IL91154A - Process for converting daonurovicin to doxorubicin by acid hydrolysis of doxorovicin oxalate extracted from 41-bromo-downorovicin - Google Patents

Process for converting daonurovicin to doxorubicin by acid hydrolysis of doxorovicin oxalate extracted from 41-bromo-downorovicin

Info

Publication number
IL91154A
IL91154A IL9115489A IL9115489A IL91154A IL 91154 A IL91154 A IL 91154A IL 9115489 A IL9115489 A IL 9115489A IL 9115489 A IL9115489 A IL 9115489A IL 91154 A IL91154 A IL 91154A
Authority
IL
Israel
Prior art keywords
doxorubicin
daunorubicin
bromo
hydrolysis
oxalic acid
Prior art date
Application number
IL9115489A
Other languages
English (en)
Hebrew (he)
Other versions
IL91154A0 (en
Original Assignee
Sicor Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Spa filed Critical Sicor Spa
Publication of IL91154A0 publication Critical patent/IL91154A0/xx
Publication of IL91154A publication Critical patent/IL91154A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL9115489A 1988-10-11 1989-07-28 Process for converting daonurovicin to doxorubicin by acid hydrolysis of doxorovicin oxalate extracted from 41-bromo-downorovicin IL91154A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8822260A IT1230505B (it) 1988-10-11 1988-10-11 Procedimento per la conversione della daunorubicina in doxorubicina.

Publications (2)

Publication Number Publication Date
IL91154A0 IL91154A0 (en) 1990-03-19
IL91154A true IL91154A (en) 1994-01-25

Family

ID=11193796

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9115489A IL91154A (en) 1988-10-11 1989-07-28 Process for converting daonurovicin to doxorubicin by acid hydrolysis of doxorovicin oxalate extracted from 41-bromo-downorovicin

Country Status (9)

Country Link
US (1) US5008380A (ko)
EP (1) EP0363604A3 (ko)
JP (1) JPH02129197A (ko)
KR (1) KR900006357A (ko)
AU (1) AU615774B2 (ko)
HU (1) HUT52516A (ko)
IL (1) IL91154A (ko)
IT (1) IT1230505B (ko)
ZA (1) ZA895727B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976830A (en) * 1996-05-24 1999-11-02 The Ohio State University Research Foundation Methods of producing doxorubicin
FR2753703B1 (fr) * 1996-09-20 1998-12-04 Procede de synthese de l'acide mercapto-3-propionique
ES2151632T3 (es) * 1996-12-16 2001-01-01 Pharmachemie Bv Un proceso para preparar epirubicina o sales de adicion de acidos de la misma a partir de daunorubicina.
RU2014133467A (ru) * 2012-02-17 2016-04-10 Селшн Корпорейшн Термочувствительные составы в виде наночастиц и способ их получения
JP6682504B2 (ja) * 2015-03-30 2020-04-15 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 エピルビシンの製造方法およびその新規な製造中間体
CN108350015A (zh) * 2015-11-05 2018-07-31 浙江海正药业股份有限公司 一种表柔比星或其盐酸盐的分离纯化方法
EP3509605A4 (en) 2016-09-09 2020-05-27 Irisys, Inc. LIPOSOMAL ANTI-CANCER COMPOSITIONS
CN106749447B (zh) * 2017-01-10 2018-02-13 鲁南制药集团股份有限公司 一种盐酸表柔比星中间体化合物
CN108484689B (zh) * 2018-03-06 2020-11-10 道中道（菏泽）制药有限公司 一种戊柔比星合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB691364A (en) * 1949-02-18 1953-05-13 Nat Starch Products Inc Polysaccharide derivatives of substituted dicarboxylic acids
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
GB1566330A (en) * 1977-02-16 1980-04-30 Farmaceutici Italia Anthracycline glycosides
JPS56156300A (en) * 1980-04-26 1981-12-02 Microbial Chem Res Found Novel preparative method of anthracyclin derivative
GB8413464D0 (en) * 1984-05-25 1984-07-04 Erba Farmitalia Anthracycline-anionic polymer conjugates
WO1986000073A1 (en) * 1984-06-14 1986-01-03 BIOGAL Gyógyszergyár Process for preparing adriamycine and halide salts thereof
WO1990000173A1 (en) * 1988-06-27 1990-01-11 Board Of Regents, The University Of Texas System 4'-deoxy-2'-halo-anthracycline antibiotics, methods for their use, and intermediates and methods for synthesis thereof

Also Published As

Publication number Publication date
KR900006357A (ko) 1990-05-08
JPH02129197A (ja) 1990-05-17
AU615774B2 (en) 1991-10-10
EP0363604A3 (en) 1990-07-25
EP0363604A2 (en) 1990-04-18
AU3901189A (en) 1990-04-26
IT8822260A0 (it) 1988-10-11
IL91154A0 (en) 1990-03-19
HUT52516A (en) 1990-07-28
ZA895727B (en) 1990-04-25
IT1230505B (it) 1991-10-25
US5008380A (en) 1991-04-16

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Legal Events

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