IL72729A - Trans(+_)octahydropyrazole-ring alkylated pyrazoloquinolines,their preparation and pharmaceutical compositions containing them - Google Patents

Trans(+_)octahydropyrazole-ring alkylated pyrazoloquinolines,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL72729A
IL72729A IL72729A IL7272984A IL72729A IL 72729 A IL72729 A IL 72729A IL 72729 A IL72729 A IL 72729A IL 7272984 A IL7272984 A IL 7272984A IL 72729 A IL72729 A IL 72729A
Authority
IL
Israel
Prior art keywords
octahydropyrazole
pyrazoloquinolines
trans
preparation
pharmaceutical compositions
Prior art date
Application number
IL72729A
Other languages
English (en)
Other versions
IL72729A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL72729A0 publication Critical patent/IL72729A0/xx
Publication of IL72729A publication Critical patent/IL72729A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL72729A 1983-09-26 1984-08-20 Trans(+_)octahydropyrazole-ring alkylated pyrazoloquinolines,their preparation and pharmaceutical compositions containing them IL72729A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53551983A 1983-09-26 1983-09-26

Publications (2)

Publication Number Publication Date
IL72729A0 IL72729A0 (en) 1984-11-30
IL72729A true IL72729A (en) 1988-02-29

Family

ID=24134591

Family Applications (1)

Application Number Title Priority Date Filing Date
IL72729A IL72729A (en) 1983-09-26 1984-08-20 Trans(+_)octahydropyrazole-ring alkylated pyrazoloquinolines,their preparation and pharmaceutical compositions containing them

Country Status (10)

Country Link
EP (1) EP0145121B1 (fr)
JP (4) JPS6110583A (fr)
KR (1) KR870001159B1 (fr)
CA (1) CA1270488A (fr)
DE (1) DE3484925D1 (fr)
DK (1) DK400884A (fr)
GB (1) GB2146984B (fr)
GR (1) GR80200B (fr)
HU (1) HU199836B (fr)
IL (1) IL72729A (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6392722A (ja) * 1986-10-03 1988-04-23 Unitika Ltd 熱接着繊維およびその不織布
JPS6392723A (ja) * 1986-10-06 1988-04-23 Unitika Ltd 湿潤性複合繊維およびその不織布
JPS6420322A (en) * 1987-07-13 1989-01-24 Mitsubishi Petrochemical Co Conjugated fiber
JPH01204617A (ja) * 1988-02-09 1989-08-17 Chisso Corp 敷物
GB8828669D0 (en) * 1988-12-08 1989-01-11 Lilly Industries Ltd Organic compounds
KR20000008130A (ko) * 1998-07-10 2000-02-07 조정래 폴리에스터계 탄성사용 공중합물의 제조방법
EP2661175A4 (fr) 2011-01-07 2013-12-04 Corcept Therapeutics Inc Traitement combiné associant un stéroïde et un antagoniste des récepteurs des glucocorticoïdes
US20130225633A1 (en) * 2012-02-27 2013-08-29 Corcept Therapeutics, Inc. Phenyl heterocycloalkyl glucocorticoid receptor modulators
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
AU2014352915B2 (en) 2013-11-25 2018-03-15 Corcept Therapeutics, Inc. Octahydro fused azadecalin glucocorticoid receptor modulators
KR102342620B1 (ko) 2017-03-31 2021-12-22 코어셉트 쎄라퓨틱스 인코포레이티드 자궁경부암을 치료하기 위한 글루코코르티코이드 수용체 조정제
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
WO2020132046A1 (fr) 2018-12-19 2020-06-25 Corcept Therapeutics Incorporated Méthodes de traitement du cancer comprenant l'administration d'un modulateur du récepteur des glucocorticoïdes et d'un agent chimiothérapeutique anticancéreux
CN113194931B (zh) 2018-12-19 2023-11-10 科塞普特治疗公司 含有瑞拉可兰、杂芳基-酮稠合的氮杂十氢化萘化合物的药物制剂
JP2022523376A (ja) 2019-02-22 2022-04-22 コーセプト セラピューティクス， インコーポレイテッド レラコリラント、ヘテロアリール－ケトン縮合アザデカリングルココルチコイド受容体調節物質の治療用途
CA3158745A1 (fr) 2019-12-11 2021-06-17 Corcept Therapeutics Incorporated Methodes de traitement d'une prise de poids induite par medicaments antipsychotiques avec du miricorilant

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198415A (en) * 1979-01-22 1980-04-15 Eli Lilly And Company Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines
US4230861A (en) * 1979-01-22 1980-10-28 Eli Lilly And Company 1-And/or 7-substituted-6-hydroxy (or oxo)-3-decahydroquinoline carboxylic acids
SU776048A1 (ru) * 1979-06-05 1983-09-23 Институт Бисорганической Химии Ан Бсср Производные 8-аза-16-оксагона-17-онов, про вл ющие противовоспалительную,мембраностабилизирующую и антифибринолитическую активность,и способ их получени
US4252945A (en) * 1979-07-11 1981-02-24 E. R. Squibb & Sons, Inc. Process for preparing pyrazolo[1,5-c]-quinazoline derivatives and novel intermediates
US4367231A (en) * 1979-09-14 1983-01-04 Eli Lilly And Company Method of using octahydro pyrazolo[3,4-g]quinolines
ES524452A0 (es) * 1982-11-03 1985-04-16 Lilly Co Eli Un procedimiento para la preparacion de derivados de pirazolo-quinolinas.

Also Published As

Publication number Publication date
HU199836B (en) 1990-03-28
JPH05194511A (ja) 1993-08-03
DK400884D0 (da) 1984-08-22
JPH0660183B2 (ja) 1994-08-10
KR850002480A (ko) 1985-05-13
KR870001159B1 (ko) 1987-06-13
EP0145121A2 (fr) 1985-06-19
HUT34750A (en) 1985-04-28
GB2146984A (en) 1985-05-01
DE3484925D1 (de) 1991-09-19
CA1270488A (fr) 1990-06-19
JPS6110583A (ja) 1986-01-18
GB8421159D0 (en) 1984-09-26
IL72729A0 (en) 1984-11-30
GR80200B (en) 1985-01-02
DK400884A (da) 1985-03-27
JPH0625251A (ja) 1994-02-01
EP0145121A3 (en) 1988-04-27
GB2146984B (en) 1987-04-08
EP0145121B1 (fr) 1991-08-14
JPH0568475B2 (fr) 1993-09-29
JPH05194527A (ja) 1993-08-03

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