IL60889A0 - Insulin crystal supsension and process for the preparation thereof - Google Patents

Insulin crystal supsension and process for the preparation thereof

Info

Publication number
IL60889A0
IL60889A0 IL60889A IL6088980A IL60889A0 IL 60889 A0 IL60889 A0 IL 60889A0 IL 60889 A IL60889 A IL 60889A IL 6088980 A IL6088980 A IL 6088980A IL 60889 A0 IL60889 A0 IL 60889A0
Authority
IL
Israel
Prior art keywords
supsension
preparation
crystals
insulin crystal
insulin
Prior art date
Application number
IL60889A
Other versions
IL60889A (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL60889A0 publication Critical patent/IL60889A0/en
Publication of IL60889A publication Critical patent/IL60889A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C07K14/625—Extraction from natural sources

Abstract

1. A process for the structural transformation of rhombohedrally crystallized insulin, preferably of pig origin, having a 4-Zn structure to rhombohedrons having a 2-Zn structure, which comprises maintaining the crystals having a 4-Zn structure in an aqueous medium containing less than 6% of sodium chloride, the pH of which medium is adjusted to 4.5 to 6.0 and maintained stable by addition of a buffer, at a temperature ranging from room temperature to 45 degrees C until in a sample crystals of the 4-Zn structure are no longer present.
IL60889A 1979-08-22 1980-08-21 Insulin crystal suspension and process for the preparation thereof IL60889A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792933946 DE2933946A1 (en) 1979-08-22 1979-08-22 INSULIN CRYSTAL SUSPENSION AND METHOD FOR THEIR PRODUCTION.

Publications (2)

Publication Number Publication Date
IL60889A0 true IL60889A0 (en) 1980-10-26
IL60889A IL60889A (en) 1983-07-31

Family

ID=6079022

Family Applications (1)

Application Number Title Priority Date Filing Date
IL60889A IL60889A (en) 1979-08-22 1980-08-21 Insulin crystal suspension and process for the preparation thereof

Country Status (12)

Country Link
EP (1) EP0025868B1 (en)
JP (1) JPS5632412A (en)
AT (1) ATE1281T1 (en)
AU (1) AU539091B2 (en)
CA (1) CA1155439A (en)
DE (2) DE2933946A1 (en)
DK (1) DK149347C (en)
ES (1) ES494260A0 (en)
GR (1) GR69915B (en)
IE (1) IE50188B1 (en)
IL (1) IL60889A (en)
ZA (1) ZA805152B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534488A (en) * 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
AR002976A1 (en) * 1995-03-31 1998-05-27 Lilly Co Eli PARENTERAL PHARMACEUTICAL FORMULATIONS OF LONG-TERM EFFECT OF INSULIN; CRYSTALS OF SUCH ANALOGUES APPLICABLE IN SUCH FORMULATIONS AND PROCEDURE OF THE FORMULATIONS MENTIONED
AU6700696A (en) 1995-07-25 1997-02-26 Novartis Ag Transforming growth factor beta crystals
ATE219942T1 (en) * 1997-03-20 2002-07-15 Novo Nordisk As THERAPEUTIC POWDER FORMULATION FOR PULMONARY USE CONTAINING CRYSTALLINE INSULIN
DE102009001969A1 (en) 2009-03-30 2010-10-07 Robert Bosch Gmbh sensor module
EP3908599A4 (en) * 2019-01-10 2022-11-09 Biocon Limited Preparative crystallization of recombinant human insulin

Also Published As

Publication number Publication date
IE50188B1 (en) 1986-03-05
DK149347C (en) 1986-10-20
ES8205752A1 (en) 1982-08-01
ZA805152B (en) 1981-08-26
DK149347B (en) 1986-05-12
ES494260A0 (en) 1982-08-01
DE3060628D1 (en) 1982-08-19
JPS5632412A (en) 1981-04-01
ATE1281T1 (en) 1982-07-15
GR69915B (en) 1982-07-21
EP0025868A1 (en) 1981-04-01
CA1155439A (en) 1983-10-18
EP0025868B1 (en) 1982-06-30
AU6162180A (en) 1981-04-09
DK359380A (en) 1981-02-23
IE801762L (en) 1981-03-22
DE2933946A1 (en) 1981-03-12
AU539091B2 (en) 1984-09-13
IL60889A (en) 1983-07-31

Similar Documents

Publication Publication Date Title
SE8304045L (en) DERIVATIVES OF MORPHOLINYL-DAUNORUBICIN AND MORPHOLINYL-DOXORUBICIN, AND ANALOGS THEREOF, AND PROCEDURE FOR PREPARING THEREOF
IL60889A0 (en) Insulin crystal supsension and process for the preparation thereof
ATE32071T1 (en) CYCLOHEXENONE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE TO COMBAT UNDESIRABLE PLANT GROWTH.
FI881040A0 (en) FREEZING FOR CRYSTALLINE CEFADROXYL MONOHYDRATE.
NO175861C (en) Process for preparing anhydrous crystalline lactulose
HUT39329A (en) Compound hindering formation of pollen consisting as reagent derivatives of pirazol and process for production of the reagent
PT84467A (en) Process for preparing 1-phenylimidazolcarbonic acid amides and of growth plant regulators containing the same
GB1520160A (en) Process for producing sodium fluoride from sodium silicofluoride
GB889769A (en) Slowly acting insulin preparation in crystalline form
ES8201521A1 (en) Derivatives of 2-methylpropionic acid, process for their preparation and pharmaceutical compositions containing them.
ES8506689A1 (en) Cumalincarboxylic-acid esters, process for their preparation and agricultural fungicides.
JPS6474987A (en) Novel proline acylase and its production
GB1492837A (en) Insulin preparations having antidiabetic activity and process for their manufacture
JPS54138896A (en) Production of alpha-iron oxyhydroxide
SU1681500A1 (en) METHOD OF SYNTHESIS OF P-SUBSTITUTED DERIVATIVES OF α-PHENOXYPROPIONIC ACID
JPS56108800A (en) Novel estradiol derivative, and antitumor agent containing the same
SU1743148A1 (en) Method of nitrilotriacetic acid synthesis
ES8600208A1 (en) Process for preparing N-benzyloxycarbonyl-L-aspartic acid
GB902609A (en) Process for the preparation of gluconic acid monohydrate
SU1579088A1 (en) METHOD OF CULTIVATION OF CUTTING CRYSTALS OF POTABORATE POTASSIUM
ES468322A1 (en) Procedure for the preparation of a benciclan derivative (Machine-translation by Google Translate, not legally binding)
JPS5686196A (en) Substance fr-900148 and its preparation
GB1001721A (en) Method of crystallising monosodium glutamate monohydrate