DE60039640D1 - Vorrichtung und Verfahren zur Durchführung von wärmetauschenden chemischen Reaktionen - Google Patents

Vorrichtung und Verfahren zur Durchführung von wärmetauschenden chemischen Reaktionen

Info

Publication number
DE60039640D1
DE60039640D1 DE60039640T DE60039640T DE60039640D1 DE 60039640 D1 DE60039640 D1 DE 60039640D1 DE 60039640 T DE60039640 T DE 60039640T DE 60039640 T DE60039640 T DE 60039640T DE 60039640 D1 DE60039640 D1 DE 60039640D1
Authority
DE
Germany
Prior art keywords
chamber
heat exchanging
chemical reactions
flexible wall
performing heat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60039640T
Other languages
English (en)
Inventor
Ronald Chang
Douglas B Dority
Lee A Christel
Kurt E Petersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cepheid
Original Assignee
Cepheid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cepheid filed Critical Cepheid
Application granted granted Critical
Publication of DE60039640D1 publication Critical patent/DE60039640D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F13/00—Arrangements for modifying heat-transfer, e.g. increasing, decreasing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0332—Cuvette constructions with temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00963—Pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00968—Type of sensors
    • B01J2219/0097—Optical sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28D—HEAT-EXCHANGE APPARATUS, NOT PROVIDED FOR IN ANOTHER SUBCLASS, IN WHICH THE HEAT-EXCHANGE MEDIA DO NOT COME INTO DIRECT CONTACT
    • F28D21/00—Heat-exchange apparatus not covered by any of the groups F28D1/00 - F28D20/00
    • F28D2021/0019—Other heat exchangers for particular applications; Heat exchange systems not otherwise provided for
    • F28D2021/0077—Other heat exchangers for particular applications; Heat exchange systems not otherwise provided for for tempering, e.g. with cooling or heating circuits for temperature control of elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G01N2035/00376—Conductive heating, e.g. heated plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0403—Sample carriers with closing or sealing means
    • G01N2035/0405—Sample carriers with closing or sealing means manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer
DE60039640T 1999-12-21 2000-12-15 Vorrichtung und Verfahren zur Durchführung von wärmetauschenden chemischen Reaktionen Expired - Lifetime DE60039640D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/468,690 US6660228B1 (en) 1998-03-02 1999-12-21 Apparatus for performing heat-exchanging, chemical reactions

Publications (1)

Publication Number Publication Date
DE60039640D1 true DE60039640D1 (de) 2008-09-04

Family

ID=23860833

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60014967T Expired - Lifetime DE60014967T2 (de) 1999-12-21 2000-12-15 Vorrichtung zur durchführung von wärmetauschenden chemischen reaktionen
DE60039640T Expired - Lifetime DE60039640D1 (de) 1999-12-21 2000-12-15 Vorrichtung und Verfahren zur Durchführung von wärmetauschenden chemischen Reaktionen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60014967T Expired - Lifetime DE60014967T2 (de) 1999-12-21 2000-12-15 Vorrichtung zur durchführung von wärmetauschenden chemischen reaktionen

Country Status (6)

