IL64080A0 - Benzo(b)thiophenes - Google Patents
Benzo(b)thiophenesInfo
- Publication number
- IL64080A0 IL64080A0 IL64080A IL6408081A IL64080A0 IL 64080 A0 IL64080 A0 IL 64080A0 IL 64080 A IL64080 A IL 64080A IL 6408081 A IL6408081 A IL 6408081A IL 64080 A0 IL64080 A0 IL 64080A0
- Authority
- IL
- Israel
- Prior art keywords
- thiophenes
- benzo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/76—Dibenzothiophenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19873680A | 1980-10-20 | 1980-10-20 | |
| US06/256,470 US4436748A (en) | 1980-10-20 | 1981-04-22 | Benzo[b]thiophenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL64080A0 true IL64080A0 (en) | 1982-01-31 |
Family
ID=26894105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL64080A IL64080A0 (en) | 1980-10-20 | 1981-10-19 | Benzo(b)thiophenes |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4436748A (no) |
| EP (2) | EP0155981A3 (no) |
| JP (1) | JPS57122080A (no) |
| AU (1) | AU7654781A (no) |
| CA (1) | CA1196923A (no) |
| DE (1) | DE3173647D1 (no) |
| DK (1) | DK460681A (no) |
| ES (3) | ES506228A0 (no) |
| FI (1) | FI813246L (no) |
| GR (1) | GR74692B (no) |
| IL (1) | IL64080A0 (no) |
| NO (4) | NO813526L (no) |
| PT (1) | PT73845B (no) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4537976A (en) * | 1981-04-22 | 1985-08-27 | Hoechst-Roussel Pharmaceuticals Inc. | Benzo[b]thiophenes |
| US4710876A (en) * | 1985-06-05 | 1987-12-01 | General Electric Company | System and method for the display of surface structures contained within the interior region of a solid body |
| US5554781A (en) * | 1994-03-30 | 1996-09-10 | Reierson; Robert L. | Monoalkyl phosphonic acid ester production process |
| DE69525763T2 (de) * | 1994-04-11 | 2002-10-02 | Chugai Seiyaku K.K., Tokio/Tokyo | 4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENE, DIE LDL OXIDATION HEMMEN |
| US5523416A (en) * | 1994-07-22 | 1996-06-04 | Eli Lilly And Company | Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes |
| JP3280578B2 (ja) * | 1996-08-30 | 2002-05-13 | シャープ株式会社 | 電子写真感光体 |
| MY118009A (en) * | 1996-09-25 | 2004-08-30 | Lilly Co Eli | Process for the synthesis of benzothiophenes |
| ZA9710262B (en) * | 1996-11-19 | 1999-05-13 | Lilly Co Eli | Process for the synthesis of benzothiophenes |
| US20030032779A1 (en) * | 1997-06-10 | 2003-02-13 | Lars Ohman | Estrogen receptor ligands |
| EP0980386A2 (en) * | 1997-06-10 | 2000-02-23 | Karo Bio Ab | Estrogen receptor crystals and ligands |
| WO1999051587A1 (fr) * | 1998-04-01 | 1999-10-14 | Ono Pharmaceutical Co., Ltd. | Derives de thiophene condenses et medicaments contenant ceux-ci comme principe actif |
| US6569879B2 (en) * | 2000-02-18 | 2003-05-27 | Merck & Co., Inc. | Aryloxyacetic acids for diabetes and lipid disorders |
| DE102007044832A1 (de) | 2007-09-18 | 2009-04-02 | Otto Bock Healthcare Ip Gmbh & Co. Kg | Aufrichtrollstuhl |
| JO3805B1 (ar) | 2013-10-10 | 2021-01-31 | Araxes Pharma Llc | مثبطات كراس جي12سي |
| EP3573970A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer |
| US11279689B2 (en) | 2017-01-26 | 2022-03-22 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer |
| US11358959B2 (en) * | 2017-01-26 | 2022-06-14 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| WO2018140512A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| EP3630747A1 (en) | 2017-05-25 | 2020-04-08 | Araxes Pharma LLC | Quinazoline derivatives as modulators of mutant kras, hras or nras |
| CN110869358A (zh) | 2017-05-25 | 2020-03-06 | 亚瑞克西斯制药公司 | Kras的共价抑制剂 |
| JP7187819B2 (ja) * | 2018-05-22 | 2022-12-13 | Jnc株式会社 | 液晶性化合物、液晶組成物および液晶表示素子 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2645572A (en) | 1949-12-22 | 1953-07-14 | Univ Michigan | 3-thianaphthenyloxyacetic acid, its salts and esters, and herbicidal composition thereof |
| BR6352285D0 (pt) | 1962-08-28 | 1973-07-17 | Mobil Oil Corp | Composicoes pesticidas e processo de fabricacao dos compostos ativos usados nos mesmos |
| US3288808A (en) | 1965-01-21 | 1966-11-29 | Mobil Oil Corp | Benzothienyl carbamates |
| GB1138163A (en) | 1965-05-21 | 1968-12-27 | Bristol Myers Co | Benzothiophene derivatives having anti-fertility properties |
| US3636050A (en) | 1968-02-07 | 1972-01-18 | Mobil Oil Corp | N-benzothienylchloroacetamides |
| US3480671A (en) | 1969-01-16 | 1969-11-25 | Stauffer Chemical Co | Alpha-naphthoxy acetamide compositions |
| US3952013A (en) * | 1969-02-12 | 1976-04-20 | Fisons Limited | 1-Thiachromone-2-carboxylic acids and derivatives |
| CH530388A (de) | 1970-03-20 | 1972-11-15 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Aryloxy- und Arylthioalkansäureamiden |
| US3836542A (en) | 1971-06-07 | 1974-09-17 | Mobil Oil Corp | Derivatives of hydroxybenzo(b)thiophene |
| FR2221445B1 (no) * | 1973-03-12 | 1979-04-20 | Crown Zellerbach Corp | |
| US3953601A (en) | 1973-03-16 | 1976-04-27 | Aktiebolaget Astra | Dibenzothiophene derivatives as serum lipid lowering agents |
| DE2442829A1 (de) * | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
| AU509682B2 (en) | 1975-10-28 | 1980-05-22 | Eli Lilly And Company | 2-Aroyl-3-Phenylbenzothiophene Derivatives |
| DE2909754A1 (de) | 1979-03-13 | 1980-09-18 | Thomae Gmbh Dr K | Neue benzofuran- und benzothiophenderivate, deren herstellung und deren verwendung als arzneimittel |
-
1981
- 1981-04-22 US US06/256,470 patent/US4436748A/en not_active Expired - Fee Related
- 1981-10-14 ES ES506228A patent/ES506228A0/es active Granted
- 1981-10-16 AU AU76547/81A patent/AU7654781A/en not_active Abandoned
- 1981-10-16 FI FI813246A patent/FI813246L/fi not_active Application Discontinuation
- 1981-10-16 EP EP84108392A patent/EP0155981A3/en not_active Withdrawn
- 1981-10-16 DE DE8181108387T patent/DE3173647D1/de not_active Expired
- 1981-10-16 EP EP81108387A patent/EP0050326B1/en not_active Expired
- 1981-10-19 IL IL64080A patent/IL64080A0/xx unknown
- 1981-10-19 NO NO813526A patent/NO813526L/no unknown
- 1981-10-19 PT PT73845A patent/PT73845B/pt unknown
- 1981-10-19 CA CA000388259A patent/CA1196923A/en not_active Expired
- 1981-10-19 JP JP56165895A patent/JPS57122080A/ja active Pending
- 1981-10-19 DK DK460681A patent/DK460681A/da not_active Application Discontinuation
- 1981-10-19 GR GR66296A patent/GR74692B/el unknown
-
1982
- 1982-09-01 ES ES515436A patent/ES515436A0/es active Granted
-
1983
- 1983-08-16 ES ES524980A patent/ES524980A0/es active Granted
-
1984
- 1984-10-09 NO NO844043A patent/NO844043L/no unknown
- 1984-10-09 NO NO844042A patent/NO844042L/no unknown
- 1984-12-11 NO NO844957A patent/NO844957L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES8301961A1 (es) | 1983-01-01 |
| PT73845A (en) | 1981-11-01 |
| NO844042L (no) | 1982-04-21 |
| JPS57122080A (en) | 1982-07-29 |
| ES506228A0 (es) | 1983-01-01 |
| ES8502987A1 (es) | 1985-02-01 |
| DE3173647D1 (en) | 1986-03-13 |
| ES8406467A1 (es) | 1984-07-01 |
| EP0050326A3 (en) | 1982-07-21 |
| NO813526L (no) | 1982-04-21 |
| ES524980A0 (es) | 1985-02-01 |
| EP0050326A2 (en) | 1982-04-28 |
| DK460681A (da) | 1982-04-21 |
| ES515436A0 (es) | 1984-07-01 |
| EP0050326B1 (en) | 1986-01-29 |
| NO844957L (no) | 1982-04-21 |
| PT73845B (en) | 1983-06-28 |
| EP0155981A2 (en) | 1985-10-02 |
| GR74692B (no) | 1984-08-04 |
| AU7654781A (en) | 1982-04-29 |
| US4436748A (en) | 1984-03-13 |
| NO844043L (no) | 1982-04-21 |
| FI813246L (fi) | 1982-04-21 |
| CA1196923A (en) | 1985-11-19 |
| EP0155981A3 (en) | 1985-10-30 |
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