ES2054096T3 - Nuevas somatotropinas. - Google Patents

Nuevas somatotropinas.

Info

Publication number
ES2054096T3
ES2054096T3 ES89910508T ES89910508T ES2054096T3 ES 2054096 T3 ES2054096 T3 ES 2054096T3 ES 89910508 T ES89910508 T ES 89910508T ES 89910508 T ES89910508 T ES 89910508T ES 2054096 T3 ES2054096 T3 ES 2054096T3
Authority
ES
Spain
Prior art keywords
somatotropins
new
somatotropin
glutamine
variant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89910508T
Other languages
English (en)
Inventor
Gwen Grabowski Krivi
Michael Robert Schlittler
Bernard Norman Violand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of ES2054096T3 publication Critical patent/ES2054096T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Una variante de somatotropina en la cual la asparagina localizada entre las posiciones 95-101 de la somatotropina de mamífero es reemplazada por glutamina.
ES89910508T 1988-08-29 1989-08-28 Nuevas somatotropinas. Expired - Lifetime ES2054096T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/237,358 US5089473A (en) 1988-08-29 1988-08-29 Somatotropin variants and their use

Publications (1)

Publication Number Publication Date
ES2054096T3 true ES2054096T3 (es) 1994-08-01

Family

ID=22893393

Family Applications (2)

Application Number Title Priority Date Filing Date
ES89870130T Pending ES2016069A4 (es) 1988-08-29 1989-08-28 Nuevas somatotropinas.
ES89910508T Expired - Lifetime ES2054096T3 (es) 1988-08-29 1989-08-28 Nuevas somatotropinas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES89870130T Pending ES2016069A4 (es) 1988-08-29 1989-08-28 Nuevas somatotropinas.

Country Status (14)

Country Link
US (1) US5089473A (es)
EP (2) EP0403601B1 (es)
JP (1) JP2784232B2 (es)
AU (1) AU614879B2 (es)
BG (1) BG60324B2 (es)
BR (1) BR8907068A (es)
CA (1) CA1340122C (es)
DE (1) DE68906261T2 (es)
ES (2) ES2016069A4 (es)
HU (1) HUT54409A (es)
IL (1) IL91457A (es)
NZ (1) NZ230458A (es)
WO (1) WO1990002182A1 (es)
ZA (1) ZA896557B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631227A (en) * 1985-09-18 1997-05-20 The Upjohn Company Somatotropin analogs
US5130422A (en) * 1988-08-29 1992-07-14 Monsanto Company Variant somatotropin-encoding DNA
IE912345A1 (en) * 1990-08-03 1992-02-12 Pharmacia Ab Treatment of human lactation failure
US20020137890A1 (en) * 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
GB9823071D0 (en) * 1998-10-21 1998-12-16 Affibody Technology Ab A method
US6238706B1 (en) 1999-05-06 2001-05-29 Grofish L.L.C. Method of stimulating growth in aquatic animals using growth hormones
US7611700B2 (en) * 2002-09-09 2009-11-03 Hanall Pharmaceuticals, Co., Ltd. Protease resistant modified interferon alpha polypeptides
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
US8592555B2 (en) 2008-08-11 2013-11-26 Emd Millipore Corporation Immunoglobulin-binding proteins with improved specificity
SG162687A1 (en) 2008-12-24 2010-07-29 Millipore Corp Caustic stable chromatography ligands
US8703717B2 (en) 2009-02-03 2014-04-22 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
ES2610356T3 (es) 2009-02-03 2017-04-27 Amunix Operating Inc. Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos
US8680050B2 (en) * 2009-02-03 2014-03-25 Amunix Operating Inc. Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same
US9849188B2 (en) 2009-06-08 2017-12-26 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
SG10201604559TA (en) 2011-06-08 2016-07-28 Emd Millipore Corp Chromatography matrices including novel staphylococcus aureus protein a based ligands

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79124B (es) 1982-12-22 1984-10-02 Genentech Inc
US5037806A (en) * 1985-02-22 1991-08-06 Monsanto Company Biologically active method using somatotropins
ES8800957A1 (es) 1985-02-22 1987-12-01 Monsanto Co Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina
EP0263206B1 (en) * 1986-10-08 1990-12-12 The Upjohn Company Enhanced bioactivity of mammalian somatotropin through selective deamidation
ATE57937T1 (de) * 1985-09-18 1990-11-15 Upjohn Co Erhoehte biowirkung von saeugetier-somatotropin durch selektive deamidierung.
IL82017A (en) 1986-03-27 1996-01-19 Monsanto Co Increased production of protein in bacteria by using a ribosomal linker site based on bacteriophage T7 gene 01
DE68929273T2 (de) * 1988-08-24 2001-07-05 American Cyanamid Co Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung

Also Published As

Publication number Publication date
IL91457A0 (en) 1990-04-29
JP2784232B2 (ja) 1998-08-06
DE68906261D1 (de) 1993-06-03
WO1990002182A1 (en) 1990-03-08
BG60324B2 (en) 1994-07-25
IL91457A (en) 1994-04-12
JPH03501856A (ja) 1991-04-25
EP0403601B1 (en) 1993-04-28
EP0403601A1 (en) 1990-12-27
ES2016069A4 (es) 1990-10-16
AU4316089A (en) 1990-03-23
US5089473A (en) 1992-02-18
HUT54409A (en) 1991-02-28
AU614879B2 (en) 1991-09-12
NZ230458A (en) 1991-11-26
EP0363342A1 (en) 1990-04-11
BR8907068A (pt) 1990-10-02
CA1340122C (en) 1998-11-10
DE68906261T2 (de) 1993-11-11
ZA896557B (en) 1990-08-29

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