Family

ID=33314051

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9734491A IL97344A (en) 1990-02-23 1991-02-24 Synergistic preparations containing B-lactam antibiotics and cationic oligopeptides for the treatment of inflammation

Country Status (14)

Country Link
US (1) US5409898A (cs)
EP (1) EP0516747A4 (cs)
JP (1) JPH05506645A (cs)
CN (1) CN1054900A (cs)
AU (1) AU650262B2 (cs)
CA (1) CA2076529A1 (cs)
CZ (1) CZ47791A3 (cs)
FI (1) FI923747A0 (cs)
HU (1) HUT63567A (cs)
IE (1) IE910630A1 (cs)
IL (1) IL97344A (cs)
NZ (1) NZ237202A (cs)
OA (1) OA10059A (cs)
WO (1) WO1991012815A1 (cs)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613734B2 (en) * 1988-01-06 2003-09-02 The Scripps Research Institute Peptides-containing liposomal surfactants
US5885965A (en) * 1991-11-01 1999-03-23 Periodontix, Inc. Anti-fungal D-amino acid histatin-based peptides
US5646119A (en) * 1991-11-01 1997-07-08 Periodontix, Inc. D-amino acid histatin-based peptides as anti-fungal and anti-bacterial agents
US6458349B1 (en) 1995-06-02 2002-10-01 Human Genome Sciences, Inc. Chemokine β-4 polypeptides
US6391589B1 (en) 1994-08-23 2002-05-21 Human Genome Sciences, Inc. Human chemokine beta-10 mutant polypeptides
US6174995B1 (en) 1994-08-23 2001-01-16 Haodong Li Human chemokines, CKβ4 and CKβ10/MCP-4
WO1996035804A1 (en) * 1995-05-08 1996-11-14 Merck & Co., Inc. A novel biochemical interaction in bacteria
US5747453A (en) * 1995-06-06 1998-05-05 Alza Corporation Method for increasing the electrotransport flux of polypeptides
US6290948B1 (en) * 1996-05-14 2001-09-18 Smithkline Beecham Corporation Method of treating sepsis and ARDS using chamohine beta-10
US6180604B1 (en) 1996-08-21 2001-01-30 Micrologix Biotech Inc. Compositions and methods for treating infections using analogues of indolicidin
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
NL1008139C2 (nl) * 1998-01-27 1999-07-28 Stichting Tech Wetenschapp Antimicrobiële peptiden.
WO1999042119A1 (en) 1998-02-18 1999-08-26 Harbor-Ucla Research And Education Institute Antimicrobial peptides and derived metapeptides
US7820619B1 (en) 1998-02-18 2010-10-26 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Antimicrobial peptides and derived metapeptides
US6191168B1 (en) 1998-06-02 2001-02-20 Edward Rubenstein Methods for the use of nonprotein amino acids as therapeutic agents
US6835536B2 (en) 2001-08-21 2004-12-28 Micrologix Biotech Inc. Antimicrobial cationic peptides and formulations thereof
CA2457885A1 (en) 2001-08-24 2003-03-06 Micrologix Biotech Inc. Antimicrobial and anti-inflammatory peptides
AR039475A1 (es) 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
EP1534752B1 (en) 2002-05-01 2011-08-03 Human Genome Sciences, Inc. Antibodies that specifically bind to chemokine beta-4
AR039774A1 (es) 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
PE20070403A1 (es) * 2005-07-27 2007-05-15 Wyeth Corp COMPOSICION FARMACEUTICA QUE COMPRENDE CEFEPIME Y DERIVADOS DE 6-ALQUILIDEN-PENEM BICICLICOS COMO INHIBIDORES DE ß-LACTAMASA
EP2536408A1 (en) * 2010-02-16 2012-12-26 Wockhardt Research Centre Efflux pump inhibitors
EA029419B1 (ru) 2010-11-19 2018-03-30 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Нейтрализующие антитела против ccl20
WO2012068187A1 (en) * 2010-11-19 2012-05-24 Merck Sharp & Dohme Corp. Poly(amide) polymers for the delivery of oligonucleotides
CN107320727A (zh) * 2016-04-29 2017-11-07 四川大学 抗菌肽与抗生素组合抗菌药物及其使用方法
US20230414719A1 (en) * 2020-11-09 2023-12-28 Arizona Board Of Regents On Behalf Of Arizona State University Methods of using platelet factor 4 as an antimicrobial agent

