KR830003214A - Insulin crystal suspension and preparation method thereof - Google Patents

Insulin crystal suspension and preparation method thereof Download PDF

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Publication number
KR830003214A
KR830003214A KR1019800003280A KR800003280A KR830003214A KR 830003214 A KR830003214 A KR 830003214A KR 1019800003280 A KR1019800003280 A KR 1019800003280A KR 800003280 A KR800003280 A KR 800003280A KR 830003214 A KR830003214 A KR 830003214A
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KR
South Korea
Prior art keywords
preparation
crystal suspension
insulin
insulin crystal
rhombohedron
Prior art date
Application number
KR1019800003280A
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Korean (ko)
Other versions
KR850000144B1 (en
Inventor
터로프 호오스트
Original Assignee
하인리히 벡커,베른하르트 벡크
훽스트 아크티엔 게젤샤프트
베른하르트 벡크
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Application filed by 하인리히 벡커,베른하르트 벡크, 훽스트 아크티엔 게젤샤프트, 베른하르트 벡크 filed Critical 하인리히 벡커,베른하르트 벡크
Priority to KR1019800003280A priority Critical patent/KR850000144B1/en
Publication of KR830003214A publication Critical patent/KR830003214A/en
Application granted granted Critical
Publication of KR850000144B1 publication Critical patent/KR850000144B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음No content

Description

인슐린 결정 현탁액 및 그의 제조방법Insulin crystal suspension and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

실온 내지 45°C 범위의 온도에서, 염화나트륨을 6% 이하 함유하며 매질의 pH가 4.5 내지 6.0으로 조절된 후 이에 완충제를 가하여 안정화된 pH의 수용성 매질중에 4―Zn 구조의 표본 결정이 더 이상 존재하지 않을 때까지 4―Zn 구조를 갖는 결정을 유지시킴을 특징으로 하여 4―Zn 구조를 갖는 능면체형 결정성 인슐린, 바람직하게는 돼지 인슐린을 2―Zn 구조를 갖는 능면체로 구조적 전환시키는 방법.At temperatures ranging from room temperature to 45 ° C., sample crystals of 4-Zn structure are no longer present in aqueous media at pH pH containing 6% or less sodium chloride and the pH of the medium adjusted to 4.5-6.0 followed by buffering. A method for structurally converting a rhombohedral crystalline insulin having a 4-Zn structure, preferably porcine insulin, into a rhombohedron having a 2-Zn structure, characterized by maintaining a crystal having a 4-Zn structure until not. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019800003280A 1980-08-20 1980-08-20 Process for structural transformation of insalin crystal KR850000144B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019800003280A KR850000144B1 (en) 1980-08-20 1980-08-20 Process for structural transformation of insalin crystal

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019800003280A KR850000144B1 (en) 1980-08-20 1980-08-20 Process for structural transformation of insalin crystal

Publications (2)

Publication Number Publication Date
KR830003214A true KR830003214A (en) 1983-06-18
KR850000144B1 KR850000144B1 (en) 1985-02-28

Family

ID=19217468

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800003280A KR850000144B1 (en) 1980-08-20 1980-08-20 Process for structural transformation of insalin crystal

Country Status (1)

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KR (1) KR850000144B1 (en)

Also Published As

Publication number Publication date
KR850000144B1 (en) 1985-02-28

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