GR74692B - - Google Patents

Info

Publication number
GR74692B
GR74692B GR66296A GR810166296A GR74692B GR 74692 B GR74692 B GR 74692B GR 66296 A GR66296 A GR 66296A GR 810166296 A GR810166296 A GR 810166296A GR 74692 B GR74692 B GR 74692B
Authority
GR
Greece
Application number
GR66296A
Inventor
Helen Hunong
James Arthur Profitt
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of GR74692B publication Critical patent/GR74692B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/76—Dibenzothiophenes
GR66296A 1980-10-20 1981-10-19 GR74692B (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19873680A 1980-10-20 1980-10-20
US06/256,470 US4436748A (en) 1980-10-20 1981-04-22 Benzo[b]thiophenes

Publications (1)

Publication Number Publication Date
GR74692B true GR74692B (el) 1984-08-04

Family

ID=26894105

Family Applications (1)

Application Number Title Priority Date Filing Date
GR66296A GR74692B (el) 1980-10-20 1981-10-19

Country Status (13)

Country Link
US (1) US4436748A (el)
EP (2) EP0155981A3 (el)
JP (1) JPS57122080A (el)
AU (1) AU7654781A (el)
CA (1) CA1196923A (el)
DE (1) DE3173647D1 (el)
DK (1) DK460681A (el)
ES (3) ES506228A0 (el)
FI (1) FI813246L (el)
GR (1) GR74692B (el)
IL (1) IL64080A0 (el)
NO (4) NO813526L (el)
PT (1) PT73845B (el)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537976A (en) * 1981-04-22 1985-08-27 Hoechst-Roussel Pharmaceuticals Inc. Benzo[b]thiophenes
US4710876A (en) * 1985-06-05 1987-12-01 General Electric Company System and method for the display of surface structures contained within the interior region of a solid body
US5554781A (en) * 1994-03-30 1996-09-10 Reierson; Robert L. Monoalkyl phosphonic acid ester production process
AU683552B2 (en) * 1994-04-11 1997-11-13 Chugai Seiyaku Kabushiki Kaisha 4,6-DI-t-butyl-2,3-dihydrobenzothiophene derivative
US5523416A (en) * 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
JP3280578B2 (ja) * 1996-08-30 2002-05-13 シャープ株式会社 電子写真感光体
MY118009A (en) * 1996-09-25 2004-08-30 Lilly Co Eli Process for the synthesis of benzothiophenes
ZA9710262B (en) * 1996-11-19 1999-05-13 Lilly Co Eli Process for the synthesis of benzothiophenes
AU735703B2 (en) * 1997-06-10 2001-07-12 Karo Bio Ab Estrogen receptor ligands
US20030032779A1 (en) * 1997-06-10 2003-02-13 Lars Ohman Estrogen receptor ligands
AU3053199A (en) 1998-04-01 1999-10-25 Ono Pharmaceutical Co. Ltd. Fused thiophene derivatives and drugs containing the same as the active ingredient
US6569879B2 (en) * 2000-02-18 2003-05-27 Merck & Co., Inc. Aryloxyacetic acids for diabetes and lipid disorders
DE102007044832A1 (de) 2007-09-18 2009-04-02 Otto Bock Healthcare Ip Gmbh & Co. Kg Aufrichtrollstuhl
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Ｋｒａｓ ｇ１２ｃ之抑制劑
WO2018140513A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
WO2018140514A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
WO2018140599A1 (en) * 2017-01-26 2018-08-02 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
EP3573954A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
EP3630747A1 (en) 2017-05-25 2020-04-08 Araxes Pharma LLC Quinazoline derivatives as modulators of mutant kras, hras or nras
AU2018271990A1 (en) 2017-05-25 2019-12-12 Araxes Pharma Llc Covalent inhibitors of KRAS
JP7187819B2 (ja) * 2018-05-22 2022-12-13 Jnc株式会社 液晶性化合物、液晶組成物および液晶表示素子

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2645572A (en) 1949-12-22 1953-07-14 Univ Michigan 3-thianaphthenyloxyacetic acid, its salts and esters, and herbicidal composition thereof
ES291167A1 (es) 1962-08-28 1969-12-01 Mobil Oil Corp Procedimiento de preparacion de carbamatos de benzotiofe- nos.
US3288808A (en) 1965-01-21 1966-11-29 Mobil Oil Corp Benzothienyl carbamates
DE1300575B (de) 1965-05-21 1969-08-07 Bristol Myers Co Benzo[b]thiophene
US3636050A (en) 1968-02-07 1972-01-18 Mobil Oil Corp N-benzothienylchloroacetamides
US3480671A (en) 1969-01-16 1969-11-25 Stauffer Chemical Co Alpha-naphthoxy acetamide compositions
US3952013A (en) * 1969-02-12 1976-04-20 Fisons Limited 1-Thiachromone-2-carboxylic acids and derivatives
CH530389A (de) 1970-03-20 1972-11-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen Aryloxy- und Arylthioalkansäureamiden
US3836542A (en) 1971-06-07 1974-09-17 Mobil Oil Corp Derivatives of hydroxybenzo(b)thiophene
GB1425278A (en) * 1973-03-12 1976-02-18 Crown Zellerbach Corp Process for producing mercaptophenols engine exhaust brake unit for vehicles with combustible gas- operated ottocycle internal combustion engines
US3953601A (en) 1973-03-16 1976-04-27 Aktiebolaget Astra Dibenzothiophene derivatives as serum lipid lowering agents
DE2442829A1 (de) * 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
AU509682B2 (en) 1975-10-28 1980-05-22 Eli Lilly And Company 2-Aroyl-3-Phenylbenzothiophene Derivatives
DE2909754A1 (de) 1979-03-13 1980-09-18 Thomae Gmbh Dr K Neue benzofuran- und benzothiophenderivate, deren herstellung und deren verwendung als arzneimittel

Also Published As

Publication number Publication date
JPS57122080A (en) 1982-07-29
NO844042L (no) 1982-04-21
ES8406467A1 (es) 1984-07-01
EP0050326B1 (en) 1986-01-29
ES8301961A1 (es) 1983-01-01
AU7654781A (en) 1982-04-29
ES524980A0 (es) 1985-02-01
EP0155981A2 (en) 1985-10-02
ES8502987A1 (es) 1985-02-01
DK460681A (da) 1982-04-21
NO813526L (no) 1982-04-21
NO844043L (no) 1982-04-21
ES515436A0 (es) 1984-07-01
ES506228A0 (es) 1983-01-01
EP0050326A3 (en) 1982-07-21
PT73845B (en) 1983-06-28
DE3173647D1 (en) 1986-03-13
US4436748A (en) 1984-03-13
CA1196923A (en) 1985-11-19
EP0050326A2 (en) 1982-04-28
EP0155981A3 (en) 1985-10-30
NO844957L (no) 1982-04-21
IL64080A0 (en) 1982-01-31
FI813246L (fi) 1982-04-21
PT73845A (en) 1981-11-01

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