DK463989D0 - Farmaceutisk virksom kombination - Google Patents
Farmaceutisk virksom kombinationInfo
- Publication number
- DK463989D0 DK463989D0 DK463989A DK463989A DK463989D0 DK 463989 D0 DK463989 D0 DK 463989D0 DK 463989 A DK463989 A DK 463989A DK 463989 A DK463989 A DK 463989A DK 463989 D0 DK463989 D0 DK 463989D0
- Authority
- DK
- Denmark
- Prior art keywords
- pharmaceutical active
- active combination
- thrombosis
- component
- pharmaceutical composition
- Prior art date
Links
- 208000007536 Thrombosis Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 102000007625 Hirudins Human genes 0.000 abstract 1
- 108010007267 Hirudins Proteins 0.000 abstract 1
- 102000001938 Plasminogen Activators Human genes 0.000 abstract 1
- 108010001014 Plasminogen Activators Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 1
- 229940006607 hirudin Drugs 0.000 abstract 1
- 229940127126 plasminogen activator Drugs 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888822147A GB8822147D0 (en) | 1988-09-21 | 1988-09-21 | Pharmaceutically active combination |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK463989D0 true DK463989D0 (da) | 1989-09-20 |
| DK463989A DK463989A (da) | 1990-03-22 |
Family
ID=10643975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK463989A DK463989A (da) | 1988-09-21 | 1989-09-20 | Farmaceutisk virksom kombination |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5126134A (da) |
| EP (1) | EP0365468B1 (da) |
| JP (1) | JPH02121934A (da) |
| KR (1) | KR0149001B1 (da) |
| AT (1) | ATE101524T1 (da) |
| AU (1) | AU628854B2 (da) |
| CA (1) | CA1336493C (da) |
| DE (1) | DE68913132T2 (da) |
| DK (1) | DK463989A (da) |
| GB (1) | GB8822147D0 (da) |
| IE (1) | IE62434B1 (da) |
| IL (1) | IL91706A (da) |
| NZ (1) | NZ230691A (da) |
| PH (1) | PH27420A (da) |
| ZA (1) | ZA897173B (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8927722D0 (en) * | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
| US5837808A (en) * | 1991-08-20 | 1998-11-17 | Baxter International Inc. | Analogs of hirudin |
| WO1993014199A1 (en) * | 1992-01-13 | 1993-07-22 | Abbott Laboratories | A pump-1 catalyzed method of making low molecular weight urokinase-type plasminogen activator |
| ZA936478B (en) * | 1992-09-03 | 1994-09-30 | Regeneron Pharma | Dorsal tissue affecting factor and compositions |
| WO1994008034A1 (fr) * | 1992-09-28 | 1994-04-14 | Japan Energy Corporation | Nouvelle variante d'hirudine, son procede de production, et anticoagulant la contenant comme ingredient actif |
| DE4323754C1 (de) * | 1993-07-15 | 1994-12-01 | Gruenenthal Gmbh | Bifunktionelle Urokinasevarianten mit verbesserten fibrinolytischen Eigenschaften und thrombinhemmender Wirkung |
| US5972648A (en) * | 1993-09-28 | 1999-10-26 | Japan Energy Corporation | Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients |
| US5510330A (en) * | 1994-03-25 | 1996-04-23 | Boehringer Mannheim Gmbh | Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof. |
| US5759542A (en) * | 1994-08-05 | 1998-06-02 | New England Deaconess Hospital Corporation | Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases |
| DE4440892A1 (de) * | 1994-11-17 | 1996-05-23 | Gruenenthal Gmbh | Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften |
| US7759506B2 (en) | 2002-02-25 | 2010-07-20 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| GB2394498B (en) * | 2002-10-23 | 2006-08-09 | Engineering Business Ltd | Mounting of offshore structures |
| GB0306547D0 (en) * | 2003-03-21 | 2003-04-23 | Engineering Business Ltd | Apparatus for creating a local reduction in wave height |
| EP1635764A4 (en) * | 2003-06-17 | 2009-10-21 | Roger G Harrison | CONJUGATE FOR THE SPECIFIC TARGETING OF ANTICANCER AGENTS ON CANCER CELLS AND PRODUCTION OF THE CONJUGATE |
| US20110002978A1 (en) | 2003-06-17 | 2011-01-06 | Harrison Roger G | Enzyme prodrug cancer therapy selectively targeted to tumor cells or tumor vasculature and methods of production and use thereof |
| CA2552758A1 (en) * | 2004-01-13 | 2005-08-04 | Vasogenix Pharmaceuticals, Inc. | Methods for treating acute myocardial infarction by administering calcitonin gene related peptide and compositions containing the same |
| WO2005067890A2 (en) * | 2004-01-13 | 2005-07-28 | Vasogenix Pharmaceuticals, Inc. | Controlled release cgrp delivery composition for cardiovascular and renal indications |
| JP2007517911A (ja) * | 2004-01-13 | 2007-07-05 | バソジェニックス ファーマシューティカルズ， インコーポレイテッド | 心臓血管の適応症および腎臓の適応症に対してｃｇｒｐを使用する方法 |
| ATE414010T1 (de) * | 2004-08-03 | 2008-11-15 | Ihc Engineering Business Ltd | Zugangsverfahren zwischen schiffskonstruktionen und gerät |
| GB0503083D0 (en) * | 2005-02-15 | 2005-03-23 | Engineering Business Ltd | Launch and recovery apparatus and method |
| NZ561664A (en) | 2005-02-24 | 2011-02-25 | Diffusion Pharmaceuticals Llc | Trans carotenoids, their synthesis, formulation and uses |
| GB2428656B (en) | 2005-08-01 | 2009-08-05 | Engineering Business Ltd | Gangway apparatus |
| GB2434823A (en) * | 2006-02-06 | 2007-08-08 | Engineering Business Ltd | Transport and installation of offshore structures |
| CN101687757A (zh) | 2007-04-13 | 2010-03-31 | 扩散药品有限公司 | 双极性反式类胡萝卜素作为预治疗及其在周围血管疾病的治疗中的应用 |
| US20090214469A1 (en) * | 2008-02-25 | 2009-08-27 | Jeffrey Gold | Methods and Compositions for the Treatment of Sepsis |
| EP2445339B1 (en) * | 2009-06-22 | 2019-08-07 | Diffusion Pharmaceuticals LLC | Diffusion enhancing compound and its use with a thrombolytic |
| JP2013527231A (ja) | 2010-06-02 | 2013-06-27 | ディフュージョン・ファーマシューティカルズ・エルエルシー | 双極性トランスカロテノイドの経口製剤 |
| US9987241B2 (en) | 2014-09-25 | 2018-06-05 | The Board Of Regents Of The University Of Oklahoma | Enzyme conjugate and prodrug cancer therapy |
| CN109152839A (zh) | 2016-03-24 | 2019-01-04 | 扩散药品有限公司 | 双极性反式类胡萝卜素连同化疗和放射治疗在治疗癌症中的用途 |
| WO2020032951A1 (en) | 2018-08-09 | 2020-02-13 | The Board Of Regents Of The University Of Oklahoma | Antimalarial enzyme conjugates, kits containing same, and methods of producing and using same |
| US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
| PE20211664A1 (es) | 2018-12-28 | 2021-08-26 | Catalyst Biosciences Inc | Polipeptidos de activador de plasminogeno, tipo urocinasa, modificados y metodos de uso |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8003402A (nl) * | 1980-06-11 | 1982-01-04 | Leuven Res & Dev Vzw | Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking. |
| DE3342139A1 (de) * | 1983-11-22 | 1985-05-30 | Ciba-Geigy Ag, Basel | Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel |
| JPS61112018A (ja) * | 1984-11-06 | 1986-05-30 | Mitsubishi Chem Ind Ltd | 線溶増強剤 |
| DE3544318A1 (de) * | 1985-12-14 | 1987-06-19 | Behringwerke Ag | Mittel aus einem plasmin-inhibitor und einem plasminogen-aktivator zur behandlung von thrombosen |
| JP2739050B2 (ja) * | 1988-01-28 | 1998-04-08 | ヘキスト薬品工業株式会社 | 抗血液凝固剤 |
| DE3804600A1 (de) * | 1988-02-13 | 1989-08-24 | Basf Ag | Mischung aus einer thrombolytisch wirkenden und einer antithrombotischen substanz |
-
1988
- 1988-09-21 GB GB888822147A patent/GB8822147D0/en active Pending
-
1989
- 1989-09-12 AT AT89810676T patent/ATE101524T1/de not_active IP Right Cessation
- 1989-09-12 DE DE68913132T patent/DE68913132T2/de not_active Revoked
- 1989-09-12 EP EP89810676A patent/EP0365468B1/en not_active Revoked
- 1989-09-13 AU AU41352/89A patent/AU628854B2/en not_active Ceased
- 1989-09-18 US US07/408,836 patent/US5126134A/en not_active Expired - Fee Related
- 1989-09-19 NZ NZ230691A patent/NZ230691A/en unknown
- 1989-09-19 PH PH39253A patent/PH27420A/en unknown
- 1989-09-19 CA CA000611903A patent/CA1336493C/en not_active Expired - Fee Related
- 1989-09-20 IE IE301589A patent/IE62434B1/en not_active IP Right Cessation
- 1989-09-20 KR KR1019890013492A patent/KR0149001B1/ko not_active Expired - Fee Related
- 1989-09-20 IL IL91706A patent/IL91706A/xx not_active IP Right Cessation
- 1989-09-20 JP JP1242356A patent/JPH02121934A/ja active Pending
- 1989-09-20 DK DK463989A patent/DK463989A/da not_active Application Discontinuation
- 1989-09-20 ZA ZA897173A patent/ZA897173B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL91706A0 (en) | 1990-06-10 |
| DE68913132D1 (de) | 1994-03-24 |
| US5126134A (en) | 1992-06-30 |
| ZA897173B (en) | 1990-09-26 |
| ATE101524T1 (de) | 1994-03-15 |
| KR0149001B1 (ko) | 1998-10-15 |
| IE893015L (en) | 1990-03-21 |
| CA1336493C (en) | 1995-08-01 |
| KR900004349A (ko) | 1990-04-12 |
| EP0365468B1 (en) | 1994-02-16 |
| IL91706A (en) | 1997-07-13 |
| IE62434B1 (en) | 1995-02-08 |
| NZ230691A (en) | 1992-03-26 |
| PH27420A (en) | 1993-06-21 |
| AU4135289A (en) | 1990-03-29 |
| JPH02121934A (ja) | 1990-05-09 |
| GB8822147D0 (en) | 1988-10-26 |
| DK463989A (da) | 1990-03-22 |
| EP0365468A1 (en) | 1990-04-25 |
| DE68913132T2 (de) | 1994-07-07 |
| AU628854B2 (en) | 1992-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |