IL81663A - Apparatus for performing automated amplification of nucleic acid sequences using heating and cooling steps - Google Patents

Apparatus for performing automated amplification of nucleic acid sequences using heating and cooling steps

Info

Publication number
IL81663A
IL81663A IL81663A IL8166387A IL81663A IL 81663 A IL81663 A IL 81663A IL 81663 A IL81663 A IL 81663A IL 8166387 A IL8166387 A IL 8166387A IL 81663 A IL81663 A IL 81663A
Authority
IL
Israel
Prior art keywords
heating
nucleic acid
acid sequences
cooling steps
performing automated
Prior art date
Application number
IL81663A
Other languages
English (en)
Other versions
IL81663A0 (en
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27125619&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL81663(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of IL81663A0 publication Critical patent/IL81663A0/xx
Publication of IL81663A publication Critical patent/IL81663A/xx

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Medicinal Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heat-Exchange Devices With Radiators And Conduit Assemblies (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Compression-Type Refrigeration Machines With Reversible Cycles (AREA)
IL81663A 1986-02-25 1987-02-24 Apparatus for performing automated amplification of nucleic acid sequences using heating and cooling steps IL81663A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83336886A 1986-02-25 1986-02-25
US89906186A 1986-08-22 1986-08-22

Publications (2)

Publication Number Publication Date
IL81663A0 IL81663A0 (en) 1987-09-16
IL81663A true IL81663A (en) 1991-05-12

Family

ID=27125619

Family Applications (1)

Application Number Title Priority Date Filing Date
IL81663A IL81663A (en) 1986-02-25 1987-02-24 Apparatus for performing automated amplification of nucleic acid sequences using heating and cooling steps

Country Status (13)

