IL74409A - Cloning of the p195 gene of p. falciparum and fragments thereof - Google Patents
Cloning of the p195 gene of p. falciparum and fragments thereofInfo
- Publication number
- IL74409A IL74409A IL7440985A IL7440985A IL74409A IL 74409 A IL74409 A IL 74409A IL 7440985 A IL7440985 A IL 7440985A IL 7440985 A IL7440985 A IL 7440985A IL 74409 A IL74409 A IL 74409A
- Authority
- IL
- Israel
- Prior art keywords
- sequence
- protein
- dna sequence
- dna
- falciparum
- Prior art date
Links
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- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
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- 239000003153 chemical reaction reagent Substances 0.000 description 1
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- 239000003593 chromogenic compound Substances 0.000 description 1
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- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
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- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
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- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
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- 238000006192 iodination reaction Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 description 1
- 229940057428 lactoperoxidase Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
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- 229940124735 malaria vaccine Drugs 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
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- 238000010369 molecular cloning Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 1
- YFCUZWYIPBUQBD-ZOWNYOTGSA-N n-[(3s)-7-amino-1-chloro-2-oxoheptan-3-yl]-4-methylbenzenesulfonamide;hydron;chloride Chemical compound Cl.CC1=CC=C(S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl)C=C1 YFCUZWYIPBUQBD-ZOWNYOTGSA-N 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
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- 239000002157 polynucleotide Substances 0.000 description 1
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- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 1
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- 239000002243 precursor Substances 0.000 description 1
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- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
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- 229960002180 tetracycline Drugs 0.000 description 1
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
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- 239000003981 vehicle Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848404692A GB8404692D0 (en) | 1984-02-22 | 1984-02-22 | Cloning of dna for protozoal antigens |
| GB848424340A GB8424340D0 (en) | 1984-09-26 | 1984-09-26 | Cloning of dna |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL74409A0 IL74409A0 (en) | 1985-05-31 |
| IL74409A true IL74409A (en) | 1994-08-26 |
Family
ID=26287348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL7440985A IL74409A (en) | 1984-02-22 | 1985-02-21 | Cloning of the p195 gene of p. falciparum and fragments thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5597708A (de) |
| EP (1) | EP0154454B1 (de) |
| JP (2) | JP2584733B2 (de) |
| AT (1) | ATE64957T1 (de) |
| AU (1) | AU592749B2 (de) |
| CA (1) | CA1340103C (de) |
| DE (1) | DE3583347D1 (de) |
| DK (1) | DK79985A (de) |
| GB (1) | GB2154592A (de) |
| HU (1) | HU200794B (de) |
| IL (1) | IL74409A (de) |
| NZ (1) | NZ211191A (de) |
| PH (1) | PH25993A (de) |
| ZW (1) | ZW2485A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0153188B1 (de) * | 1984-02-21 | 1991-10-09 | National Research Development Corporation | Herstellung von Malaria-Impfstoffen |
| IL76338A (en) * | 1984-09-11 | 1994-08-26 | Saramane Pty Ltd | Plasmodium plasmodium immunogenic polypeptides, AND molecules encoding them, a method for preparing the polypeptides and preparations containing the polypeptide |
| ZW8386A1 (en) * | 1985-04-11 | 1986-07-23 | Inst Medical W & E Hall | Highly repetitive antigens of plasmodium falciparum |
| US4978621A (en) * | 1985-09-03 | 1990-12-18 | Scripps Clinic And Research Foundation | Merozoite surface antigens |
| JPS63502002A (ja) * | 1985-12-24 | 1988-08-11 | ザ・ワルタ−・アンド・エリザ・ホ−ル・インスティテュ−ト・オヴ・メディカル・リサ−チ | 無性の血中段階におけるプラズモジウム・ファルシパルムの抗原 |
| EP0252588A3 (de) * | 1986-05-12 | 1989-07-12 | Smithkline Beecham Corporation | Verfahren zur Isolierung und Reinigung von P. falciparum CS-Protein in rekombinantem E. coli sowie seine Verwendung als Impfstoff |
| US5001225A (en) * | 1986-12-08 | 1991-03-19 | Georgetown University | Monoclonal antibodies to a pan-malarial antigen |
| GB8706599D0 (en) * | 1987-03-19 | 1987-04-23 | Hoffmann La Roche | Plasmodium falciparum merozoite antigen peptides |
| DE3737238A1 (de) * | 1987-11-03 | 1989-05-18 | Behringwerke Ag | Rekombinantes histidinreiches protein (37 kd antigen) von plasmodium falciparum, seine herstellung und verwendung |
| AT388934B (de) * | 1987-11-13 | 1989-09-25 | Wellcome Found | Rekombinationskonjugatprotein und neue vakzinen |
| DE3831351A1 (de) * | 1987-12-30 | 1989-07-13 | Behringwerke Ag | Malaria-spezifische dna-sequenzen, ihre expressionsprodukte und deren verwendung |
| US6333406B1 (en) | 1988-08-12 | 2001-12-25 | Joseph W. Inselburg | Gene encoding protein antigens of Plasmodium falciparum and uses therefor |
| US5756101A (en) * | 1991-07-01 | 1998-05-26 | Pasteur Merieux Serums Et Vaccins | Malaria recombinant poxvirus |
| US6855316B1 (en) * | 1994-02-14 | 2005-02-15 | University Of Hawaii | Baculovirus produced Plasmodium falciparum vaccine |
| FR2744723A1 (fr) * | 1996-02-14 | 1997-08-14 | Pasteur Institut | Proteine recombinante contenant un fragment c-terminal d'une proteine msp-1 d'un plasmodium infectieux pour l'homme pour la production de vaccins anti-paludiques |
| FR2744724B1 (fr) | 1996-02-14 | 2002-08-02 | Pasteur Institut | Proteine recombinante contenant un fragment c-terminal de la proteine msp-1 d'un plasmodium infectieux pour l'homme pour la production de vaccins anti-paludiques |
| DE19640817A1 (de) | 1996-10-02 | 1998-05-14 | Hermann Prof Dr Bujard | Rekombinantes Herstellungsverfahren für ein vollständiges Malaria-Antigen gp190/MSP 1 |
| UY27304A1 (es) | 2001-05-24 | 2002-12-31 | Avanir Pharmaceuticals | Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación |
| US20040082048A1 (en) * | 2002-10-15 | 2004-04-29 | Viswanath Nittala Venkata Narasimha | Genes and protein sequences useful as drug targets for therapeutic action against protozoa |
| TW200418829A (en) * | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
| AU2004268941A1 (en) | 2003-08-22 | 2005-03-10 | Avanir Pharmaceuticals | Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases |
| JP2008534502A (ja) | 2005-03-24 | 2008-08-28 | アバニール・ファーマシューティカルズ | マクロファージ遊走阻止因子の阻害剤としてのチエノピリジノン誘導体 |
| GB0605689D0 (en) * | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic compounds |
| US7931908B2 (en) | 2007-02-23 | 2011-04-26 | Philadelphia Health Education Corporation | Chimeric MSP-based malaria vaccine |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2145092B (en) * | 1983-01-28 | 1988-04-07 | Univ New York | Protective peptide antigen |
| US4466917A (en) * | 1981-02-12 | 1984-08-21 | New York University | Malaria vaccine |
| IL65496A (en) * | 1981-04-15 | 1985-10-31 | Wellcome Found | Protozoal antigen,its preparation and vaccine containing it |
| AU569722B2 (en) * | 1983-01-28 | 1988-02-18 | Saramane Pty Ltd | Expression of plasmodium falciparum polypeptides from cloned cdna |
| US4767622A (en) * | 1983-08-19 | 1988-08-30 | University Of Illinois | Method and materials for development of immunological responses protective against malarial infection |
| GB8404378D0 (en) * | 1984-02-20 | 1984-03-28 | Biogen Nv | Dna sequence recombinant dna molecules |
-
1985
- 1985-02-21 NZ NZ211191A patent/NZ211191A/en unknown
- 1985-02-21 DE DE8585301173T patent/DE3583347D1/de not_active Expired - Lifetime
- 1985-02-21 EP EP85301173A patent/EP0154454B1/de not_active Expired - Lifetime
- 1985-02-21 ZW ZW24/85A patent/ZW2485A1/xx unknown
- 1985-02-21 CA CA000474837A patent/CA1340103C/en not_active Expired - Fee Related
- 1985-02-21 PH PH31892A patent/PH25993A/en unknown
- 1985-02-21 GB GB08504429A patent/GB2154592A/en not_active Withdrawn
- 1985-02-21 IL IL7440985A patent/IL74409A/en not_active IP Right Cessation
- 1985-02-21 DK DK79985A patent/DK79985A/da not_active Application Discontinuation
- 1985-02-21 HU HU85648A patent/HU200794B/hu not_active IP Right Cessation
- 1985-02-21 AT AT85301173T patent/ATE64957T1/de not_active IP Right Cessation
- 1985-02-21 AU AU39046/85A patent/AU592749B2/en not_active Ceased
- 1985-02-22 JP JP60034280A patent/JP2584733B2/ja not_active Expired - Lifetime
-
1993
- 1993-09-16 JP JP5230426A patent/JP2893626B2/ja not_active Expired - Lifetime
- 1993-12-02 US US08/160,158 patent/US5597708A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0154454A1 (de) | 1985-09-11 |
| DE3583347D1 (de) | 1991-08-08 |
| JP2584733B2 (ja) | 1997-02-26 |
| CA1340103C (en) | 1998-10-27 |
| NZ211191A (en) | 1988-01-08 |
| HUT37460A (en) | 1985-12-28 |
| EP0154454B1 (de) | 1991-07-03 |
| GB2154592A (en) | 1985-09-11 |
| DK79985D0 (da) | 1985-02-21 |
| JPS6119490A (ja) | 1986-01-28 |
| IL74409A0 (en) | 1985-05-31 |
| ZW2485A1 (en) | 1986-09-24 |
| AU3904685A (en) | 1985-09-05 |
| ATE64957T1 (de) | 1991-07-15 |
| DK79985A (da) | 1985-08-23 |
| AU592749B2 (en) | 1990-01-25 |
| PH25993A (en) | 1992-01-13 |
| HU200794B (en) | 1990-08-28 |
| JP2893626B2 (ja) | 1999-05-24 |
| GB8504429D0 (en) | 1985-03-27 |
| JPH06189772A (ja) | 1994-07-12 |
| US5597708A (en) | 1997-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HP | Change in proprietorship | ||
| NE | Application for restoration - patent lapsed through non-payment of renewal fees (section 60, patents law, 5727-1967) | ||
| NF | Patent restored | ||
| RH | Patent void |