IL91457A - Variants of somatotropins and preparations containing those that increase growth and increase milk yield in mammals - Google Patents
Variants of somatotropins and preparations containing those that increase growth and increase milk yield in mammalsInfo
- Publication number
- IL91457A IL91457A IL9145789A IL9145789A IL91457A IL 91457 A IL91457 A IL 91457A IL 9145789 A IL9145789 A IL 9145789A IL 9145789 A IL9145789 A IL 9145789A IL 91457 A IL91457 A IL 91457A
- Authority
- IL
- Israel
- Prior art keywords
- somatotropin
- somatotropins
- glutamine
- dna sequence
- positions
- Prior art date
Links
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- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 description 1
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- -1 succinimidyl moiety Chemical group 0.000 description 1
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- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/237,358 US5089473A (en) | 1988-08-29 | 1988-08-29 | Somatotropin variants and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL91457A0 IL91457A0 (en) | 1990-04-29 |
| IL91457A true IL91457A (en) | 1994-04-12 |
Family
ID=22893393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9145789A IL91457A (en) | 1988-08-29 | 1989-08-28 | Variants of somatotropins and preparations containing those that increase growth and increase milk yield in mammals |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5089473A (fr) |
| EP (2) | EP0363342A1 (fr) |
| JP (1) | JP2784232B2 (fr) |
| AU (1) | AU614879B2 (fr) |
| BG (1) | BG60324B2 (fr) |
| BR (1) | BR8907068A (fr) |
| CA (1) | CA1340122C (fr) |
| DE (1) | DE68906261T2 (fr) |
| ES (2) | ES2054096T3 (fr) |
| HU (1) | HUT54409A (fr) |
| IL (1) | IL91457A (fr) |
| NZ (1) | NZ230458A (fr) |
| WO (1) | WO1990002182A1 (fr) |
| ZA (1) | ZA896557B (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631227A (en) * | 1985-09-18 | 1997-05-20 | The Upjohn Company | Somatotropin analogs |
| US5130422A (en) * | 1988-08-29 | 1992-07-14 | Monsanto Company | Variant somatotropin-encoding DNA |
| IE912345A1 (en) * | 1990-08-03 | 1992-02-12 | Pharmacia Ab | Treatment of human lactation failure |
| US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| GB9823071D0 (en) * | 1998-10-21 | 1998-12-16 | Affibody Technology Ab | A method |
| US6238706B1 (en) | 1999-05-06 | 2001-05-29 | Grofish L.L.C. | Method of stimulating growth in aquatic animals using growth hormones |
| CA2498319A1 (fr) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Evolution rationnelle de cytokines pour une plus grande stabilite, les cytokines et molecules d'acide nucleique codant |
| US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
| US8592555B2 (en) | 2008-08-11 | 2013-11-26 | Emd Millipore Corporation | Immunoglobulin-binding proteins with improved specificity |
| SG195555A1 (en) | 2008-12-24 | 2013-12-30 | Emd Millipore Corp | Caustic stable chromatography ligands |
| US8703717B2 (en) | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| US8680050B2 (en) * | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
| CN102348715B (zh) | 2009-02-03 | 2017-12-08 | 阿穆尼克斯运营公司 | 延伸重组多肽和包含该延伸重组多肽的组合物 |
| US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| SG10201604559TA (en) | 2011-06-08 | 2016-07-28 | Emd Millipore Corp | Chromatography matrices including novel staphylococcus aureus protein a based ligands |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR79124B (fr) | 1982-12-22 | 1984-10-02 | Genentech Inc | |
| US5037806A (en) * | 1985-02-22 | 1991-08-06 | Monsanto Company | Biologically active method using somatotropins |
| ES8800957A1 (es) | 1985-02-22 | 1987-12-01 | Monsanto Co | Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina |
| JPS63500941A (ja) * | 1985-09-18 | 1988-04-07 | ジ・アップジョン・カンパニ− | 選択的脱アミノ化による哺乳動物ソマトトロピンの生物学的活性の増強 |
| EP0263206B1 (fr) * | 1986-10-08 | 1990-12-12 | The Upjohn Company | Bioactivité élevée de la somatotropine des mammifères par désamidation sélective |
| EP0241446B1 (fr) | 1986-03-27 | 1995-03-01 | Monsanto Company | Production stimulée de protéines par des bactéries, par utilisation d'un nouveau site de fixation de ribosomes |
| EP0355460B1 (fr) * | 1988-08-24 | 2000-12-27 | American Cyanamid Company | Stabilisation de somatotropines par modification du résidu cystéine en utilisant un site de mutagénèse dirigée ou par modification chimique |
-
1988
- 1988-08-29 US US07/237,358 patent/US5089473A/en not_active Expired - Fee Related
-
1989
- 1989-08-28 DE DE89910508T patent/DE68906261T2/de not_active Expired - Fee Related
- 1989-08-28 EP EP89870130A patent/EP0363342A1/fr active Pending
- 1989-08-28 ZA ZA896557A patent/ZA896557B/xx unknown
- 1989-08-28 WO PCT/US1989/003641 patent/WO1990002182A1/fr active IP Right Grant
- 1989-08-28 HU HU895593A patent/HUT54409A/hu unknown
- 1989-08-28 ES ES89910508T patent/ES2054096T3/es not_active Expired - Lifetime
- 1989-08-28 IL IL9145789A patent/IL91457A/en not_active IP Right Cessation
- 1989-08-28 AU AU43160/89A patent/AU614879B2/en not_active Ceased
- 1989-08-28 NZ NZ230458A patent/NZ230458A/xx unknown
- 1989-08-28 JP JP1509826A patent/JP2784232B2/ja not_active Expired - Lifetime
- 1989-08-28 EP EP89910508A patent/EP0403601B1/fr not_active Expired - Lifetime
- 1989-08-28 CA CA000609518A patent/CA1340122C/fr not_active Expired - Fee Related
- 1989-08-28 ES ES89870130T patent/ES2016069A4/es active Pending
- 1989-08-28 BR BR898907068A patent/BR8907068A/pt not_active Application Discontinuation
-
1990
- 1990-05-16 BG BG092028A patent/BG60324B2/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0403601B1 (fr) | 1993-04-28 |
| NZ230458A (en) | 1991-11-26 |
| DE68906261T2 (de) | 1993-11-11 |
| EP0363342A1 (fr) | 1990-04-11 |
| ES2016069A4 (es) | 1990-10-16 |
| JP2784232B2 (ja) | 1998-08-06 |
| CA1340122C (fr) | 1998-11-10 |
| AU4316089A (en) | 1990-03-23 |
| AU614879B2 (en) | 1991-09-12 |
| HUT54409A (en) | 1991-02-28 |
| ZA896557B (en) | 1990-08-29 |
| ES2054096T3 (es) | 1994-08-01 |
| WO1990002182A1 (fr) | 1990-03-08 |
| US5089473A (en) | 1992-02-18 |
| EP0403601A1 (fr) | 1990-12-27 |
| IL91457A0 (en) | 1990-04-29 |
| DE68906261D1 (de) | 1993-06-03 |
| BR8907068A (pt) | 1990-10-02 |
| JPH03501856A (ja) | 1991-04-25 |
| BG60324B2 (en) | 1994-07-25 |
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Legal Events
| Date | Code | Title | Description |
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| RH | Patent void |