IL95568A - 4-N-converted pyrimidinamines, a process for their preparation and pharmaceutical preparations containing them - Google Patents
4-N-converted pyrimidinamines, a process for their preparation and pharmaceutical preparations containing themInfo
- Publication number
- IL95568A IL95568A IL9556890A IL9556890A IL95568A IL 95568 A IL95568 A IL 95568A IL 9556890 A IL9556890 A IL 9556890A IL 9556890 A IL9556890 A IL 9556890A IL 95568 A IL95568 A IL 95568A
- Authority
- IL
- Israel
- Prior art keywords
- hydrogen
- indol
- loweralkyl
- compound
- compound according
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/402,415 US4983608A (en) | 1989-09-05 | 1989-09-05 | N-substituted-4-pyrimidinamines and pyrimidinediamines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL95568A0 IL95568A0 (en) | 1991-06-30 |
| IL95568A true IL95568A (en) | 1995-01-24 |
Family
ID=23591798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9556890A IL95568A (en) | 1989-09-05 | 1990-09-03 | 4-N-converted pyrimidinamines, a process for their preparation and pharmaceutical preparations containing them |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4983608A (de) |
| EP (1) | EP0417584B1 (de) |
| JP (1) | JPH07116181B2 (de) |
| KR (1) | KR0162641B1 (de) |
| AT (1) | ATE163012T1 (de) |
| AU (1) | AU626450B2 (de) |
| CA (1) | CA2024572C (de) |
| DE (1) | DE69032020T2 (de) |
| DK (1) | DK0417584T3 (de) |
| ES (1) | ES2112830T3 (de) |
| FI (1) | FI904327A0 (de) |
| GR (1) | GR3026318T3 (de) |
| IE (1) | IE903213A1 (de) |
| IL (1) | IL95568A (de) |
| NO (1) | NO903851L (de) |
| NZ (1) | NZ235145A (de) |
| PT (1) | PT95202B (de) |
| ZA (1) | ZA907033B (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5155098A (en) * | 1989-06-09 | 1992-10-13 | Hoechst-Roussel Pharmaceuticals Inc. | N-heteroaryl-purin-6-amines, and pharmaceutical compositions and methods employing them |
| US5214038A (en) * | 1991-04-15 | 1993-05-25 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof |
| US5319096A (en) * | 1992-04-03 | 1994-06-07 | Hoechst-Roussel Pharmaceuticals Inc. | (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use |
| US5459274A (en) * | 1994-05-13 | 1995-10-17 | Hoechst-Roussel Pharmaceuticals Inc. | Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines |
| US5935966A (en) * | 1995-09-01 | 1999-08-10 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| WO1997009325A1 (en) * | 1995-09-01 | 1997-03-13 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| US5852028A (en) * | 1995-12-18 | 1998-12-22 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
| ZA989365B (en) * | 1997-10-15 | 1999-04-15 | Boehringer Mannheim Pharm Corp | Preparation for treating alzheimer's disease |
| JP2002503662A (ja) | 1998-02-17 | 2002-02-05 | テュラリク インコーポレイテッド | 抗ウイルス性ピリミジン誘導体 |
| ATE336484T1 (de) | 1998-08-29 | 2006-09-15 | Astrazeneca Ab | Pyrimidine verbindungen |
| DE69933680T2 (de) * | 1998-08-29 | 2007-08-23 | Astrazeneca Ab | Pyrimidine verbindungen |
| GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
| GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
| GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| AU770600B2 (en) * | 1999-10-07 | 2004-02-26 | Amgen, Inc. | Triazine kinase inhibitors |
| US6410726B1 (en) | 2000-01-12 | 2002-06-25 | Tularik Inc. | Arylsulfonic acid salts of pyrimidine-based antiviral |
| CA2400447C (en) * | 2000-02-17 | 2008-04-22 | Amgen Inc. | Kinase inhibitors |
| GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004887D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004886D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004888D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0007371D0 (en) | 2000-03-28 | 2000-05-17 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
| GB0021726D0 (en) * | 2000-09-05 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| GB0103926D0 (en) * | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
| US7115617B2 (en) * | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
| US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
| TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| GB0205688D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| WO2003076434A1 (en) * | 2002-03-09 | 2003-09-18 | Astrazeneca Ab | 4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity |
| GB0205693D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| GB0205690D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| MXPA05001096A (es) | 2002-07-29 | 2005-11-23 | Rigel Pharmaceuticals Inc | Metodos para tratamiento o prevencion de enfermedades autoinmunes con compuestos de 2,4-diamino-pirimidina. |
| SI1534286T1 (sl) | 2002-07-29 | 2010-04-30 | Rigel Pharmaceuticals Inc | Postopki za zdravljenje ali prepreŽŤevanje avtoimunskih bolezni z 2,4-pirimidindiaminskimi spojinami |
| OA13309A (en) * | 2002-12-20 | 2007-04-13 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth. |
| UA80767C2 (en) * | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| US7109337B2 (en) * | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| GB0311276D0 (en) * | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
