IL66449A - Bis-amino compounds and their preparation - Google Patents

Bis-amino compounds and their preparation

Info

Publication number
IL66449A
IL66449A IL66449A IL6644982A IL66449A IL 66449 A IL66449 A IL 66449A IL 66449 A IL66449 A IL 66449A IL 6644982 A IL6644982 A IL 6644982A IL 66449 A IL66449 A IL 66449A
Authority
IL
Israel
Prior art keywords
bis
preparation
amino compounds
amino
compounds
Prior art date
Application number
IL66449A
Other languages
English (en)
Other versions
IL66449A0 (en
Original Assignee
Fisons Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Plc filed Critical Fisons Plc
Priority to IL7847482A priority Critical patent/IL78474A/xx
Publication of IL66449A0 publication Critical patent/IL66449A0/xx
Priority to IL78474A priority patent/IL78474A0/xx
Publication of IL66449A publication Critical patent/IL66449A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
IL66449A 1981-08-05 1982-08-02 Bis-amino compounds and their preparation IL66449A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL7847482A IL78474A (en) 1981-08-05 1982-08-02 Pharmaceutical compositions comprising certain n,n'-bis(phenylethyl)alkylene diamines
IL78474A IL78474A0 (en) 1981-08-05 1986-04-11 Pharmaceutical compositions containing certain bis-amino compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8123962 1981-08-05
GB8130595 1981-10-09
GB8130594 1981-10-09
GB8134551 1981-11-17

Publications (2)

Publication Number Publication Date
IL66449A0 IL66449A0 (en) 1982-12-31
IL66449A true IL66449A (en) 1986-12-31

Family

ID=27449264

Family Applications (1)

Application Number Title Priority Date Filing Date
IL66449A IL66449A (en) 1981-08-05 1982-08-02 Bis-amino compounds and their preparation

Country Status (20)

Country Link
US (1) US5013760A (fi)
EP (1) EP0072061B1 (fi)
AU (1) AU538078B2 (fi)
CA (1) CA1191846A (fi)
CY (1) CY1428A (fi)
DE (1) DE3263531D1 (fi)
DK (1) DK163181C (fi)
ES (1) ES514725A0 (fi)
FI (1) FI82238C (fi)
GR (1) GR77995B (fi)
HK (1) HK41388A (fi)
IE (1) IE53827B1 (fi)
IL (1) IL66449A (fi)
LU (1) LU88284I2 (fi)
MY (1) MY8700459A (fi)
NL (1) NL930078I2 (fi)
NO (1) NO154492C (fi)
NZ (1) NZ201479A (fi)
PT (1) PT75380B (fi)
SG (1) SG46287G (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0132267B1 (en) * 1983-01-21 1989-01-18 FISONS plc Aromatic amines
GB8301754D0 (en) * 1983-01-21 1983-02-23 Fisons Plc Formulation
EP0142283B1 (en) * 1983-10-25 1991-01-30 FISONS plc Phenylethylamines, process for their preparation and compositions containing them
US4720586A (en) * 1983-12-06 1988-01-19 Fisons, Plc Substituted 3,4-dihydroxy-phenylethylamino compounds
AU587217B2 (en) * 1985-01-15 1989-08-10 Glaxo Group Limited Amine derivatives
EP0223598B1 (en) * 1985-11-20 1991-06-12 FISONS plc Catecholamine derivatives, processes for their preparation and pharmaceutical compositions thereof
US5602174A (en) * 1986-02-15 1997-02-11 Beecham Wuefling Gmbh & Co. Treatment
GB8603765D0 (en) * 1986-02-15 1986-03-19 Beecham Wuelfung Gmbh & Co Kg Compounds
GB2192394A (en) * 1986-07-11 1988-01-13 Glaxo Group Ltd Amine derivatives
US5753714A (en) * 1987-02-03 1998-05-19 Merrell Pharmaceuticals Inc. Polyamine derivatives
EP0314725A1 (en) * 1987-05-19 1989-05-10 FISONS plc 2-(3,4-dihydroxyphenyl)ethylamines, their preparation and use as pharmaceutical
IT1254521B (it) * 1992-03-17 1995-09-25 Zambon Spa Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare
IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare
IT1271008B (it) * 1994-09-13 1997-05-26 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare
IT1271007B (it) * 1994-09-13 1997-05-26 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
JP5400163B2 (ja) 2008-10-21 2014-01-29 ジヨンソン・アンド・ジヨンソン・フアーマシユーチカル・リサーチ・アンド・デベロツプメント・エルエルシー インビボにおける血管運動反応を評価するための動物モデル
CN105001103B (zh) * 2015-05-31 2017-11-03 江苏同禾药业有限公司 一种盐酸多培沙明中间体的合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2653977A (en) * 1953-09-29 Chxnx
US2739981A (en) * 1952-08-26 1956-03-27 American Home Prod Diamines and salts thereof
US2937185A (en) * 1956-08-13 1960-05-17 Lakeside Lab Inc Diamino alkanols and alkanones
US3013020A (en) * 1958-01-24 1961-12-12 Miles Lab N,n'-bis-phenyl-alkylene-diamines
GB1004071A (en) * 1961-07-03 1965-09-08 Council Scient Ind Res Substituted ª‰-phenethylamines and a process for the production thereof
GB1025699A (en) * 1965-01-08 1966-04-14 Boehringer & Soehne Gmbh New n,n-diphenyl-alkylene-ª‡,ªÏ-diamines
DE1768297B1 (de) * 1968-04-26 1971-12-16 Beiersdorf Ag Substituierte Alkylendiamine und deren Salze
US3867454A (en) * 1971-03-10 1975-02-18 Sterling Drug Inc 1,1-BRIDGED-BIS(N-aralkyl-2-aminoethanols)
US3933913A (en) * 1971-06-01 1976-01-20 Smithkline Corporation N,N'-bis[3-substituted-4-hydroxypheyl)-2-hydroxyethyl)]-polymethylenediamines
GB1440440A (en) * 1972-10-06 1976-06-23 Manuf Prod Pharma Tetrahydronaphthalene derivatives
DK449974A (fi) * 1973-08-31 1975-04-28 Sandoz Ag
US3928323A (en) * 1973-12-18 1975-12-23 Millmaster Onyx Corp Anti-microbial quaternary ammonium co-polymers
US3960959A (en) * 1973-12-19 1976-06-01 Sandoz Ltd. N,N'-bis{6-[(3,4-dihydroxyphenyl)alkylamino]-hexyl}hexamethylenediamines and the salts thereof
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
US4163063A (en) * 1976-01-02 1979-07-31 University Of Iowa Research Foundation Aminotetralin adrenergic β-agonists
GB8301754D0 (en) * 1983-01-21 1983-02-23 Fisons Plc Formulation

Also Published As

Publication number Publication date
FI82238B (fi) 1990-10-31
LU88284I2 (fr) 1994-05-04
ES8405757A1 (es) 1984-06-16
IE821872L (en) 1983-02-05
PT75380A (en) 1982-09-01
AU8670282A (en) 1983-02-10
CY1428A (en) 1988-09-02
US5013760A (en) 1991-05-07
DE3263531D1 (en) 1985-06-20
HK41388A (en) 1988-06-10
NZ201479A (en) 1986-07-11
EP0072061A1 (en) 1983-02-16
GR77995B (fi) 1984-09-26
DK163181B (da) 1992-02-03
EP0072061B1 (en) 1985-05-15
CA1191846A (en) 1985-08-13
MY8700459A (en) 1987-12-31
NO154492B (no) 1986-06-23
IL66449A0 (en) 1982-12-31
NL930078I2 (nl) 1993-11-16
NO822671L (no) 1983-02-07
DK349582A (da) 1983-02-06
FI822630A0 (fi) 1982-07-28
FI82238C (fi) 1991-02-11
IE53827B1 (en) 1989-03-15
SG46287G (en) 1987-11-13
ES514725A0 (es) 1984-06-16
PT75380B (en) 1986-02-12
NL930078I1 (nl) 1993-09-16
NO154492C (no) 1986-10-01
FI822630L (fi) 1983-02-06
DK163181C (da) 1992-06-22
AU538078B2 (en) 1984-07-26

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
EXP Patent expired