IL85773A - 19, 11 beta-aryl- bridged steroids, processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

19, 11 beta-aryl- bridged steroids, processes for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number
IL85773A
IL85773A IL8577388A IL8577388A IL85773A IL 85773 A IL85773 A IL 85773A IL 8577388 A IL8577388 A IL 8577388A IL 8577388 A IL8577388 A IL 8577388A IL 85773 A IL85773 A IL 85773A
Authority
IL
Israel
Prior art keywords
radical
group
hydrogen atom
hydroxy
compound
Prior art date
Application number
IL8577388A
Other languages
English (en)
Other versions
IL85773A0 (en
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IL85773A0 publication Critical patent/IL85773A0/xx
Publication of IL85773A publication Critical patent/IL85773A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0063—Nitrogen and oxygen at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • External Artificial Organs (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL8577388A 1987-03-18 1988-03-17 19, 11 beta-aryl- bridged steroids, processes for the preparation thereof and pharmaceutical compositions containing the same IL85773A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873708942 DE3708942A1 (de) 1987-03-18 1987-03-18 19,11ss-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate

Publications (2)

Publication Number Publication Date
IL85773A0 IL85773A0 (en) 1988-09-30
IL85773A true IL85773A (en) 1994-01-01

Family

ID=6323462

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8577388A IL85773A (en) 1987-03-18 1988-03-17 19, 11 beta-aryl- bridged steroids, processes for the preparation thereof and pharmaceutical compositions containing the same

Country Status (19)

Country Link
US (1) US5095129A (fr)
EP (1) EP0283428B1 (fr)
JP (1) JP2588267B2 (fr)
CN (3) CN1033033C (fr)
AT (1) ATE69055T1 (fr)
AU (1) AU628015B2 (fr)
CA (1) CA1326015C (fr)
DD (1) DD273262A5 (fr)
DE (2) DE3708942A1 (fr)
ES (1) ES2040373T3 (fr)
FI (1) FI101883B (fr)
GR (1) GR3003362T3 (fr)
HU (2) HU206368B (fr)
IE (1) IE62480B1 (fr)
IL (1) IL85773A (fr)
NZ (1) NZ223924A (fr)
PT (1) PT87007B (fr)
WO (1) WO1988007051A1 (fr)
ZA (1) ZA881962B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5446178A (en) * 1987-03-18 1995-08-29 Schering Aktiengesellschaft Process for preparing 19,11β-bridged steroids
DE3832303A1 (de) * 1988-09-20 1990-04-12 Schering Ag 11ss-phenyl-14ssh-steroide
DE3917274A1 (de) * 1989-05-24 1990-11-29 Schering Ag 9(alpha)-hydroxy-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate
DE3921059A1 (de) * 1989-06-23 1991-01-10 Schering Ag 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
DD289541A5 (de) * 1989-08-04 1991-05-02 ��@�K@�������������@�K@��������������@��������k�� Verfahren zur herstellung von 11beta-aryl-16 alpha, 17 alph-cyclohexanoestra-4,9-dienen
DE4038128A1 (de) * 1990-11-27 1992-06-04 Schering Ag 8-en-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate
US5439913A (en) * 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
DE4235220A1 (de) * 1992-10-13 1994-06-16 Schering Ag Gestagen wirksame 19,11ß-überbrückte 4-Estrene
DE4413184A1 (de) * 1994-04-12 1995-10-19 Schering Ag 10,11-C¶3¶-überbrückte Steroide
DE4413185A1 (de) * 1994-04-12 1995-10-19 Schering Ag 11beta,19-überbrückte 13alpha-Alkylsteroide
DE4417880A1 (de) * 1994-05-18 1995-11-23 Schering Ag 19,11beta-Überbrückte 18-Nor-Steroide, Verfahren zu ihrer Herstellung, diese Steroide enthaltende Arzneimittel sowie deren Verwendung zur Herstellung von Arzneimitteln
US5639598A (en) * 1994-05-19 1997-06-17 The Trustees Of The University Of Pennsylvania Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
US5780220A (en) * 1994-05-19 1998-07-14 Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting HIV replication
DE4424222C1 (de) * 1994-07-09 1995-09-14 Metallgesellschaft Ag Gelöstes Methyllithium enthaltendes Synthesemittel sowie Verfahren zu deren Herstellung
DE4434488A1 (de) * 1994-09-14 1996-03-21 Schering Ag Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US5521166A (en) * 1994-12-19 1996-05-28 Ortho Pharmaceitical Corporation Antiprogestin cyclophasic hormonal regimen
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
IL118974A (en) * 1995-08-17 2001-09-13 Akzo Nobel Nv History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
DE19652408C2 (de) * 1996-12-06 2002-04-18 Schering Ag Steroidester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneimitteln
US6090798A (en) * 1997-12-19 2000-07-18 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with glucocorticoid antagonists
GB0000313D0 (en) 2000-01-10 2000-03-01 Astrazeneca Uk Ltd Formulation
EP3693376A1 (fr) 2006-10-24 2020-08-12 Allergan Pharmaceuticals International Limited Compositions pour supprimer la prolifération endométriale
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
EP2550288A1 (fr) 2010-03-22 2013-01-30 Repros Therapeutics Inc. Compositions et procédés pour l'apport non toxique d'antiprogestines
US11103514B2 (en) 2010-05-26 2021-08-31 Corcept Therapeutics, Inc. Treatment of muscular dystrophy
CN103555806B (zh) * 2013-11-16 2015-05-13 江南大学 一种高效利用亚麻刺盘孢霉合成7α-羟基-雄甾烯酮的方法
JP6821582B2 (ja) 2015-03-02 2021-01-27 コーセプト セラピューティクス， インコーポレイテッド Ａｃｔｈ分泌腫瘍を処置するための糖質コルチコイドレセプターアンタゴニストおよびソマトスタチンアナログの使用
EP3277281B1 (fr) 2015-03-30 2022-01-05 Corcept Therapeutics, Inc. Utilisation d'antagonistes de récepteurs de glucocorticoïdes en association avec des glucocorticoïdes pour traiter une insuffisance surrénale
WO2017027851A1 (fr) 2015-08-13 2017-02-16 Corcept Therapeutics, Inc. Procédé permettant d'établir un diagnostic différentiel du syndrome de cushing en fonction de l'hormone adrénocorticotrope (acth)
WO2017127448A1 (fr) 2016-01-19 2017-07-27 Corcept Therapeutics, Inc. Diagnostic différentiel du syndrome de cushing ectopique
AU2018244928B2 (en) 2017-03-31 2023-10-19 Corcept Therapeutics, Inc. Glucocorticoid receptor modulators to treat cervical cancer
US11213526B2 (en) 2017-06-20 2022-01-04 Corcept Therapeutics, Inc. Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators
EP4263807A2 (fr) 2020-12-18 2023-10-25 Instil Bio (Uk) Limited Traitement de lymphocytes infiltrant les tumeurs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2522328B1 (fr) * 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
FR2576025B1 (fr) * 1985-01-14 1987-01-23 Roussel Uclaf Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
CN1080267C (zh) 2002-03-06
US5095129A (en) 1992-03-10
AU1420988A (en) 1988-10-10
CN1141926A (zh) 1997-02-05
FI894364A0 (fi) 1989-09-15
IE62480B1 (en) 1995-02-08
EP0283428A1 (fr) 1988-09-21
JP2588267B2 (ja) 1997-03-05
PT87007B (pt) 1992-06-30
FI101883B1 (fi) 1998-09-15
HU210532A9 (en) 1995-04-28
ZA881962B (en) 1988-09-08
ATE69055T1 (de) 1991-11-15
DD273262A5 (de) 1989-11-08
CN1057770C (zh) 2000-10-25
PT87007A (pt) 1988-04-01
EP0283428B1 (fr) 1991-10-30
FI101883B (fi) 1998-09-15
NZ223924A (en) 1991-12-23
HU911518D0 (en) 1991-11-28
WO1988007051A1 (fr) 1988-09-22
DE3708942A1 (de) 1988-09-29
CA1326015C (fr) 1994-01-11
CN88102162A (zh) 1988-11-23
GR3003362T3 (en) 1993-02-17
AU628015B2 (en) 1992-09-10
CN1033033C (zh) 1996-10-16
IE880793L (en) 1988-09-18
IL85773A0 (en) 1988-09-30
CN1135488A (zh) 1996-11-13
JPH02503194A (ja) 1990-10-04
DE3865863D1 (fr) 1991-12-05
ES2040373T3 (es) 1993-10-16
HU206368B (en) 1992-10-28

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Legal Events

Date Code Title Description
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees