IL94482A - Transdominant repressor mutant of retroviral protein, dna encoding the protein and process for their preparation and use thereof - Google Patents

Transdominant repressor mutant of retroviral protein, dna encoding the protein and process for their preparation and use thereof

Info

Publication number
IL94482A
IL94482A IL9448290A IL9448290A IL94482A IL 94482 A IL94482 A IL 94482A IL 9448290 A IL9448290 A IL 9448290A IL 9448290 A IL9448290 A IL 9448290A IL 94482 A IL94482 A IL 94482A
Authority
IL
Israel
Prior art keywords
viral
protein
transdominant
htlv
hiv
Prior art date
Application number
IL9448290A
Other languages
English (en)
Other versions
IL94482A0 (en
Original Assignee
Univ Duke
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898915602A external-priority patent/GB8915602D0/en
Priority claimed from GB898924396A external-priority patent/GB8924396D0/en
Application filed by Univ Duke, Novartis Ag filed Critical Univ Duke
Publication of IL94482A0 publication Critical patent/IL94482A0/xx
Publication of IL94482A publication Critical patent/IL94482A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036Retroviridae, e.g. leukemia viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/14011Deltaretrovirus, e.g. bovine leukeamia virus
    • C12N2740/14022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16311Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • AIDS & HIV (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL9448290A 1989-05-25 1990-05-23 Transdominant repressor mutant of retroviral protein, dna encoding the protein and process for their preparation and use thereof IL94482A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35687889A 1989-05-25 1989-05-25
GB898915602A GB8915602D0 (en) 1989-07-07 1989-07-07 Multivalent repressor of gene function
GB898924396A GB8924396D0 (en) 1989-10-30 1989-10-30 Multivalent repressor of gene function
US44267089A 1989-11-29 1989-11-29

Publications (2)

Publication Number Publication Date
IL94482A0 IL94482A0 (en) 1991-03-10
IL94482A true IL94482A (en) 2003-09-17

Family

ID=27450368

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9448290A IL94482A (en) 1989-05-25 1990-05-23 Transdominant repressor mutant of retroviral protein, dna encoding the protein and process for their preparation and use thereof

Country Status (13)

Country Link
EP (1) EP0406557B1 (hu)
JP (2) JP3126378B2 (hu)
KR (1) KR100215949B1 (hu)
AT (1) ATE207122T1 (hu)
AU (2) AU648256B2 (hu)
CA (1) CA2032158C (hu)
DE (1) DE69033829T2 (hu)
DK (1) DK0406557T3 (hu)
ES (1) ES2166748T3 (hu)
FI (1) FI110437B (hu)
HU (2) HU217091B (hu)
IL (1) IL94482A (hu)
WO (1) WO1990014427A2 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0554389T4 (da) * 1990-10-17 2002-11-11 Us Health Molekylære kloner af HIV-1 og anvendelse deraf
US5534408A (en) * 1993-09-24 1996-07-09 University Of Massachusetts Medical Center 2-deoxystreptamine aminoglycoside inhibition of HIV RRE/Rev binding
US5650306A (en) * 1993-06-07 1997-07-22 University Of Michigan Recombinant nucleic acids for inhibiting HIV gene expression
WO1995004546A1 (en) * 1993-08-06 1995-02-16 Kai Juhani Ernst Krohn Novel mutated human and simian immunodeficiency viruses and vaccines containing said viruses
US6228369B1 (en) 1993-12-13 2001-05-08 Transgene S.A. Composition of trans-dominant variants of viral proteins for obtaining an anti-viral effect
US5981258A (en) * 1993-12-13 1999-11-09 Transgene S.A. Composition of trans-dominant variants of viral proteins for obtaining an antiviral effect
FR2713651B1 (fr) * 1993-12-13 1996-04-19 Transgene Sa Nouvelle composition pour un effet antiviral.
ES2177922T3 (es) 1996-01-26 2002-12-16 Virco Bvba Metodo de valoracion la quimioterapia de pacientes hiv-positivos basado en la sensibilidad fenotipica a los farmacos de las cepas de hiv delpaciente.
EP0914444A1 (en) * 1996-06-06 1999-05-12 Novartis AG Vectors comprising sar elements
US6776986B1 (en) 1996-06-06 2004-08-17 Novartis Ag Inhibition of HIV-1 replication by antisense RNA expression
NZ333190A (en) * 1996-06-06 2001-03-30 Systemix Inc Inhibition of HIV-1 replication by antisense RNA expression using transduced hematopoietic cells
CA2355836A1 (en) * 1998-12-22 2000-06-29 Subsidiary No. 3, Inc. Genetic suppressor elements against human immunodeficiency virus
AU2493300A (en) * 1999-01-06 2000-07-24 Regents Of The University Of California, The Modulation of hiv replication using sam68
WO2004064501A2 (en) 2003-01-23 2004-08-05 Gala Design Inc. Transgenic animals expressing transdominant negative retroviral nucleic acids and proteins
JP5653549B1 (ja) 2014-05-30 2015-01-14 株式会社松風 イオン徐放性歯科用レジン系仮封材組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935372A (en) * 1986-05-20 1990-06-19 Dana Farber Cancer Institute Art nucleotide segments, vectors, cell lines methods of preparation and use

Also Published As

Publication number Publication date
AU648256B2 (en) 1994-04-21
AU5738890A (en) 1990-12-18
HU211530A9 (en) 1995-11-28
CA2032158A1 (en) 1990-11-26
AU678478B2 (en) 1997-05-29
JP3126378B2 (ja) 2001-01-22
JPH04500009A (ja) 1992-01-09
FI910371A0 (fi) 1991-01-24
WO1990014427A3 (en) 1991-01-10
HU217091B (hu) 1999-11-29
WO1990014427A2 (en) 1990-11-29
EP0406557A2 (en) 1991-01-09
JPH10165188A (ja) 1998-06-23
EP0406557B1 (en) 2001-10-17
HUT56135A (en) 1991-07-29
CA2032158C (en) 2009-09-15
DE69033829T2 (de) 2002-04-04
HU904245D0 (en) 1991-06-28
ATE207122T1 (de) 2001-11-15
JP3159671B2 (ja) 2001-04-23
DE69033829D1 (de) 2001-11-22
FI110437B (fi) 2003-01-31
DK0406557T3 (da) 2002-02-11
EP0406557A3 (en) 1991-05-02
ES2166748T3 (es) 2002-05-01
IL94482A0 (en) 1991-03-10
AU6757394A (en) 1994-11-17
KR100215949B1 (ko) 1999-08-16
KR920701440A (ko) 1992-08-11

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