Country Link
US (3) US6660228B1 (de)
EP (2) EP1239964B1 (de)
AT (2) ATE279260T1 (de)
AU (1) AU3075301A (de)
DE (2) DE60014967T2 (de)
WO (1) WO2001045845A1 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8293064B2 (en) * 1998-03-02 2012-10-23 Cepheid Method for fabricating a reaction vessel
US6818185B1 (en) * 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
US6403037B1 (en) * 2000-02-04 2002-06-11 Cepheid Reaction vessel and temperature control system
US6935997B2 (en) * 2000-09-14 2005-08-30 Rutgers, The State University Of New Jersey Patterning technology for folded sheet structures
WO2005055804A2 (en) 2003-12-02 2005-06-23 Musc Foundation For Research Development Methods and compositions for diagnosing epithelial cell cancer
US7981616B2 (en) 2004-02-27 2011-07-19 Musc Foundation For Research Development Enhanced detection of RNA using a panel of truncated gene-specific primers for reverse transcription
CA2571642A1 (en) 2004-07-09 2006-02-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Educatio N Identification of markers in lung and breast cancer
TWI392863B (zh) * 2004-08-05 2013-04-11 Universal Bio Research Co Ltd 反應容器、反應容器液體導入裝置、液體導入反應測定裝置及液體導入裝置
US8056881B2 (en) 2004-10-13 2011-11-15 University Of Virginia Patent Foundation Electrostatic actuation for management of flow in micro-total analysis systems (μ-TAS) and related method thereof
US20060094028A1 (en) * 2004-11-04 2006-05-04 Welch Allyn, Inc. Rapid diagnostic assay
JP4922185B2 (ja) * 2004-12-22 2012-04-25 ユニバーシティ・オブ・ヴァージニア・パテント・ファウンデーション マイクロデバイスまたはナノスケールデバイスにおける熱用途または非熱用途のためのマイクロ波の使用
JP5335420B2 (ja) * 2005-05-24 2013-11-06 リー エイチ． アングロス， ｉｎｓｉｔｕ熱誘導抗原回復・着色装置および方法
WO2007030240A2 (en) * 2005-08-01 2007-03-15 University Of Virginia Patent Foundation Microdevices for chemical sensing and chemical actuation
AU2006283177B2 (en) 2005-08-23 2011-11-17 University Of Virginia Patent Foundation Passive components for micro-fluidic flow profile shaping and related method thereof
US20110033922A1 (en) * 2005-10-04 2011-02-10 Landers James P Microchip-based acoustic trapping or capture of cells for forensic analysis and related method thereof
US8916375B2 (en) 2005-10-12 2014-12-23 University Of Virginia Patent Foundation Integrated microfluidic analysis systems
US8119352B2 (en) 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
WO2008004695A1 (fr) * 2006-07-07 2008-01-10 Universal Bio Research Co., Ltd. Contenant de réaction et dispositif de réaction
US7548081B1 (en) * 2007-07-31 2009-06-16 Agilent Technologies, Inc. System and method for controlling environmental parameters of a device under test
JP5598766B2 (ja) * 2008-04-10 2014-10-01 デナトール アクティエボラグ 生体試料を保管し調整する装置
CA2760982C (en) * 2009-05-15 2019-01-15 Biomerieux, Inc. System and methods for rapid identification and/or characterization of a microbial agent in a sample
US20110081686A1 (en) * 2009-10-01 2011-04-07 Vical Incorporated Reactor for Bulk Manufacture of PCR Amplicons
AU2011216253B2 (en) * 2010-02-12 2015-07-02 Northwestern University Assay card for sample acquisition, treatment and reaction
WO2011148432A1 (ja) * 2010-05-28 2011-12-01 栄研化学株式会社 ピペット
BR112013001647A2 (pt) 2010-07-23 2016-05-24 Beckman Coulter Inc sistema e método contendo unidades analíticas
DE102010048443B4 (de) * 2010-10-15 2015-05-21 Technische Universität Braunschweig Carolo-Wilhelmina Verfahren zur durchführung von zeitaufgelösten untersuchungen an zellproben
KR101420094B1 (ko) 2010-10-27 2014-07-17 (주)바이오니아 다양한 생체시료분석을 위한 전자동실시간정량증폭장비, 다양한 생체시료분석을 위한 자동정제 및 반응준비 장치, 전자동 핵산정제 및 실시간 정량 유전자증폭 방법, 전자동 핵산정제방법, 실시간정량ｐｃｒ을 이용한 병원균의 전자동 생균수검사방법, 정량면역ｐｃｒ을 이용한 전자동 항원농도획득방법 및 타겟항원에 라벨링된 부착용 타겟핵산의 정제방법
EP2517791A1 (de) * 2011-04-18 2012-10-31 Vibod GmbH Probenrohr mit verbesserter Klappe
US9737891B2 (en) 2011-06-01 2017-08-22 Streck, Inc. Rapid thermocycler system for rapid amplification of nucleic acids and related methods
KR101481054B1 (ko) 2011-11-15 2015-01-14 한국기계연구원 핵산 자동 분석 장치
WO2013116041A1 (en) * 2012-01-31 2013-08-08 Argos Therapeutics, Inc. Centrifuge vessels suitable for live cell processing and associated systems and methods
US10132728B2 (en) 2012-04-27 2018-11-20 Cepheid Apparatus with heterogeneous processing modules
CN104583757A (zh) 2012-06-28 2015-04-29 弗洛雷森特里克公司 化学指示剂装置
AU2013202793B2 (en) 2012-07-31 2014-09-18 Gen-Probe Incorporated System, method and apparatus for automated incubation
EP2883039A1 (de) 2012-08-10 2015-06-17 Streck Inc. Optisches echtzeitsystem für echtzeit-polymerasekettenreaktion
US9274044B2 (en) * 2012-11-28 2016-03-01 Wyatt Technology Corporation Cuvette for light scattering measurements incorporating evaporation inhibition means
WO2014093360A1 (en) 2012-12-10 2014-06-19 Landers James P Frequency-based filtering of mechanical actuation using fluidic device
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
EP3014251A1 (de) 2013-06-28 2016-05-04 Streck Inc. Vorrichtungen für echtzeit-polymerasekettenreaktionen
DE102013114132A1 (de) * 2013-12-16 2015-06-18 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Aufschlussreaktor und Analysegerät zur Bestimmung eines Aufschlussparameters einer Flüssigkeitsprobe
EP3325975A1 (de) 2015-07-24 2018-05-30 Cepheid Molekulares diagnostisches testsystem
US10758908B2 (en) * 2015-09-03 2020-09-01 Tetracore, Inc. Self-metering of fluid into a reaction chamber
US20180264476A1 (en) * 2015-09-16 2018-09-20 Fluoresentric, Inc. Apparatus, systems and methods for dynamic flux amplification of samples
CN105400680B (zh) * 2015-12-11 2017-12-15 舟山医院 一种荧光定量pcr仪
TWI713536B (zh) * 2016-06-15 2020-12-21 諾貝爾生物有限公司 用於生物熱反應的封蓋系統及其方法
EP3545288A1 (de) * 2016-11-22 2019-10-02 TA Instruments-Waters LLC Thermische analyse durch direkte thermische injektion
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
SG10201702235TA (en) * 2017-03-20 2018-10-30 Star Array Pte Ltd Apparatus for amplification of nucleic acids
EP3685159A4 (de) * 2017-09-21 2021-06-09 Becton, Dickinson and Company Kit zur probenahme von gefährlichen schadstoffen und schnelltest
TWI667999B (zh) * 2018-05-17 2019-08-11 廣達電腦股份有限公司 動態調整螢光成像的方法及裝置
US11254979B2 (en) 2020-06-01 2022-02-22 Shaheen Innovations Holding Limited Systems and devices for infectious disease screening
US11730193B2 (en) 2019-12-15 2023-08-22 Shaheen Innovations Holding Limited Hookah device
CA3180786A1 (en) 2020-06-01 2021-05-28 Imad Lahoud An infectious disease screening system
CA3180787A1 (en) 2020-06-01 2021-12-09 Imad Lahoud An infectious disease screening device
CA3197077A1 (en) 2020-10-30 2022-05-05 Ronald Chang Diagnostic assay system with replaceable processing modules and remote monitoring
KR20230129190A (ko) 2021-01-13 2023-09-06 세페이드 손실 메카트로닉스 시스템 및 추정 방법
DE102022201532A1 (de) 2022-02-15 2023-08-17 Robert Bosch Gesellschaft mit beschränkter Haftung Verfahren zur Kalibrierung eines Analysesystems für Lab-on-Chip-Kartuschen

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1247520A (en) * 1967-10-23 1971-09-22 Ole Rues Container for laboratory use
US3708886A (en) 1970-11-09 1973-01-09 Lyoflo Stopper Corp Lyoflo-stopper
AT381466B (de) * 1977-03-16 1986-10-27 Ballies Uwe Trennroehrchen fuer zentrifugaltrennung
US4192429A (en) 1978-03-02 1980-03-11 Becton, Dickinson And Company Vented vacuum tube and stopper
US4479578A (en) * 1981-04-09 1984-10-30 The West Company Single barrel two-compartment medicament container assembly
US5038852A (en) 1986-02-25 1991-08-13 Cetus Corporation Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US5333675C1 (en) 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US5656493A (en) 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
US4902624A (en) 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
US4810653A (en) 1987-11-23 1989-03-07 Eastman Kodak Company Cuvette with non-flexing thermally conductive wall
CA1329698C (en) 1989-06-12 1994-05-24 Mark Joseph Devaney, Jr. Temperature control device
US5098660A (en) 1990-01-08 1992-03-24 Eastman Kodak Company Transfer apparatus for chemical reaction pack
DE69126690T2 (de) * 1990-04-06 1998-01-02 Perkin Elmer Corp Automatisiertes labor für molekularbiologie
FI915731A0 (fi) 1991-12-05 1991-12-05 Derek Henry Potter Foerfarande och anordning foer reglering av temperaturen i ett flertal prov.
US5376313A (en) 1992-03-27 1994-12-27 Abbott Laboratories Injection molding a plastic assay cuvette having low birefringence
KR100346861B1 (ko) 1992-07-01 2003-01-08 슈우지 우에다 세라믹스제가열냉각기
JPH0634546A (ja) 1992-07-17 1994-02-08 Tosoh Corp 蛍光検出器
EP0662345B1 (de) 1994-01-06 2000-05-31 Johnson & Johnson Clinical Diagnostics, Inc. Vorrichtung zum Erwärmen einer Flüssigkeitsführenden Kammer von einer Reaktionscuvette
CA2143365A1 (en) 1994-03-14 1995-09-15 Hugh V. Cottingham Nucleic acid amplification method and apparatus
ATE198511T1 (de) 1994-04-29 2001-01-15 Perkin Elmer Corp Verfahren und vorrichtung zur echtzeiterfassung der produkte von nukleinsäureamplifikation
US5639428A (en) 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
US5721136A (en) 1994-11-09 1998-02-24 Mj Research, Inc. Sealing device for thermal cycling vessels
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
EP0965842B1 (de) * 1996-05-20 2010-03-17 Precision System Science Co., Ltd. Prozess und apparat zur kontrolle magnetischer teilchen mit hilfe einer pipettier-maschine
US5945070A (en) * 1996-10-31 1999-08-31 Merck & Co., Inc. Reaction vessel filter for combinatorial chemistry or biological use
US5811296A (en) 1996-12-20 1998-09-22 Johnson & Johnson Clinical Diagnostics, Inc. Blocked compartments in a PCR reaction vessel
US6565815B1 (en) 1997-02-28 2003-05-20 Cepheid Heat exchanging, optically interrogated chemical reaction assembly
US5958349A (en) 1997-02-28 1999-09-28 Cepheid Reaction vessel for heat-exchanging chemical processes
US5786182A (en) 1997-05-02 1998-07-28 Biomerieux Vitek, Inc. Dual chamber disposable reaction vessel for amplification reactions, reaction processing station therefor, and methods of use
US5882601A (en) * 1997-06-18 1999-03-16 Merck & Co., Ltd. Deflected septum seal access port
WO1999033559A1 (en) 1997-12-24 1999-07-08 Cepheid Integrated fluid manipulation cartridge
AU743740B2 (en) 1998-03-23 2002-02-07 Cepheid Multi-site reactor system with dynamic, independent control of individual reaction sites
ES2183563T3 (es) 1998-05-19 2003-03-16 Cepheid Sistema de deteccion optico multicanal.
DE19847759A1 (de) * 1998-10-16 2000-04-20 Dade Behring Marburg Gmbh Auswechselbare Schwingpipettiernadel
US6485692B1 (en) * 1998-12-04 2002-11-26 Symyx Technologies, Inc. Continuous feed parallel reactor
EP1045038A1 (de) 1999-04-08 2000-10-18 Hans-Knöll-Institut Für Naturstoff-Forschung E.V. Thermisches Kreisprozessgerät mit Wärmeblock
US6325114B1 (en) * 2000-02-01 2001-12-04 Incyte Genomics, Inc. Pipetting station apparatus

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ATE279260T1 (de) 2004-10-15
WO2001045845A1 (en) 2001-06-28
EP1239964A1 (de) 2002-09-18
US7462323B1 (en) 2008-12-09
EP1462176A2 (de) 2004-09-29
US20110176971A1 (en) 2011-07-21
EP1462176A3 (de) 2004-10-13
DE60014967D1 (de) 2004-11-18
US6660228B1 (en) 2003-12-09
EP1239964B1 (de) 2004-10-13
DE60014967T2 (de) 2005-10-13
AU3075301A (en) 2001-07-03
EP1462176B1 (de) 2008-07-23
US8303895B2 (en) 2012-11-06
ATE401958T1 (de) 2008-08-15
US20080286151A1 (en) 2008-11-20

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