Country Link
EP (2) EP0236069B1 (xx)
JP (2) JP2613877B2 (xx)
KR (1) KR910006599B1 (xx)
AT (1) ATE152529T1 (xx)
AU (2) AU612316B2 (xx)
CA (1) CA1339653C (xx)
DE (3) DE776967T1 (xx)
DK (1) DK97887A (xx)
ES (1) ES2033666T1 (xx)
GR (1) GR920300087T1 (xx)
IE (1) IE81124B1 (xx)
IL (1) IL81663A (xx)
NZ (1) NZ219388A (xx)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1339653C (en) * 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
IL86724A (en) * 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
CA1323293C (en) * 1987-12-11 1993-10-19 Keith C. Backman Assay using template-dependent nucleic acid probe reorganization
FI79342C (fi) * 1987-12-23 1989-12-11 Orion Yhtymae Oy Apparat, del av en apparat och foerfarande foer maongfaldigande av nukleinsyror.
JP2846018B2 (ja) * 1988-01-21 1999-01-13 ジェネンテク，インコーポレイテッド 核酸配列の増幅および検出
US5024934A (en) * 1988-03-14 1991-06-18 The Board Of Regents, The University Of Texas System Detection of minimal numbers of neoplastic cells carrying DNA translocations by DNA sequence amplification
DE3808942A1 (de) * 1988-03-17 1989-09-28 Bio Med Gmbh Ges Fuer Biotechn Inkubator, insbes. fuer die polymerase-ketten-methode
GB2233476B (en) * 1988-03-26 1992-01-29 Peter Duncan Goodearl Dean Reaction temperature control
GB8807297D0 (en) * 1988-03-26 1988-04-27 Dean P D G Intelligent heating block
GB8814962D0 (en) * 1988-06-23 1988-07-27 Lep Scient Ltd Biochemical reaction machine
DE68927373T2 (de) * 1988-06-24 1997-03-20 Amgen Inc., Thousand Oaks, Calif. Verfahren und mittel zum nachweis von nukleinsäuresequenzen
US5066584A (en) * 1988-09-23 1991-11-19 Cetus Corporation Methods for generating single stranded dna by the polymerase chain reaction
US5075216A (en) * 1988-09-23 1991-12-24 Cetus Corporation Methods for dna sequencing with thermus aquaticus dna polymerase
US4865986A (en) * 1988-10-06 1989-09-12 Coy Corporation Temperature control apparatus
GB8826364D0 (en) * 1988-11-10 1988-12-14 Sykes B C Improvements in/relating to temperature sequencing
CA1338505C (en) * 1989-02-03 1996-08-06 John Bruce Findlay Containment cuvette for pcr and method of use
GB8917963D0 (en) * 1989-08-05 1989-09-20 Scras Apparatus for repeated automatic execution of a thermal cycle for treatment of biological samples
WO1991007504A1 (en) * 1989-11-21 1991-05-30 Kindconi Pty. Ltd. Improved dna polymerisation device
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
US7273749B1 (en) 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US6716580B2 (en) 1990-06-11 2004-04-06 Somalogic, Inc. Method for the automated generation of nucleic acid ligands
AT394911B (de) * 1990-09-12 1992-07-27 Vaillant Gmbh Elektronischer raumtemperatur-regler
KR100236506B1 (ko) * 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US6703236B2 (en) 1990-11-29 2004-03-09 Applera Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
FR2672301A1 (fr) * 1991-02-01 1992-08-07 Larzul Daniel Procede et dispositif pour amplifier le nombre d'une sequence definie d'acide nucleique dans un echantillon biologique.
US5270183A (en) * 1991-02-08 1993-12-14 Beckman Research Institute Of The City Of Hope Device and method for the automated cycling of solutions between two or more temperatures
CA2065719A1 (en) 1991-04-30 1992-10-31 John B. Findlay Nucleic acid amplification and detection methods using rapid polymerase chain reaction cycle
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
AU2140592A (en) * 1991-05-17 1992-12-30 Chiron Corporation Inhibitor of nf-kappa b transcriptional activator and uses thereof
WO1992020778A1 (en) * 1991-05-24 1992-11-26 Kindconi Pty Limited Biochemical reaction control
DK0519338T3 (da) 1991-06-20 1996-10-28 Hoffmann La Roche Forbedrede fremgangsmåder til nukleinsyreamplifikation
AU645915B2 (en) * 1991-07-23 1994-01-27 F. Hoffmann-La Roche Ag Improvements in the in situ PCR
FI915731A0 (fi) * 1991-12-05 1991-12-05 Derek Henry Potter Foerfarande och anordning foer reglering av temperaturen i ett flertal prov.
US5567583A (en) * 1991-12-16 1996-10-22 Biotronics Corporation Methods for reducing non-specific priming in DNA detection
US6033854A (en) * 1991-12-16 2000-03-07 Biotronics Corporation Quantitative PCR using blocking oligonucleotides
US5348853A (en) * 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
EP0636413B1 (en) * 1993-07-28 2001-11-14 PE Corporation (NY) Nucleic acid amplification reaction apparatus and method
CA2130013C (en) * 1993-09-10 1999-03-30 Rolf Moser Apparatus for automatic performance of temperature cycles
CA2130517C (en) * 1993-09-10 1999-10-05 Walter Fassbind Array of reaction containers for an apparatus for automatic performance of temperature cycles
US5597694A (en) * 1993-10-07 1997-01-28 Massachusetts Institute Of Technology Interspersed repetitive element-bubble amplification of nucleic acids
US5622822A (en) 1994-09-13 1997-04-22 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using polyethyleneimine and an anionic phosphate ester surfactant and amplification of same
US5582988A (en) 1994-09-15 1996-12-10 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same
US5705366A (en) 1994-09-15 1998-01-06 Johnson & Johnson Clinical Diagnostics, Inc. Coamplification of target nucleic acids using volume exclusion agent in reaction composition, test kit and test device useful therefor
GB9501234D0 (en) * 1995-01-23 1995-03-15 Marshall Biotech Ltd Thermoregulator
CA2257109C (en) 1996-06-04 2009-10-06 University Of Utah Research Foundation Monitoring hybridization during pcr
ATE251496T1 (de) * 1997-03-28 2003-10-15 Pe Corp Ny Einrichtung für thermozyklier-geräten für pcr
US7133726B1 (en) 1997-03-28 2006-11-07 Applera Corporation Thermal cycler for PCR
US6893877B2 (en) 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
CN1528880A (zh) * 1998-02-10 2004-09-15 东洋钢钣株式会社 用于制备固定化dna文库的装置，基因扩增的装置，温度控制方法以及系统比较基因的方法
MXPA01007352A (es) * 1999-01-19 2003-06-06 Somalogic Inc Metodo y aparato para la generacion automatizada de ligandos de acido nucleico.
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
CN1348396A (zh) 1999-03-19 2002-05-08 金克克国际有限公司 用于高效筛选的多通孔测试板
JP2001136954A (ja) * 1999-08-31 2001-05-22 Toshiba Corp 核酸処理器及び核酸処理方法
DE19946427C2 (de) * 1999-09-28 2002-07-04 Lange Gmbh Dr Bruno Verfahren und Vorrichtung zum definierten gleichzeitigen Wärmebehandeln von mehreren Probenbehältern
DE29917313U1 (de) 1999-10-01 2001-02-15 MWG-BIOTECH AG, 85560 Ebersberg Vorrichtung zur Durchführung chemischer oder biologischer Reaktionen
AU2001238606A1 (en) 2000-02-18 2001-08-27 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US7727479B2 (en) 2000-09-29 2010-06-01 Applied Biosystems, Llc Device for the carrying out of chemical or biological reactions
WO2003000419A2 (en) * 2001-06-21 2003-01-03 Hybaid Limited Sample well plate
KR100459896B1 (ko) * 2002-03-06 2004-12-04 삼성전자주식회사 Ｐｃｒ 칩을 구동하기 위한 온도 제어 방법 및 그 장치
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
AU2003302264A1 (en) 2002-12-20 2004-09-09 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US8676383B2 (en) 2002-12-23 2014-03-18 Applied Biosystems, Llc Device for carrying out chemical or biological reactions
AU2003223108A1 (en) * 2003-03-31 2004-10-25 Council Of Scientific And Industrial Research Rapid heat-mediated method for enzyme-linked immunosorbent assay procedure
JP2007529015A (ja) 2004-03-12 2007-10-18 バイオトローブ， インコーポレイテッド ナノリットルのアレイローディング
EP2415524A2 (en) 2005-03-30 2012-02-08 F. Hoffmann-La Roche AG Sealed Device
DE602005021967D1 (de) 2005-09-06 2010-08-05 Roche Diagnostics Gmbh Vorrichtung mit komprimierbarer Matrix und homogenem Strömungsprofil
US8232091B2 (en) 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
EP2489745B1 (en) 2006-06-05 2017-01-11 California Institute Of Technology Real time micro arrays
EP1886727A1 (en) 2006-07-14 2008-02-13 Roche Diagnostics GmbH Analytical device
JP4918409B2 (ja) 2006-07-26 2012-04-18 西川ゴム工業株式会社 核酸配列の増幅方法
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
EP1962084A1 (en) 2007-02-21 2008-08-27 Roche Diagnostics GmbH Apparatus for emitting and detecting beams of light
EP2127751B1 (en) 2008-05-19 2012-05-16 Roche Diagnostics GmbH Improved cooler / heater arrangement with solid film lubricant
JP5372418B2 (ja) * 2008-06-23 2013-12-18 株式会社日立ハイテクノロジーズ 核酸分析装置，自動分析装置、及び分析方法
CN102164674B (zh) * 2008-09-23 2014-07-16 皇家飞利浦电子股份有限公司 热循环设备
WO2011031377A1 (en) 2009-09-09 2011-03-17 Helixis, Inc. Optical system for multiple reactions
CN103003448B (zh) 2010-04-09 2015-06-17 生命技术公司 使用动态控制改进热循环仪的热均匀性
EP2598660B1 (en) 2010-07-26 2017-03-15 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
WO2012018639A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
US20160214110A1 (en) 2013-09-16 2016-07-28 Life Technologies Corporation Apparatuses, Systems and Methods for Providing Thermocycler Thermal Uniformity
JP5820459B2 (ja) * 2013-12-18 2015-11-24 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． サーモサイクルデバイス
KR20160123356A (ko) 2014-02-18 2016-10-25 라이프 테크놀로지스 코포레이션 스케일러블 유전자증폭기를 제공하고 열전 장치를 격리시키기 위한 장치, 시스템 및 방법
EP3154338B1 (en) 2014-06-10 2020-01-29 Biomatrica, INC. Stabilization of thrombocytes at ambient temperatures
EP2985603A1 (en) 2014-08-13 2016-02-17 Yantai AusBio Laboratories Co., Ltd. Method for carrying out a ligand binding assay and device for carrying out such a method
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
JP6827048B2 (ja) 2015-12-08 2021-02-10 バイオマトリカ，インク． 赤血球沈降速度の低下
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
EP3937780A4 (en) 2019-03-14 2022-12-07 InSilixa, Inc. METHODS AND SYSTEMS FOR TIMED FLUORESCENCE-BASED DETECTION
CN113467539B (zh) * 2021-06-09 2023-03-14 上海闻泰信息技术有限公司 基于余热回收的温控系统、控温方法和电子设备

