IL79537A - Process for manufacture of a granular delayed-release form of pharmaceutically active substances and the granules produced thereby - Google Patents

Process for manufacture of a granular delayed-release form of pharmaceutically active substances and the granules produced thereby

Info

Publication number
IL79537A
IL79537A IL79537A IL7953786A IL79537A IL 79537 A IL79537 A IL 79537A IL 79537 A IL79537 A IL 79537A IL 7953786 A IL7953786 A IL 7953786A IL 79537 A IL79537 A IL 79537A
Authority
IL
Israel
Prior art keywords
manufacture
active substances
pharmaceutically active
release form
granules produced
Prior art date
Application number
IL79537A
Other languages
English (en)
Other versions
IL79537A0 (en
Original Assignee
Zyma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zyma Sa filed Critical Zyma Sa
Publication of IL79537A0 publication Critical patent/IL79537A0/xx
Publication of IL79537A publication Critical patent/IL79537A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL79537A 1985-07-31 1986-07-28 Process for manufacture of a granular delayed-release form of pharmaceutically active substances and the granules produced thereby IL79537A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858519310A GB8519310D0 (en) 1985-07-31 1985-07-31 Granular active substances

Publications (2)

Publication Number Publication Date
IL79537A0 IL79537A0 (en) 1986-10-31
IL79537A true IL79537A (en) 1991-01-31

Family

ID=10583125

Family Applications (1)

Application Number Title Priority Date Filing Date
IL79537A IL79537A (en) 1985-07-31 1986-07-28 Process for manufacture of a granular delayed-release form of pharmaceutically active substances and the granules produced thereby

Country Status (23)

Country Link
US (1) US4728513A (fr)
JP (1) JPS6229514A (fr)
AT (1) AT392901B (fr)
AU (1) AU596804B2 (fr)
BE (1) BE905200A (fr)
CH (1) CH670566A5 (fr)
DE (1) DE3625458A1 (fr)
DK (1) DK361786A (fr)
ES (1) ES2000577A6 (fr)
FI (1) FI863074A (fr)
FR (1) FR2585570B1 (fr)
GB (2) GB8519310D0 (fr)
GR (1) GR862017B (fr)
HU (1) HU196304B (fr)
IL (1) IL79537A (fr)
IT (1) IT1195985B (fr)
LU (1) LU86523A1 (fr)
NL (1) NL8601961A (fr)
NZ (1) NZ217028A (fr)
PH (1) PH23531A (fr)
PT (1) PT83093B (fr)
SE (1) SE8603247L (fr)
ZA (1) ZA865691B (fr)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4726952A (en) * 1983-08-11 1988-02-23 Mission Pharmacal Slow-release sodium fluoride tablet, method of making, and method of treatment of osteoporosis
EP0272265B1 (fr) * 1985-09-25 1991-05-22 Gergely, Gerhard, Dr. Pastille de desintegration et son procede de fabrication
CH669523A5 (fr) * 1986-06-25 1989-03-31 Mepha Ag
US4859467A (en) * 1986-09-25 1989-08-22 Colgate-Palmotive Company Sustained release fluoride composition
GB8707416D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
GB8707421D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
DE3712095A1 (de) * 1987-04-10 1988-10-20 Lentia Gmbh Bindemittelfreies granulat mit verzoegerter wirkstoffabgabe
US5178868A (en) * 1988-10-26 1993-01-12 Kabi Pharmacia Aktiebolaq Dosage form
IT1227899B (it) * 1988-12-23 1991-05-14 Poli Ind Chimica Spa Rivestimento totale o parziale di principi attivi farmaceutici e relative composizioni
US4970081A (en) * 1989-01-03 1990-11-13 Sterling Drug Inc. Controlled-release, low-dose aspirin formulation and method of treating vascular occlusive disease therewith
IE69270B1 (en) * 1989-01-03 1996-08-21 Sterling Winthrop Inc Controlled-release low-dose aspirin
US5084287A (en) * 1990-03-15 1992-01-28 Warner-Lambert Company Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat
US5013728A (en) * 1990-05-04 1991-05-07 Colgate - Palmolive Company Composition for treating osteoporosis and hormonal imbalance
US5153005A (en) * 1990-12-11 1992-10-06 Colgate-Palmolive Company Composition and method for preventing fluorosis
US6613332B1 (en) 1991-06-21 2003-09-02 The University Of Cincinnati Oral administration of therapeutic proteins
JPH06508371A (ja) 1991-06-21 1994-09-22 ユニバーシティー オブ シンシナティ 経口投与できる治療用タンパク質及びその製法
US5266331A (en) * 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
US5286493A (en) * 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
US5681585A (en) 1991-12-24 1997-10-28 Euro-Celtique, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5958459A (en) * 1991-12-24 1999-09-28 Purdue Pharma L.P. Opioid formulations having extended controlled released
US5273760A (en) * 1991-12-24 1993-12-28 Euroceltigue, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US7070806B2 (en) * 1992-01-27 2006-07-04 Purdue Pharma Lp Controlled release formulations coated with aqueous dispersions of acrylic polymers
FI101039B (fi) * 1992-10-09 1998-04-15 Eeva Kristoffersson Menetelmä lääkepellettien valmistamiseksi
US20080075781A1 (en) * 1992-11-25 2008-03-27 Purdue Pharma Lp Controlled release oxycodone compositions
DK0603992T4 (da) * 1992-12-22 2001-03-05 Univ Cincinnati Oral indgivelse af immunologisk aktive biomolekyler og andre terapeutiske proteiner
DE4319649A1 (de) * 1993-03-18 1994-09-22 Asta Medica Ag Feste Flupirtin enthaltende orale Darreichungsformen mit kontrollierter Wirkstoffabgabe
US20070275062A1 (en) * 1993-06-18 2007-11-29 Benjamin Oshlack Controlled release oxycodone compositions
US7740881B1 (en) 1993-07-01 2010-06-22 Purdue Pharma Lp Method of treating humans with opioid formulations having extended controlled release
IL110014A (en) * 1993-07-01 1999-11-30 Euro Celtique Sa Solid controlled-release oral dosage forms of opioid analgesics
US5879705A (en) * 1993-07-27 1999-03-09 Euro-Celtique S.A. Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
US5843480A (en) * 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
US20020006438A1 (en) * 1998-09-25 2002-01-17 Benjamin Oshlack Sustained release hydromorphone formulations exhibiting bimodal characteristics
US5674529A (en) * 1995-06-06 1997-10-07 Church & Dwight Co., Inc. Alkalinizing potassium salt controlled release preparations
FR2760190B1 (fr) * 1997-02-28 1999-04-09 Adir Composition pharmaceutique pour la liberation programmee de dexfenfluramine
AU8293498A (en) 1997-07-02 1999-01-25 Euro-Celtique S.A. Stabilized sustained release tramadol formulations
US6806294B2 (en) 1998-10-15 2004-10-19 Euro-Celtique S.A. Opioid analgesic
FR2785539B1 (fr) * 1998-11-06 2004-04-09 Prographarm Laboratoires Particules enrobees d'ibuprofene cristallin granule
DE19928312A1 (de) * 1999-06-16 2000-12-21 Schering Ag Arzneimittelzubereitung mit verzögerter Wirkstoffabgabe
US6475493B1 (en) 1999-09-02 2002-11-05 Norstrum Pharmaceuticals, Inc. Controlled release pellet formulation
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
AU764453B2 (en) 1999-10-29 2003-08-21 Euro-Celtique S.A. Controlled release hydrocodone formulations
CN101317825A (zh) 2000-10-30 2008-12-10 欧罗赛铁克股份有限公司 控释氢可酮制剂
UA81224C2 (uk) * 2001-05-02 2007-12-25 Euro Celtic S A Дозована форма оксикодону та її застосування
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
US6884619B2 (en) 2001-07-17 2005-04-26 Yale University Inhibition of BEHAB cleavage and primary central nervous system (CNS) tumors
PE20030527A1 (es) 2001-10-24 2003-07-26 Gruenenthal Chemie Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen
US7410965B2 (en) * 2002-05-29 2008-08-12 Gruenenthal Gmbh Delayed release pharmaceutical composition containing 1-dimethyl-amino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol
US20050100577A1 (en) * 2003-11-10 2005-05-12 Parker Theodore L. Expandable medical device with beneficial agent matrix formed by a multi solvent system
US7387793B2 (en) 2003-11-14 2008-06-17 Eurand, Inc. Modified release dosage forms of skeletal muscle relaxants
WO2005095950A1 (fr) * 2004-03-30 2005-10-13 Pfizer Products Inc. Procede et dispositif pour l'evaluation de compositions pharmaceutiques
DE102004035938A1 (de) * 2004-07-23 2006-02-16 Röhm GmbH & Co. KG Verfahren zur Herstellung von überzogenen Arzneiformen mit stabilem Wirkstofffreigabeprofil
JPWO2006059716A1 (ja) * 2004-12-03 2008-06-05 武田薬品工業株式会社 固形製剤
JP5124267B2 (ja) * 2005-02-25 2013-01-23 武田薬品工業株式会社 顆粒の製造方法
EP2049087A2 (fr) * 2006-07-21 2009-04-22 LAB International SRL Système de délivrance hydrophile empêchant les utilisations abusives
DE102006051020A1 (de) * 2006-10-26 2008-04-30 Evonik Röhm Gmbh Verwendung von (Meth)acrylat-Copolymeren in Retard-Arzneiformen zur Verringerung des Einflusses von Ethanol auf die Wirkstofffreisetzung
WO2008065502A1 (fr) * 2006-11-29 2008-06-05 Pfizer Products Inc. Compositions pharmaceutiques constituées a) de nanoparticules comprenant des polymères entériques et b) de la caséine
US20100119612A1 (en) * 2007-04-17 2010-05-13 Bend Research, Inc Nanoparticles comprising non-crystalline drug
US20100080852A1 (en) * 2007-05-03 2010-04-01 Ronald Arthur Beyerinck Phamaceutical composition comprising nanoparticles and casein
WO2008135855A2 (fr) * 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticules contenant un inhibiteur de la protéine de transfert d'ester de cholestéryle et un polymère non ionisable
WO2008135828A2 (fr) * 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticules comprenant un médicament, de l'éthylcellulose et un sel biliaire
US20080279930A1 (en) * 2007-05-07 2008-11-13 Bernd Terhaag Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof
US9545384B2 (en) 2007-06-04 2017-01-17 Bend Research, Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate
EP2162120B1 (fr) * 2007-06-04 2016-05-04 Bend Research, Inc Nanoparticules comportant un polymère cellulosique non ionisable et un copolymère bloc amphiphile non ionisable
US20100215747A1 (en) * 2007-07-13 2010-08-26 Corey Jay Bloom Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers
WO2009011367A1 (fr) * 2007-07-17 2009-01-22 Asahi Kasei Chemicals Corporation Composition aqueuse
US9233078B2 (en) * 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
EP2231169B1 (fr) * 2007-12-06 2016-05-04 Bend Research, Inc. Compositions pharmaceutiques comprenant des nanoparticules et une matière de remise en suspension
CN103432093B (zh) * 2013-08-31 2015-03-25 西南大学 甲磺酸普立地诺骨架缓释片及其制备方法
CA2902911C (fr) 2014-10-31 2017-06-27 Purdue Pharma Methodes et compositions destinees au traitement du trouble de deficit d'attention
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US904848A (en) * 1908-05-27 1908-11-24 William W Devore Artificial whirlpool.
AT64577B (de) * 1913-04-28 1914-04-25 Carl Georg Rodeck Volksbelustigungsvorrichtung mit sich drehenden Plattformen.
US1689138A (en) * 1927-10-15 1928-10-23 Playground & Gymnasium Equipme Bathers' inclined rotary water platform
NL137652C (fr) * 1962-07-11
DE2010110A1 (de) * 1970-03-04 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Mikrokapseln mit Hilfe von synthetischen Koazervaten
DE2336218C3 (de) * 1973-07-17 1985-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Orale Arzneiform
JPS52139715A (en) * 1976-05-14 1977-11-21 Nippon Kayaku Co Ltd Coated granules of alkali polyacrylate
EP0052075A1 (fr) * 1980-11-12 1982-05-19 Ciba-Geigy Ag Granule pharmaceutique à action retardée
JPS5867616A (ja) * 1981-10-15 1983-04-22 Tanabe Seiyaku Co Ltd 腸溶性マイクロカプセル
US4543886A (en) * 1983-03-09 1985-10-01 Intamin Inc. Amusement ride including a rotating loading terminal
DK62184D0 (da) * 1984-02-10 1984-02-10 Benzon As Alfred Diffusionsovertrukket polydepotpraeparat
CH658188A5 (de) * 1984-03-23 1986-10-31 Ciba Geigy Ag Lagerstabile schnellzerfallende pharmazeutische presslinge.
CH666405A5 (de) * 1985-06-24 1988-07-29 Ciba Geigy Ag Feste, haltbare darreichungsformen mit elastischem filmueberzug.
GB8521494D0 (en) * 1985-08-29 1985-10-02 Zyma Sa Controlled release tablet

Also Published As

Publication number Publication date
NZ217028A (en) 1989-08-29
GR862017B (en) 1986-12-23
JPS6229514A (ja) 1987-02-07
BE905200A (fr) 1987-01-30
FR2585570B1 (fr) 1990-03-23
GB8519310D0 (en) 1985-09-04
ES2000577A6 (es) 1988-03-01
FR2585570A1 (fr) 1987-02-06
AT392901B (de) 1991-07-10
IL79537A0 (en) 1986-10-31
PT83093B (pt) 1989-01-30
HU196304B (en) 1988-11-28
IT1195985B (it) 1988-11-03
LU86523A1 (fr) 1987-02-04
PH23531A (en) 1989-08-25
HUT41630A (en) 1987-05-28
GB2178313B (en) 1989-08-23
ATA205686A (de) 1990-12-15
DK361786A (da) 1987-02-01
DK361786D0 (da) 1986-07-30
SE8603247D0 (sv) 1986-07-29
SE8603247L (sv) 1987-02-01
FI863074A (fi) 1987-02-01
ZA865691B (en) 1987-03-25
AU6068586A (en) 1987-02-05
GB2178313A (en) 1987-02-11
FI863074A0 (fi) 1986-07-28
PT83093A (en) 1986-08-01
CH670566A5 (fr) 1989-06-30
NL8601961A (nl) 1987-02-16
DE3625458A1 (de) 1987-02-12
GB8618153D0 (en) 1986-09-03
US4728513A (en) 1988-03-01
AU596804B2 (en) 1990-05-17
IT8648323A0 (it) 1986-07-29

Similar Documents

Publication Publication Date Title
IL79537A (en) Process for manufacture of a granular delayed-release form of pharmaceutically active substances and the granules produced thereby
ZA817794B (en) A granular delayed-release form of pharmaceutical active substances
ZA937483B (en) Process for the preparation of drug pellets
HUT41642A (en) Process for producing tablets of regulated dissolution of the active agents
NO174996C (no) Fremgangsmåte for fremstilling av et granulat og en tablett inneholdende granulatet
HUT41418A (en) Process for producing pharmaceutical compositions containing anticoagulator polipeptides and process for producing the active agents
GR890100314A (en) Process for the preparation of drug absorbates
AU569335B2 (en) Slow-release pharmaceutical pellets
PT81999B (en) Process for the preparation of a modified plasminogen
HUT39707A (en) Herbicides containing derivatives of cyclohexanon and process for production of the active substances
ZA894302B (en) Process for the preparation of granules
HUT45024A (en) Insecticides and acaricides containing as active substance 1-aryl-pirosole-derivatives and process for production of the active substance
PT76168A (en) Process for the preparation of a fertiliser with controlled liberation of the active substances
HUT50586A (en) Fungicides containing as active substance substituated imidasolile-methil-oxiranes and substituated imidasolile-prophenes and process for production of the active substance
IL91017A0 (en) Process and installation for the manufacture of a complex egg-based product
GB2178749B (en) A process for the manufacture of a solid urea-formaldehyde-resin
HRP920575A2 (en) Solid oral administration forms containing ifosfamide n active agent and a process for the production of the
HUT47206A (en) Fungicides containing as active substances substituated piridin-derivaitves and process for production of the active substances
HUT50507A (en) Insecticides and process for production of the active substance
GB8727476D0 (en) Production of accumulation of granular material
HUT49458A (en) Fungicides containing derivatives of hydroxi-ethil-asole and process for production of the active substances
HUT41360A (en) Fertilizer containing zeolite and process for the production thereof
HUT47584A (en) Pesticides containing as active substance subsituated bicyclo-oktans and process for production of the active substance
GB2209741B (en) Process for the granulating of sulphur and a sulphur granulator
IE862038L (en) Granular delayed-release form of pharmaceutically active¹substances