IL91788A - קוינולילאוקסאזול-2-אונים, תהליך להכנם ותכשירי רוקחות המכילים אותם - Google Patents

קוינולילאוקסאזול-2-אונים, תהליך להכנם ותכשירי רוקחות המכילים אותם

Info

Publication number
IL91788A
IL91788A IL9178889A IL9178889A IL91788A IL 91788 A IL91788 A IL 91788A IL 9178889 A IL9178889 A IL 9178889A IL 9178889 A IL9178889 A IL 9178889A IL 91788 A IL91788 A IL 91788A
Authority
IL
Israel
Prior art keywords
compound
group
alkyl
formula
optionally substituted
Prior art date
Application number
IL9178889A
Other languages
English (en)
Other versions
IL91788A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL91788A0 publication Critical patent/IL91788A0/xx
Publication of IL91788A publication Critical patent/IL91788A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
IL9178889A 1988-10-24 1989-09-26 קוינולילאוקסאזול-2-אונים, תהליך להכנם ותכשירי רוקחות המכילים אותם IL91788A (he)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/261,435 US4886811A (en) 1988-10-24 1988-10-24 Qunolyloxazole-2-ones useful as proteinkinase C inhibitors

Publications (2)

Publication Number Publication Date
IL91788A0 IL91788A0 (en) 1990-06-10
IL91788A true IL91788A (he) 1994-04-12

Family

ID=22993289

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9178889A IL91788A (he) 1988-10-24 1989-09-26 קוינולילאוקסאזול-2-אונים, תהליך להכנם ותכשירי רוקחות המכילים אותם

Country Status (21)

Country Link
US (1) US4886811A (he)
EP (1) EP0365863B1 (he)
JP (2) JP2879454B2 (he)
KR (1) KR0162637B1 (he)
CN (1) CN1025854C (he)
AR (1) AR246733A1 (he)
AT (1) ATE110074T1 (he)
AU (1) AU613302B2 (he)
CA (1) CA2000804C (he)
DE (1) DE68917556T2 (he)
DK (1) DK461389A (he)
ES (1) ES2061863T3 (he)
FI (1) FI93112C (he)
HU (1) HUT58088A (he)
IE (1) IE893011L (he)
IL (1) IL91788A (he)
NO (1) NO894210L (he)
NZ (1) NZ230718A (he)
PH (1) PH27450A (he)
PT (1) PT91870B (he)
ZA (1) ZA897259B (he)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5036093A (en) * 1987-10-09 1991-07-30 Du Pont Merck Pharmaceutical Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
DE3907414A1 (de) * 1989-03-08 1990-09-13 Hoechst Ag Die anwendung inhalierter schleifendiuretika zur behandlung von allergen-induzierten nasalen reaktionen
US5190957A (en) * 1989-11-13 1993-03-02 Merrell Dow Pharmaceuticals Inc. Treatment of multi-drug resistant tumors with quinolyl-and isoquinolyloxazole-2-ones
US5182293A (en) * 1989-11-13 1993-01-26 Merrell Dow Pharmaceuticals Inc. Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones
PH27309A (en) * 1989-11-13 1993-05-28 Merrell Dow Pharma Prevention of glycoprotein enveloped virus infectivity by quinolyl-and isoquinolyloxazone-2-ones
ZA908936B (en) * 1989-11-13 1991-09-25 Merrell Dow Pharma Treatment of multi-drug resistant tumors with quinolyloxazole-2-ones
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6395494B1 (en) 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
JPH08510451A (ja) * 1993-05-13 1996-11-05 ネオルックス コーポレイション 異常増殖性平滑筋細胞に関連した病因の予防及び治療
GB9819382D0 (en) * 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
GB9929216D0 (en) * 1999-12-11 2000-02-02 Univ Bristol Isoquinoline and Quinoline Containing substances
WO2006130090A1 (en) * 2005-06-03 2006-12-07 Pronas Pharma Ab Use of a substance which inhibits endothelin type b and 5-hydroxytryptamine type 1b receptor upregulation in the treatment of ischemic disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3025215A (en) * 1959-07-29 1962-03-13 Monsanto Chemicals Bis (8-quinolyl carbonate) derivatives
US3857877A (en) * 1973-01-12 1974-12-31 Karamchand Premchand Private 8-hydroxy quinoline derivatives
US4565820A (en) * 1980-07-28 1986-01-21 Pfizer Inc. Hypoglycemic 5-pyrrolyl, indolyl and quinolyl substituted oxazolidine-2,4-diones and their use
GB8505492D0 (en) * 1985-03-04 1985-04-03 Roussel Lab Ltd Chemical compounds
US4738972A (en) * 1985-05-21 1988-04-19 Pfizer Inc. Hypoglycemic thiazolidinediones
US4673680A (en) * 1985-09-18 1987-06-16 Pendleton Robert G α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
US4698353A (en) * 1985-11-13 1987-10-06 Merrell Dow Pharmaceuticals Inc. Cardiotonic heterocyclic oxazolones
US4728661A (en) * 1985-11-13 1988-03-01 Merrell Dow Pharmaceuticals Inc. Cardiotonic phenyl oxazolones
US4670450A (en) * 1985-11-13 1987-06-02 Merrell Dow Pharmaceuticals Inc. Cardiotonic thiazolones
US4681940A (en) * 1985-11-19 1987-07-21 American Home Products Corporation 5-[3-[[2-quinolyl]methoxy]phenyl]-1,3-oxazoles

Also Published As

Publication number Publication date
AU4249389A (en) 1990-04-26
CN1025854C (zh) 1994-09-07
CA2000804C (en) 1999-04-06
FI93112C (fi) 1995-02-27
JPH11152285A (ja) 1999-06-08
CN1042145A (zh) 1990-05-16
EP0365863A3 (en) 1990-11-07
EP0365863A2 (en) 1990-05-02
DK461389A (da) 1990-04-25
KR900006307A (ko) 1990-05-07
JPH02164878A (ja) 1990-06-25
FI93112B (fi) 1994-11-15
NZ230718A (en) 1990-11-27
AR246733A1 (es) 1994-09-30
HU895410D0 (en) 1990-01-28
AU613302B2 (en) 1991-07-25
JP2879454B2 (ja) 1999-04-05
ZA897259B (en) 1990-07-25
ES2061863T3 (es) 1994-12-16
US4886811A (en) 1989-12-12
EP0365863B1 (en) 1994-08-17
NO894210L (no) 1990-04-25
JP2983970B2 (ja) 1999-11-29
NO894210D0 (no) 1989-10-23
IE893011L (en) 1990-04-24
IL91788A0 (en) 1990-06-10
KR0162637B1 (ko) 1998-12-01
DE68917556D1 (de) 1994-09-22
FI894459A0 (fi) 1989-09-20
HUT58088A (en) 1992-01-28
PH27450A (en) 1993-07-02
DK461389D0 (da) 1989-09-19
DE68917556T2 (de) 1994-12-15
FI894459A (fi) 1990-04-25
ATE110074T1 (de) 1994-09-15
PT91870B (pt) 1995-05-31
PT91870A (pt) 1990-04-30
CA2000804A1 (en) 1990-04-24

Similar Documents

Publication Publication Date Title
US4886811A (en) Qunolyloxazole-2-ones useful as proteinkinase C inhibitors
CN101541782A (zh) 作为凝血酶受体拮抗剂的二环和三环衍生物
JPH0561273B2 (he)
US4990519A (en) Method of using quinolyloxazole-2-ones as proteinkinase C inhibitors
KR0166359B1 (ko) 중추 신경계 약제로서 유용한 치환 시클로헥센
US4999431A (en) Process for preparing quinoline aldehyde and ketone derivatives
CA2214533C (en) Quinolyloxazole-2-ones useful as proteinkinase c inhibitors
NO169960B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive, substituerte 1h-imidazoler og deres ikke-toksiske, farmasoeytisk akseptable syreaddisjonssalter
US5190957A (en) Treatment of multi-drug resistant tumors with quinolyl-and isoquinolyloxazole-2-ones
EP1659112B1 (fr) Dérivés d'arylpipérazine comme ligands sélectifs du récepteur D3 de la dopamine
CA3227149A1 (en) Deuterated compounds
US5061715A (en) Prevention of glycoprotein enveloped virus infectivity by quinolyl- and isoquinolyloxazole-2-zones
US5750523A (en) Pyridazinone derivatives
US5026861A (en) Substituted 1,5-dihydro-4-(N-methylhydroxylamino)-2H-pyrrol-2-ones
JPH0529029B2 (he)
KR0168645B1 (ko) 퀴놀릴옥사졸-2-온 및 이소퀴놀릴옥사졸-2-온의 다약제 내성 종양의 치료 용도
JP3038032B2 (ja) 血小板凝集抑制薬
CA2099630A1 (en) Heterocyclyl-phenoxyalkyl-piperidinylpyridazines as antiviral agents
IE904078A1 (en) Novel pyridyloxyazole-2-ones useful as proteinkinase¹c inhibitors
WO1998022443A1 (fr) Derives de n-(imidazolylbutyle) benzenesulfonamide ayant une activite antithrombotique
US5109010A (en) Dibenzofuranyl substituted 1,5-dihydro-4-(N-methylhydroxylamino)-2H-pyrrol-2-ones
JPH02311479A (ja) キノリン誘導体
JP2003513096A (ja) スルタムおよびスルトンから誘導された抗生物質オキサゾリジノン
JPH10120632A (ja) Ｎ−シクロアルキル−〔ω−（３，４−ジヒドロ−２−ナフタレニル）アルキル〕アミン誘導体及びそれを含有する医薬組成物
MXPA06008313A (en) Substituted quinolines and their use as mycobacterial inhibitors

Legal Events

Date Code Title Description
RH Patent void
HC Change of name of proprietor(s)

Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.