YU48127B - PROCEDURE FOR THE PREPARATION OF ACYL-UREIDO DERIVATIVES D - (-) - ALPHA-AMINOBENZYLPENICILLIN AND THEIR PHARMACEUTICALALLY ACCEPTABLE SALTS - Google Patents
PROCEDURE FOR THE PREPARATION OF ACYL-UREIDO DERIVATIVES D - (-) - ALPHA-AMINOBENZYLPENICILLIN AND THEIR PHARMACEUTICALALLY ACCEPTABLE SALTSInfo
- Publication number
- YU48127B YU48127B YU20589A YU20589A YU48127B YU 48127 B YU48127 B YU 48127B YU 20589 A YU20589 A YU 20589A YU 20589 A YU20589 A YU 20589A YU 48127 B YU48127 B YU 48127B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- alpha
- pharmaceuticalally
- aminobenzylpenicillin
- acyl
- preparation
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
POSTUPAK ZA DOBIJANJE ACIL-UREIDO DERIVATA D-(-)-ALFA-AMINOBENZILPENICILINA I NJIHOVIH FARMACEUTSKI PRIHVATLJIVIH SOLI kod koga se jedinjenja opšte formule I U kojoj je R=Ph, R1 = H. Na, K, dobijaju iz prethodno nagrad-jenog ampicilina, naznačen time, što se alfa-amino grupa ampicilina aciluje in situ sa 1-hlorkarbonil-im-idazolidonom-2, na 10В°-15В°C i pH = 7-8, u vodenoj sredini, posle čega se rastvor i dalje meša na temperaturi od 15В°C uz održavanje pH i zatim mu se dodaju ohladjeni izopropanol, i/ili n-butanol i/ili butil acetat, posle čega se kristalinična azlocilin kiselina taloži ukapav anjem HCl i/ili po potrebi prevodi u svoje farmaceutski prihvatljive alkalne soli. - Prijava sadrži još 1 zavisan zahtev.A process for the preparation of ACYL-UREIDO DERIVATIVES D - (-) - ALPHA-AMINOBENZYLPENICILLIN AND THEIR PHARMACEUTICALALLY ACCEPTABLE SALTS wherein the compounds of general formula IU wherein R = Ph, R1 = H. Na, K are obtained from the previously awarded ampicil, ampic characterized in that the alpha-amino group of ampicillin is acylated in situ with 1-chlorocarbonyl-im-idazolidone-2 at 10V ° -15V ° C and pH = 7-8 in aqueous medium, after which the solution is still stirred at at a temperature of 15V ° C while maintaining the pH and then chilled isopropanol, and / or n-butanol and / or butyl acetate are added, after which the crystalline azlocylin acid is precipitated by dropwise addition of HCl and / or optionally converted to its pharmaceutically acceptable alkali salts. . - The application contains 1 more dependent request.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
YU20589A YU48127B (en) | 1989-01-30 | 1989-01-30 | PROCEDURE FOR THE PREPARATION OF ACYL-UREIDO DERIVATIVES D - (-) - ALPHA-AMINOBENZYLPENICILLIN AND THEIR PHARMACEUTICALALLY ACCEPTABLE SALTS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
YU20589A YU48127B (en) | 1989-01-30 | 1989-01-30 | PROCEDURE FOR THE PREPARATION OF ACYL-UREIDO DERIVATIVES D - (-) - ALPHA-AMINOBENZYLPENICILLIN AND THEIR PHARMACEUTICALALLY ACCEPTABLE SALTS |
Publications (2)
Publication Number | Publication Date |
---|---|
YU20589A YU20589A (en) | 1990-10-31 |
YU48127B true YU48127B (en) | 1997-05-28 |
Family
ID=25548847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU20589A YU48127B (en) | 1989-01-30 | 1989-01-30 | PROCEDURE FOR THE PREPARATION OF ACYL-UREIDO DERIVATIVES D - (-) - ALPHA-AMINOBENZYLPENICILLIN AND THEIR PHARMACEUTICALALLY ACCEPTABLE SALTS |
Country Status (1)
Country | Link |
---|---|
YU (1) | YU48127B (en) |
-
1989
- 1989-01-30 YU YU20589A patent/YU48127B/en unknown
Also Published As
Publication number | Publication date |
---|---|
YU20589A (en) | 1990-10-31 |
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