IL92307A0 - Hydroxy-1,2,3,4-tetrahydroamino-acridines,a process for their preparation and pharmaceutical compositions containing them - Google Patents
Hydroxy-1,2,3,4-tetrahydroamino-acridines,a process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL92307A0 IL92307A0 IL92307A IL9230789A IL92307A0 IL 92307 A0 IL92307 A0 IL 92307A0 IL 92307 A IL92307 A IL 92307A IL 9230789 A IL9230789 A IL 9230789A IL 92307 A0 IL92307 A0 IL 92307A0
- Authority
- IL
- Israel
- Prior art keywords
- hydroxy
- preparation
- loweralkyl
- tetrahydroamino
- acridines
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 230000006949 cholinergic function Effects 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000007074 memory dysfunction Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
- C07D219/12—Amino-alkylamino radicals attached in position 9
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27178888A | 1988-11-16 | 1988-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL92307A0 true IL92307A0 (en) | 1990-07-26 |
Family
ID=23037088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL92307A IL92307A0 (en) | 1988-11-16 | 1989-11-14 | Hydroxy-1,2,3,4-tetrahydroamino-acridines,a process for their preparation and pharmaceutical compositions containing them |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0369388B1 (de) |
| KR (1) | KR0156241B1 (de) |
| AT (1) | ATE89553T1 (de) |
| CA (1) | CA2003023C (de) |
| DE (1) | DE68906647T2 (de) |
| DK (1) | DK168290B1 (de) |
| ES (1) | ES2054987T3 (de) |
| FI (1) | FI90417C (de) |
| HU (2) | HU208674B (de) |
| IE (1) | IE63038B1 (de) |
| IL (1) | IL92307A0 (de) |
| NO (1) | NO894547L (de) |
| NZ (1) | NZ231376A (de) |
| PT (1) | PT92319B (de) |
| ZA (1) | ZA898720B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200462B (de) * | 1990-09-27 | 1993-02-21 | Hoechst Roussel Pharma | |
| GB2264707A (en) * | 1991-06-18 | 1993-09-08 | Roger Michael Marchbanks | Acridine derivatives for treating alzheimer's disease |
| US5422350A (en) * | 1992-09-10 | 1995-06-06 | Warner-Lambert Company | Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use |
| US5466696A (en) * | 1992-09-10 | 1995-11-14 | Warner Lambert Company | Tacrine and cytochrome P450 oxidase inhibitors and methods of use |
| WO2019207604A1 (en) * | 2018-04-25 | 2019-10-31 | Rajiv Gandhi Centre For Biotechnology | Tacrine derivatives targeting nmda receptor, acetylcholine esterase, butyryl choline and beta secretase activity |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3582995D1 (de) * | 1984-10-25 | 1991-07-04 | Hoechst Roussel Pharma | 9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel. |
| EP0282959A3 (de) * | 1987-03-17 | 1989-05-31 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituierte 9-Amino-tetrahydroacridine und verwandte Verbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
-
1989
- 1989-11-14 DE DE89121037T patent/DE68906647T2/de not_active Expired - Fee Related
- 1989-11-14 AT AT89121037T patent/ATE89553T1/de not_active IP Right Cessation
- 1989-11-14 IL IL92307A patent/IL92307A0/xx unknown
- 1989-11-14 FI FI895416A patent/FI90417C/fi not_active IP Right Cessation
- 1989-11-14 ES ES89121037T patent/ES2054987T3/es not_active Expired - Lifetime
- 1989-11-14 NZ NZ231376A patent/NZ231376A/en unknown
- 1989-11-14 EP EP89121037A patent/EP0369388B1/de not_active Expired - Lifetime
- 1989-11-14 KR KR1019890016456A patent/KR0156241B1/ko not_active Expired - Fee Related
- 1989-11-15 PT PT92319A patent/PT92319B/pt active IP Right Grant
- 1989-11-15 ZA ZA898720A patent/ZA898720B/xx unknown
- 1989-11-15 CA CA002003023A patent/CA2003023C/en not_active Expired - Fee Related
- 1989-11-15 IE IE365989A patent/IE63038B1/en not_active IP Right Cessation
- 1989-11-15 DK DK571989A patent/DK168290B1/da not_active IP Right Cessation
- 1989-11-15 NO NO89894547A patent/NO894547L/no unknown
- 1989-11-16 HU HU593189A patent/HU208674B/hu unknown
-
1995
- 1995-06-22 HU HU95P/P00336P patent/HU211701A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2054987T3 (es) | 1994-08-16 |
| PT92319A (pt) | 1990-05-31 |
| NO894547D0 (no) | 1989-11-15 |
| PT92319B (pt) | 1995-08-09 |
| DK168290B1 (da) | 1994-03-07 |
| EP0369388A1 (de) | 1990-05-23 |
| DE68906647T2 (de) | 1993-10-07 |
| NZ231376A (en) | 1992-05-26 |
| KR0156241B1 (ko) | 1998-11-16 |
| HU211701A9 (en) | 1995-12-28 |
| FI90417B (fi) | 1993-10-29 |
| FI90417C (fi) | 1994-02-10 |
| FI895416A0 (fi) | 1989-11-14 |
| ATE89553T1 (de) | 1993-06-15 |
| IE63038B1 (en) | 1995-03-22 |
| IE893659L (en) | 1990-05-16 |
| HU208674B (en) | 1993-12-28 |
| KR900007809A (ko) | 1990-06-02 |
| CA2003023C (en) | 2001-05-29 |
| EP0369388B1 (de) | 1993-05-19 |
| DE68906647D1 (de) | 1993-06-24 |
| HU895931D0 (en) | 1990-02-28 |
| CA2003023A1 (en) | 1990-05-16 |
| NO894547L (no) | 1990-05-18 |
| HUT53087A (en) | 1990-09-28 |
| DK571989A (da) | 1990-05-17 |
| DK571989D0 (da) | 1989-11-15 |
| ZA898720B (en) | 1990-08-29 |
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