IL91706A - Pharmaceutical compositions comprising in separate dosage form a plasminogen activator and hirudin - Google Patents

Pharmaceutical compositions comprising in separate dosage form a plasminogen activator and hirudin

Info

Publication number
IL91706A
IL91706A IL91706A IL9170689A IL91706A IL 91706 A IL91706 A IL 91706A IL 91706 A IL91706 A IL 91706A IL 9170689 A IL9170689 A IL 9170689A IL 91706 A IL91706 A IL 91706A
Authority
IL
Israel
Prior art keywords
hirudin
dosage form
plasminogen activator
separate dosage
pharmaceutical compositions
Prior art date
Application number
IL91706A
Other languages
English (en)
Other versions
IL91706A0 (en
Original Assignee
Ciba Geigy
Ucp Gen- Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10643975&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL91706(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy, Ucp Gen- Pharma Ag filed Critical Ciba Geigy
Publication of IL91706A0 publication Critical patent/IL91706A0/xx
Publication of IL91706A publication Critical patent/IL91706A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
IL91706A 1988-09-21 1989-09-20 Pharmaceutical compositions comprising in separate dosage form a plasminogen activator and hirudin IL91706A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888822147A GB8822147D0 (en) 1988-09-21 1988-09-21 Pharmaceutically active combination

Publications (2)

Publication Number Publication Date
IL91706A0 IL91706A0 (en) 1990-06-10
IL91706A true IL91706A (en) 1997-07-13

Family

ID=10643975

Family Applications (1)

Application Number Title Priority Date Filing Date
IL91706A IL91706A (en) 1988-09-21 1989-09-20 Pharmaceutical compositions comprising in separate dosage form a plasminogen activator and hirudin

Country Status (15)

