IL73104A - 2-amino-5-hydroxy-4-methylpyrimidine derivatives,process for their preparation and pharmaceutical compositions containing them - Google Patents

2-amino-5-hydroxy-4-methylpyrimidine derivatives,process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL73104A
IL73104A IL73104A IL7310484A IL73104A IL 73104 A IL73104 A IL 73104A IL 73104 A IL73104 A IL 73104A IL 7310484 A IL7310484 A IL 7310484A IL 73104 A IL73104 A IL 73104A
Authority
IL
Israel
Prior art keywords
amino
compositions containing
hydroxy
preparation
pharmaceutical compositions
Prior art date
Application number
IL73104A
Other languages
English (en)
Other versions
IL73104A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL73104A0 publication Critical patent/IL73104A0/xx
Publication of IL73104A publication Critical patent/IL73104A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)
  • Hydrogenated Pyridines (AREA)
IL73104A 1983-10-03 1984-09-26 2-amino-5-hydroxy-4-methylpyrimidine derivatives,process for their preparation and pharmaceutical compositions containing them IL73104A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/538,233 US4554276A (en) 1983-10-03 1983-10-03 2-Amino-5-hydroxy-4-methylpyrimidine derivatives

Publications (2)

Publication Number Publication Date
IL73104A0 IL73104A0 (en) 1984-12-31
IL73104A true IL73104A (en) 1987-12-20

Family

ID=24146051

Family Applications (1)

Application Number Title Priority Date Filing Date
IL73104A IL73104A (en) 1983-10-03 1984-09-26 2-amino-5-hydroxy-4-methylpyrimidine derivatives,process for their preparation and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (1) US4554276A (fr)
EP (1) EP0138464B1 (fr)
JP (1) JPS6094970A (fr)
KR (1) KR860001818B1 (fr)
AT (1) ATE47999T1 (fr)
AU (1) AU548268B2 (fr)
CA (1) CA1215985A (fr)
DD (1) DD232698A5 (fr)
DE (1) DE3480474D1 (fr)
DK (1) DK162222C (fr)
EG (1) EG16355A (fr)
ES (1) ES536499A0 (fr)
FI (1) FI84479C (fr)
GR (1) GR80512B (fr)
HU (1) HU194186B (fr)
IE (1) IE57633B1 (fr)
IL (1) IL73104A (fr)
NO (1) NO170883C (fr)
NZ (1) NZ209740A (fr)
PH (1) PH21038A (fr)
PL (1) PL148590B1 (fr)
PT (1) PT79278B (fr)
SU (1) SU1342417A3 (fr)
YU (1) YU44058B (fr)
ZA (1) ZA847731B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711888A (en) 1985-07-24 1987-12-08 Pfizer Inc. Hydroxy and alkoxy pyrimidines
IE58373B1 (en) * 1986-06-18 1993-09-08 Bloomfield Frederick Jacob 5-Lipoxygenase pathway inhibitors
WO1989000423A1 (fr) * 1987-07-09 1989-01-26 Pfizer Inc. 2-amino-5-hydroxy-4-pyrimidones
MX14001A (es) * 1987-12-02 1993-06-01 Pfizer Procedimiento para preparar derivados de hidroxipirimidinas
US4910204A (en) * 1988-06-28 1990-03-20 Pfizer Inc. 2-amino-5-hydroxy-4-pyrimidones
EP0373827B1 (fr) * 1988-12-14 1993-10-27 Pfizer Inc. Dérivés de 5-hydroxy et 5-méthoxy-2-amino-pyrimidines comme inhibiteurs de la production d'interleukine-1
US5071852A (en) * 1988-12-14 1991-12-10 Pfizer Inc. Derivatives of 5-hydroxy and 5-methoxy 2-amino-pyrimidines as inhibitors of interleukin-1 production
US4940712A (en) * 1989-05-26 1990-07-10 Pfizer Inc. Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors
US5204118A (en) * 1989-11-02 1993-04-20 Mcneil-Ppc, Inc. Pharmaceutical compositions and methods for treating the symptoms of overindulgence
US5177079A (en) * 1991-01-31 1993-01-05 Warner-Lambert Company 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
US5248682A (en) * 1991-01-31 1993-09-28 Warner-Lambert Company 2-substituted-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
US5220025A (en) * 1992-02-24 1993-06-15 Warner-Lambert Company 2-substituted amino-4, 6-di-tertiary-butyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents
AU4566093A (en) * 1992-07-08 1994-01-31 Shell Internationale Research Maatschappij B.V. Piperidine derivatives
AU698313B2 (en) * 1994-03-14 1998-10-29 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
ATE274510T1 (de) 1998-06-19 2004-09-15 Chiron Corp Glycogen synthase kinase 3 inhibitoren
SE0000774D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0000773D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
WO2002000683A2 (fr) * 2000-06-23 2002-01-03 Vanderbilt University Nouveaux antioxydants a rupture de chaine
US20020192299A1 (en) * 2000-12-28 2002-12-19 Rajneesh Taneja Pharmaceutical compositions of a non-enteric coated proton pump inhibitor with a carbonate salt and bicarbonate salt combination
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
EP2260837A1 (fr) * 2001-06-01 2010-12-15 Pozen, Inc. Compositions pharmaceutiques pour l'administration coordonnée d'AINS
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
US20040082618A1 (en) * 2002-07-03 2004-04-29 Rajneesh Taneja Liquid dosage forms of acid labile drugs
US20040121004A1 (en) * 2002-12-20 2004-06-24 Rajneesh Taneja Dosage forms containing a PPI, NSAID, and buffer
US20070243251A1 (en) * 2002-12-20 2007-10-18 Rajneesh Taneja Dosage Forms Containing A PPI, NSAID, and Buffer
WO2004080979A1 (fr) * 2003-03-14 2004-09-23 Lg Life Sciences Ltd. Nouveaux derives de 3-(2-amino-4-pyrimidinyl)-4-hydroxyphenyl cetone
DE102004054080A1 (de) * 2004-11-09 2006-05-11 Wella Ag Haut- oder Haarbehandlungsmittel mit Schutzeffekt
AP2007004047A0 (en) 2005-01-20 2007-06-30 Pfizer Ltd Substituted triazole derivatives as oxtocin antagonists
US8367669B2 (en) * 2005-06-15 2013-02-05 Vanderbilt University Inhibitors of hemeprotein-catalyzed lipid peroxidation
US9133212B1 (en) 2005-06-15 2015-09-15 Vanderbilt University Inhibitors of hemeprotein-catalyzed lipid peroxidation
NZ587202A (en) * 2008-01-04 2013-03-28 Schabar Res Associates Llc Methods for measuring a patient response upon administration of a drug and compositions thereof
MX2011002515A (es) 2008-09-09 2011-04-07 Astrazeneca Ab Metodo de administracion de una composicion farmaceutica a un paciente que lo necesita.
MX2011013467A (es) 2009-06-25 2012-02-13 Astrazeneca Ab Metodo para tratar un paciente que corre el riesgo de desarollar una ulcera asociada a antiinflamatorio no esteroide (aine).
BR112014016085A8 (pt) 2011-12-28 2017-07-04 Pozen Inc composições aprimoradas e métodos para distribuição de omeprazol mais ácido acetilsalicílico
US11331307B2 (en) 2020-07-15 2022-05-17 Schabar Research Associates, Llc Unit oral dose compositions composed of ibuprofen and famotidine for the treatment of acute pain and the reduction of the severity and/or risk of heartburn
US11324727B2 (en) 2020-07-15 2022-05-10 Schabar Research Associates, Llc Unit oral dose compositions composed of naproxen sodium and famotidine for the treatment of acute pain and the reduction of the severity of heartburn and/or the risk of heartburn

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000138A (en) * 1966-03-31 1976-12-28 Imperial Chemical Industries Limited Organic compounds and compositions containing them
US3932617A (en) * 1974-05-24 1976-01-13 The Upjohn Company Interferon induction
DE2814984A1 (de) * 1978-04-07 1979-10-18 Bayer Ag Pyrimidin(5)yl-(thiono)(thiol)- phosphor(phosphon)-saeureester bzw. -esteramide, verfahren zu ihrer herstellung und ihre verwendung als insektizide und akarizide
IN153791B (fr) * 1979-03-10 1984-08-18 Soc D Etudes Prod Chimique
US4416885A (en) * 1979-11-02 1983-11-22 Huve Pierre M Use of isopropylaminopyrimidine in the chemotherapy of muscular dystrophy, myopathy and myotonia
OA07362A (fr) * 1980-10-27 1984-06-30 May & Baker Ltd Dérivés de la pyrimidine, leur procédé de préparation et les compositions les contenant.
US4435396A (en) * 1982-05-10 1984-03-06 Pfizer Inc. Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor

Also Published As

Publication number Publication date
JPH0528707B2 (fr) 1993-04-27
IL73104A0 (en) 1984-12-31
IE842494L (en) 1985-04-03
NZ209740A (en) 1987-04-30
DK472184A (da) 1985-04-04
EG16355A (en) 1987-04-30
FI843864A0 (fi) 1984-10-02
DK472184D0 (da) 1984-10-02
ATE47999T1 (de) 1989-12-15
DD232698A5 (de) 1986-02-05
HU194186B (en) 1988-01-28
AU548268B2 (en) 1985-12-05
FI843864L (fi) 1985-04-04
NO843968L (no) 1985-04-09
IE57633B1 (en) 1993-02-10
JPS6094970A (ja) 1985-05-28
NO170883B (no) 1992-09-14
PL148590B1 (en) 1989-11-30
FI84479B (fi) 1991-08-30
EP0138464A2 (fr) 1985-04-24
ES8601924A1 (es) 1985-11-16
NO170883C (no) 1992-12-23
HUT35651A (en) 1985-07-29
GR80512B (en) 1985-02-01
KR860001818B1 (ko) 1986-10-24
CA1215985A (fr) 1986-12-30
YU44058B (en) 1990-02-28
DK162222C (da) 1992-03-02
FI84479C (fi) 1991-12-10
EP0138464A3 (en) 1986-08-20
DE3480474D1 (de) 1989-12-21
PT79278A (en) 1984-10-01
PT79278B (en) 1986-11-18
DK162222B (da) 1991-09-30
EP0138464B1 (fr) 1989-11-15
KR850003402A (ko) 1985-06-17
US4554276A (en) 1985-11-19
SU1342417A3 (ru) 1987-09-30
AU3376884A (en) 1985-04-18
PL249833A1 (en) 1985-06-04
ZA847731B (en) 1986-05-28
ES536499A0 (es) 1985-11-16
PH21038A (en) 1987-07-03
YU169584A (en) 1987-02-28

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