IL85509A - Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride and their production - Google Patents
Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride and their productionInfo
- Publication number
- IL85509A IL85509A IL85509A IL8550988A IL85509A IL 85509 A IL85509 A IL 85509A IL 85509 A IL85509 A IL 85509A IL 8550988 A IL8550988 A IL 8550988A IL 85509 A IL85509 A IL 85509A
- Authority
- IL
- Israel
- Prior art keywords
- biologically active
- multivesicular liposomes
- active substances
- hydrochloride
- emulsion
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title abstract 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title abstract 2
- 229940088623 biologically active substance Drugs 0.000 title abstract 2
- 239000013543 active substance Substances 0.000 abstract 3
- 239000000839 emulsion Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000007762 w/o emulsion Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878704171A GB8704171D0 (en) | 1987-02-23 | 1987-02-23 | Multivesicular liposomes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL85509A0 IL85509A0 (en) | 1988-08-31 |
| IL85509A true IL85509A (en) | 1992-03-29 |
Family
ID=10612750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL85509A IL85509A (en) | 1987-02-23 | 1988-02-23 | Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride and their production |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0280503B9 (de) |
| JP (1) | JP2843566B2 (de) |
| KR (1) | KR970004907B1 (de) |
| AT (1) | ATE87823T1 (de) |
| AU (1) | AU602190B2 (de) |
| CA (1) | CA1323568C (de) |
| DE (1) | DE3879987T2 (de) |
| DK (1) | DK172057B1 (de) |
| ES (1) | ES2053722T4 (de) |
| FI (1) | FI95439C (de) |
| GB (1) | GB8704171D0 (de) |
| GR (1) | GR3007581T3 (de) |
| IE (1) | IE62221B1 (de) |
| IL (1) | IL85509A (de) |
| NO (1) | NO174087C (de) |
| NZ (1) | NZ223599A (de) |
| PT (1) | PT86805B (de) |
| ZA (1) | ZA881241B (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2033714A1 (en) * | 1990-01-25 | 1991-07-26 | Alberto Ferro | Pharmaceutical preparations |
| NZ237464A (en) * | 1990-03-21 | 1995-02-24 | Depotech Corp | Liposomes with at least two separate chambers encapsulating two separate biologically active substances |
| DE4108903A1 (de) * | 1990-08-06 | 1992-02-13 | Nattermann A & Cie | Pharmazeutisches produkt |
| DE4122661C2 (de) * | 1990-08-06 | 1996-07-11 | Nattermann A & Cie | Pharmazeutisches Produkt zur Behandlung von Pneumocystis-carinii-Pneumonie |
| ES2041597B1 (es) * | 1992-05-05 | 1994-06-01 | Bazaco Joan Freixas | Nuevo procedimiento para la preparacion de liposomas que encapsulan productos farmaceuticos y cosmeticos. |
| EP0695169B1 (de) * | 1993-04-22 | 2002-11-20 | SkyePharma Inc. | Multivesikuläre liposomen mit verkapseltem cyclodextrin und pharmakologisch wirksamen verbindungen sowie verfahren zu deren verwendung |
| JP3002702B2 (ja) * | 1993-11-16 | 2000-01-24 | スカイファーム インコーポレーテッド | 活性物質の制御放出を有する小胞 |
| US5993850A (en) * | 1994-09-13 | 1999-11-30 | Skyepharma Inc. | Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances |
| US5931809A (en) * | 1995-07-14 | 1999-08-03 | Depotech Corporation | Epidural administration of therapeutic compounds with sustained rate of release |
| US6306432B1 (en) * | 1997-09-08 | 2001-10-23 | Chiron Corporation | High and low load formulations of IGF-I in multivesicular liposomes |
| ES2343767T3 (es) * | 1997-09-18 | 2010-08-09 | Pacira Pharmaceuticals, Inc. | Composiciones anestesicas liposomicas de liberacion sostenida. |
| JP4575592B2 (ja) | 1997-11-14 | 2010-11-04 | パシラ ファーマシューティカルズ インコーポレーテッド | 多小胞リポソームの製造 |
| JP4937453B2 (ja) | 1999-05-27 | 2012-05-23 | ユーロ−セルティック エス． ア． | 抗感染剤および／または抗炎症剤を適用するための製剤 |
| US7300667B1 (en) | 1999-05-27 | 2007-11-27 | Euro-Celtique, S.A. | Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract |
| CN101190183B (zh) * | 2006-11-29 | 2010-05-12 | 上海医药工业研究院 | 一种盐酸可乐定多泡脂质体及其制备方法 |
| EP2300168B1 (de) | 2008-07-15 | 2019-10-02 | 3 Nine AB | Verfahren und filter zur erfassung von wirkstoffen in der luft |
| ITBO20090012A1 (it) * | 2009-01-15 | 2010-07-16 | Vincenza Dolo | Composizione biocida e suo uso. |
| WO2011127456A2 (en) | 2010-04-09 | 2011-10-13 | Pacira Pharmaceuticals, Inc. | Method for formulating large diameter synthetic membrane vesicles |
| US9770414B2 (en) * | 2010-05-13 | 2017-09-26 | Pacira Pharmaceuticals, Inc. | Sustained release formulation of methotrexate as a disease-modifying antirheumatic drug (DMARD) and an anti-cancer agent |
| CN103260702B (zh) * | 2010-10-28 | 2018-07-27 | 帕西拉制药有限公司 | 非甾体类抗炎药的缓释制剂 |
| CN109983013A (zh) | 2016-11-18 | 2019-07-05 | 帕西拉制药有限公司 | 美洛昔康锌复合物微粒多囊脂质体制剂及其制备方法 |
| US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12151024B2 (en) | 2021-01-22 | 2024-11-26 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| GB2627096A (en) | 2021-10-14 | 2024-08-14 | Pacira Pharmaceuticals Inc | Bupivacaine multivesicular liposome formulations and uses thereof |
| US12251468B1 (en) | 2024-05-20 | 2025-03-18 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12251472B1 (en) | 2024-05-20 | 2025-03-18 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12246092B1 (en) | 2024-05-20 | 2025-03-11 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH624011A5 (de) * | 1977-08-05 | 1981-07-15 | Battelle Memorial Institute |
-
1987
- 1987-02-23 GB GB878704171A patent/GB8704171D0/en active Pending
-
1988
- 1988-02-22 NO NO880768A patent/NO174087C/no not_active IP Right Cessation
- 1988-02-23 NZ NZ223599A patent/NZ223599A/xx unknown
- 1988-02-23 DK DK093988A patent/DK172057B1/da not_active IP Right Cessation
- 1988-02-23 ZA ZA881241A patent/ZA881241B/xx unknown
- 1988-02-23 AU AU12055/88A patent/AU602190B2/en not_active Expired
- 1988-02-23 JP JP63040522A patent/JP2843566B2/ja not_active Expired - Lifetime
- 1988-02-23 CA CA000559596A patent/CA1323568C/en not_active Expired - Lifetime
- 1988-02-23 AT AT88301512T patent/ATE87823T1/de not_active IP Right Cessation
- 1988-02-23 DE DE8888301512T patent/DE3879987T2/de not_active Expired - Lifetime
- 1988-02-23 IL IL85509A patent/IL85509A/xx not_active IP Right Cessation
- 1988-02-23 EP EP88301512A patent/EP0280503B9/de not_active Expired - Lifetime
- 1988-02-23 PT PT86805A patent/PT86805B/pt not_active IP Right Cessation
- 1988-02-23 IE IE48688A patent/IE62221B1/en not_active IP Right Cessation
- 1988-02-23 ES ES88301512T patent/ES2053722T4/es not_active Expired - Lifetime
- 1988-02-23 FI FI880841A patent/FI95439C/fi active IP Right Grant
- 1988-02-23 KR KR1019880001859A patent/KR970004907B1/ko not_active Expired - Fee Related
-
1993
- 1993-04-08 GR GR930400190T patent/GR3007581T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0280503B1 (de) | 1993-04-07 |
| FI95439B (fi) | 1995-10-31 |
| DK172057B1 (da) | 1997-10-06 |
| DK93988A (da) | 1988-08-24 |
| GR3007581T3 (de) | 1993-08-31 |
| ZA881241B (en) | 1988-08-23 |
| FI95439C (fi) | 1996-02-12 |
| NO880768L (no) | 1988-08-24 |
| IE62221B1 (en) | 1995-01-11 |
| NO174087C (no) | 1994-03-16 |
| DE3879987T2 (de) | 1993-07-15 |
| KR890012638A (ko) | 1989-09-18 |
| EP0280503A3 (en) | 1989-10-11 |
| FI880841A0 (fi) | 1988-02-23 |
| AU1205588A (en) | 1988-08-25 |
| DE3879987D1 (de) | 1993-05-13 |
| NZ223599A (en) | 1990-09-26 |
| NO880768D0 (no) | 1988-02-22 |
| JPH01125318A (ja) | 1989-05-17 |
| ATE87823T1 (de) | 1993-04-15 |
| FI880841L (fi) | 1988-08-24 |
| PT86805B (pt) | 1992-05-29 |
| AU602190B2 (en) | 1990-10-04 |
| CA1323568C (en) | 1993-10-26 |
| NO174087B (no) | 1993-12-06 |
| EP0280503B9 (de) | 2004-04-21 |
| IL85509A0 (en) | 1988-08-31 |
| DK93988D0 (da) | 1988-02-23 |
| JP2843566B2 (ja) | 1999-01-06 |
| ES2053722T3 (es) | 1994-08-01 |
| GB8704171D0 (en) | 1987-04-01 |
| ES2053722T4 (es) | 2004-06-01 |
| PT86805A (pt) | 1988-03-01 |
| KR970004907B1 (ko) | 1997-04-08 |
| EP0280503A2 (de) | 1988-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| HC | Change of name of proprietor(s) | ||
| KB | Patent renewed | ||
| EXP | Patent expired |