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3505023A (en) * 1967-11-13 1970-04-07 Research Corp Thermally conditioned spot plate
US3847200A (en) * 1972-05-01 1974-11-12 Brinkmann Instr Inc Apparatus for concentrating laboratory specimens by evaporation
FR2360846A1 (fr) * 1976-06-21 1978-03-03 Luce Joseph Etuve-refrigerateur a organe unique de chauffe et de refrigeration
FR2413708A1 (fr) * 1977-12-30 1979-07-27 Poudres & Explosifs Ste Nale Procede et installation de regulation de la temperature d'un corps a partir d'un fluide
JPS5526435A (en) * 1978-08-16 1980-02-25 Hitachi Ltd Programmer
DD157983A3 (de) 1980-08-19 1982-12-22 Dieter Baumert Anordnung zur aufschaltung einer stoergroesse fuer die regelung der heiz-u.kuehlleistung einer peltierbatterie eines thermostaten
EP0058428B1 (en) * 1981-02-18 1985-10-09 Eisai Co., Ltd. An enzyme immuno-assay for simultaneously measuring a plurality of samples and test vessel for carrying out this method
JPS5875064A (ja) * 1981-10-30 1983-05-06 Eisai Co Ltd 生化学的検査や免疫反応に用いられる測定装置
DE3149624A1 (de) * 1981-12-15 1983-06-23 Georg 6050 Offenbach May Vorrichtung zur regelung der temperatur von stoffen
DE3238535A1 (de) * 1982-10-18 1984-04-19 Planer Products Ltd., Sunbury-on-Thames, Middlesex Verfahren und apparat zum gesteuerten kuehlen eines produktes
JPS59100905A (ja) 1982-12-01 1984-06-11 Omron Tateisi Electronics Co プログラム制御装置
JPS59112254A (ja) * 1982-12-20 1984-06-28 Komatsu Electron Kk 試料の加熱冷却装置
US4683194A (en) * 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
JPS6130597A (ja) * 1984-07-20 1986-02-12 Nippon Zeon Co Ltd ポリヌクレオチド合成装置
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DK171161B1 (da) * 1985-03-28 1996-07-08 Hoffmann La Roche Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve
CA1339653C (en) * 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
JPH0467957A (ja) * 1990-07-09 1992-03-03 Fujitsu Ltd プリンタのインパクトドット印字ヘッド

Also Published As

Publication number Publication date
IE81124B1 (en) 2000-03-22
DK97887A (da) 1987-08-26
DE3752057T2 (de) 1997-09-25
EP0776967A3 (en) 1997-09-10
DK97887D0 (da) 1987-02-25
JPS62240862A (ja) 1987-10-21
NZ219388A (en) 1989-02-24
GR920300087T1 (en) 1992-12-30
JPH07303468A (ja) 1995-11-21
DE236069T1 (de) 1993-02-04
ATE152529T1 (de) 1997-05-15
EP0776967A2 (en) 1997-06-04
ES2033666T1 (es) 1993-04-01
DE776967T1 (de) 1997-11-20
AU612316B2 (en) 1991-07-11
CA1339653C (en) 1998-02-03
KR910006599B1 (ko) 1991-08-29
DE3752057D1 (de) 1997-06-05
JP2613877B2 (ja) 1997-05-28
EP0236069A2 (en) 1987-09-09
KR870007945A (ko) 1987-09-23
EP0236069B1 (en) 1997-05-02
IL81663A0 (en) 1987-09-16
AU653932B2 (en) 1994-10-20
AU6918087A (en) 1987-08-27
EP0236069A3 (en) 1990-10-03
AU7609291A (en) 1991-09-12

Similar Documents

Publication Publication Date Title
IL81663A (en) Apparatus for performing automated amplification of nucleic acid sequences using heating and cooling steps
JP4103964B2 (ja) 温度勾配ブロックを含む熱サイクル装置
Nagai et al. High-throughput PCR in silicon based microchamber array
DK1452608T3 (da) Automatiseret udförelse af polymerasekædereaktion
DE60029256D1 (de) Vorrichtung zum schnellen thermischen recycling
EP2061866B1 (en) Rapid thermocycler
DE69818869D1 (de) Einrichtung für Thermozyklier-Geräten für PCR
NO20021340L (no) Innretning for gjennomföring av kjemiske eller biologiske reaksjoner
RU99114775A (ru) Реакторы
ATE401958T1 (de) Vorrichtung und verfahren zur durchführung von wärmetauschenden chemischen reaktionen
ATE202012T1 (de) Vorrichtung und verfahren zur cyclischen probenaufbereitung bei verschiedenen temperaturen und verwendung der vorrichtung
DE69429038D1 (de) Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung
DE68905618D1 (de) Verfahren und vorrichtungen zur waermebehandlung von kohlenstoffstahldraehten, um so ein feines perlitisches gefuege zu bekommen.
NO874164D0 (no) Masseundersoekelsesmetode for deteksjon av enkeltbasemutasjoner i multiple loci i genomisk dna ved bruk av denatureringsgradient-gelelektroforese fulgt av effektiv overfoering og hybredisering til forskjellige prober.

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired