IL80776A - N-benzoyl urea compounds,process for their preparation and antitumorous compositions containing them - Google Patents

N-benzoyl urea compounds,process for their preparation and antitumorous compositions containing them

Info

Publication number
IL80776A
IL80776A IL80776A IL8077686A IL80776A IL 80776 A IL80776 A IL 80776A IL 80776 A IL80776 A IL 80776A IL 8077686 A IL8077686 A IL 8077686A IL 80776 A IL80776 A IL 80776A
Authority
IL
Israel
Prior art keywords
preparation
compositions containing
urea compounds
benzoyl urea
antitumorous
Prior art date
Application number
IL80776A
Other languages
English (en)
Other versions
IL80776A0 (en
Original Assignee
Ishihara Sangyo Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ishihara Sangyo Kaisha filed Critical Ishihara Sangyo Kaisha
Publication of IL80776A0 publication Critical patent/IL80776A0/xx
Publication of IL80776A publication Critical patent/IL80776A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL80776A 1985-12-11 1986-11-26 N-benzoyl urea compounds,process for their preparation and antitumorous compositions containing them IL80776A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP27818085 1985-12-11
JP27988485 1985-12-12
JP60280694 1985-12-13

Publications (2)

Publication Number Publication Date
IL80776A0 IL80776A0 (en) 1987-02-27
IL80776A true IL80776A (en) 1991-03-10

Family

ID=27336532

Family Applications (1)

Application Number Title Priority Date Filing Date
IL80776A IL80776A (en) 1985-12-11 1986-11-26 N-benzoyl urea compounds,process for their preparation and antitumorous compositions containing them

Country Status (14)

Country Link
US (1) US4863924A (fr)
EP (1) EP0226104B1 (fr)
JP (1) JPH0745473B2 (fr)
KR (1) KR870006016A (fr)
AR (1) AR244667A1 (fr)
AT (1) ATE60760T1 (fr)
AU (1) AU594098B2 (fr)
DE (1) DE3677478D1 (fr)
DK (2) DK164054C (fr)
ES (1) ES2033675T3 (fr)
GR (1) GR3001905T3 (fr)
IL (1) IL80776A (fr)
NZ (1) NZ218440A (fr)
PL (1) PL151012B1 (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212208A (en) * 1984-06-15 1988-04-29 Ishihara Sangyo Kaisha N-benzoyl-n'-pyrimidinyloxyphenyl ureas and pharmaceutical compositions
JPS62185013A (ja) * 1986-02-08 1987-08-13 Green Cross Corp:The 易吸収性医薬組成物
US5166180A (en) * 1988-01-11 1992-11-24 Duphar International Research B.V. Method of treating hematologic diseases and pharmaceutical composition to be used therefor
DK5489A (da) * 1988-01-11 1989-07-12 Duphar Int Res Anvendelse af substituerede amidforbindelser til fremstilling af farmaceutiske praeparater til behandling af haematologiske sygdomme
JPH029855A (ja) * 1988-03-31 1990-01-12 Ishihara Sangyo Kaisha Ltd 置換ベンゼン誘導体、それらの製造方法及びそれらを含有する抗癌性組成物
US5202487A (en) * 1988-09-13 1993-04-13 L'oreal 2-substituted para-aminophenols and their use for dyeing keratinous fibres
FR2637282B1 (fr) * 1988-09-13 1990-12-07 Oreal Para-aminophenols 2-substitues et leur utilisation pour la teinture des fibres keratiniques
JPH02196719A (ja) * 1989-01-24 1990-08-03 Green Cross Corp:The 粉末状医薬組成物
NZ234551A (en) * 1989-07-28 1991-10-25 Ishihara Sangyo Kaisha Benzoylurea derivatives and antitumour compositions
US6344476B1 (en) * 1997-05-23 2002-02-05 Bayer Corporation Inhibition of p38 kinase activity by aryl ureas
US7329670B1 (en) * 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US20080300281A1 (en) * 1997-12-22 2008-12-04 Jacques Dumas Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US20080269265A1 (en) * 1998-12-22 2008-10-30 Scott Miller Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
CA2359244C (fr) 1999-01-13 2013-10-08 Bayer Corporation Diphenyle urees a substitution .omega.-carboxy aryle en tant qu'inhibiteurs de la kinase p38
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1140840B1 (fr) 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. Diphenylurees a substituants -g(v)-carboxyaryles, inhibitrices de kinase raf
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
ME00275B (fr) 1999-01-13 2011-02-10 Bayer Corp DIPHENYLUREES A SUBSTITUANTS ω-CARBOXYARYLES, INHIBITRICES DE KINASE RAF
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
EP1437344A4 (fr) * 2001-09-28 2006-09-20 Takeda Pharmaceutical Derives de benzene et procede de preparation et d'utilisation associe
ES2275931T5 (es) * 2001-12-03 2018-10-23 Bayer Healthcare Llc Compuestos de aril-urea en combinación con otros agentes citostáticos o citotóxicos para tratamiento de cánceres humanos
US20040023961A1 (en) * 2002-02-11 2004-02-05 Bayer Corporation Aryl ureas with raf kinase and angiogenisis inhibiting activity
WO2003068229A1 (fr) * 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation N-oxydes de pyridine, de quinoline, et d'isoquinoline en tant qu'inhibiteurs de kinase
DK1478358T3 (da) 2002-02-11 2013-10-07 Bayer Healthcare Llc Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese
WO2003068746A1 (fr) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Aryle-urees en tant qu'inhibiteurs de kinase
UY28213A1 (es) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
PT1626714E (pt) 2003-05-20 2007-08-24 Bayer Pharmaceuticals Corp Diarilureias para doenças mediadas por pdgfr
ES2297490T3 (es) 2003-07-23 2008-05-01 Bayer Pharmaceuticals Corporation Omega-carboxiarildifenilurea fluoro sustituida para el tratamiento y prevencion de enfermadades y afecciones.
EP1689376A2 (fr) * 2003-11-28 2006-08-16 Novartis AG Derives de diaryluree utilises en traitement de maladies dependant de proteines kinases
JP5304241B2 (ja) 2005-03-07 2013-10-02 バイエル・ヘルスケア・エルエルシー 癌の処置用のオメガ−カルボキシアリール置換ジフェニルウレアを含む医薬組成物
KR102381581B1 (ko) 2014-01-16 2022-04-04 에프엠씨 코포레이션 제초제로서의 피리미디닐옥시 벤젠 유도체
CA2969816C (fr) 2015-03-18 2022-03-01 E I Du Pont De Nemours And Company Derives de pyrimidinyloxy pyridine substitues utilises comme herbicides
TWI713530B (zh) * 2015-06-05 2020-12-21 美商艾佛艾姆希公司 作為除草劑之嘧啶氧基苯衍生物
AU2016292811B2 (en) 2015-07-13 2021-02-18 Fmc Corporation Aryloxypyrimidinyl ethers as herbicides
WO2018204164A1 (fr) 2017-05-02 2018-11-08 Fmc Corporation Composés pyrimidinyloxy benzo-fusionnés utilisés en tant qu'herbicides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5615272A (en) * 1979-07-17 1981-02-14 Ishihara Sangyo Kaisha Ltd N-benzoyl-n'-phenylurea compound, its preparation, and insecticide containing the same
CA1233822A (fr) * 1982-12-30 1988-03-08 David T. Chou Benzoyl urees pesticides et procede de preparation
NZ212208A (en) * 1984-06-15 1988-04-29 Ishihara Sangyo Kaisha N-benzoyl-n'-pyrimidinyloxyphenyl ureas and pharmaceutical compositions
JPS6133176A (ja) * 1984-07-24 1986-02-17 Ishihara Sangyo Kaisha Ltd Ｎ−ニトロベンゾイル−ｎ’−ピリダジニルオキシフエニルウレア系化合物、それらの製造方法及びそれらを含有する抗癌剤
JPS6193163A (ja) * 1984-10-12 1986-05-12 Ishihara Sangyo Kaisha Ltd Ｎ−ベンゾイル−ｎ′−フエニルウレア系化合物、それらの製造方法並びにそれらを含有する抗癌剤
US4727077A (en) * 1985-02-20 1988-02-23 Ishihara Sangyo Kaisha Ltd. Benzoyl urea compounds, process for their production, and antitumorous compositions containing them

Also Published As

Publication number Publication date
AU594098B2 (en) 1990-03-01
GR3001905T3 (en) 1992-11-23
DK164054C (da) 1992-09-28
PL262901A1 (en) 1988-09-29
EP0226104A2 (fr) 1987-06-24
EP0226104A3 (en) 1988-09-07
KR870006016A (ko) 1987-07-08
AU6558186A (en) 1987-06-18
NZ218440A (en) 1989-06-28
DE3677478D1 (de) 1991-03-14
DK596586A (da) 1987-06-12
PL151012B1 (en) 1990-07-31
ATE60760T1 (de) 1991-02-15
AR244667A1 (es) 1993-11-30
JPH0745473B2 (ja) 1995-05-17
DK118391A (da) 1991-06-18
JPS6399056A (ja) 1988-04-30
US4863924A (en) 1989-09-05
IL80776A0 (en) 1987-02-27
DK596586D0 (da) 1986-12-11
DK118391D0 (da) 1991-06-18
DK164054B (da) 1992-05-04
EP0226104B1 (fr) 1991-02-06
ES2033675T3 (es) 1993-04-01

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Legal Events

Date Code Title Description
KB Patent renewed