DK305490D0 - Vaevsplasminogenaktivator-analoger med forbedret aktivitet - Google Patents

Vaevsplasminogenaktivator-analoger med forbedret aktivitet

Info

Publication number
DK305490D0
DK305490D0 DK305490A DK305490A DK305490D0 DK 305490 D0 DK305490 D0 DK 305490D0 DK 305490 A DK305490 A DK 305490A DK 305490 A DK305490 A DK 305490A DK 305490 D0 DK305490 D0 DK 305490D0
Authority
DK
Denmark
Prior art keywords
plasminogen activator
improved activity
analogs
activator analogs
activity
Prior art date
Application number
DK305490A
Other languages
English (en)
Other versions
DK305490A (da
Inventor
Richard Mark Edwards
Keith Dawson
Anthony Fallon
Steward Craig
Original Assignee
British Bio Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Bio Technology filed Critical British Bio Technology
Publication of DK305490D0 publication Critical patent/DK305490D0/da
Publication of DK305490A publication Critical patent/DK305490A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B4/00—Electrothermal treatment of ores or metallurgical products for obtaining metals or alloys
    • C22B4/02—Light metals
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B4/00—Electrothermal treatment of ores or metallurgical products for obtaining metals or alloys
    • C22B4/06—Alloys
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C1/00—Making non-ferrous alloys
    • C22C1/02—Making non-ferrous alloys by melting
    • C22C1/026—Alloys based on aluminium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/20—Recycling

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Metallurgy (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geology (AREA)
  • Manufacturing & Machinery (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Environmental & Geological Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK305490A 1988-06-24 1990-12-21 Vaevsplasminogenaktivator-analoger med forbedret aktivitet DK305490A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888815135A GB8815135D0 (en) 1988-06-24 1988-06-24 Proteins & nucleic acids
PCT/GB1989/000705 WO1989012681A1 (en) 1988-06-24 1989-06-23 Tissue plasminogen activator analogues having improved activity

Publications (2)

Publication Number Publication Date
DK305490D0 true DK305490D0 (da) 1990-12-21
DK305490A DK305490A (da) 1991-02-20

Family

ID=10639339

Family Applications (1)

Application Number Title Priority Date Filing Date
DK305490A DK305490A (da) 1988-06-24 1990-12-21 Vaevsplasminogenaktivator-analoger med forbedret aktivitet

Country Status (15)

Country Link
US (1) US5232847A (da)
EP (1) EP0352904A1 (da)
JP (1) JPH03505524A (da)
KR (1) KR900702018A (da)
AU (1) AU627475B2 (da)
DK (1) DK305490A (da)
FI (1) FI906322A0 (da)
GB (1) GB8815135D0 (da)
HU (1) HUT61593A (da)
IL (1) IL90745A0 (da)
NO (1) NO905561L (da)
NZ (1) NZ229691A (da)
PT (1) PT90976A (da)
WO (1) WO1989012681A1 (da)
ZA (1) ZA894800B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
JPH0595786A (ja) * 1991-10-07 1993-04-20 Green Cross Corp:The 変異ヒトプロウロキナーゼ
DK0643772T3 (da) * 1992-06-03 1998-02-02 Genentech Inc Glycosyleringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber
WO1997038123A1 (en) * 1996-04-05 1997-10-16 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987004722A1 (en) * 1986-01-31 1987-08-13 Genetics Institute, Inc. Novel thrombolytic proteins
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
GB8608014D0 (en) * 1986-04-02 1986-05-08 Beecham Group Plc Compounds
AU7090687A (en) * 1986-04-02 1987-10-08 Beecham Group Plc Modified tissue-type plasminogen activators
ATE118815T1 (de) * 1987-06-04 1995-03-15 Zymogenetics Inc Gewebs-plasminogen-aktivator-analoge mit modifizierten wachstumsfaktordomänen.
AU613942B2 (en) * 1987-06-30 1991-08-15 Genentech Inc. Improved processes for the treatment of vascular disease
JPH03500002A (ja) * 1987-07-06 1991-01-10 ジェネティックス・インスチチュート・インコーポレーテッド 新規な血栓崩壊蛋白
US4963357A (en) * 1987-10-09 1990-10-16 Monsanto Company Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
JPH02273179A (ja) * 1988-12-12 1990-11-07 Yamanouchi Pharmaceut Co Ltd 新規な血栓溶解蛋白質，その製造法および該蛋白質からなる医薬

Also Published As

Publication number Publication date
GB8815135D0 (en) 1988-08-03
FI906322A0 (fi) 1990-12-20
HUT61593A (en) 1993-01-28
DK305490A (da) 1991-02-20
ZA894800B (en) 1990-05-30
EP0352904A1 (en) 1990-01-31
JPH03505524A (ja) 1991-12-05
WO1989012681A1 (en) 1989-12-28
IL90745A0 (en) 1990-03-19
AU3838189A (en) 1990-01-12
NZ229691A (en) 1992-03-26
HU893786D0 (en) 1991-05-28
AU627475B2 (en) 1992-08-27
NO905561L (no) 1991-02-22
KR900702018A (ko) 1990-12-05
US5232847A (en) 1993-08-03
NO905561D0 (no) 1990-12-21
PT90976A (pt) 1989-12-29

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment