IL76090A - 26,26,26,27,27,27,-hexafluoro-25-hydroxycholest-1,4,6-trien-3-one and-1alpha,2alpha-epoxycholest-4,6-dien-3-one and 25-ester derivatives thereof - Google Patents

26,26,26,27,27,27,-hexafluoro-25-hydroxycholest-1,4,6-trien-3-one and-1alpha,2alpha-epoxycholest-4,6-dien-3-one and 25-ester derivatives thereof

Info

Publication number
IL76090A
IL76090A IL76090A IL7609082A IL76090A IL 76090 A IL76090 A IL 76090A IL 76090 A IL76090 A IL 76090A IL 7609082 A IL7609082 A IL 7609082A IL 76090 A IL76090 A IL 76090A
Authority
IL
Israel
Prior art keywords
epoxycholest
hydroxycholest
2alpha
1alpha
trien
Prior art date
Application number
IL76090A
Other languages
English (en)
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of IL76090A publication Critical patent/IL76090A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL76090A 1981-07-27 1982-07-19 26,26,26,27,27,27,-hexafluoro-25-hydroxycholest-1,4,6-trien-3-one and-1alpha,2alpha-epoxycholest-4,6-dien-3-one and 25-ester derivatives thereof IL76090A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/286,790 US4358406A (en) 1981-07-27 1981-07-27 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
IL66351A IL66351A (en) 1981-07-27 1982-07-19 26,26,26,27,27-hexafluoro-1alpha,25-dihydroxycholecalciferol and esters thereof and their preparation

Publications (1)

Publication Number Publication Date
IL76090A true IL76090A (en) 1987-12-31

Family

ID=23100174

Family Applications (5)

Application Number Title Priority Date Filing Date
IL76090A IL76090A (en) 1981-07-27 1982-07-19 26,26,26,27,27,27,-hexafluoro-25-hydroxycholest-1,4,6-trien-3-one and-1alpha,2alpha-epoxycholest-4,6-dien-3-one and 25-ester derivatives thereof
IL66351A IL66351A (en) 1981-07-27 1982-07-19 26,26,26,27,27-hexafluoro-1alpha,25-dihydroxycholecalciferol and esters thereof and their preparation
IL76091A IL76091A (en) 1981-07-27 1982-07-19 26,26,26,27,27,27-hexafluoro-1alpha,3beta,25-trihydroxy-cholest-5-ene and-cholest-5,7-diene and ester derivatives thereof
IL76090A IL76090A0 (en) 1981-07-27 1985-08-14 26,26,26,27,27,27-hexafluoro-25-hydroxycholest-1,4,6-trien-3-one and-1a,2a-epoxycholest-4,6-dien-3-one and 25-ester derivatives thereof
IL76091A IL76091A0 (en) 1981-07-27 1985-08-14 26,26,26,27,27,27-hexafluoro-1alpha,3beta,25-trihydroxy-cholest-5-ene and-cholest-5,7-diene and ester derivatives thereof

Family Applications After (4)

Application Number Title Priority Date Filing Date
IL66351A IL66351A (en) 1981-07-27 1982-07-19 26,26,26,27,27-hexafluoro-1alpha,25-dihydroxycholecalciferol and esters thereof and their preparation
IL76091A IL76091A (en) 1981-07-27 1982-07-19 26,26,26,27,27,27-hexafluoro-1alpha,3beta,25-trihydroxy-cholest-5-ene and-cholest-5,7-diene and ester derivatives thereof
IL76090A IL76090A0 (en) 1981-07-27 1985-08-14 26,26,26,27,27,27-hexafluoro-25-hydroxycholest-1,4,6-trien-3-one and-1a,2a-epoxycholest-4,6-dien-3-one and 25-ester derivatives thereof
IL76091A IL76091A0 (en) 1981-07-27 1985-08-14 26,26,26,27,27,27-hexafluoro-1alpha,3beta,25-trihydroxy-cholest-5-ene and-cholest-5,7-diene and ester derivatives thereof

Country Status (14)

Country Link
US (1) US4358406A (OSRAM)
JP (1) JPS58501176A (OSRAM)
AU (2) AU552210B2 (OSRAM)
BE (1) BE893943A (OSRAM)
CH (2) CH656134A5 (OSRAM)
DE (2) DE3248900T1 (OSRAM)
DK (2) DK162282C (OSRAM)
FR (1) FR2510566B1 (OSRAM)
GB (2) GB2102806B (OSRAM)
IE (2) IE54370B1 (OSRAM)
IL (5) IL76090A (OSRAM)
IT (1) IT1157309B (OSRAM)
NL (1) NL8220265A (OSRAM)
WO (1) WO1983000335A1 (OSRAM)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634692A (en) * 1981-08-28 1987-01-06 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol
US4411833A (en) * 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US4448726A (en) * 1983-05-11 1984-05-15 Wisconsin Alumni Research Foundation Ring A- and triene-modified vitamin D compounds
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
ZA859138B (en) * 1984-12-19 1986-08-27 Hoffmann La Roche Cholecalciferol derivatives
EP0205025A1 (en) * 1985-05-27 1986-12-17 Sumitomo Pharmaceuticals Company, Limited Fluorine derivatives of vitamin D3 and cell differentiation-inducing agents containing the same as an active ingredient
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
CA1314872C (en) 1986-04-25 1993-03-23 Toshio Nishizawa Fluorine derivatives of vitamin d _and process for producing the same
JPH0764804B2 (ja) * 1986-04-25 1995-07-12 住友製薬株式会社 活性型ビタミンｄ３のフッ素誘導体
US4853378A (en) * 1986-10-20 1989-08-01 Sumitomo Chemical Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
AU5185790A (en) * 1989-02-16 1990-09-05 University Of Georgia Research Foundation, Inc., The Treatment of tibial dyschondroplasia
FI934891L (fi) * 1991-05-06 1993-12-03 Procter & Gamble Kombinerade kalcium- och vitamin d-supplement
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2147264C (en) * 1992-10-16 2006-05-16 Tetsuhiro Mikami Vitamin d derivatives and a process for producing them
BR9405735A (pt) * 1993-02-19 1995-12-05 Wisconsin Alumni Res Found Uso de 26,26,26,27,27,27-hexaflúor-1-alfa 25-dihidróxi colecalciferol para o tratamento de distúrbios do metabolismo do cálcio
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
KR20010043558A (ko) * 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
US6080879A (en) * 1998-05-19 2000-06-27 Tetrionics, Inc. Hexafluoro-vitamin synthesis and crystallization method, solvent and product
MX2010007266A (es) * 2007-12-28 2010-11-30 Wisconsin Alumni Res Found Análogos de vitamina d, (20s)-23, 23-difluoro-2-metilen-19-nor-bis homopregnacalciferol.
KR20170096238A (ko) 2009-01-27 2017-08-23 베르그 엘엘씨 화학요법과 연관된 부작용을 경감시키기 위한 비타민 ｄ３ 및 이의 유사물
WO2011019617A2 (en) 2009-08-14 2011-02-17 Cytotech Labs, Llc Vitamin d3 and analogs thereof for treating alopecia
HRP20230747T1 (hr) * 2011-09-08 2024-01-05 Sage Therapeutics, Inc. Neuroaktivni steroidi, pripravci i njihova uporaba
WO2014194133A1 (en) 2013-05-29 2014-12-04 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
ES2536256B2 (es) * 2013-11-20 2016-02-01 Universidade De Santiago De Compostela Análogos de vitamina d con interés farmacéutico
MD3319611T2 (ro) 2015-07-06 2021-06-30 Sage Therapeutics Inc Oxisteroli și metode de utilizare a acestora
PT3436022T (pt) 2016-04-01 2022-07-04 Sage Therapeutics Inc Oxisteróis e métodos de utilização dos mesmos
US11149056B2 (en) 2016-09-30 2021-10-19 Sage Therapeutics, Inc. C7 substituted oxysterols and methods of use thereof
CN111960938B (zh) * 2020-08-20 2022-06-17 甘肃皓天医药科技有限责任公司 用于制备氟骨化醇的中间体的制备方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL45897A (en) * 1974-10-22 1978-12-17 Yeda Res & Dev Process for the preparation of 1 hydroxy-provitamin d3
US4199518A (en) * 1978-03-30 1980-04-22 Diamond Shamrock Corporation 1α,3β-Dihydroxy-steroid-5-enes from 1α,2α-epoxy-steroid-4,6-dien-3-ones
PH16989A (en) * 1978-11-07 1984-05-04 Res Inst Medicine Chem Process for the preparation of 1-hydroxylated vitamin d compounds
US4226788A (en) * 1979-03-28 1980-10-07 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol

Also Published As

Publication number Publication date
NL8220265A (nl) 1983-06-01
IE891226L (en) 1983-01-27
IT8222574A0 (it) 1982-07-26
AU6056086A (en) 1986-12-18
GB2102806B (en) 1985-02-27
IL76091A0 (en) 1985-12-31
DK137083A (da) 1983-03-25
GB8311517D0 (en) 1983-06-02
IL76091A (en) 1987-12-31
AU586267B2 (en) 1989-07-06
JPS58501176A (ja) 1983-07-21
BE893943A (fr) 1982-11-16
DE3248900T1 (de) 1983-07-07
CH656134A5 (de) 1986-06-13
GB2102806A (en) 1983-02-09
DK554084A (da) 1984-11-22
DK165695C (da) 1993-06-07
AU552210B2 (en) 1986-05-22
GB2118556B (en) 1985-02-27
US4358406A (en) 1982-11-09
IE821797L (en) 1983-01-27
JPH0348903B2 (OSRAM) 1991-07-25
FR2510566B1 (fr) 1985-06-28
IL66351A0 (en) 1982-11-30
DK165695B (da) 1993-01-04
DK162282C (da) 1992-03-16
DK162282B (da) 1991-10-07
GB2118556A (en) 1983-11-02
IL76090A0 (en) 1985-12-31
IE54370B1 (en) 1989-09-13
WO1983000335A1 (en) 1983-02-03
DK137083D0 (da) 1983-03-25
AU8760582A (en) 1983-03-17
IT1157309B (it) 1987-02-11
DK554084D0 (da) 1984-11-22
IE54369B1 (en) 1989-09-13
CH655307A5 (de) 1986-04-15
DE3250034C2 (OSRAM) 1991-02-28
IL66351A (en) 1987-12-31
FR2510566A1 (fr) 1983-02-04
DE3248900C2 (OSRAM) 1990-12-13

Similar Documents

Publication Publication Date Title
IL76090A (en) 26,26,26,27,27,27,-hexafluoro-25-hydroxycholest-1,4,6-trien-3-one and-1alpha,2alpha-epoxycholest-4,6-dien-3-one and 25-ester derivatives thereof
PH21641A (en) 1,8-naphthyridine and 1,5,8-azanaphthyridine derivatives
IL61930A0 (en) 25-hydroxy-26,26,26,27,27,27-hexafluoroch-olecalciferol and derivatives thereof
ZA832903B (en) 1,8-naphthyridine and 1,5,8-azanaphthyridine derivatives
IL64933A0 (en) 1 alpha,25-dihydroxy-2 beta-fluorovitamin d3 and derivatives thereof
IL64774A (en) Hexahydro-trans and tetrahydropyridoindole derivatives
GB2048254B (en) 19,20 -didehydro-19-hydroxy and 19-oxo-prostaglandin derivatives
AU537214B2 (en) 1,1-alkanediol-penicilin derivatives and analogues
IL65387A0 (en) 2,3,4-trinor-m-inter-phenylene-prostaglandin derivatives and a process for the preparation thereof
DE3267874D1 (en) 1,4-dihydropyridine derivatives and processes for preparing the same
EG15753A (en) Pest-combating agents,their prepotion and use
IL65308A (en) 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)-penicillanates and their preparation
EP0079392A4 (en) COMPOSITE OXYALCOXIDES AND DERIVATIVES THEREOF.
AU550725B2 (en) 17,18-dehydrovincaminol derivatives and their preparation
ZW7782A1 (en) 2,4-disubstituted-5-thiazolecarboxylic acids and derivatives
PH16669A (en) Erythromycylamine 11,12-carbonate and derivatives thereof
EG16141A (en) 1,2,4-triazol-1-yl-propionitrile derivatives their preparation and use
DE3266355D1 (en) Octahydrotetracyanoquinodimethane and derivatives thereof
ZA825796B (en) 1,2-dithiol-3-ylideneammonium derivatives
PH17601A (en) Trifluoromethanessulfonanilides,and their use
JPS57188530A (en) 1,1-diphenylalk-1-ene and manufacture
JPS57158761A (en) 4(5)-alkylthioimidazole derivative, manufacture and medicinal composition
ZA823838B (en) 1,2,3,4,4a,9b-hexahydro-4a-piperazinylmethyl-4-dibenzofuranone or-dibenzofuranol derivatives
GB2095247B (en) N-(b-amenoethyl)-4-hydroxy-2,2,6,6-tetramethyl-piperidene and derivatives thereof
DE3368640D1 (en) 5,2',3',4',4",6"-hexadeoxykanamycin and its 1-n-acylated derivative

Legal Events

Date Code Title Description
KB Patent renewed
EXP Patent expired