IL59203A - Acyloxyalkyl-6-(alpha,alpha-disubstituted acetamido)penicillanates and their salts,their production and pharmaceutical compositions containing them - Google Patents

Acyloxyalkyl-6-(alpha,alpha-disubstituted acetamido)penicillanates and their salts,their production and pharmaceutical compositions containing them

Info

Publication number
IL59203A
IL59203A IL59203A IL5920380A IL59203A IL 59203 A IL59203 A IL 59203A IL 59203 A IL59203 A IL 59203A IL 5920380 A IL5920380 A IL 5920380A IL 59203 A IL59203 A IL 59203A
Authority
IL
Israel
Prior art keywords
alpha
penicillanates
acyloxyalkyl
acetamido
disubstituted
Prior art date
Application number
IL59203A
Other languages
English (en)
Other versions
IL59203A0 (en
Original Assignee
Rech Applications Therap
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27449109&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL59203(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rech Applications Therap filed Critical Rech Applications Therap
Publication of IL59203A0 publication Critical patent/IL59203A0/xx
Publication of IL59203A publication Critical patent/IL59203A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
IL59203A 1979-02-13 1980-01-23 Acyloxyalkyl-6-(alpha,alpha-disubstituted acetamido)penicillanates and their salts,their production and pharmaceutical compositions containing them IL59203A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB7905020 1979-02-13
GB7921341 1979-06-19
GB7927761 1979-08-09
GB7939473 1979-11-14

Publications (2)

Publication Number Publication Date
IL59203A0 IL59203A0 (en) 1980-05-30
IL59203A true IL59203A (en) 1982-12-31

Family

ID=27449109

Family Applications (1)

Application Number Title Priority Date Filing Date
IL59203A IL59203A (en) 1979-02-13 1980-01-23 Acyloxyalkyl-6-(alpha,alpha-disubstituted acetamido)penicillanates and their salts,their production and pharmaceutical compositions containing them

Country Status (33)

