IL91620A0 - 4,5-diaryl-2-substituted thioimidazoles,their preparation and pharmaceutical compositions containing them - Google Patents

4,5-diaryl-2-substituted thioimidazoles,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL91620A0
IL91620A0 IL91620A IL9162089A IL91620A0 IL 91620 A0 IL91620 A0 IL 91620A0 IL 91620 A IL91620 A IL 91620A IL 9162089 A IL9162089 A IL 9162089A IL 91620 A0 IL91620 A0 IL 91620A0
Authority
IL
Israel
Prior art keywords
thioimidazoles
diaryl
substituted
preparation
pharmaceutical compositions
Prior art date
Application number
IL91620A
Other languages
English (en)
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of IL91620A0 publication Critical patent/IL91620A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
IL91620A 1988-09-14 1989-09-13 4,5-diaryl-2-substituted thioimidazoles,their preparation and pharmaceutical compositions containing them IL91620A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/244,170 US4900744A (en) 1988-09-14 1988-09-14 Antihypercholesterolemic 4,5-diaryl-2-substituted thioimidazoles

Publications (1)

Publication Number Publication Date
IL91620A0 true IL91620A0 (en) 1990-04-29

Family

ID=22921646

Family Applications (1)

Application Number Title Priority Date Filing Date
IL91620A IL91620A0 (en) 1988-09-14 1989-09-13 4,5-diaryl-2-substituted thioimidazoles,their preparation and pharmaceutical compositions containing them

Country Status (13)

Country Link
US (1) US4900744A (de)
EP (1) EP0359197B1 (de)
JP (1) JPH02174762A (de)
KR (1) KR900004697A (de)
AT (1) ATE83772T1 (de)
AU (1) AU615572B2 (de)
DE (1) DE68904018T2 (de)
DK (1) DK451389A (de)
ES (1) ES2053896T3 (de)
GR (1) GR3006839T3 (de)
IL (1) IL91620A0 (de)
NZ (1) NZ230624A (de)
ZA (1) ZA897022B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5290814A (en) * 1988-11-21 1994-03-01 Burroughs Wellcome Co. Anti-atherosclerotic diaryl compounds
JPH05502235A (ja) * 1989-12-12 1993-04-22 ローン―プーラン・サント イミダゾール類
MX9203711A (es) * 1990-01-12 1992-07-01 Rhone Poulenc Rorer Sa Derivados de imidazol y composiciones farmaceuticas que los contienen.
US5011851A (en) * 1990-02-13 1991-04-30 Bristol-Myers Squibb Co. Imidazole carboxylic acids and esters and inhibition of blood platelet aggregation therewith
GB9019838D0 (en) * 1990-09-11 1990-10-24 Smith Kline French Lab Compounds
US5179117A (en) * 1991-12-20 1993-01-12 Du Pont Merck Pharmaceutical Company Antihypercholesterolemic 2-substituted imidazoles
US5364875A (en) * 1992-05-11 1994-11-15 The Du Pont Merck Pharmaceutical Company Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
US5310748A (en) * 1992-05-11 1994-05-10 The Du Pont Merck Pharmaceutical Company Imidazoles for the treatment of atherosclerosis
AU5322494A (en) 1992-10-02 1994-04-26 Trustees Of Dartmouth College Bispecific reagents for redirected targeting of low density lipoprotein
US5491152A (en) * 1994-03-23 1996-02-13 The Du Pont Merck Pharmaceutical Company Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US465438A (en) * 1891-12-15 Alcide frangois trouard
US3636003A (en) * 1969-11-17 1972-01-18 Geigy Chem Corp Substituted 2-mercaptoimidazole derivatives
DE2823197A1 (de) * 1978-05-24 1979-11-29 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3228271A1 (de) * 1982-07-29 1984-02-02 A. Nattermann & Cie GmbH, 5000 Köln Triphenylimidazolyloxyalkansaeuren und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3323870A1 (de) * 1983-07-02 1985-01-03 A. Nattermann & Cie GmbH, 5000 Köln Neue imidazol-2-ylthioalkansaeuren und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
ZA854550B (en) * 1984-06-18 1986-04-30 Smithkline Beckman Corp Leukotriene antagonists
US4743613A (en) * 1986-04-08 1988-05-10 Smithkline Beckman Corporation Ester prodrugs of dopamine-β-hydroxylase, inhibitors, composition containing them, and method of using them to inhibit dopamine-β-hydroxylase activity
US4734421A (en) * 1986-10-29 1988-03-29 Merck & Co., Inc. Anti-inflammatory substituted 2-benzyl-mercapto-imidazole and pyrimidine derivatives compositions and method of use therefor
US4935438A (en) * 1987-12-29 1990-06-19 Smithkline Beckman Corporation Dopamine-β-hydroxylase inhibitors

Also Published As

Publication number Publication date
NZ230624A (en) 1991-06-25
ATE83772T1 (de) 1993-01-15
ZA897022B (en) 1991-05-29
JPH02174762A (ja) 1990-07-06
DE68904018T2 (de) 1993-04-29
EP0359197B1 (de) 1992-12-23
KR900004697A (ko) 1990-04-12
DK451389D0 (da) 1989-09-13
EP0359197A1 (de) 1990-03-21
US4900744A (en) 1990-02-13
DE68904018D1 (de) 1993-02-04
GR3006839T3 (de) 1993-06-30
DK451389A (da) 1990-03-15
AU4136189A (en) 1990-03-22
ES2053896T3 (es) 1994-08-01
AU615572B2 (en) 1991-10-03

Similar Documents

Publication Publication Date Title
AU6128590A (en) Novel compounds
HUT52764A (en) Process for producing pyrimidindione derivatives and pharmaceutical compositions containing them as active components
AU586691B2 (en) Diamino-androstane derivatives, process for their preparation and pharmaceutical compositions containing them
AU657106B2 (en) Preparation and use of N-iodopropargyl oxycarbonyl amino acid esters and derivatives as antimicrobial agents
IL91620A0 (en) 4,5-diaryl-2-substituted thioimidazoles,their preparation and pharmaceutical compositions containing them
IL90724A0 (en) Novel esters and pharmaceutical compositions containing same
IL86080A0 (en) Bicyclic compounds,processes for preparation thereof and pharmaceutical composition comprising the same
AU3309489A (en) 2-alkyl-3-benzoylbenzofurans and pharmaceutical compositions containing them
KR900006301A (ko) 1,4-디아자비사이클로[3.2.2]노난의 제조방법
EG19557A (en) A process for the preparation of pharmaceutical preparation
IL65213A0 (en) Morpholine derivatives,their preparation and pharmaceutical compositions containing them
AU2742288A (en) Novel compound effective as cerebral insufficiency improver
JPS5639074A (en) Pyrimidine derivative
ES8203092A1 (es) Procedimiento para la preparacion de nuevos derivados este- roide-espiro-oxatiazolidinos
IL91261A0 (en) Pharmaceutical compositions containing carbinolo-imidazoles
NO167382C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-hydroxy-4-(substituerte alkenyl)cyklohexancarboxylsyrer.
IT1247921B (it) Composti ad attivita' anticolinesterasi, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono