IL75369A - 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids,their preparation and antibacterial agents containing them - Google Patents

7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids,their preparation and antibacterial agents containing them

Info

Publication number
IL75369A
IL75369A IL75369A IL7536985A IL75369A IL 75369 A IL75369 A IL 75369A IL 75369 A IL75369 A IL 75369A IL 7536985 A IL7536985 A IL 7536985A IL 75369 A IL75369 A IL 75369A
Authority
IL
Israel
Prior art keywords
dihalogeno
cyclopropyl
dihydro
oxo
amino
Prior art date
Application number
IL75369A
Other languages
English (en)
Other versions
IL75369A0 (en
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of IL75369A0 publication Critical patent/IL75369A0/xx
Publication of IL75369A publication Critical patent/IL75369A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL75369A 1984-06-04 1985-05-31 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids,their preparation and antibacterial agents containing them IL75369A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843420743 DE3420743A1 (de) 1984-06-04 1984-06-04 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Publications (2)

Publication Number Publication Date
IL75369A0 IL75369A0 (en) 1985-09-29
IL75369A true IL75369A (en) 1988-10-31

Family

ID=6237565

Family Applications (1)

Application Number Title Priority Date Filing Date
IL75369A IL75369A (en) 1984-06-04 1985-05-31 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids,their preparation and antibacterial agents containing them

Country Status (22)

Country Link
US (2) US5571812A (pt)
EP (1) EP0167763B1 (pt)
JP (1) JPS611667A (pt)
KR (1) KR920005112B1 (pt)
AR (1) AR243510A1 (pt)
AT (1) ATE36155T1 (pt)
AU (1) AU575651B2 (pt)
DD (1) DD240012A5 (pt)
DE (2) DE3420743A1 (pt)
DK (2) DK164596C (pt)
ES (3) ES8607277A1 (pt)
FI (1) FI852203L (pt)
GR (1) GR851316B (pt)
HK (1) HK7291A (pt)
HU (1) HU208821B (pt)
IE (1) IE57815B1 (pt)
IL (1) IL75369A (pt)
NO (1) NO173546C (pt)
NZ (1) NZ212272A (pt)
PH (2) PH23577A (pt)
PT (1) PT80578B (pt)
ZA (1) ZA854167B (pt)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
US5468861A (en) * 1984-06-04 1995-11-21 Bayer Aktiengesellschaft 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
IN162769B (pt) * 1984-11-13 1988-07-09 Kyorin Seiyaku Kk
US4771054A (en) * 1985-01-23 1988-09-13 Warner-Lambert Company Antibacterial agents
JPS61225181A (ja) * 1986-02-04 1986-10-06 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
JPS61205258A (ja) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
JPH0635457B2 (ja) * 1985-06-28 1994-05-11 杏林製薬株式会社 ピリドンカルボン酸誘導体およびその製造方法
AU594983B2 (en) * 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
JPS62246541A (ja) * 1986-01-20 1987-10-27 Kyorin Pharmaceut Co Ltd ベンゾイル酢酸エステル誘導体とその製造方法
US4788320A (en) * 1986-01-20 1988-11-29 Kyorin Pharmaceutical Co., Ltd. Benzoylacetic acid ester derivatives and process for their preparations
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
DE3606698A1 (de) * 1986-03-01 1987-09-03 Bayer Ag 7-(1-pyrrolidinyl)-chinoloncarbonsaeure -derivate
DK164287A (da) * 1986-03-31 1987-10-01 Sankyo Co Quinolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling deraf og deres anvendelse
US4771055A (en) * 1986-07-28 1988-09-13 Warner-Lambert Company 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids
DE3635218A1 (de) * 1986-10-16 1988-04-21 Bayer Ag 7-amino-1-cyclopropyl-8-chlor-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3641312A1 (de) * 1986-12-03 1988-06-09 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
DE3702393A1 (de) * 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
EP0339406A1 (en) * 1988-04-19 1989-11-02 Hokuriku Pharmaceutical Co.,Ltd Quinoline-3-carboxylic acid derivatives, process for preparing the same, and composition exhibiting excellent antibacterial effect containing the same
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
US5137892A (en) * 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
DE4120646A1 (de) * 1991-06-22 1992-12-24 Bayer Ag 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
US5221676A (en) * 1992-02-06 1993-06-22 Warner-Lambert Company 7-substituted quinolones and naphthyridones as antibacterial agents
US5430028A (en) * 1992-05-26 1995-07-04 Ss Pharmaceutical Co., Ltd. 5-aminoquinolone carboxylic acid derivative and antibacterial agent containing the same as active ingredient
EP0596395B1 (de) * 1992-11-04 2000-06-28 Clariant GmbH Verfahren zur Herstellung fluorierter Benzile
CA2114981A1 (en) * 1993-02-09 1994-08-10 Kazumi Ogata Quinolonecarboxylic acid derivatives
DE4342186A1 (de) 1993-12-10 1995-06-14 Bayer Ag Eintopfverfahren zur Herstellung von 3-Chinoloncarbonsäurederivaten
EP1258478A4 (en) * 2000-02-25 2006-03-15 Daiichi Seiyaku Co PROCESS FOR THE PREPARATION OF CHINOLONCARBOXYLIC ACIDS AND THEIR INTERMEDIATE PRODUCTS
DE10026903A1 (de) * 2000-06-03 2002-01-10 Cpc Cellular Process Chemistry Verfahren zur Herstellung von Chinolon-3-carbonsäuren
US7361719B2 (en) * 2002-01-31 2008-04-22 Micro Science Tech Co., Ltd. Monomer with anti-microbial character, polymer using the same, and manufacturing method thereof
TW200425530A (en) * 2002-09-05 2004-11-16 Nanosys Inc Nanostructure and nanocomposite based compositions and photovoltaic devices
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
DE102004035203A1 (de) 2004-07-21 2006-02-16 Bayer Healthcare Ag Substituierte Chinolone
US7576216B2 (en) 2004-07-30 2009-08-18 Abbott Laboratories Preparation of pyridonecarboxylic acid antibacterials
WO2006015194A2 (en) * 2004-07-30 2006-02-09 Abbott Laboratories Preparation of pyridonecarboxylic acid antibacterials
MX2007012642A (es) * 2005-04-11 2008-01-11 Abbott Lab Composiciones farmaceuticas que tienen perfiles mejorados de disolucion para farmacos poco solubles.
DE102006005861A1 (de) 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituierte Chinolone III
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
UA106556C2 (uk) * 2013-05-13 2014-09-10 Наталья Николаевна Деркач СПОСІБ ОДЕРЖАННЯ (1-ЦИКЛОПРОПІЛ-6-ФТОР-1,4-ДИГІДРО-8-МЕТОКСІ-7-[(4aS,7aS)-ОКТАГІДРО-6Н-ПІРОЛО[3,4-b]-4-ОКСО-3-ХІНОЛІНКАРБОНОВОЇ КИСЛОТИ

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR223983A1 (es) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
JPS5845426B2 (ja) * 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
JPS5630964A (en) * 1979-08-22 1981-03-28 Kyorin Pharmaceut Co Ltd Novel substituted quinolinecarboxylic acid and its preparation
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
SE440354B (sv) * 1981-02-19 1985-07-29 Kyorin Seiyaku Kk Kinolinkarboxylsyraderivat
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3248507A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen Mikrobizide mittel auf chinoloncarbonsaeure basis
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS60123837A (ja) * 1983-12-09 1985-07-02 Mitsubishi Paper Mills Ltd ハロゲン化銀写真乳剤
IL74244A (en) * 1984-02-17 1988-06-30 Warner Lambert Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
DE3420116A1 (de) * 1984-05-30 1985-12-05 Bayer Ag, 5090 Leverkusen Immunstimulierende mittel
DE3420798A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS60222448A (ja) * 1984-09-11 1985-11-07 Kyorin Pharmaceut Co Ltd アニリン類とその製造方法
US4771054A (en) * 1985-01-23 1988-09-13 Warner-Lambert Company Antibacterial agents
JPS61205258A (ja) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法

Also Published As

Publication number Publication date
DK164596B (da) 1992-07-20
DK249885A (da) 1985-12-05
HK7291A (en) 1991-02-01
ES8702400A1 (es) 1987-01-01
FI852203A0 (fi) 1985-05-31
ES553084A0 (es) 1987-01-01
DK249885D0 (da) 1985-06-03
DK159391D0 (da) 1991-09-12
DD240012A5 (de) 1986-10-15
JPS611667A (ja) 1986-01-07
ES553083A0 (es) 1987-01-16
GR851316B (pt) 1985-11-25
JPH0369343B2 (pt) 1991-10-31
HUT38336A (en) 1986-05-28
DE3420743A1 (de) 1985-12-05
DK166276B (da) 1993-03-29
HU208821B (en) 1994-01-28
DK166276C (da) 1993-08-23
NO173546C (no) 1993-12-29
NO852025L (no) 1985-12-05
NZ212272A (en) 1988-05-30
KR920005112B1 (ko) 1992-06-26
ES8607277A1 (es) 1986-06-16
US5969141A (en) 1999-10-19
FI852203L (fi) 1985-12-05
PT80578A (en) 1985-07-01
AU4329385A (en) 1985-12-12
PT80578B (pt) 1987-11-11
AU575651B2 (en) 1988-08-04
ES543836A0 (es) 1986-06-16
IL75369A0 (en) 1985-09-29
DK164596C (da) 1992-12-07
PH24947A (en) 1990-12-26
ZA854167B (en) 1986-01-29
ES8702907A1 (es) 1987-01-16
KR860000281A (ko) 1986-01-27
IE57815B1 (en) 1993-04-21
NO173546B (no) 1993-09-20
DE3564108D1 (en) 1988-09-08
ATE36155T1 (de) 1988-08-15
EP0167763B1 (de) 1988-08-03
DK159391A (da) 1991-09-12
HU910254D0 (en) 1991-08-28
PH23577A (en) 1989-09-11
US5571812A (en) 1996-11-05
AR243510A1 (es) 1993-08-31
EP0167763A1 (de) 1986-01-15
IE851365L (en) 1985-12-04

Similar Documents

Publication Publication Date Title
IL75369A (en) 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids,their preparation and antibacterial agents containing them
CY1487A (en) 7-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinotinecarboxylic acids,processes for their preparation and also antibacterial agents containing these substances
PT79971A (en) Antibacterial agents
IE872696L (en) 1-tertiary-alkyl-substituted naphthyridine-and¹quinoline-carboxylic acid antibacterial agents
AU572702B2 (en) Alkyl-1-cyclopropyl -1, 4-dihydro-4-oxo-quinoline carboxylic acids, preparation and antibacterial agent thereof
PH22341A (en) Antibacterial agents ii
IL78759A0 (en) Animal yield-promoting agents comprising thienylureas and-isoureas,certain such novel compounds and their preparation
DE3666820D1 (en) 5,6-difluoronaphthyridines and 5,6,8-trifluoro-quinolines as antibacterial agents
PH21230A (en) Novel napthyridine and quinoline antibacterial agents
IL71036A (en) Quinolonecarboxylic acids,their preparation and antibacterial compositions containing them
ZA877471B (en) 1-tertiary-alkyl-substituted naphthyridine-and quinoline-carboxylic acid antibacterial agents
IL87553A0 (en) 4-oxo-3-quinolinecarboxylic acids and derivatives thereof,their preparation and antibacterial compositions containing them
IL87569A (en) 4-oxo-3-quinolinecarboxylic acids,their preparation and antibacterial compositions containing them
ZA85853B (en) Antibacterial agents
IL75366A0 (en) Substituted phenylsulphonylureas,their preparation and their use as plant-treatment agents
EP0228137A3 (en) Anaerobe-selective antibacterial compositions and methods
GB8529182D0 (en) Antibacterial preparations
IL74064A (en) 1,7-disubstituted-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives and antibacterial compositions containing them
IE840444L (en) Quinolonecarboxylic acids
IE863141L (en) Quinoline-3-carboxylic acid antibacterial agents
ZA868394B (en) Antimicrobial agents and process for their manufacture
KE3876A (en) 7-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid,processes for their preparation and antibacterial agents containing them
ZA857077B (en) 7-(pyridinyl)-1-alkyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid having antibacterial activity and preparation thereof
ZA886402B (en) 4-oxo-3-quinolinecarboxylic acids useful as antibacterial agents and preparation thereof
ZA852365B (en) Antibacterial agents

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed