IL94163A - Insulin analogues - Google Patents

Insulin analogues

Info

Publication number
IL94163A
IL94163A IL9416390A IL9416390A IL94163A IL 94163 A IL94163 A IL 94163A IL 9416390 A IL9416390 A IL 9416390A IL 9416390 A IL9416390 A IL 9416390A IL 94163 A IL94163 A IL 94163A
Authority
IL
Israel
Prior art keywords
insulin
leu
cys
analogue
chain
Prior art date
Application number
IL9416390A
Other languages
English (en)
Other versions
IL94163A0 (en
Inventor
Panayotis G Katsoyannis
Original Assignee
Sinai School Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinai School Medicine filed Critical Sinai School Medicine
Priority to IL11143790A priority Critical patent/IL111437A/en
Publication of IL94163A0 publication Critical patent/IL94163A0/xx
Priority to IL11143794A priority patent/IL111437A0/xx
Publication of IL94163A publication Critical patent/IL94163A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
IL9416390A 1989-04-20 1990-04-22 Insulin analogues IL94163A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL11143790A IL111437A (en) 1989-04-20 1990-04-22 Insulin analogues
IL11143794A IL111437A0 (en) 1989-04-20 1994-10-28 Insulin analogues

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34092989A 1989-04-20 1989-04-20

Publications (2)

Publication Number Publication Date
IL94163A0 IL94163A0 (en) 1991-01-31
IL94163A true IL94163A (en) 1995-08-31

Family

ID=23335524

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9416390A IL94163A (en) 1989-04-20 1990-04-22 Insulin analogues

Country Status (15)

Country Link
EP (1) EP0469084B1 (ja)
JP (1) JPH04504858A (ja)
AT (1) ATE120762T1 (ja)
AU (1) AU631868B2 (ja)
CA (1) CA2014896A1 (ja)
DE (1) DE69018461T2 (ja)
FI (1) FI914898A0 (ja)
GR (1) GR1000908B (ja)
HU (1) HU210142B (ja)
IE (1) IE67353B1 (ja)
IL (1) IL94163A (ja)
NO (1) NO301544B1 (ja)
PT (1) PT93832B (ja)
WO (1) WO1990012814A1 (ja)
ZA (1) ZA902965B (ja)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK158390D0 (da) * 1990-07-02 1990-07-02 Novo Nordisk As Nye peptider
DK33591D0 (ja) * 1991-02-27 1991-02-27 Novo Nordisk As
US5268453A (en) * 1991-08-08 1993-12-07 Scios Inc. Tissue-selective insulin analogs
GB9316895D0 (en) * 1993-08-13 1993-09-29 Guy S And St Thomas Hospitals Hepatoselective insulin analogues
US5873358A (en) * 1993-01-29 1999-02-23 Aradigm Corporation Method of maintaining a diabetic patient's blood glucose level in a desired range
US5915378A (en) * 1993-01-29 1999-06-29 Aradigm Corporation Creating an aerosolized formulation of insulin
US5970973A (en) * 1993-01-29 1999-10-26 Aradigm Corporation Method of delivering insulin lispro
US5888477A (en) * 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US6024090A (en) 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US6131567A (en) * 1993-01-29 2000-10-17 Aradigm Corporation Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
US5743250A (en) * 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
TW360548B (en) * 1993-04-08 1999-06-11 Powderject Res Ltd Products for therapeutic use
US6342225B1 (en) 1993-08-13 2002-01-29 Deutshces Wollforschungsinstitut Pharmaceutical active conjugates
AUPP609198A0 (en) * 1998-09-22 1998-10-15 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
EP1174437A4 (en) * 1999-04-26 2006-03-15 Ajinomoto Kk HORMONAL INHIBITOR STIMULATING MELANOCYTES
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
US7906618B2 (en) 2004-08-18 2011-03-15 Kaneka Corporation Peptide capable of binding to insulin-binding protein and adsorbent
ES2368500T3 (es) 2005-08-16 2011-11-17 Novo Nordisk A/S Método para producir polipéptidos de insulina maduros.
CN101541830A (zh) 2006-09-22 2009-09-23 诺沃-诺迪斯克有限公司 蛋白酶抗性的胰岛素类似物
JP5503968B2 (ja) 2006-09-27 2014-05-28 ノボ・ノルデイスク・エー／エス 成熟インスリンポリペプチドの作製方法
WO2009099763A1 (en) 2008-01-30 2009-08-13 Indiana University Research And Technology Corporation Ester-based peptide prodrugs
WO2009112583A2 (en) 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
EP2910571B1 (en) 2008-03-18 2016-10-05 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
CN102245633A (zh) * 2008-12-09 2011-11-16 诺沃—诺迪斯克有限公司 新的胰岛素类似物
WO2010080606A1 (en) 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Insulin analogs
AU2009335715B2 (en) * 2008-12-19 2016-09-15 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
CA2802485C (en) 2010-06-16 2019-09-17 Indiana University Research And Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
CN103119057B (zh) 2010-06-24 2016-06-15 印第安纳大学研究及科技有限公司 基于酰胺的胰岛素前药
JP6392123B2 (ja) 2011-12-20 2018-09-19 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ 糖尿病治療のためのｃｔｐ系インスリンアナローグ
EP3395358B1 (en) 2012-09-26 2019-11-06 Indiana University Research and Technology Corporation Insulin analog dimers
CN105358531B (zh) 2013-03-14 2017-11-14 利兰-斯坦福大学初级学院的董事会 线粒体醛脱氢酶‑2调节剂和其使用方法
US20160024169A1 (en) 2013-03-14 2016-01-28 Indiana University Research And Technology Corporation Insulin-incretin conjugates
ES2676065T3 (es) 2013-10-07 2018-07-16 Novo Nordisk A/S Nuevo derivado de un análogo de la insulina
JP6701208B2 (ja) 2014-09-24 2020-05-27 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション 脂質化アミド系インスリンプロドラッグ
WO2016049190A1 (en) 2014-09-24 2016-03-31 Indiana University Research And Technology Corporation Incretin-insulin conjugates
MA49116A (fr) 2016-12-16 2020-03-25 Novo Nordisk As Compositions pharmaceutiques contenant de l'insuline

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation

Also Published As

Publication number Publication date
ZA902965B (en) 1991-02-27
IE901404L (en) 1990-10-20
HU903398D0 (en) 1991-12-30
NO914085D0 (no) 1991-10-17
CA2014896A1 (en) 1990-10-20
DE69018461T2 (de) 1995-08-03
WO1990012814A1 (en) 1990-11-01
AU5541590A (en) 1990-11-16
AU631868B2 (en) 1992-12-10
IE67353B1 (en) 1996-03-20
PT93832A (pt) 1990-11-20
GR1000908B (el) 1993-03-16
HUT59941A (en) 1992-07-28
PT93832B (pt) 1996-09-30
EP0469084B1 (en) 1995-04-05
IL94163A0 (en) 1991-01-31
JPH04504858A (ja) 1992-08-27
EP0469084A1 (en) 1992-02-05
DE69018461D1 (de) 1995-05-11
NO301544B1 (no) 1997-11-10
NO914085L (no) 1991-11-28
GR900100290A (en) 1991-09-27
FI914898A0 (fi) 1991-10-17
HU210142B (en) 1995-02-28
ATE120762T1 (de) 1995-04-15

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Legal Events

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KB Patent renewed
RH Patent void