IL90104A - Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena - Google Patents
Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomenaInfo
- Publication number
- IL90104A IL90104A IL9010489A IL9010489A IL90104A IL 90104 A IL90104 A IL 90104A IL 9010489 A IL9010489 A IL 9010489A IL 9010489 A IL9010489 A IL 9010489A IL 90104 A IL90104 A IL 90104A
- Authority
- IL
- Israel
- Prior art keywords
- sample
- light
- electrochemiluminescent
- wavelengths
- electrode
- Prior art date
Links
- 238000005259 measurement Methods 0.000 title claims abstract description 76
- 238000001514 detection method Methods 0.000 claims description 56
- 238000000034 method Methods 0.000 claims description 31
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- 238000012546 transfer Methods 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000004044 response Effects 0.000 abstract description 3
- 239000000523 sample Substances 0.000 description 100
- 239000012491 analyte Substances 0.000 description 44
- 239000000126 substance Substances 0.000 description 23
- 239000003153 chemical reaction reagent Substances 0.000 description 20
- 125000006850 spacer group Chemical group 0.000 description 20
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 14
- 239000000203 mixture Substances 0.000 description 13
- 238000003556 assay Methods 0.000 description 10
- 230000008859 change Effects 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 238000010276 construction Methods 0.000 description 7
- 229910052697 platinum Inorganic materials 0.000 description 7
- 239000002243 precursor Substances 0.000 description 7
- 206010036618 Premenstrual syndrome Diseases 0.000 description 6
- 239000003638 chemical reducing agent Substances 0.000 description 6
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 6
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- 238000003487 electrochemical reaction Methods 0.000 description 4
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- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
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- 108090001008 Avidin Proteins 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
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- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 229920005372 Plexiglas® Polymers 0.000 description 2
- 229910021607 Silver chloride Inorganic materials 0.000 description 2
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- 238000011144 upstream manufacturing Methods 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 101100368725 Bacillus subtilis (strain 168) tagF gene Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
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- 239000008280 blood Substances 0.000 description 1
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- 230000023077 detection of light stimulus Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical group Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
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- 238000011065 in-situ storage Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- AMGQUBHHOARCQH-UHFFFAOYSA-N indium;oxotin Chemical compound [In].[Sn]=O AMGQUBHHOARCQH-UHFFFAOYSA-N 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- DHAFIDRKDGCXLV-UHFFFAOYSA-N n,n-dimethylformamide;1-methylpyrrolidin-2-one Chemical compound CN(C)C=O.CN1CCCC1=O DHAFIDRKDGCXLV-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229910052762 osmium Inorganic materials 0.000 description 1
- SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
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- 229910052702 rhenium Inorganic materials 0.000 description 1
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 description 1
- 229910052703 rhodium Inorganic materials 0.000 description 1
- 239000010948 rhodium Substances 0.000 description 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229910052713 technetium Inorganic materials 0.000 description 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
- XOLBLPGZBRYERU-UHFFFAOYSA-N tin dioxide Chemical compound O=[Sn]=O XOLBLPGZBRYERU-UHFFFAOYSA-N 0.000 description 1
- 229910001887 tin oxide Inorganic materials 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229940125725 tranquilizer Drugs 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/305—Electrodes, e.g. test electrodes; Half-cells optically transparent or photoresponsive electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/08—Optical fibres; light guides
- G01N2201/0833—Fibre array at detector, resolving
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Electrochemistry (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Control Of El Displays (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18709588A | 1988-04-28 | 1988-04-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL90104A0 IL90104A0 (en) | 1989-12-15 |
| IL90104A true IL90104A (en) | 1994-08-26 |
Family
ID=22687576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9010489A IL90104A (en) | 1988-04-28 | 1989-04-27 | Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0411042B1 (de) |
| JP (1) | JPH03504043A (de) |
| AT (1) | ATE142335T1 (de) |
| AU (1) | AU619842B2 (de) |
| CA (1) | CA1325527C (de) |
| DE (1) | DE68927101T2 (de) |
| IL (1) | IL90104A (de) |
| WO (1) | WO1989010552A1 (de) |
| ZA (1) | ZA893143B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0522677B1 (de) * | 1991-07-10 | 1996-12-18 | TDK Corporation | Verfahren zur Messung der Konzentration eines Immuno-Reaktanden unter Verwendung von Elektrochemilumineszenz |
| US5395752A (en) * | 1993-03-19 | 1995-03-07 | Ciba Corning Diagnostics Corp. | Long emission wavelength chemiluminescent compounds and their use in test assays |
| US5466416A (en) * | 1993-05-14 | 1995-11-14 | Ghaed; Ali | Apparatus and methods for carrying out electrochemiluminescence test measurements |
| DE4342942A1 (de) * | 1993-12-16 | 1995-06-22 | Boehringer Mannheim Gmbh | Vorrichtung und Verfahren zur Erzeugung optisch detektierbarer Signale durch Anlegen elektrischer Potentiale an Probeflüssigkeiten |
| KR100449615B1 (ko) * | 1995-03-10 | 2004-12-08 | 메소 스케일 테크놀러지즈, 엘엘시 | 다-배열,다-특이적전기화학발광시험법 |
| FR2764381A1 (fr) * | 1997-06-09 | 1998-12-11 | Univ De Neuchatel | Detecteur electrochimioluminescent |
| US7063946B2 (en) * | 2001-09-10 | 2006-06-20 | Meso Scale Technologies, Llc. | Methods, reagents, kits and apparatus for protein function analysis |
| ATE530895T1 (de) * | 2006-08-25 | 2011-11-15 | Hoffmann La Roche | Zelle zur durchführung elektrochemilumineszenter messungen |
| CN107855142B (zh) * | 2017-11-01 | 2024-07-05 | 深圳市第二人民医院 | 一种基于微流控技术的检测芯片及检测设备 |
| CN115343350B (zh) * | 2022-08-30 | 2025-06-17 | 南京国科精准医学科技有限公司 | 一种电化学发光检测装置以及使用方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1049808A (en) * | 1975-02-10 | 1979-03-06 | Arthur Fontijn | Chemiluminescent method and apparatus for determining the photochemical reactivity of organic pollutants |
| US4236895A (en) * | 1979-06-11 | 1980-12-02 | Meloy Laboratories, Inc. | Analytical apparatus and method employing purified ozone |
| US4280815A (en) * | 1979-06-18 | 1981-07-28 | Technicon Instruments Corporation | Electrochemiluminescent immunoassay and apparatus therefor |
| DE3013765A1 (de) * | 1980-04-10 | 1981-10-15 | Philips Patentverwaltung Gmbh, 2000 Hamburg | Detektroranordnung, insbesondere fuer die fluessigkeitschromatografie |
| DE3029092C2 (de) * | 1980-07-31 | 1984-09-06 | Siemens AG, 1000 Berlin und 8000 München | Detektor für die Chemilumineszenz-Gasanalyse |
| US5238808A (en) * | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
-
1989
- 1989-04-27 IL IL9010489A patent/IL90104A/en unknown
- 1989-04-27 ZA ZA893143A patent/ZA893143B/xx unknown
- 1989-04-27 CA CA000597988A patent/CA1325527C/en not_active Expired - Fee Related
- 1989-04-28 DE DE68927101T patent/DE68927101T2/de not_active Expired - Fee Related
- 1989-04-28 JP JP1505273A patent/JPH03504043A/ja active Pending
- 1989-04-28 AT AT89905570T patent/ATE142335T1/de not_active IP Right Cessation
- 1989-04-28 AU AU35524/89A patent/AU619842B2/en not_active Ceased
- 1989-04-28 WO PCT/US1989/001805 patent/WO1989010552A1/en not_active Ceased
- 1989-04-28 EP EP89905570A patent/EP0411042B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0411042B1 (de) | 1996-09-04 |
| AU619842B2 (en) | 1992-02-06 |
| ATE142335T1 (de) | 1996-09-15 |
| CA1325527C (en) | 1993-12-28 |
| WO1989010552A1 (en) | 1989-11-02 |
| EP0411042A1 (de) | 1991-02-06 |
| DE68927101D1 (de) | 1996-10-10 |
| IL90104A0 (en) | 1989-12-15 |
| DE68927101T2 (de) | 1997-03-27 |
| JPH03504043A (ja) | 1991-09-05 |
| AU3552489A (en) | 1989-11-24 |
| ZA893143B (en) | 1990-01-31 |
| EP0411042A4 (en) | 1991-11-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed |