IL60889A - Insulin crystal suspension and process for the preparation thereof - Google Patents
Insulin crystal suspension and process for the preparation thereofInfo
- Publication number
- IL60889A IL60889A IL60889A IL6088980A IL60889A IL 60889 A IL60889 A IL 60889A IL 60889 A IL60889 A IL 60889A IL 6088980 A IL6088980 A IL 6088980A IL 60889 A IL60889 A IL 60889A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- crystal suspension
- crystals
- insulin crystal
- insulin
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
- 239000013078 crystal Substances 0.000 title abstract 3
- 102000004877 Insulin Human genes 0.000 title abstract 2
- 108090001061 Insulin Proteins 0.000 title abstract 2
- 229940125396 insulin Drugs 0.000 title abstract 2
- 239000000725 suspension Substances 0.000 title 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
1. A process for the structural transformation of rhombohedrally crystallized insulin, preferably of pig origin, having a 4-Zn structure to rhombohedrons having a 2-Zn structure, which comprises maintaining the crystals having a 4-Zn structure in an aqueous medium containing less than 6% of sodium chloride, the pH of which medium is adjusted to 4.5 to 6.0 and maintained stable by addition of a buffer, at a temperature ranging from room temperature to 45 degrees C until in a sample crystals of the 4-Zn structure are no longer present.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792933946 DE2933946A1 (en) | 1979-08-22 | 1979-08-22 | INSULIN CRYSTAL SUSPENSION AND METHOD FOR THEIR PRODUCTION. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL60889A0 IL60889A0 (en) | 1980-10-26 |
| IL60889A true IL60889A (en) | 1983-07-31 |
Family
ID=6079022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL60889A IL60889A (en) | 1979-08-22 | 1980-08-21 | Insulin crystal suspension and process for the preparation thereof |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0025868B1 (en) |
| JP (1) | JPS5632412A (en) |
| AT (1) | ATE1281T1 (en) |
| AU (1) | AU539091B2 (en) |
| CA (1) | CA1155439A (en) |
| DE (2) | DE2933946A1 (en) |
| DK (1) | DK149347C (en) |
| ES (1) | ES8205752A1 (en) |
| GR (1) | GR69915B (en) |
| IE (1) | IE50188B1 (en) |
| IL (1) | IL60889A (en) |
| ZA (1) | ZA805152B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5534488A (en) * | 1993-08-13 | 1996-07-09 | Eli Lilly And Company | Insulin formulation |
| US5474978A (en) * | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| US5504188A (en) * | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
| YU18596A (en) * | 1995-03-31 | 1998-07-10 | Eli Lilly And Company | Analogous formulations of monomer insulin |
| JP4246795B2 (en) | 1995-07-25 | 2009-04-02 | ノバルティス アクチエンゲゼルシャフト | β-type transforming growth factor crystals |
| EP0971729B1 (en) * | 1997-03-20 | 2002-07-03 | Novo Nordisk A/S | Therapeutic powder formulation for pulmonary administration, containing crystalline insulin |
| DE102009001969A1 (en) | 2009-03-30 | 2010-10-07 | Robert Bosch Gmbh | sensor module |
| EP3908599A4 (en) * | 2019-01-10 | 2022-11-09 | Biocon Limited | PREPARATIVE CRYSTALLIZATION OF RECOMBINANT HUMAN INSULIN |
-
1979
- 1979-08-22 DE DE19792933946 patent/DE2933946A1/en not_active Withdrawn
-
1980
- 1980-08-14 ES ES494260A patent/ES8205752A1/en not_active Expired
- 1980-08-16 DE DE8080104879T patent/DE3060628D1/en not_active Expired
- 1980-08-16 EP EP80104879A patent/EP0025868B1/en not_active Expired
- 1980-08-16 AT AT80104879T patent/ATE1281T1/en not_active IP Right Cessation
- 1980-08-20 GR GR62708A patent/GR69915B/el unknown
- 1980-08-21 DK DK359380A patent/DK149347C/en not_active IP Right Cessation
- 1980-08-21 ZA ZA00805152A patent/ZA805152B/en unknown
- 1980-08-21 IE IE1762/80A patent/IE50188B1/en unknown
- 1980-08-21 CA CA000358705A patent/CA1155439A/en not_active Expired
- 1980-08-21 IL IL60889A patent/IL60889A/en unknown
- 1980-08-21 AU AU61621/80A patent/AU539091B2/en not_active Ceased
- 1980-08-22 JP JP11487980A patent/JPS5632412A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES494260A0 (en) | 1982-08-01 |
| CA1155439A (en) | 1983-10-18 |
| DE2933946A1 (en) | 1981-03-12 |
| ATE1281T1 (en) | 1982-07-15 |
| DE3060628D1 (en) | 1982-08-19 |
| ZA805152B (en) | 1981-08-26 |
| JPS5632412A (en) | 1981-04-01 |
| IE50188B1 (en) | 1986-03-05 |
| EP0025868A1 (en) | 1981-04-01 |
| DK149347B (en) | 1986-05-12 |
| GR69915B (en) | 1982-07-21 |
| DK149347C (en) | 1986-10-20 |
| IL60889A0 (en) | 1980-10-26 |
| ES8205752A1 (en) | 1982-08-01 |
| EP0025868B1 (en) | 1982-06-30 |
| AU539091B2 (en) | 1984-09-13 |
| IE801762L (en) | 1981-03-22 |
| DK359380A (en) | 1981-02-23 |
| AU6162180A (en) | 1981-04-09 |
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