IL65943A - Derivatives of n-dihydrothiazolyl-4-hydroxy quinoline-3-carboxamide and their salts,process for preparing them and compositions containing them - Google Patents

Derivatives of n-dihydrothiazolyl-4-hydroxy quinoline-3-carboxamide and their salts,process for preparing them and compositions containing them

Info

Publication number
IL65943A
IL65943A IL65943A IL6594382A IL65943A IL 65943 A IL65943 A IL 65943A IL 65943 A IL65943 A IL 65943A IL 6594382 A IL6594382 A IL 6594382A IL 65943 A IL65943 A IL 65943A
Authority
IL
Israel
Prior art keywords
dihydrothiazolyl
carboxamide
derivatives
salts
preparing
Prior art date
Application number
IL65943A
Other languages
English (en)
Other versions
IL65943A0 (en
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8111607A external-priority patent/FR2507602A1/fr
Priority claimed from FR8204331A external-priority patent/FR2523130A1/fr
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of IL65943A0 publication Critical patent/IL65943A0/xx
Publication of IL65943A publication Critical patent/IL65943A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL65943A 1981-06-12 1982-06-01 Derivatives of n-dihydrothiazolyl-4-hydroxy quinoline-3-carboxamide and their salts,process for preparing them and compositions containing them IL65943A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8111607A FR2507602A1 (fr) 1981-06-12 1981-06-12 Nouveau derive dihydrothiazole de la quinoleine, ses sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR8204331A FR2523130A1 (fr) 1982-03-15 1982-03-15 Nouveaux derives de la n-dihydrothiazolyl-3-quinoleine carboxamide, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant

Publications (2)

Publication Number Publication Date
IL65943A0 IL65943A0 (en) 1982-09-30
IL65943A true IL65943A (en) 1985-12-31

Family

ID=26222434

Family Applications (1)

Application Number Title Priority Date Filing Date
IL65943A IL65943A (en) 1981-06-12 1982-06-01 Derivatives of n-dihydrothiazolyl-4-hydroxy quinoline-3-carboxamide and their salts,process for preparing them and compositions containing them

Country Status (16)

Country Link
US (1) US4450166A (de)
EP (1) EP0067772B1 (de)
KR (1) KR880000808B1 (de)
AU (1) AU552029B2 (de)
CA (1) CA1216795A (de)
DE (1) DE3262536D1 (de)
DK (1) DK150070C (de)
ES (1) ES8304567A1 (de)
FI (1) FI78087C (de)
GR (1) GR77201B (de)
HU (1) HU190796B (de)
IE (1) IE53520B1 (de)
IL (1) IL65943A (de)
MA (1) MA19488A1 (de)
NZ (1) NZ200931A (de)
PT (1) PT75023B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2557570B1 (fr) * 1984-01-04 1986-04-18 Adir Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
US4602014A (en) * 1984-07-09 1986-07-22 Ciba-Geigy Corporation Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodiazepine receptor modulators
US4560692A (en) * 1984-07-18 1985-12-24 Hoffmann-La Roche Inc. 4-Piperidino-2-phenylquinolines
US4786644A (en) * 1987-11-27 1988-11-22 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-quinolinecarboxamide
ATE296290T1 (de) 1998-02-26 2005-06-15 Neurogen Corp Substituierte cycloalkyl-4-oxonicotinische karboxamide; gaba gehirn-rezeptorligande
BR0010308A (pt) * 1999-05-06 2002-01-08 Neurogen Corp Composto, composição farmacêutica, uso de um composto, e, métodos para o tratamento de uma doença ou distúrbio associados com o agonismo patogênico, agonismo inverso ou antagonismo do receptor de gabaa, para localizar receptores de gabaa em uma amostra de tecido, para inibir a ligação de um composto de benzodiazepina a um receptor de gabaa e para alterar a atividade da transdução de sinal dos receptores de gabaa, e, composição farmacêutica embalada
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
DK1773816T3 (en) 2004-06-24 2015-01-26 Vertex Pharma Modulators of ATP-binding cassette transporters
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
US20090105272A1 (en) * 2005-12-24 2009-04-23 Grootenhuis Peter D J Prodrugs of modulators of ABC transporters
JP5409010B2 (ja) 2005-12-28 2014-02-05 バーテックス ファーマシューティカルズ インコーポレイテッド Ｎ−［２，４−ビス（１，１−ジメチルエチル）−５−ヒドロキシフェニル］−１，４−ジヒドロ−４−オキソキノリン−３−カルボキサミドの固体形態
NZ624460A (en) 2009-03-20 2015-12-24 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
CN104470518A (zh) 2012-02-27 2015-03-25 沃泰克斯药物股份有限公司 药物组合物及其施用
CA2963945C (en) 2014-10-07 2023-01-10 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1364605A (fr) * 1962-03-01 1964-06-26 Procédé de préparation d'amides des acides carboxyliques
FR2281761A1 (fr) * 1974-08-13 1976-03-12 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2324304A2 (fr) * 1975-09-22 1977-04-15 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2340735A1 (fr) * 1976-02-11 1977-09-09 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2377400A2 (fr) * 1977-01-18 1978-08-11 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2443467A1 (fr) * 1978-12-08 1980-07-04 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2482596A1 (fr) * 1980-05-19 1981-11-20 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament

Also Published As

Publication number Publication date
MA19488A1 (fr) 1982-12-31
DE3262536D1 (en) 1985-04-18
IE53520B1 (en) 1988-12-07
EP0067772A1 (de) 1982-12-22
FI78087B (fi) 1989-02-28
GR77201B (de) 1984-09-11
KR840000541A (ko) 1984-02-25
IL65943A0 (en) 1982-09-30
FI822067A0 (fi) 1982-06-10
AU8482782A (en) 1982-12-16
PT75023B (fr) 1985-05-17
US4450166A (en) 1984-05-22
KR880000808B1 (ko) 1988-05-11
AU552029B2 (en) 1986-05-22
IE821394L (en) 1982-12-12
HU190796B (en) 1986-11-28
ES512852A0 (es) 1983-03-01
FI78087C (fi) 1989-06-12
ES8304567A1 (es) 1983-03-01
NZ200931A (en) 1984-12-14
DK262782A (da) 1982-12-13
EP0067772B1 (de) 1985-03-13
DK150070C (da) 1987-11-09
DK150070B (da) 1986-12-01
CA1216795A (fr) 1987-01-20
PT75023A (fr) 1982-07-01

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