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE436645C (sv) * 1976-04-29 1996-07-22 Bonnierfoeretagen Ab Antigeniskt aktiv polypeptid, som kan användas vid cancerdiagnosticering och vid framställning av antikroppar
US4543252A (en) * 1982-01-21 1985-09-24 The Regents Of The University Of California Cationic oligopeptides having microbicidal activity
US4659692A (en) * 1982-11-19 1987-04-21 The Regents Of The University Of California Cationic oligopeptides having microbicidal activity
US4810777A (en) * 1987-03-04 1989-03-07 The United States Of America As Represented By The Department Of Health And Human Services Antimicrobial compounds
US5254535A (en) * 1989-04-17 1993-10-19 The Children's Hospital Of Pennsylvania Composition and treatment with biologically active peptides and antibiotic
US5045531A (en) * 1989-12-18 1991-09-03 Magainin Sciences Inc. Wound treatment employing biologically active ion channel forming peptides and proteins

Also Published As

Publication number Publication date
OA10059A (en) 1996-10-14
CN1054900A (zh) 1991-10-02
AU650262B2 (en) 1994-06-16
EP0516747A1 (en) 1992-12-09
FI923747A (fi) 1992-08-20
IE910630A1 (en) 1991-08-28
WO1991012815A1 (en) 1991-09-05
AU7485691A (en) 1991-09-18
JPH05506645A (ja) 1993-09-30
CA2076529A1 (en) 1991-08-24
NZ237202A (en) 1994-01-26
US5409898A (en) 1995-04-25
IL97344A0 (en) 1992-05-25
HUT63567A (en) 1993-09-28
FI923747A0 (fi) 1992-08-20
HU9202720D0 (en) 1992-12-28
CZ47791A3 (en) 1993-04-14
EP0516747A4 (en) 1993-03-24

Similar Documents

Publication Publication Date Title
US5409898A (en) Compositions and methods for treating infections caused by organisms sensitive to β-lactam antibiotics
US5578572A (en) Anti-gram-positive bacterial methods and materials
JP3860838B2 (ja) 抗微生物性陽イオン性ペプチドおよびそのスクリーニング方法
JP7267251B2 (ja) 抗菌組成物及び医薬組成物
RU2234940C2 (ru) Способ лечения стафилококковых инфекций у млекопитающего (варианты)
KR102544364B1 (ko) Romo1 유래 항균 펩타이드 및 그 변이체
US20080234188A1 (en) Antimicrobial Peptides
CN115397994A (zh) 新型多肽、融合多肽和包含其的抗革兰氏阴性菌的抗生素
CN111171159A (zh) 抗浮游菌和胞内菌感染的抗菌肽tat-kr-12及其制备方法与应用
US20220160842A1 (en) Method of treating infective endocarditis
US20220193186A1 (en) Method of treating and preventing bone and joint infections
WO2008104777A2 (en) Peptide
Ghiselli et al. Therapeutic efficacy of the polymyxin-like peptide ranalexin in an experimental model of endotoxemia
RU2813626C1 (ru) Модифицированный эндолизин и антибактериальные композиции на его основе для лечения инфекций, вызванных бактериями Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli
PL166731B1 (pl) Sposób wytwarzania środka do leczenia infekcji wywołanych przez organizmy wrażliwe na antybiotykiβ-laktamowe
PT96859A (pt) Processo para a preparacao de composicoes farmaceuticas e metodos para o tratamento de infeccoes provocadas por organismos sensiveis aos antibioticos beta-lactamicos

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees