DK359380A - PROCEDURE FOR STRUCTURAL TRANSFORMATION OF RHOMBOEDRIC CRYSTALLIZED INSULIN AND THE EFFECTIVE CRYSTAL SUSPENSION OF INSULIN PREPARED BY THE PROCEDURE - Google Patents

PROCEDURE FOR STRUCTURAL TRANSFORMATION OF RHOMBOEDRIC CRYSTALLIZED INSULIN AND THE EFFECTIVE CRYSTAL SUSPENSION OF INSULIN PREPARED BY THE PROCEDURE

Info

Publication number
DK359380A
DK359380A DK359380A DK359380A DK359380A DK 359380 A DK359380 A DK 359380A DK 359380 A DK359380 A DK 359380A DK 359380 A DK359380 A DK 359380A DK 359380 A DK359380 A DK 359380A
Authority
DK
Denmark
Prior art keywords
procedure
insulin
rhomboedric
structural transformation
crystallized
Prior art date
Application number
DK359380A
Other languages
Danish (da)
Other versions
DK149347C (en
DK149347B (en
Inventor
H Thurow
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK359380A publication Critical patent/DK359380A/en
Publication of DK149347B publication Critical patent/DK149347B/en
Application granted granted Critical
Publication of DK149347C publication Critical patent/DK149347C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C07K14/625—Extraction from natural sources

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)

Abstract

1. A process for the structural transformation of rhombohedrally crystallized insulin, preferably of pig origin, having a 4-Zn structure to rhombohedrons having a 2-Zn structure, which comprises maintaining the crystals having a 4-Zn structure in an aqueous medium containing less than 6% of sodium chloride, the pH of which medium is adjusted to 4.5 to 6.0 and maintained stable by addition of a buffer, at a temperature ranging from room temperature to 45 degrees C until in a sample crystals of the 4-Zn structure are no longer present.
DK359380A 1979-08-22 1980-08-21 PROCEDURE FOR PREPARING INSULIN PREPARATIONS WITH CRYSTALS WITH 2-ZN STRUCTURE DK149347C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2933946 1979-08-22
DE19792933946 DE2933946A1 (en) 1979-08-22 1979-08-22 INSULIN CRYSTAL SUSPENSION AND METHOD FOR THEIR PRODUCTION.

Publications (3)

Publication Number Publication Date
DK359380A true DK359380A (en) 1981-02-23
DK149347B DK149347B (en) 1986-05-12
DK149347C DK149347C (en) 1986-10-20

Family

ID=6079022

Family Applications (1)

Application Number Title Priority Date Filing Date
DK359380A DK149347C (en) 1979-08-22 1980-08-21 PROCEDURE FOR PREPARING INSULIN PREPARATIONS WITH CRYSTALS WITH 2-ZN STRUCTURE

Country Status (12)

Country Link
EP (1) EP0025868B1 (en)
JP (1) JPS5632412A (en)
AT (1) ATE1281T1 (en)
AU (1) AU539091B2 (en)
CA (1) CA1155439A (en)
DE (2) DE2933946A1 (en)
DK (1) DK149347C (en)
ES (1) ES8205752A1 (en)
GR (1) GR69915B (en)
IE (1) IE50188B1 (en)
IL (1) IL60889A (en)
ZA (1) ZA805152B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534488A (en) * 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
AR002976A1 (en) * 1995-03-31 1998-05-27 Lilly Co Eli PARENTERAL PHARMACEUTICAL FORMULATIONS OF LONG-TERM EFFECT OF INSULIN; CRYSTALS OF SUCH ANALOGUES APPLICABLE IN SUCH FORMULATIONS AND PROCEDURE OF THE FORMULATIONS MENTIONED
ATE236929T1 (en) 1995-07-25 2003-04-15 Novartis Pharma Gmbh TRANSFORMING GROWTH FACTOR BETA CRYSTAL
EP0971729B1 (en) * 1997-03-20 2002-07-03 Novo Nordisk A/S Therapeutic powder formulation for pulmonary administration, containing crystalline insulin
DE102009001969A1 (en) 2009-03-30 2010-10-07 Robert Bosch Gmbh sensor module
EP3908599A4 (en) * 2019-01-10 2022-11-09 Biocon Limited Preparative crystallization of recombinant human insulin

Also Published As

Publication number Publication date
ES494260A0 (en) 1982-08-01
GR69915B (en) 1982-07-21
AU6162180A (en) 1981-04-09
DE2933946A1 (en) 1981-03-12
EP0025868A1 (en) 1981-04-01
ATE1281T1 (en) 1982-07-15
DK149347C (en) 1986-10-20
IL60889A (en) 1983-07-31
ZA805152B (en) 1981-08-26
IE50188B1 (en) 1986-03-05
AU539091B2 (en) 1984-09-13
ES8205752A1 (en) 1982-08-01
DK149347B (en) 1986-05-12
EP0025868B1 (en) 1982-06-30
IE801762L (en) 1981-03-22
CA1155439A (en) 1983-10-18
IL60889A0 (en) 1980-10-26
DE3060628D1 (en) 1982-08-19
JPS5632412A (en) 1981-04-01

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