IL87643A - Thiazoles, their preparation and pharmaceutical preparations containing them - Google Patents

Thiazoles, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL87643A
IL87643A IL8764388A IL8764388A IL87643A IL 87643 A IL87643 A IL 87643A IL 8764388 A IL8764388 A IL 8764388A IL 8764388 A IL8764388 A IL 8764388A IL 87643 A IL87643 A IL 87643A
Authority
IL
Israel
Prior art keywords
thiadiazol
methyl
tetrahydropyridine
azabicyclo
alkyl
Prior art date
Application number
IL8764388A
Other languages
English (en)
Hebrew (he)
Other versions
IL87643A0 (en
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27449981&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL87643(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB878721342A external-priority patent/GB8721342D0/en
Priority claimed from GB888801758A external-priority patent/GB8801758D0/en
Priority claimed from GB888812145A external-priority patent/GB8812145D0/en
Priority claimed from GB888817311A external-priority patent/GB8817311D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of IL87643A0 publication Critical patent/IL87643A0/xx
Publication of IL87643A publication Critical patent/IL87643A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL8764388A 1987-09-10 1988-09-01 Thiazoles, their preparation and pharmaceutical preparations containing them IL87643A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB878721342A GB8721342D0 (en) 1987-09-10 1987-09-10 Therapeutic agents
GB888801758A GB8801758D0 (en) 1988-01-27 1988-01-27 Therapeutic agents
GB888812145A GB8812145D0 (en) 1988-05-23 1988-05-23 Therapeutic agents
GB888817311A GB8817311D0 (en) 1988-07-20 1988-07-20 Therapeutic agents

Publications (2)

Publication Number Publication Date
IL87643A0 IL87643A0 (en) 1989-02-28
IL87643A true IL87643A (en) 1994-05-30

Family

ID=27449981

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8764388A IL87643A (en) 1987-09-10 1988-09-01 Thiazoles, their preparation and pharmaceutical preparations containing them

Country Status (10)

Country Link
EP (1) EP0307142B1 (fr)
JP (1) JPH01104070A (fr)
KR (1) KR890005103A (fr)
AT (1) ATE111464T1 (fr)
AU (1) AU626209B2 (fr)
DE (1) DE3851498T2 (fr)
DK (1) DK503188A (fr)
IL (1) IL87643A (fr)
NZ (1) NZ225999A (fr)
PT (1) PT88422B (fr)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3854932T2 (de) * 1987-04-15 1996-06-13 Beecham Group Plc Am Brückenkopf substituierte Azabicyclenderivate
CA2000041A1 (fr) * 1988-10-13 1990-04-13 Barry S. Orlek Composes
GB8830226D0 (en) * 1988-12-23 1989-02-22 Beecham Group Plc Novel compounds
US5264444A (en) * 1989-02-22 1993-11-23 Novo Nordisk A/S Piperidine compounds and use
US5328925A (en) * 1989-02-22 1994-07-12 Novo Nordisk A/S Piperidine compounds and their use
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
US5260311A (en) * 1989-02-22 1993-11-09 Novo Nordisk A/S Piperidine compounds and their use
US5106853A (en) * 1989-05-15 1992-04-21 Merck Sharp & Dohme, Ltd. Oxadiazole and its salts, their use in treating dementia
ATE153024T1 (de) * 1989-08-16 1997-05-15 Beecham Group Plc Azabicyclische verbindungen
EP0427390B1 (fr) * 1989-10-07 1996-03-27 Beecham Group Plc Composés azabicycliques, procédé et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant
EP0459568A3 (en) * 1990-05-31 1992-09-30 Merck Sharp & Dohme Ltd. Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use
US5376668A (en) * 1990-08-21 1994-12-27 Novo Nordisk A/S Heterocyclic compounds
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK198390D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5124460A (en) * 1991-05-06 1992-06-23 Merck Sharp & Dohme Ltd. Enantioselective synthesis of 3-substituted 1-azabicyclo (2.2.1)heptanes
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
GB9127279D0 (en) * 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
WO1993014089A1 (fr) * 1992-01-13 1993-07-22 Novo Nordisk A/S Composes heterocycliques, leur preparation et leur utilisation
AU3901393A (en) * 1992-04-10 1993-11-18 Zeneca Limited Biphenylylquinuclidine derivatives as squalene synthase inhibitors
SE9201478D0 (sv) * 1992-05-11 1992-05-11 Kabi Pharmacia Ab Heteroaromatic quinuclidinenes, their use and preparation
GB9211796D0 (en) * 1992-06-04 1992-07-15 Ici Plc Heterocyclic derivatives
GB9216721D0 (en) * 1992-08-06 1992-09-23 Ici Plc Therapeutic heterocyclic derivatives
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
DE69330069D1 (en) * 1992-12-21 2001-05-03 Syngenta Ltd Chinuclidin derivate als squalen synthase inhibitoren
CZ285030B6 (cs) * 1993-08-19 1999-05-12 Novo Nordisk A/S Použití thiadiazolových a oxadiazolových sloučenin pro výrobu farmaceutického prostředku a farmacetický prostředek pro léčení schizofrenie nebo schizofrenních nemocí
US5753683A (en) * 1993-08-19 1998-05-19 Novo Nordisk A/S Antipsychotic method
US6271229B1 (en) 1993-08-19 2001-08-07 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
US6265419B1 (en) 1993-12-21 2001-07-24 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
US5545638A (en) * 1993-12-21 1996-08-13 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
IL112024A (en) * 1993-12-21 1999-07-14 Novo Nordisk As Pharmaceutical compositions comprising tetrahydropyridine derivatives substituted with oxadiazole or thiadiazole for treating gastrointestinal motility disorders
US5821370A (en) * 1994-10-24 1998-10-13 Eli Lilly And Company Heterocyclic compounds and their preparation and use
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
US5565475A (en) * 1994-11-08 1996-10-15 Muhlhauser; Mark A. Method of treating urinary bladder dysfunctions with 3-tetrahydropyridine derivatives
US5510478A (en) * 1994-11-30 1996-04-23 American Home Products Corporation 2-arylamidothiazole derivatives with CNS activity
JPH11500113A (ja) * 1995-02-17 1999-01-06 ノボ ノルディスク アクティーゼルスカブ ヘテロ環化合物類の使用
GB9510459D0 (en) 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
US5712270A (en) * 1995-11-06 1998-01-27 American Home Products Corporation 2-arylamidothiazole derivatives with CNS activity
US5889019A (en) * 1995-11-29 1999-03-30 Eli Lilly And Company Heterocyclic compounds and their use
CA2238555A1 (fr) * 1995-11-29 1997-06-05 Charles Howard Mitch Composes heterocycliques et leur utilisation
NZ324988A (en) * 1995-12-07 1999-08-30 Lilly Co Eli Composition for treating pain comprising a selected muscarinic compound and an analgesic or nsaid
US5914338A (en) * 1996-04-02 1999-06-22 Novo Nordisk Heterocyclic compounds and their preparation and use
JP2000513712A (ja) * 1996-04-24 2000-10-17 ノボ ノルディスク アクティーゼルスカブ 複素環化合物およびその調製およびその使用
EP0901490B1 (fr) * 1996-05-13 2004-04-07 Syngenta Limited Amines bicycliques utilisees comme insecticides
US6117890A (en) * 1996-08-01 2000-09-12 Eli Lilly And Company Method for treating bipolar disorder
EP0821954A1 (fr) * 1996-08-01 1998-02-04 Eli Lilly And Company Méthode de traitement d'arriération mentale
US6090829A (en) * 1996-08-01 2000-07-18 Eli Lilly And Company Method for treating excessive aggression
EP0821956A1 (fr) * 1996-08-01 1998-02-04 Eli Lilly And Company Méthode de traitement de troubles disruptifs de comportement
US6043258A (en) * 1996-08-01 2000-03-28 Eli Lilly And Company Method for treating disruptive behavior disorders with xanomeline
US5834458A (en) * 1996-10-09 1998-11-10 Eli Lilly And Company Heterocyclic compounds and their use
GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
GB9624611D0 (en) * 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
TW370451B (en) 1996-11-26 1999-09-21 Zeneca Ltd Bicyclic amine derivatives
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
US6034108A (en) * 1997-07-28 2000-03-07 Eli Lilly And Company Method for treating mental retardation
US7332508B2 (en) * 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
BRPI0709171A2 (pt) 2006-03-24 2011-06-28 Array Biopharma Inc ativadores de glicoquinase, composição, usos dos referidos ativadores e métodos para preparação dos mesmos
RU2009133258A (ru) * 2007-02-15 2011-03-20 Арджента Дискавери Лимитед (Gb) Гетероциклические производные в качестве ингибиторов мускариновых рецепторов типа мз
JP2008270387A (ja) * 2007-04-18 2008-11-06 Matsushita Electric Ind Co Ltd プリント配線板
EP2072506A1 (fr) * 2007-12-21 2009-06-24 Bayer CropScience AG Thiazolyloxyphenylamidine ou thiadiazolyloxyphenylamidine et son utilisation en tant que fongicide
US20110294835A1 (en) 2008-05-15 2011-12-01 The Board Of Trustees Of The University Of Illinois Muscarinic Agonists as Cognitive Enhancers
WO2012149524A1 (fr) 2011-04-29 2012-11-01 The University Of Toledo Agonistes muscariniques en tant qu'agents d'amélioration de la mémoire de travail et de la flexibilité cognitive

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3770749A (en) * 1971-07-01 1973-11-06 Monsanto Co 3-pyridyl-1,2,4-thiadiazole-5-carboxamides
BE789441A (fr) * 1971-09-30 1973-03-29 Ciba Geigy Nouvel herbicide selectif et procede pour sa preparation
US4226609A (en) * 1979-03-01 1980-10-07 Olin Corporation Selected 3-trichloromethyl-5-cyclic amine-1,2,4-thiadiazole compounds and their use as ammonium nitrification inhibitors
EP0018497B1 (fr) * 1979-04-06 1982-04-28 Bayer Ag Azolyloxy-acétamides, procédé pour leur préparation et leur utilisation comme herbicides
US4282144A (en) * 1979-06-01 1981-08-04 Eastman Kodak Company Azo dyes derived from 5-membered heterocyclic amines and aromatic amine couplers containing sulfo groups, or salts thereof
US4301069A (en) * 1980-06-13 1981-11-17 Eastman Kodak Company Azo dyes from five membered ring heterocyclic amines and aniline, tetrahydroquinoline and benzomorpholine couplers containing thiosulfate alkyl groups
DE3038636A1 (de) * 1980-10-13 1982-05-27 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von substituierten oxyessigsaeureamiden
DE3422861A1 (de) * 1984-06-20 1986-01-02 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von heteroaryloxyacetamiden
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
EP0261763B1 (fr) * 1986-06-27 1994-02-09 Beecham Group Plc Composés N-hétérocycliques bicycliques pontés
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
JP3353406B2 (ja) * 1993-08-16 2002-12-03 富士電機株式会社 燃料電池発電装置

Also Published As

Publication number Publication date
ATE111464T1 (de) 1994-09-15
IL87643A0 (en) 1989-02-28
EP0307142B1 (fr) 1994-09-14
NZ225999A (en) 1992-04-28
DE3851498T2 (de) 1995-05-04
DE3851498D1 (de) 1994-10-20
KR890005103A (ko) 1989-05-11
AU626209B2 (en) 1992-07-23
DK503188D0 (da) 1988-09-09
JPH01104070A (ja) 1989-04-21
PT88422B (pt) 1992-10-30
AU2207388A (en) 1989-03-16
PT88422A (pt) 1989-07-31
EP0307142A1 (fr) 1989-03-15
DK503188A (da) 1989-05-01

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Legal Events

Date Code Title Description
MM9K Patent not in force due to non-payment of renewal fees