US3847200A - Apparatus for concentrating laboratory specimens by evaporation - Google Patents

Apparatus for concentrating laboratory specimens by evaporation Download PDF

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Publication number
US3847200A
US3847200A US24882072A US3847200A US 3847200 A US3847200 A US 3847200A US 24882072 A US24882072 A US 24882072A US 3847200 A US3847200 A US 3847200A
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Prior art keywords
plurality
chambers
vessels
air
respective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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Inventor
R Kopp
H Holland
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BRINKMANN INSTRUMENTS Inc A CORP OF DE
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BRINKMANN INSTR Inc
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • G01N1/4022Concentrating samples by thermal techniques; Phase changes
    • G01N2001/4027Concentrating samples by thermal techniques; Phase changes evaporation leaving a concentrated sample

Abstract

Apparatus is disclosed for concentrating chemical and biological specimens which are present in dilute solutions in solvent liquids. By means of a pressure differential and air jet nozzles, the vapor layer which normally appears above the specimens is continuously dispelled. The evaporating areas are maintained under sub-atmospheric pressure both to augment the evaporation process and induce a jet stream of air which impinges on the specimen surface. The specimen containers are heated from a controlled source, such as a thermostatically controlled heat sink.

Description

United States Patent 1191 Kopp et al. Nov. 12, 1974 1 APPARATUS FOR CONCENTRATING 2.803.888 8/1957 Cerletti 159 010. 11 LABORATORY SPECIMENS BY EVAPORATION 2:771:645 11 1956 -Martin 34/105 l [75] Inventors 'jggfi 'g' 32553 122 FOREIGN PATENTS OR APPLICATIONS of 451,686 10/1948 Canada l59/DlG. 11

[73] Asslgneez i g Primary Examiner-Norman Yudkoff Assistant Examiner-Frank Sever [22] Filed: May 1, 1972 Attorney, Agent, or FirmEisenman, Allsopp & 121 Appl. No; 248,820 Stmck 57 ABSTRA T [52] US. Cl. 159/16 R, 23/274, 23/292 1 C [51] Int. Cl B0ld l/l4 App f is dlsclosed Concentrating and [58] Fi ld f S h 159/16 R D16 1 11 16; biological specimens which are present in dtlutc solu- 34/104 105 tions in solvent liquids, By means of a pressure differential and air jet nozzles, the vapor layer which nor [56] R f n Ci d mally appears above the specimens is continuously UNITED STATES PATENTS dispelled. The evaporating areas are maintained under 5 sub-atmospheric pressure both to augment the evapo- 2,33; 5 159/16 R ration process and induce a jet stream of air which img' 9/1973 32 B; pinges on the specimen surface. The specimen con- 217T684 7/1879 Elmerw: tainers are heated from a controlled source, such as a 20 7 2 3/1378 E m thermostatically controlled heat sink. 937,l 14 10/1909 Suzuki 3,084,537 4/1963 Shipstead 159 16 3 3 D'awmg 1 2 APPARATUS FOR CONCENTRATING DESCRIPTION OF THE PREFERRED LABORATORY SPECIMENS BY EVAPORATION EMBODIMENT BACKGROUND OF THE INVENTION The invention 18 illustrated as embodied in a speci- 5 men-evaporating apparatus including a housing assem- The invention is concerned with apparatus for conbly 10 for holding a plurality of specimens to be evapocentrating chemical and biological specimens which rated and connected to a vacuum pump 11, preferab) occur in a highly diluted or attenuated form in an through a fume condenser 12. Th h evaporatable medium. mg mbly as best seen In FIG. 2, includes a ba {mu-m u Conventionally, laboratory specimens are COIIC'fl- 1' foffi more volatllfi liquids or H 12mmlgmumhwmSmmmm\m% 0 a l I i m 2x3115322 L ml will if lffilfil'fil I 10 ex aust to h 1S sphere m order to prevent the accumulation f t hiatus l5 and led by titer. m the laboratory. It is also known in; 0 vd rs I llS ltmpmm atmospheric pressure in the chamber 27 and with the vapor layer being continuously dispelled, an accelerated evaporation rate occurs without the necessity of resorting to higher evaporating temperatures which Referring to FIG. 3, there is illustrated a modification,

of the invention in which the cover assembly 24' includes nozzle tubes 33 (which can correspond in num-. bet to the number of rows of specimen vials) supported by the end walls of the cover assembly 24. The nozzle tubes 33are vented at their ends to the atmosphere and include at equally spaced points along their lengths radial bores 34-l, 34-2 34-36 directed downwardly to the respective" specimen holders. in this modification, the entire inside chamber 35 of the cover assembly defines the exhaust manifold and the spaces within the nozzle tubes 33 define the intake manifold. With the chamber 35 placed under sub-atmospheric pressure, the system functions identically with that described above having reference to FIG. 2.

While the invention has been described having reference to the preferred embodiments thereof, it will be understood that it can take various other forms and arrangements within the scope of the invention. llt should not, therefore, be. regarded as limited except as defined in the following claims We claim: I

' 1. Apparatus for concentrating laboratory specimens byevaporation comprising a base receptacle for a plurality of specimen vessels and including a heat sink having a plurality of individual chambers adapted to have seated therein open vessels containing laboratory specimens, a heat source for the-heat sink including means to regulate the temperature thereof, a detachable cover assembly adapted to be seated in substantially air-tight relationship on the base over the chambers, said cover assembly comprising depending side walls including opposing end portions to engage the base in air-tight relationship, at least one rigid horizontal tube member carried by and joined to the opposing side walls and open to the atmosphere through at least one sidewall, the tube member passing horizontally over a plurality of said chambers in close proximity thereto and carrying a plurality of downwardly directed air orifices aligned respectively with the plurality of chambers below, and means to establish sub-atmospheric pressure in the closed, space whereby air is drawn into the tube member and discharged downwardly in a plurality of jet streams into the respective vessels disposed in the by evaporation comprising a base for receiving a plurality of specimen vessels, a heat source for the vessels including meansto regulate the temperature thereof, a detachable cover assembly adapted to be seated in substantially air-tight relationship on the base over the vessels, said cover assembly comprising depending side walls to engage the base and a substantially flat, horizontallydisposed top surface, manifold means carried by the side wallsbetween the top surface and the cham-

Claims (3)

1. Apparatus for concentrating laboratory specimens by evaporation comprising a base receptacle for a plurality of specimen vessels and including a heat sink having a plurality of individual chambers adapted to have seated therein open vessels containing laboratory specimens, a heat source for the heat sink including means to regulate the temperature thereof, a detachable cover assembly adapted to be seated in substantially air-tight relationship on the base over the chambers, said cover assembly comprising depending side walls including opposing end portions to engage the base in air-tight relationship, at least one rigid horizontal tube member carried by and joined to the opposing side walls and open to the atmosphere through at least one side wall, the tube member passing horizontally over a plurality of said chambers in close proximity thereto and carrying a plurality of downwardly directed air orifices aligned respectively with the plurality of chambers below, and means to establish subatmospheric pressure in the closed space whereby air is drawn into the tube member and discharged downwardly in a plurality of jet streams into the respective vessels disposed in the chambers.
2. Apparatus as set forth in claim 1, including a common rack for supporting said plurality of specimen vessels in positions in vertical alignment with the respective chambers in the heat sink, said rack having downwardly extending legs to carry the respective specimen vessels above a supporting surface, and means forming guide slots in the receptacle to receive the legs and to cause the respective vessels to be lowered into their corresponding chambers.
3. Apparatus for concentrating laboratory specimens by evaporation comprising a base for receiving a plurality of specimen vessels, a heat source for the vessels including means to regulate the temperature thereof, a detachable cover assembly adapted to be seated in substantially air-tight relationship on the base over the vessels, said cover assembly comprising depending side walls to engage the base and a substantially flat, horizontally disposed top surface, manifold means carried by the side walls between the top surface and the chambers and defining an air conduit both to the underside of the top surface and to the respective vessels below, the air path to the chambers including a plurality of downwardly directed openings defining air nozzles above The respective chambers, inlet means connecting the manifold to the atmosphere, and means to establish sub-atmospheric pressure in the closed space whereby air is drawn into the conduit and caused to impinge both on the underside of the top surface and downwardly in a plurality of jet streams directed into the respective vessels.
US3847200A 1972-05-01 1972-05-01 Apparatus for concentrating laboratory specimens by evaporation Expired - Lifetime US3847200A (en)

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Application Number Priority Date Filing Date Title
US3847200A US3847200A (en) 1972-05-01 1972-05-01 Apparatus for concentrating laboratory specimens by evaporation

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3847200A US3847200A (en) 1972-05-01 1972-05-01 Apparatus for concentrating laboratory specimens by evaporation
GB635473A GB1427034A (en) 1972-05-01 1973-02-08 Apparatus for concentrating laboratory specimens by evaporation
DE19732307274 DE2307274A1 (en) 1972-05-01 1973-02-14 Apparatus for concentration of laboratory samples by evaporation

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DE (1) DE2307274A1 (en)
GB (1) GB1427034A (en)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4465554A (en) * 1982-02-25 1984-08-14 Mobil Oil Corporation Hot jet evaporator
EP0178793A2 (en) * 1984-10-18 1986-04-23 Analytical Bio-Chemistry Laboratories, Inc. Automatic evaporator system
EP0259307A1 (en) * 1984-11-09 1988-03-16 Zymark Corp Control of laboratory evaporation.
EP0425216A2 (en) * 1989-10-23 1991-05-02 Zymark Corporation Laboratory evaporation apparatus
EP0488769A2 (en) * 1990-11-29 1992-06-03 The Perkin-Elmer Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
EP0711603A1 (en) * 1994-11-11 1996-05-15 Boehringer Mannheim Gmbh System for incubating sample fluids
US5585068A (en) * 1990-02-20 1996-12-17 Biochemical Diagnostics, Inc. Apparatus for automatically separating a compound from a plurality of discrete liquid specimens
EP0776967A3 (en) * 1986-02-25 1997-09-10 Perkin Elmer Corp Heat exchanger for use in a temperature cycling instrument
EP1027933A1 (en) * 1999-02-10 2000-08-16 Büchi Labortechnik AG Device and method for sample treatment
US6132684A (en) * 1997-10-31 2000-10-17 Becton Dickinson And Company Sample tube holder
EP1174703A2 (en) * 2000-07-18 2002-01-23 Volker Barkey Evaporator for samples
WO2003008953A2 (en) * 2001-07-17 2003-01-30 E.I. Du Pont De Nemours And Company Sublimation screening test and apparatus
US20030108450A1 (en) * 2000-05-11 2003-06-12 Irm Llc Specimen plate lid and method of using
US20040151638A1 (en) * 2002-07-17 2004-08-05 Lecloux Daniel David Sublimation screening test and apparatus
US20050158211A1 (en) * 2004-01-16 2005-07-21 Piacenza Donna A. Pipette device with pivotable nozzle assembly
US20060242857A1 (en) * 2005-04-11 2006-11-02 Eppendorf Ag Apparatus, a system incorporating such apparatus, and a method to dry microtitration filter tray cavities and received filters therein
US20090010809A1 (en) * 2007-07-03 2009-01-08 Hadjis Peter T Manual pipette filler
US20090007701A1 (en) * 2007-07-03 2009-01-08 Hadjis Peter T Pivoting pipette device
USD802158S1 (en) * 2014-05-23 2017-11-07 John Bethune Ampoule stand

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2644356B1 (en) * 1989-03-20 1992-11-20 Jouan Process for the concentration of samples by solvent evaporation and centrifugal evaporator-concentrator for carrying out this method
DE50001774D1 (en) 1999-09-29 2003-05-22 Tecan Trading Ag Maennedorf Thermocycler and lifting element for microtiter plate
US7169355B1 (en) 2000-02-02 2007-01-30 Applera Corporation Apparatus and method for ejecting sample well trays
WO2009030342A1 (en) * 2007-08-28 2009-03-12 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Receptacle
WO2017143310A1 (en) * 2016-02-18 2017-08-24 Siemens Healthcare Diagnostics Inc. Rack for a filtration device

