FR2510566B1 - 26,26,26,27,27,27-hexafluoro-1 a, 25-dihydroxycholecalciferol et derives de ce compose - Google Patents

26,26,26,27,27,27-hexafluoro-1 a, 25-dihydroxycholecalciferol et derives de ce compose

Info

Publication number
FR2510566B1
FR2510566B1 FR8212994A FR8212994A FR2510566B1 FR 2510566 B1 FR2510566 B1 FR 2510566B1 FR 8212994 A FR8212994 A FR 8212994A FR 8212994 A FR8212994 A FR 8212994A FR 2510566 B1 FR2510566 B1 FR 2510566B1
Authority
FR
France
Prior art keywords
dihydroxycholecalciferol
hexafluoro
derivatives
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8212994A
Other languages
English (en)
French (fr)
Other versions
FR2510566A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of FR2510566A1 publication Critical patent/FR2510566A1/fr
Application granted granted Critical
Publication of FR2510566B1 publication Critical patent/FR2510566B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR8212994A 1981-07-27 1982-07-26 26,26,26,27,27,27-hexafluoro-1 a, 25-dihydroxycholecalciferol et derives de ce compose Expired FR2510566B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/286,790 US4358406A (en) 1981-07-27 1981-07-27 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same

Publications (2)

Publication Number Publication Date
FR2510566A1 FR2510566A1 (fr) 1983-02-04
FR2510566B1 true FR2510566B1 (fr) 1985-06-28

Family

ID=23100174

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8212994A Expired FR2510566B1 (fr) 1981-07-27 1982-07-26 26,26,26,27,27,27-hexafluoro-1 a, 25-dihydroxycholecalciferol et derives de ce compose

Country Status (14)

Country Link
US (1) US4358406A (OSRAM)
JP (1) JPS58501176A (OSRAM)
AU (2) AU552210B2 (OSRAM)
BE (1) BE893943A (OSRAM)
CH (2) CH656134A5 (OSRAM)
DE (2) DE3250034C2 (OSRAM)
DK (2) DK162282C (OSRAM)
FR (1) FR2510566B1 (OSRAM)
GB (2) GB2102806B (OSRAM)
IE (2) IE54370B1 (OSRAM)
IL (5) IL76090A (OSRAM)
IT (1) IT1157309B (OSRAM)
NL (1) NL8220265A (OSRAM)
WO (1) WO1983000335A1 (OSRAM)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634692A (en) * 1981-08-28 1987-01-06 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol
US4411833A (en) * 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US4448726A (en) * 1983-05-11 1984-05-15 Wisconsin Alumni Research Foundation Ring A- and triene-modified vitamin D compounds
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
ZA859138B (en) * 1984-12-19 1986-08-27 Hoffmann La Roche Cholecalciferol derivatives
EP0205025A1 (en) * 1985-05-27 1986-12-17 Sumitomo Pharmaceuticals Company, Limited Fluorine derivatives of vitamin D3 and cell differentiation-inducing agents containing the same as an active ingredient
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
JPH0764804B2 (ja) * 1986-04-25 1995-07-12 住友製薬株式会社 活性型ビタミンｄ３のフッ素誘導体
CA1314872C (en) 1986-04-25 1993-03-23 Toshio Nishizawa Fluorine derivatives of vitamin d _and process for producing the same
US4853378A (en) * 1986-10-20 1989-08-01 Sumitomo Chemical Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
WO1990009179A1 (en) * 1989-02-16 1990-08-23 University Of Georgia Research Foundation, Inc. Treatment of tibial dyschondroplasia
AU666313B2 (en) * 1991-05-06 1996-02-08 Procter & Gamble Company, The Combined calcium and vitamin D supplements
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
PT665221E (pt) * 1992-10-16 2000-06-30 Chugai Pharmaceutical Co Ltd Derivado da vitamina d e processo para a sua producao
AU6247194A (en) * 1993-02-19 1994-09-14 Wisconsin Alumni Research Foundation Use of 26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxycholecalcife rol for the treatment of calcium metabolism disorders
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
IL139241A0 (en) 1998-05-13 2001-11-25 Novo Nordisk As Meiosis regulating compounds
US6080879A (en) * 1998-05-19 2000-06-27 Tetrionics, Inc. Hexafluoro-vitamin synthesis and crystallization method, solvent and product
JP2011508743A (ja) * 2007-12-28 2011-03-17 ウィスコンシン アラムナイ リサーチ ファンデーション （２０ｓ）−２３，２３−ジフルオロ−２−メチレン−１９−ノル−ビスホモプレグナカルシフェロール−ビタミンｄ類縁体
AU2010208323B2 (en) 2009-01-27 2016-03-10 Berg Llc Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (en) 2009-08-14 2019-05-22 Berg LLC Vitamin d3 and analogs thereof for treating alopecia
FI2753632T3 (fi) * 2011-09-08 2023-08-02 Sage Therapeutics Inc Neuroaktiivisia steroideja, koostumuksia ja niiden käyttöjä
RS67266B1 (sr) 2013-03-13 2025-10-31 Sage Therapeutics Inc Neuroaktivni steroidi i postupci za njihovu upotrebu
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
ES2536256B2 (es) 2013-11-20 2016-02-01 Universidade De Santiago De Compostela Análogos de vitamina d con interés farmacéutico
FI3828194T3 (fi) 2015-07-06 2025-07-17 Sage Therapeutics Inc Oxysteroleita ja menetelmiä niiden käyttämiseksi
US20190330259A1 (en) 2016-04-01 2019-10-31 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
JP7149266B2 (ja) 2016-09-30 2022-10-06 セージ セラピューティクス， インコーポレイテッド Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法
MA46566A (fr) 2016-10-18 2019-08-28 Sage Therapeutics Inc Oxystérols et leurs procédés d'utilisation
CN111960938B (zh) * 2020-08-20 2022-06-17 甘肃皓天医药科技有限责任公司 用于制备氟骨化醇的中间体的制备方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL45897A (en) * 1974-10-22 1978-12-17 Yeda Res & Dev Process for the preparation of 1 hydroxy-provitamin d3
US4199518A (en) * 1978-03-30 1980-04-22 Diamond Shamrock Corporation 1α,3β-Dihydroxy-steroid-5-enes from 1α,2α-epoxy-steroid-4,6-dien-3-ones
PH16989A (en) * 1978-11-07 1984-05-04 Res Inst Medicine Chem Process for the preparation of 1-hydroxylated vitamin d compounds
US4226788A (en) * 1979-03-28 1980-10-07 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol

Also Published As

Publication number Publication date
IL66351A0 (en) 1982-11-30
DE3248900T1 (de) 1983-07-07
IL76091A (en) 1987-12-31
IT8222574A0 (it) 1982-07-26
IL76091A0 (en) 1985-12-31
WO1983000335A1 (en) 1983-02-03
US4358406A (en) 1982-11-09
NL8220265A (nl) 1983-06-01
IL66351A (en) 1987-12-31
AU586267B2 (en) 1989-07-06
DK554084D0 (da) 1984-11-22
IL76090A0 (en) 1985-12-31
DK162282B (da) 1991-10-07
CH656134A5 (de) 1986-06-13
IE821797L (en) 1983-01-27
DK162282C (da) 1992-03-16
FR2510566A1 (fr) 1983-02-04
JPS58501176A (ja) 1983-07-21
CH655307A5 (de) 1986-04-15
IL76090A (en) 1987-12-31
AU552210B2 (en) 1986-05-22
GB8311517D0 (en) 1983-06-02
IE54370B1 (en) 1989-09-13
DK165695C (da) 1993-06-07
AU8760582A (en) 1983-03-17
AU6056086A (en) 1986-12-18
JPH0348903B2 (OSRAM) 1991-07-25
GB2118556B (en) 1985-02-27
GB2102806B (en) 1985-02-27
DE3250034C2 (OSRAM) 1991-02-28
DK165695B (da) 1993-01-04
DK137083A (da) 1983-03-25
DE3248900C2 (OSRAM) 1990-12-13
GB2118556A (en) 1983-11-02
DK554084A (da) 1984-11-22
IE891226L (en) 1983-01-27
IT1157309B (it) 1987-02-11
GB2102806A (en) 1983-02-09
IE54369B1 (en) 1989-09-13
BE893943A (fr) 1982-11-16
DK137083D0 (da) 1983-03-25

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