Country Link
US (1) US5126134A (de)
EP (1) EP0365468B1 (de)
JP (1) JPH02121934A (de)
KR (1) KR0149001B1 (de)
AT (1) ATE101524T1 (de)
AU (1) AU628854B2 (de)
CA (1) CA1336493C (de)
DE (1) DE68913132T2 (de)
DK (1) DK463989A (de)
GB (1) GB8822147D0 (de)
IE (1) IE62434B1 (de)
IL (1) IL91706A (de)
NZ (1) NZ230691A (de)
PH (1) PH27420A (de)
ZA (1) ZA897173B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
US5837808A (en) * 1991-08-20 1998-11-17 Baxter International Inc. Analogs of hirudin
WO1993014199A1 (en) * 1992-01-13 1993-07-22 Abbott Laboratories A pump-1 catalyzed method of making low molecular weight urokinase-type plasminogen activator
DK0662146T3 (da) * 1992-09-03 2000-11-13 Univ California Dorsalvævpåvirkende faktor og præparat
EP0625580A4 (en) * 1992-09-28 1994-12-21 Japan Energy Corporation Novel hirudine variant, process for producing the same, and anticoagulant containing the same as active ingredient.
DE4323754C1 (de) * 1993-07-15 1994-12-01 Gruenenthal Gmbh Bifunktionelle Urokinasevarianten mit verbesserten fibrinolytischen Eigenschaften und thrombinhemmender Wirkung
US5972648A (en) * 1993-09-28 1999-10-26 Japan Energy Corporation Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients
US5510330A (en) * 1994-03-25 1996-04-23 Boehringer Mannheim Gmbh Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
US5759542A (en) * 1994-08-05 1998-06-02 New England Deaconess Hospital Corporation Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
DE4440892A1 (de) * 1994-11-17 1996-05-23 Gruenenthal Gmbh Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
GB2394498B (en) * 2002-10-23 2006-08-09 Engineering Business Ltd Mounting of offshore structures
GB0306547D0 (en) * 2003-03-21 2003-04-23 Engineering Business Ltd Apparatus for creating a local reduction in wave height
WO2004112717A2 (en) * 2003-06-17 2004-12-29 Harrison Roger G Conjugate for the specific targeting of anticancer agents to cancer cells and production thereof
US20110002978A1 (en) 2003-06-17 2011-01-06 Harrison Roger G Enzyme prodrug cancer therapy selectively targeted to tumor cells or tumor vasculature and methods of production and use thereof
EP1703895A2 (de) * 2004-01-13 2006-09-27 Vasogenix Pharmaceuticals, Inc. Zusammensetzung zur cgrp anwendung mit kontrollierter freigabe zur behandlung von kardiovaskulären oder nieren indikationen
WO2005070444A2 (en) * 2004-01-13 2005-08-04 Vasogenix Pharmaceuticals, Inc. Methods for treating acute myocardial infarction by calcitonin gene related peptide and compositions containing the same
CA2552758A1 (en) * 2004-01-13 2005-08-04 Vasogenix Pharmaceuticals, Inc. Methods for treating acute myocardial infarction by administering calcitonin gene related peptide and compositions containing the same
US7984525B2 (en) * 2004-08-03 2011-07-26 Ihc Engineering Business Limited Access method between marine structures and apparatus
GB0503083D0 (en) * 2005-02-15 2005-03-23 Engineering Business Ltd Launch and recovery apparatus and method
KR101315904B1 (ko) 2005-02-24 2013-10-08 디퓨젼 파마슈티컬즈 엘엘씨 트랜스 카로티노이드, 이들의 합성, 제제화 및 용도
GB2428656B (en) 2005-08-01 2009-08-05 Engineering Business Ltd Gangway apparatus
GB2434823A (en) * 2006-02-06 2007-08-08 Engineering Business Ltd Transport and installation of offshore structures
EP2589588A1 (de) 2007-04-13 2013-05-08 Diffusion Pharmaceuticals Llc Verwendung von bipolaren Trans-Carotinoiden als Vorbehandlung und bei der Behandlung von peripherer Gefässkrankheit
US20090214469A1 (en) * 2008-02-25 2009-08-27 Jeffrey Gold Methods and Compositions for the Treatment of Sepsis
US10130689B2 (en) 2009-06-22 2018-11-20 Diffusion Pharmaceuticals Llc Diffusion enhancing compounds and their use alone or with thrombolytics
CN103124498A (zh) 2010-06-02 2013-05-29 扩散药品有限公司 双极性反式类胡萝卜素的口服制剂
US9987241B2 (en) 2014-09-25 2018-06-05 The Board Of Regents Of The University Of Oklahoma Enzyme conjugate and prodrug cancer therapy
EP3432929A4 (de) 2016-03-24 2019-11-27 Diffusion Pharmaceuticals LLC Verwendung von bipolaren transkarotinoiden mit chemotherapie und strahlentherapie zur behandlung von krebs
WO2020032951A1 (en) 2018-08-09 2020-02-13 The Board Of Regents Of The University Of Oklahoma Antimalarial enzyme conjugates, kits containing same, and methods of producing and using same
US11613744B2 (en) 2018-12-28 2023-03-28 Vertex Pharmaceuticals Incorporated Modified urokinase-type plasminogen activator polypeptides and methods of use
WO2020140101A1 (en) 2018-12-28 2020-07-02 Catalyst Biosciences, Inc. Modified urokinase-type plasminogen activator polypeptides and methods of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
JPS61112018A (ja) * 1984-11-06 1986-05-30 Mitsubishi Chem Ind Ltd 線溶増強剤
DE3544318A1 (de) * 1985-12-14 1987-06-19 Behringwerke Ag Mittel aus einem plasmin-inhibitor und einem plasminogen-aktivator zur behandlung von thrombosen
JP2739050B2 (ja) * 1988-01-28 1998-04-08 ヘキスト薬品工業株式会社 抗血液凝固剤
DE3804600A1 (de) * 1988-02-13 1989-08-24 Basf Ag Mischung aus einer thrombolytisch wirkenden und einer antithrombotischen substanz

Also Published As

Publication number Publication date
KR0149001B1 (ko) 1998-10-15
AU628854B2 (en) 1992-09-24
ZA897173B (en) 1990-09-26
DK463989D0 (da) 1989-09-20
ATE101524T1 (de) 1994-03-15
DE68913132D1 (de) 1994-03-24
IE62434B1 (en) 1995-02-08
DK463989A (da) 1990-03-22
KR900004349A (ko) 1990-04-12
JPH02121934A (ja) 1990-05-09
NZ230691A (en) 1992-03-26
CA1336493C (en) 1995-08-01
PH27420A (en) 1993-06-21
DE68913132T2 (de) 1994-07-07
GB8822147D0 (en) 1988-10-26
US5126134A (en) 1992-06-30
IE893015L (en) 1990-03-21
IL91706A0 (en) 1990-06-10
EP0365468A1 (de) 1990-04-25
AU4135289A (en) 1990-03-29
EP0365468B1 (de) 1994-02-16

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Legal Events

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RH1 Patent not in force