Country Link
US (2) US4840944A (fr)
AR (1) AR230286A1 (fr)
AT (1) AT368507B (fr)
AU (1) AU532531B2 (fr)
CA (1) CA1230113A (fr)
CH (2) CH646436A5 (fr)
CS (1) CS234015B2 (fr)
CY (1) CY1205A (fr)
DD (1) DD149529A5 (fr)
DE (2) DE3050895C2 (fr)
DK (1) DK160943C (fr)
ES (1) ES8101596A1 (fr)
FI (2) FI73220C (fr)
FR (1) FR2449089A1 (fr)
GB (2) GB2108107B (fr)
GR (1) GR74091B (fr)
HK (1) HK5684A (fr)
HU (1) HU182604B (fr)
IE (2) IE49880B1 (fr)
IL (1) IL59203A (fr)
IT (1) IT1147306B (fr)
KE (1) KE3309A (fr)
LU (1) LU82164A1 (fr)
MA (1) MA18731A1 (fr)
MY (1) MY8500006A (fr)
NL (1) NL8000775A (fr)
NZ (1) NZ192762A (fr)
PH (1) PH16326A (fr)
PL (1) PL125079B1 (fr)
PT (1) PT70805A (fr)
SE (2) SE446186B (fr)
SG (1) SG43783G (fr)
YU (1) YU42659B (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE449103B (sv) * 1979-03-05 1987-04-06 Pfizer Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
US4714761A (en) * 1979-03-05 1987-12-22 Pfizer Inc. 6,6-dihalopenicillanic acid 1,1-dioxides and process
US4420426A (en) 1979-03-05 1983-12-13 Pfizer Inc. 6-Alpha-halopenicillanic acid 1,1-dioxides
US4309347A (en) * 1979-05-16 1982-01-05 Pfizer Inc. Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4364957A (en) * 1979-09-26 1982-12-21 Pfizer Inc. Bis-esters of alkanediols as antibacterial agents
US4342768A (en) * 1979-10-22 1982-08-03 Pfizer Inc. Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
IL61880A (en) * 1980-01-21 1984-11-30 Bristol Myers Co 2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them
FI67553C (fi) * 1980-01-21 1985-04-10 Bristol Myers Co Foerfarande foer framstaellning av en terapeutiskt anvaendbar 2beta-klormetyl-2alfa-metylpenam-3alfa-karboxylsyrasulfon sater och estrar daerav
US4340539A (en) 1980-01-21 1982-07-20 Bristol-Myers Company Derivatives of 6-bromo penicillanic acid
US4488994A (en) * 1980-09-08 1984-12-18 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
IE51516B1 (en) * 1980-10-06 1987-01-07 Leo Pharm Prod Ltd 1,1-dioxapenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate napsylate
IL64009A (en) * 1980-10-31 1984-09-30 Rech Applications Therap Crystalline 1,1-dioxopenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate tosylate hydrates,their production and pharmaceutical compositions containing them
US4380512A (en) * 1980-12-11 1983-04-19 Bristol-Myers Company 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone and salts and esters thereof
US4474698A (en) * 1980-12-11 1984-10-02 Pfizer Inc. Process for preparing esters of penicillanic acid sulfone
US4419284A (en) 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
IN159362B (fr) * 1981-03-23 1987-05-09 Pfizer
US4381263A (en) * 1981-03-23 1983-04-26 Pfizer Inc. Process for the preparation of penicillanic acid esters
US4393001A (en) 1981-03-23 1983-07-12 Pfizer Inc. Intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates
IN157669B (fr) * 1981-03-23 1986-05-17 Pfizer
US4376076A (en) 1981-03-23 1983-03-08 Pfizer Inc. Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide
US4321196A (en) 1981-03-23 1982-03-23 Pfizer Inc. Bis-esters of methanediol with acetonides of ampicillin or amoxicillin and penicillanic acid 1,1-dioxide
US4444687A (en) * 1981-06-08 1984-04-24 Bristol-Myers Company 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone methylene diol mixed esters
US4582829A (en) * 1981-09-09 1986-04-15 Pfizer Inc. Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds
US4540687A (en) * 1981-09-09 1985-09-10 Pfizer Inc. Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds
EP0074777B1 (fr) * 1981-09-09 1987-10-14 Pfizer Inc. Esters de 6-(2-amino-2-(4-acyloxy-phényl)acétamido) pénicillanoyloxyméthyle, antibactériens
US4351840A (en) * 1981-09-18 1982-09-28 Pfizer Inc. Antibacterial esters of resorcinol with ampicillin and penicillanic acid 1,1-dioxide derivatives
US4359472A (en) 1981-12-22 1982-11-16 Pfizer Inc. Bis-hydroxymethyl carbonate bridged antibacterial agents
US4457924A (en) * 1981-12-22 1984-07-03 Pfizer, Inc. 1,1-Alkanediol dicarboxylate linked antibacterial agents
US4452796A (en) * 1982-06-14 1984-06-05 Pfizer Inc. 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
EP0084730A1 (fr) * 1982-01-22 1983-08-03 Beecham Group Plc Esters de dérivés de pénicilline avec des inhibiteurs de bêta-lactamase, leur préparation et leur application
US4444686A (en) * 1982-01-25 1984-04-24 Pfizer Inc. Crystalline penicillin ester intermediate
US4432987A (en) * 1982-04-23 1984-02-21 Pfizer Inc. Crystalline benzenesulfonate salts of sultamicillin
IT1190897B (it) * 1982-06-29 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
EP0126090A1 (fr) * 1982-10-26 1984-11-28 Beecham Group Plc COMPOSES DE $g(b)-LACTAME, LEUR PREPARATION ET LEUR UTILISATION
US4530792A (en) * 1982-11-01 1985-07-23 Pfizer Inc. Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate
IL67637A0 (en) * 1983-01-07 1983-05-15 Orvet Bv Preparation of 1'-ethoxycarbonyl-oxyethyl esters of penicillins and novel intermediates
US4868297A (en) * 1982-12-06 1989-09-19 Pfizer Inc. Process for preparing sultamicillin and analogs
US4462934A (en) * 1983-03-31 1984-07-31 Pfizer Inc. Bis-esters of dicarboxylic acids with amoxicillin and certain hydroxymethylpenicillanate 1,1-dioxides
US4536393A (en) * 1983-06-06 1985-08-20 Pfizer Inc. 6-(Aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor
JPH01139584A (ja) * 1987-11-25 1989-06-01 Yoshitomi Pharmaceut Ind Ltd ペニシラン酸化合物の製造法
KR910009271B1 (ko) * 1989-06-20 1991-11-08 김영설 1,1-디옥소페닐실라노일 옥시메틸 D-6-[α-(메틸렌아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염
CA2078217C (fr) * 1990-04-13 2000-02-22 Dennis M. Godek Procede d'obtention d'un intermediaire de la sultamicilline
ES2161602B1 (es) * 1999-04-08 2003-02-16 Asturpharma S A Sintesis de 6-(d-alfa-(bencilidenaminofenilacetamido))penicilanato de 1,1-dioxopenicilanoiloximetilo y analogos. nuevos intermedios para la sintesis de sultamicilina.
WO2007004239A1 (fr) * 2005-07-06 2007-01-11 Morepen Laboratories Limited Nouvelle forme polymorphique du tosylate de sultamicilline et procede correspondant
TR201922977A2 (tr) * 2019-12-31 2021-07-26 T C Erciyes Ueniversitesi Penisilin türevleri ve bunların sentezlenmesi için yöntem
CN115385934A (zh) * 2022-10-26 2022-11-25 北京纳百生物科技有限公司 一种舒巴坦半抗原及其合成方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1303491A (fr) * 1970-03-24 1973-01-17
GB1335718A (en) * 1971-05-05 1973-10-31 Leo Pharm Prod Ltd Penicillin esters salts thereof and methods for their preparation
US3838152A (en) * 1971-10-07 1974-09-24 American Home Prod Poly alpha-amino penicillins
GB1467604A (en) * 1974-06-27 1977-03-16 Toyama Chemical Co Ltd Bis-type penicillins and process for producing the same
GB1573614A (en) * 1976-02-25 1980-08-28 Leo Pharm Prod Ltd Amidinopenicillanoyloxyalkyl cephalosporanates
GB1578128A (en) * 1976-03-30 1980-11-05 Leo Pharm Prod Ltd Amidinopenicillanoyloxyalkyl amoxycillinates
GB1579931A (en) * 1976-04-15 1980-11-26 Leo Pharm Prod Ltd Bis-penicillanoyl-oxy-alkanes
IN149747B (fr) * 1977-06-07 1982-04-03 Pfizer
US4197240A (en) * 1977-12-23 1980-04-08 Yeda Research And Development Co. Ltd. Penicillin derivatives
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide

Also Published As

Publication number Publication date
CA1230113A (fr) 1987-12-08
NL8000775A (nl) 1980-08-15
IT8019865A0 (it) 1980-02-12
IT1147306B (it) 1986-11-19
ES488494A0 (es) 1980-12-16
AT368507B (de) 1982-10-25
GB2108107A (en) 1983-05-11
US4840944A (en) 1989-06-20
HK5684A (en) 1984-01-20
DE3050895C2 (fr) 1989-05-03
CS234015B2 (en) 1985-03-14
DE3005164C2 (de) 1986-06-26
CH645902A5 (de) 1984-10-31
FI800411A (fi) 1980-08-14
SE8404462D0 (sv) 1984-09-05
DD149529A5 (de) 1981-07-15
IE832654L (en) 1980-08-13
MA18731A1 (fr) 1980-10-01
FR2449089B1 (fr) 1983-06-10
GB2108107B (en) 1983-09-01
GR74091B (fr) 1984-06-06
DK59480A (da) 1980-08-14
PL125079B1 (en) 1983-03-31
LU82164A1 (fr) 1980-09-24
AR230286A1 (es) 1984-03-01
ATA61580A (de) 1982-02-15
FI870555A (fi) 1987-02-11
PT70805A (en) 1980-03-01
GB2044255A (en) 1980-10-15
CY1205A (en) 1983-12-31
NZ192762A (en) 1984-10-19
CH646436A5 (de) 1984-11-30
FI870555A0 (fi) 1987-02-11
HU182604B (en) 1984-02-28
IE49881B1 (en) 1986-01-08
FI73220B (fi) 1987-05-29
YU24480A (en) 1983-04-30
DK160943C (da) 1991-10-21
IL59203A0 (en) 1980-05-30
GB2044255B (en) 1983-05-11
DK160943B (da) 1991-05-06
SG43783G (en) 1985-01-11
FI73220C (fi) 1987-09-10
PL221964A1 (fr) 1980-12-01
FI76807B (fi) 1988-08-31
SE461913B (sv) 1990-04-09
FI76807C (fi) 1988-12-12
US4342772A (en) 1982-08-03
AU532531B2 (en) 1983-10-06
MY8500006A (en) 1985-12-31
DE3005164A1 (de) 1980-08-21
IE49880B1 (en) 1986-01-08
SE446186B (sv) 1986-08-18
FR2449089A1 (fr) 1980-09-12
KE3309A (en) 1983-08-19
ES8101596A1 (es) 1980-12-16
PH16326A (en) 1983-09-05
AU5546280A (en) 1980-08-21
SE8404462L (sv) 1984-09-05
SE8001099L (sv) 1980-08-14
YU42659B (en) 1988-10-31

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