IL57219A - 10-methoxy-daunorubicin,10-methoxy-doxorubicin,their derivatives,preparation thereof,and pharmaceutical compositions comprising them - Google Patents

10-methoxy-daunorubicin,10-methoxy-doxorubicin,their derivatives,preparation thereof,and pharmaceutical compositions comprising them

Info

Publication number
IL57219A
IL57219A IL57219A IL5721979A IL57219A IL 57219 A IL57219 A IL 57219A IL 57219 A IL57219 A IL 57219A IL 5721979 A IL5721979 A IL 5721979A IL 57219 A IL57219 A IL 57219A
Authority
IL
Israel
Prior art keywords
methoxy
daunorubicin
doxorubicin
derivatives
preparation
Prior art date
Application number
IL57219A
Other languages
English (en)
Other versions
IL57219A0 (en
Inventor
Sergio Penco
Fausto Gozzi
Francesco Angelucci
Federico Arcamone
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of IL57219A0 publication Critical patent/IL57219A0/xx
Publication of IL57219A publication Critical patent/IL57219A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
IL57219A 1978-05-09 1979-05-06 10-methoxy-daunorubicin,10-methoxy-doxorubicin,their derivatives,preparation thereof,and pharmaceutical compositions comprising them IL57219A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23151/78A IT1098212B (it) 1978-05-09 1978-05-09 Antracioline antitumorali sostituite

Publications (2)

Publication Number Publication Date
IL57219A0 IL57219A0 (en) 1979-09-30
IL57219A true IL57219A (en) 1982-12-31

Family

ID=11204317

Family Applications (1)

Application Number Title Priority Date Filing Date
IL57219A IL57219A (en) 1978-05-09 1979-05-06 10-methoxy-daunorubicin,10-methoxy-doxorubicin,their derivatives,preparation thereof,and pharmaceutical compositions comprising them

Country Status (22)

Country Link
US (3) US4199571A (cs)
JP (1) JPS5513264A (cs)
AT (1) AT363186B (cs)
AU (1) AU528439B2 (cs)
BE (1) BE876099A (cs)
CA (1) CA1128503A (cs)
CH (1) CH640869A5 (cs)
CS (1) CS207789B2 (cs)
DE (1) DE2918291A1 (cs)
DK (1) DK188079A (cs)
FR (1) FR2425446A1 (cs)
GB (1) GB2021571B (cs)
HU (1) HU180298B (cs)
IE (1) IE48371B1 (cs)
IL (1) IL57219A (cs)
IT (1) IT1098212B (cs)
NL (1) NL7903539A (cs)
NO (1) NO147310C (cs)
SE (1) SE7903972L (cs)
SU (1) SU867315A3 (cs)
YU (1) YU105279A (cs)
ZA (1) ZA792177B (cs)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
US4563444A (en) * 1982-05-26 1986-01-07 Farmitalia Carlo Erba S.P.A. Anthracycline glycosides, use and compositions containing same
IT1155446B (it) * 1982-12-23 1987-01-28 Erba Farmitalia Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine
US4489206A (en) * 1983-05-13 1984-12-18 Adria Laboratories, Inc. Synthesis of (+)-4-demethoxydaunomycinone
JPH0528280Y2 (cs) * 1986-12-10 1993-07-20
EP1610763A2 (en) * 2003-03-31 2006-01-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Stable liposomes or micelles comprising a sphingolipid and a peg-lipopolymer
CA2587470A1 (en) * 2004-11-15 2006-05-18 Yissum Research Development Company Of The Hebrew University Of Jerusale M Combination therapy associating preferably a ceramide with a cytotoxic drug

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3201424A (en) * 1962-10-29 1965-08-17 American Cyanamid Co Derivatives of 1, 3, 11, 12-tetrahydroxynaphthacene and 1, 3, 6, 11-tetrahydroxynaphtacene-5, 12-quinone
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
US3686163A (en) * 1968-05-14 1972-08-22 Farmaceutici Italia Dihydrodaunomycin antibiotic and derivatives thereof
FI51808C (fi) * 1968-07-15 1977-04-12 Rhone Poulenc Sa Menetelmä uusien kasvainten naftaseenijohdannaisten valmistamiseksi.
US4020270A (en) * 1974-05-02 1977-04-26 Societa' Farmaceutici Italia S.P.A. L-lyxohex-1-enopyranose derivative
GB1461190A (en) * 1974-09-20 1977-01-13 Farmaceutici Italia Anthracycline preparation
US4133877A (en) * 1976-07-08 1979-01-09 Societa Farmaceutici Italia S.P.A. Anthracycline ethers and use therefor
GB1561719A (en) * 1976-12-22 1980-02-27 Farmaceutici Italia Anthracyclines

Also Published As

Publication number Publication date
ATA340879A (de) 1980-12-15
IL57219A0 (en) 1979-09-30
US4229355A (en) 1980-10-21
NO147310C (no) 1983-03-16
IE790906L (en) 1979-11-09
BE876099A (fr) 1979-11-08
SE7903972L (sv) 1979-11-10
NL7903539A (nl) 1979-11-13
CS207789B2 (en) 1981-08-31
CA1128503A (en) 1982-07-27
GB2021571A (en) 1979-12-05
DK188079A (da) 1979-11-10
CH640869A5 (de) 1984-01-31
JPS5513264A (en) 1980-01-30
YU105279A (en) 1982-10-31
FR2425446A1 (fr) 1979-12-07
IT1098212B (it) 1985-09-07
IT7823151A0 (it) 1978-05-09
US4199571A (en) 1980-04-22
HU180298B (en) 1983-02-28
FR2425446B1 (cs) 1982-07-30
AU4668479A (en) 1979-11-15
ZA792177B (en) 1980-05-28
AU528439B2 (en) 1983-04-28
GB2021571B (en) 1982-09-29
SU867315A3 (ru) 1981-09-23
DE2918291A1 (de) 1979-11-15
IE48371B1 (en) 1984-12-26
NO791520L (no) 1979-11-12
NO147310B (no) 1982-12-06
US4216157A (en) 1980-08-05
AT363186B (de) 1981-07-10

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