| GB0311274D0 (en) * | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
| US8178671B2 (en) * | 2003-07-30 | 2012-05-15 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds |
| TW200528101A (en) * | 2004-02-03 | 2005-09-01 | Astrazeneca Ab | Chemical compounds |
| JP2007537235A (ja) * | 2004-05-14 | 2007-12-20 | ファイザー・プロダクツ・インク | 異常細胞増殖の治療用ピリミジン誘導体 |
| WO2005111022A1 (en) * | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidines derivatives for the treatment of abnormal cell growth |
| US20060205945A1 (en) * | 2004-05-14 | 2006-09-14 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| EP1758887A1 (de) * | 2004-05-14 | 2007-03-07 | Pfizer Products Incorporated | Pyrimidinderivate zur behandlung von anormalem zellwachstum |
| US20060058525A1 (en) * | 2004-09-01 | 2006-03-16 | Rajinder Singh | Synthesis of 2,4-pyrimidinediamine compounds |
| WO2006068770A1 (en) * | 2004-11-24 | 2006-06-29 | Rigel Pharmaceuticals, Inc. | Spiro-2, 4-pyrimidinediamine compounds and their uses |
| CA2589793A1 (en) * | 2004-12-17 | 2006-06-22 | Astrazeneca Ab | 4-(4-(imidazol-4-yl)pyrimidin-2-ylamino) benzamides as cdk inhibitors |
| CA2604551A1 (en) * | 2005-05-03 | 2007-03-08 | Rigel Pharmaceuticals, Inc. | Jak kinase inhibitors and their uses |
| EP1912974A1 (de) * | 2005-07-30 | 2008-04-23 | AstraZeneca AB | Imidazolylpyrimidinverbindungen zur verwendung bei der behandlung von proliferativen erkrankungen |
| EP1934213A1 (de) * | 2005-09-30 | 2008-06-25 | Astra Zeneca AB | Imidazo [1,2-a] pyridin mit antizellproliferationswirkung |
| TW200811169A (en) * | 2006-05-26 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
| EP2134682B1 (de) | 2007-04-13 | 2011-12-14 | Sanofi | Übergangsmetallkatalysierte synthese von n-aminoindolen |
| GB2553716B (en) * | 2015-04-17 | 2020-06-17 | Univ Holy Ghost Duquesne | Pyrrolopyrimidines as antitumor agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4752610A (en) * | 1985-12-04 | 1988-06-21 | Hoechst-Roussel Pharmaceuticals Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing properties |
| US4792562A (en) | 1985-12-04 | 1988-12-20 | Hoechst-Roussel Pharmaceuticals, Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing activity |
| EP0287982B1 (de) * | 1987-04-24 | 1994-12-07 | Hoechst-Roussel Pharmaceuticals Incorporated | N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel |
| US4806554A (en) * | 1988-01-11 | 1989-02-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Pyrazol and indazolpyridinamines |
| US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
-
1989
- 1989-09-05 US US07/402,415 patent/US4983608A/en not_active Expired - Lifetime
-
1990
- 1990-09-01 DE DE69032020T patent/DE69032020T2/de not_active Expired - Lifetime
- 1990-09-01 ES ES90116826T patent/ES2112830T3/es not_active Expired - Lifetime
- 1990-09-01 EP EP90116826A patent/EP0417584B1/de not_active Expired - Lifetime
- 1990-09-01 DK DK90116826T patent/DK0417584T3/da active
- 1990-09-01 AT AT90116826T patent/ATE163012T1/de not_active IP Right Cessation
- 1990-09-03 IL IL9556890A patent/IL95568A/en unknown
- 1990-09-03 NZ NZ235145A patent/NZ235145A/en unknown
- 1990-09-03 FI FI904327A patent/FI904327A0/fi not_active IP Right Cessation
- 1990-09-04 IE IE321390A patent/IE903213A1/en not_active IP Right Cessation
- 1990-09-04 CA CA002024572A patent/CA2024572C/en not_active Expired - Lifetime
- 1990-09-04 KR KR1019900013896A patent/KR0162641B1/ko not_active IP Right Cessation
- 1990-09-04 AU AU62089/90A patent/AU626450B2/en not_active Ceased
- 1990-09-04 ZA ZA907033A patent/ZA907033B/xx unknown
- 1990-09-04 JP JP2232639A patent/JPH07116181B2/ja not_active Expired - Lifetime
- 1990-09-04 PT PT95202A patent/PT95202B/pt not_active IP Right Cessation
- 1990-09-04 NO NO90903851A patent/NO903851L/no unknown
-
1998
- 1998-03-11 GR GR980400509T patent/GR3026318T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US4983608A (en) | 1991-01-08 |
| DK0417584T3 (da) | 1998-09-23 |
| IE903213A1 (en) | 1991-03-13 |
| NZ235145A (en) | 1992-12-23 |
| PT95202B (pt) | 1997-06-30 |
| NO903851D0 (no) | 1990-09-04 |
| CA2024572C (en) | 2000-09-26 |
| KR910006277A (ko) | 1991-04-29 |
| ATE163012T1 (de) | 1998-02-15 |
| EP0417584A2 (de) | 1991-03-20 |
| EP0417584A3 (en) | 1992-02-26 |
| ES2112830T3 (es) | 1998-04-16 |
| CA2024572A1 (en) | 1991-03-06 |
| ZA907033B (en) | 1991-06-26 |
| JPH07116181B2 (ja) | 1995-12-13 |
| PT95202A (pt) | 1991-05-22 |
| NO903851L (no) | 1991-03-06 |
| KR0162641B1 (ko) | 1998-12-01 |
| AU6208990A (en) | 1991-03-14 |
| FI904327A0 (fi) | 1990-09-03 |
| AU626450B2 (en) | 1992-07-30 |
| DE69032020T2 (de) | 1998-07-09 |
| DE69032020D1 (de) | 1998-03-12 |
| GR3026318T3 (en) | 1998-06-30 |
| JPH0393784A (ja) | 1991-04-18 |
| EP0417584B1 (de) | 1998-02-04 |
| IL95568A0 (en) | 1991-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| HC | Change of name of proprietor(s) | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed |