IL61756A - Anti-cancer 2-amino-4 hydroxy quinazoline methylamino-benzamide derivatives,process for their preparation and pharmaceutical compositions including them - Google Patents

Anti-cancer 2-amino-4 hydroxy quinazoline methylamino-benzamide derivatives,process for their preparation and pharmaceutical compositions including them

Info

Publication number
IL61756A
IL61756A IL61756A IL6175680A IL61756A IL 61756 A IL61756 A IL 61756A IL 61756 A IL61756 A IL 61756A IL 6175680 A IL6175680 A IL 6175680A IL 61756 A IL61756 A IL 61756A
Authority
IL
Israel
Prior art keywords
methylamino
cancer
amino
preparation
pharmaceutical compositions
Prior art date
Application number
IL61756A
Other languages
English (en)
Other versions
IL61756A0 (en
Original Assignee
Nat Res Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Res Dev filed Critical Nat Res Dev
Publication of IL61756A0 publication Critical patent/IL61756A0/xx
Publication of IL61756A publication Critical patent/IL61756A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL61756A 1979-12-19 1980-12-18 Anti-cancer 2-amino-4 hydroxy quinazoline methylamino-benzamide derivatives,process for their preparation and pharmaceutical compositions including them IL61756A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7943715 1979-12-19
GB8006813 1980-02-28

Publications (2)

Publication Number Publication Date
IL61756A0 IL61756A0 (en) 1981-01-30
IL61756A true IL61756A (en) 1987-02-27

Family

ID=26273917

Family Applications (1)

Application Number Title Priority Date Filing Date
IL61756A IL61756A (en) 1979-12-19 1980-12-18 Anti-cancer 2-amino-4 hydroxy quinazoline methylamino-benzamide derivatives,process for their preparation and pharmaceutical compositions including them

Country Status (17)

Country Link
US (2) US4447608A (fr)
EP (1) EP0031237B1 (fr)
AU (1) AU543237B2 (fr)
CA (1) CA1184900A (fr)
DE (1) DE3069468D1 (fr)
DK (1) DK157019C (fr)
ES (3) ES8300716A1 (fr)
FI (1) FI76791C (fr)
GB (1) GB2065653B (fr)
GR (1) GR72847B (fr)
HU (1) HU193505B (fr)
IE (1) IE51188B1 (fr)
IL (1) IL61756A (fr)
NO (1) NO154919C (fr)
NZ (1) NZ195876A (fr)
PT (1) PT72232B (fr)
YU (1) YU321180A (fr)

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US4927828A (en) * 1985-03-08 1990-05-22 The Trustees Of Princeton University Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivatives
US5026851A (en) * 1985-03-08 1991-06-25 The Trustees Of Princeton University Pyrido[2,3-]pyrimidine derivatives
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US4833145A (en) * 1986-06-30 1989-05-23 The Trustees Of Princeton University 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives
US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US4902796A (en) * 1986-10-20 1990-02-20 The Trustees Of Princeton University 6-alkenyl and ethynyl derivatives of 2-amino-4-hydroxypyrido[2,3-d]pyrimidines
GB8707053D0 (en) * 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
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GB8727737D0 (en) * 1987-11-26 1987-12-31 Ici Plc Antitumour agents
JP2830008B2 (ja) * 1988-04-01 1998-12-02 武田薬品工業株式会社 縮合ピリミジン誘導体
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US5252573A (en) * 1988-12-15 1993-10-12 Imperial Chemical Industries Plc Anti-tumor agents
US4996206A (en) * 1989-12-11 1991-02-26 The Trustees Of Princeton University N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
US5160727A (en) * 1990-02-13 1992-11-03 Warner-Lambert Company Tumor cell sensitization method using quinazolinedione derivatives
US5286726A (en) * 1990-04-12 1994-02-15 The Regents Of The University Of Michigan Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
IL98167A0 (en) * 1990-05-30 1992-06-21 Ici Plc Anti-tumour quinazoline derivatives,processes for their preparation and pharmaceutical compositions comprising them
GB9013615D0 (en) 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
US6762188B1 (en) 1990-06-19 2004-07-13 Smithkline Beecham Corporation Pharmaceutically active benzoquinazoline compounds
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GB9205320D0 (en) * 1992-03-11 1992-04-22 Ici Plc Anti-tumour compounds
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US5430148A (en) * 1992-03-31 1995-07-04 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines
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GB9223352D0 (en) * 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
US5770573A (en) * 1993-12-06 1998-06-23 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using the same
US5821231A (en) * 1993-12-06 1998-10-13 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using same
AU693143B2 (en) * 1993-12-06 1998-06-25 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using the same
CA2177840A1 (fr) * 1993-12-06 1995-06-15 Thomas S. Arrhenius Peptidomimetiques cs-1, compositions et procedes pour les utiliser
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
US5837524A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polynucleotide products
JPH11507052A (ja) * 1995-06-07 1999-06-22 スージェン・インコーポレーテッド キナゾリンおよび医薬組成物
US5593999A (en) * 1995-06-07 1997-01-14 Nair; Madhavan G. Non-classical folate analogue inhibitors of glycinamide ribonucleotide formyltransferase (GARFT)
US7119174B2 (en) * 1995-12-18 2006-10-10 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
PT948604E (pt) * 1996-12-11 2004-10-29 Univ New York Medical Ct Produtos e metodos relacionados com pyk2
US6818440B2 (en) 1997-04-28 2004-11-16 Sugen, Inc. Diagnosis and treatment of alk-7 related disorders
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US7115710B2 (en) * 1997-06-11 2006-10-03 Sugen, Inc. Diagnosis and treatment of PTP related disorders
US6342593B1 (en) 1997-06-11 2002-01-29 Sugen, Inc. Diagnosis and treatment of ALP related disorders
US6388063B1 (en) 1997-06-18 2002-05-14 Sugen, Inc. Diagnosis and treatment of SAD related disorders
WO1999037787A2 (fr) * 1998-01-21 1999-07-29 Sugen, Inc. Orthologues humains du gene wart
CA2369172A1 (fr) * 1998-04-14 1999-10-21 Sugen, Inc. Proteines kinases apparentees a la famille de ste20
US6861442B1 (en) 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
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US6677382B1 (en) 1999-09-23 2004-01-13 Pharmacia Corporation Substituted N,N-bis-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
US6476057B1 (en) 1999-09-23 2002-11-05 G.D. Searle & Co. Use of substituted N, N-disubstituted cycloalkyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity
US6723752B2 (en) 1999-09-23 2004-04-20 Pharmacia Corporation (R)-chiral halogenated substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
US20030162223A1 (en) * 1999-10-22 2003-08-28 Lowery David E. Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
JP2003512838A (ja) * 1999-10-22 2003-04-08 ファルマシア・アンド・アップジョン・カンパニー ショウジョウバエｇタンパク質結合レセプター、核酸、およびそれに関連する方法。
US7364866B2 (en) * 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
WO2001036473A2 (fr) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Recepteurs couples a une proteine g
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
US6143776A (en) * 2000-02-02 2000-11-07 Sunesis Pharmaceuticals, Inc. Tosylproline analogs as thymidylate synthase inhibitors
US20030003451A1 (en) * 2000-02-23 2003-01-02 Gabriel Vogeli Novel G protein-coupled receptors
US20030027308A1 (en) * 2000-05-30 2003-02-06 Sugen Incorporated Novel human protein phosphatases identified from genomic sequencing
CA2321345A1 (fr) * 2000-10-02 2002-04-02 Abdelbast Guerfi Utilisation du graphite dans un composite pour reduire l'accumulation de glace
US20040157306A1 (en) * 2000-11-13 2004-08-12 Sugen Incorporated Mammalian protein phosphatases
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
BRPI0212215B8 (pt) 2001-08-31 2021-07-27 Btg Int Ltd compostos de ciclopenta[g]quinazolina anticâncer, uso dos mesmos para o tratamento de câncer e composição farmacêutica compreendendo dito composto
ES2373644T3 (es) 2001-08-31 2012-02-07 Btg International Limited Uso de derivados de ciclopenta[g]quinazolina para el tratamiento del c�?ncer.
WO2003042390A1 (fr) * 2001-11-13 2003-05-22 Sugen, Inc. Phosphatases proteiques de mammiferes
US7537774B2 (en) * 2005-12-23 2009-05-26 Orion Therapeautics, Llc Therapeutic formulation
JP2010511382A (ja) * 2006-12-01 2010-04-15 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 癌関連タンパク質キナーゼ
AU2008237934B2 (en) 2007-04-11 2014-03-27 Merck & Cie 18F-labelled folates
US8273617B2 (en) 2009-09-30 2012-09-25 Suvolta, Inc. Electronic devices and systems, and methods for making and using the same

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GB1021196A (en) * 1964-02-20 1966-03-02 Parke Davis & Co Novel amino acids and means for producing the same
US3471498A (en) * 1967-08-11 1969-10-07 Parke Davis & Co Certain n-p-((2,4-diamino-6-quinazolinyl)-methyl)benzoylamino acids

Also Published As

Publication number Publication date
PT72232B (en) 1981-11-02
DE3069468D1 (en) 1984-11-22
DK157019B (da) 1989-10-30
YU321180A (en) 1983-06-30
NZ195876A (en) 1983-11-18
IE802672L (en) 1981-06-19
PT72232A (en) 1981-01-01
AU6549580A (en) 1981-06-25
ES8307762A1 (es) 1983-08-01
NO154919C (no) 1987-01-14
DK157019C (da) 1990-03-26
ES508453A0 (es) 1983-09-01
FI803957L (fi) 1981-06-20
AU543237B2 (en) 1985-04-04
ES497884A0 (es) 1982-11-01
GR72847B (fr) 1983-12-07
GB2065653B (en) 1983-03-09
CA1184900A (fr) 1985-04-02
EP0031237A1 (fr) 1981-07-01
NO154919B (no) 1986-10-06
HU193505B (en) 1987-10-28
EP0031237B1 (fr) 1984-10-17
IE51188B1 (en) 1986-10-29
ES508454A0 (es) 1983-08-01
ES8300716A1 (es) 1982-11-01
US4564616A (en) 1986-01-14
DK540080A (da) 1981-06-20
FI76791C (fi) 1988-12-12
NO803868L (no) 1981-06-22
IL61756A0 (en) 1981-01-30
GB2065653A (en) 1981-07-01
FI76791B (fi) 1988-08-31
ES8308314A1 (es) 1983-09-01
US4447608A (en) 1984-05-08

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