YU48127B - PROCEDURE FOR THE PREPARATION OF ACYL-UREIDO DERIVATIVES D - (-) - ALPHA-AMINOBENZYLPENICILLIN AND THEIR PHARMACEUTICALALLY ACCEPTABLE SALTS - Google Patents

PROCEDURE FOR THE PREPARATION OF ACYL-UREIDO DERIVATIVES D - (-) - ALPHA-AMINOBENZYLPENICILLIN AND THEIR PHARMACEUTICALALLY ACCEPTABLE SALTS

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Publication number
YU48127B
YU48127B YU20589A YU20589A YU48127B YU 48127 B YU48127 B YU 48127B YU 20589 A YU20589 A YU 20589A YU 20589 A YU20589 A YU 20589A YU 48127 B YU48127 B YU 48127B
Authority
YU
Yugoslavia
Prior art keywords
alpha
pharmaceuticalally
aminobenzylpenicillin
acyl
preparation
Prior art date
Application number
YU20589A
Other languages
Serbo-Croatian (sh)
Other versions
YU20589A (en
Inventor
J. Kojić
Z. Stokić
M. Savković
R. Maksimović
Ž. Stajić
S. Husinec
Original Assignee
Icn Galenika Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icn Galenika Institut filed Critical Icn Galenika Institut
Priority to YU20589A priority Critical patent/YU48127B/en
Publication of YU20589A publication Critical patent/YU20589A/en
Publication of YU48127B publication Critical patent/YU48127B/en

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Abstract

POSTUPAK ZA DOBIJANJE ACIL-UREIDO DERIVATA D-(-)-ALFA-AMINOBENZILPENICILINA I NJIHOVIH FARMACEUTSKI PRIHVATLJIVIH SOLI kod koga se jedinjenja opšte formule I U kojoj je R=Ph, R1 = H. Na, K, dobijaju iz prethodno nagrad-jenog ampicilina, naznačen time, što se alfa-amino grupa ampicilina aciluje in situ sa 1-hlorkarbonil-im-idazolidonom-2, na 10В°-15В°C i pH = 7-8, u vodenoj sredini, posle čega se rastvor i dalje meša na temperaturi od 15В°C uz održavanje pH i zatim mu se dodaju ohladjeni izopropanol, i/ili n-butanol i/ili butil acetat, posle čega se kristalinična azlocilin kiselina taloži ukapav anjem HCl i/ili po potrebi prevodi u svoje farmaceutski prihvatljive alkalne soli. - Prijava sadrži još 1 zavisan zahtev.A process for the preparation of ACYL-UREIDO DERIVATIVES D - (-) - ALPHA-AMINOBENZYLPENICILLIN AND THEIR PHARMACEUTICALALLY ACCEPTABLE SALTS wherein the compounds of general formula IU wherein R = Ph, R1 = H. Na, K are obtained from the previously awarded ampicil, ampic characterized in that the alpha-amino group of ampicillin is acylated in situ with 1-chlorocarbonyl-im-idazolidone-2 at 10V ° -15V ° C and pH = 7-8 in aqueous medium, after which the solution is still stirred at at a temperature of 15V ° C while maintaining the pH and then chilled isopropanol, and / or n-butanol and / or butyl acetate are added, after which the crystalline azlocylin acid is precipitated by dropwise addition of HCl and / or optionally converted to its pharmaceutically acceptable alkali salts. . - The application contains 1 more dependent request.

YU20589A 1989-01-30 1989-01-30 PROCEDURE FOR THE PREPARATION OF ACYL-UREIDO DERIVATIVES D - (-) - ALPHA-AMINOBENZYLPENICILLIN AND THEIR PHARMACEUTICALALLY ACCEPTABLE SALTS YU48127B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
YU20589A YU48127B (en) 1989-01-30 1989-01-30 PROCEDURE FOR THE PREPARATION OF ACYL-UREIDO DERIVATIVES D - (-) - ALPHA-AMINOBENZYLPENICILLIN AND THEIR PHARMACEUTICALALLY ACCEPTABLE SALTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU20589A YU48127B (en) 1989-01-30 1989-01-30 PROCEDURE FOR THE PREPARATION OF ACYL-UREIDO DERIVATIVES D - (-) - ALPHA-AMINOBENZYLPENICILLIN AND THEIR PHARMACEUTICALALLY ACCEPTABLE SALTS

Publications (2)

Publication Number Publication Date
YU20589A YU20589A (en) 1990-10-31
YU48127B true YU48127B (en) 1997-05-28

Family

ID=25548847

Family Applications (1)

Application Number Title Priority Date Filing Date
YU20589A YU48127B (en) 1989-01-30 1989-01-30 PROCEDURE FOR THE PREPARATION OF ACYL-UREIDO DERIVATIVES D - (-) - ALPHA-AMINOBENZYLPENICILLIN AND THEIR PHARMACEUTICALALLY ACCEPTABLE SALTS

Country Status (1)

Country Link
YU (1) YU48127B (en)

Also Published As

Publication number Publication date
YU20589A (en) 1990-10-31

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