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5570A (en) * 1848-05-16 Nathan towson
US42398A (en) * 1864-04-19 Improvement in apparatus for concentrating milk
US201762A (en) * 1878-03-26 Improvement in apparatus for the manufacture of salt
US217684A (en) * 1879-07-22 Improvement in processes and apparatus for the manufacture of salt
US937114A (en) * 1908-10-03 1909-10-19 Tozaburo Suzuki Evaporator.
US2385962A (en) * 1941-08-23 1945-10-02 Foundry Equipment Company Method of and apparatus for conditioning molds and the like
CA451686A (en) * 1948-10-05 Nathaniel Hoyler Cyril Art of concentrating drugs, etc.
US2660513A (en) * 1949-06-30 1953-11-24 Ball Charles Olin Method of sterilizing glass containers
US2771645A (en) * 1950-12-04 1956-11-27 Dole Eng Co James Apparatus for sterilizing food containers
US2803888A (en) * 1954-04-27 1957-08-27 Cerletti Santiago Apparatus for lyophilising products contained in small bottles
US3084537A (en) * 1958-04-30 1963-04-09 Shipstead Helge Method and apparatus for determining total solids in organic liquid materials
US3565767A (en) * 1965-03-11 1971-02-23 Polycom Corp Method and apparatus for removing dissolved impurities from water

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5570A (en) * 1848-05-16 Nathan towson
US42398A (en) * 1864-04-19 Improvement in apparatus for concentrating milk
US201762A (en) * 1878-03-26 Improvement in apparatus for the manufacture of salt
US217684A (en) * 1879-07-22 Improvement in processes and apparatus for the manufacture of salt
CA451686A (en) * 1948-10-05 Nathaniel Hoyler Cyril Art of concentrating drugs, etc.
US937114A (en) * 1908-10-03 1909-10-19 Tozaburo Suzuki Evaporator.
US2385962A (en) * 1941-08-23 1945-10-02 Foundry Equipment Company Method of and apparatus for conditioning molds and the like
US2660513A (en) * 1949-06-30 1953-11-24 Ball Charles Olin Method of sterilizing glass containers
US2771645A (en) * 1950-12-04 1956-11-27 Dole Eng Co James Apparatus for sterilizing food containers
US2803888A (en) * 1954-04-27 1957-08-27 Cerletti Santiago Apparatus for lyophilising products contained in small bottles
US3084537A (en) * 1958-04-30 1963-04-09 Shipstead Helge Method and apparatus for determining total solids in organic liquid materials
US3565767A (en) * 1965-03-11 1971-02-23 Polycom Corp Method and apparatus for removing dissolved impurities from water

Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4465554A (en) * 1982-02-25 1984-08-14 Mobil Oil Corporation Hot jet evaporator
EP0178793A2 (en) * 1984-10-18 1986-04-23 Analytical Bio-Chemistry Laboratories, Inc. Automatic evaporator system
EP0178793A3 (en) * 1984-10-18 1987-12-16 Analytical Bio-Chem Lab Automatic evaporator system
EP0259307A1 (en) * 1984-11-09 1988-03-16 Zymark Corp Control of laboratory evaporation.
EP0259307A4 (en) * 1984-11-09 1988-11-22 Zymark Corp Control of laboratory evaporation.
EP0776967A3 (en) * 1986-02-25 1997-09-10 Perkin Elmer Corp Heat exchanger for use in a temperature cycling instrument
EP0425216A3 (en) * 1989-10-23 1992-03-25 Zymark Corporation Laboratory evaporation apparatus
EP0425216A2 (en) * 1989-10-23 1991-05-02 Zymark Corporation Laboratory evaporation apparatus
US5585068A (en) * 1990-02-20 1996-12-17 Biochemical Diagnostics, Inc. Apparatus for automatically separating a compound from a plurality of discrete liquid specimens
EP0488769A3 (en) * 1990-11-29 1993-05-26 Perkin-Elmer Cetus Instruments Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
US5710381A (en) * 1990-11-29 1998-01-20 The Perkin-Elmer Corporation Two piece holder for PCR sample tubes
US5475610A (en) * 1990-11-29 1995-12-12 The Perkin-Elmer Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
US5602756A (en) * 1990-11-29 1997-02-11 The Perkin-Elmer Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
EP0488769A2 (en) * 1990-11-29 1992-06-03 The Perkin-Elmer Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
US6015534A (en) * 1990-11-29 2000-01-18 The Perkin-Elmer Corporation PCR sample tube
US5670120A (en) * 1994-11-11 1997-09-23 Boehringer Mannheim Gmbh System for incubating sample liquids
EP0711603A1 (en) * 1994-11-11 1996-05-15 Boehringer Mannheim Gmbh System for incubating sample fluids
US6132684A (en) * 1997-10-31 2000-10-17 Becton Dickinson And Company Sample tube holder
WO2000047324A1 (en) * 1999-02-10 2000-08-17 Büchi Labortechnik AG Device and method for processing samples
EP1027933A1 (en) * 1999-02-10 2000-08-16 Büchi Labortechnik AG Device and method for sample treatment
US20030108450A1 (en) * 2000-05-11 2003-06-12 Irm Llc Specimen plate lid and method of using
EP1174703A2 (en) * 2000-07-18 2002-01-23 Volker Barkey Evaporator for samples
EP1174703A3 (en) * 2000-07-18 2003-04-16 Volker Barkey Evaporator for samples
US7179656B2 (en) 2001-07-17 2007-02-20 E. I. Du Pont De Nemours And Company Sublimation screening test and apparatus
US20030054565A1 (en) * 2001-07-17 2003-03-20 Lecloux Daniel David Sublimation screening test and apparatus
WO2003008953A3 (en) * 2001-07-17 2003-10-30 Du Pont Sublimation screening test and apparatus
WO2003008953A2 (en) * 2001-07-17 2003-01-30 E.I. Du Pont De Nemours And Company Sublimation screening test and apparatus
US20040151638A1 (en) * 2002-07-17 2004-08-05 Lecloux Daniel David Sublimation screening test and apparatus
US7381371B2 (en) 2004-01-16 2008-06-03 Heathrow Scientific Llc Pipette device with pivotable nozzle assembly
US20050158211A1 (en) * 2004-01-16 2005-07-21 Piacenza Donna A. Pipette device with pivotable nozzle assembly
US20060242857A1 (en) * 2005-04-11 2006-11-02 Eppendorf Ag Apparatus, a system incorporating such apparatus, and a method to dry microtitration filter tray cavities and received filters therein
US7858393B2 (en) * 2005-04-11 2010-12-28 Eppendorf Ag Method to dry microtitration filter tray cavities and received filters therein
US20090010809A1 (en) * 2007-07-03 2009-01-08 Hadjis Peter T Manual pipette filler
US20090007701A1 (en) * 2007-07-03 2009-01-08 Hadjis Peter T Pivoting pipette device
USD802158S1 (en) * 2014-05-23 2017-11-07 John Bethune Ampoule stand

Also Published As

Publication number Publication date Type
DE2307274A1 (en) 1973-11-22 application
GB1427034A (en) 1976-03-03 application

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AS Assignment

Owner name: SYBRON CORPORATION, ROCHESTER, NY., A CORP. OF NY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:BRINKMANN INSTRUMENTS, INC., (NOW BY CHANGE OF NAME) CANTIAQUE CAPITAL CORPORATION, A CORP. OF NY.;REEL/FRAME:003857/0566

Effective date: 19810427

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Owner name: BRINKMANN INSTRUMENTS INC., CANTIAGUE ROAD, WESTBU

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:SYBRON TRANSITION CORP., A CORP OF DE.;REEL/FRAME:004671/0136

Effective date: 19870204

Owner name: BRINKMANN INSTRUMENTS INC., A CORP OF DE.,NEW YORK

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SYBRON TRANSITION CORP., A CORP OF DE.;REEL/FRAME:004671/0136

Effective date: 19870204