IL53506A - Spiro-3,5"-oxazolidine-2",4"-dione derivatives of 3-descarbo-methoxy-3-deshydroxy vinca alkaloids,pharmaceutical compositions containing them and vinca alkaloid 3-carbamates as intermediates therefor - Google Patents

Spiro-3,5"-oxazolidine-2",4"-dione derivatives of 3-descarbo-methoxy-3-deshydroxy vinca alkaloids,pharmaceutical compositions containing them and vinca alkaloid 3-carbamates as intermediates therefor

Info

Publication number
IL53506A
IL53506A IL53506A IL5350677A IL53506A IL 53506 A IL53506 A IL 53506A IL 53506 A IL53506 A IL 53506A IL 5350677 A IL5350677 A IL 5350677A IL 53506 A IL53506 A IL 53506A
Authority
IL
Israel
Prior art keywords
vinca
descarbo
deshydroxy
oxazolidine
carbamates
Prior art date
Application number
IL53506A
Other languages
English (en)
Other versions
IL53506A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL53506A0 publication Critical patent/IL53506A0/xx
Publication of IL53506A publication Critical patent/IL53506A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04Dimeric indole alkaloids, e.g. vincaleucoblastine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL53506A 1976-12-06 1977-12-01 Spiro-3,5"-oxazolidine-2",4"-dione derivatives of 3-descarbo-methoxy-3-deshydroxy vinca alkaloids,pharmaceutical compositions containing them and vinca alkaloid 3-carbamates as intermediates therefor IL53506A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/747,575 US4096148A (en) 1976-12-06 1976-12-06 Oxazolidinedione derivatives of Vinca alkaloids

Publications (2)

Publication Number Publication Date
IL53506A0 IL53506A0 (en) 1978-03-10
IL53506A true IL53506A (en) 1981-09-13

Family

ID=25005690

Family Applications (1)

Application Number Title Priority Date Filing Date
IL53506A IL53506A (en) 1976-12-06 1977-12-01 Spiro-3,5"-oxazolidine-2",4"-dione derivatives of 3-descarbo-methoxy-3-deshydroxy vinca alkaloids,pharmaceutical compositions containing them and vinca alkaloid 3-carbamates as intermediates therefor

Country Status (31)

Country Link
US (1) US4096148A (da)
JP (1) JPS5371100A (da)
AR (1) AR218467A1 (da)
AT (2) AT361638B (da)
AU (1) AU513936B2 (da)
BE (1) BE861417A (da)
BG (1) BG33436A3 (da)
CA (2) CA1082180A (da)
CH (2) CH634076A5 (da)
CS (2) CS195343B2 (da)
DD (2) DD134227A5 (da)
DE (1) DE2753791A1 (da)
DK (2) DK145001C (da)
ES (2) ES464765A1 (da)
FR (1) FR2372839A1 (da)
GB (1) GB1590649A (da)
GR (2) GR67244B (da)
HK (1) HK57281A (da)
HU (2) HU180724B (da)
IE (1) IE46105B1 (da)
IL (1) IL53506A (da)
MX (1) MX4326E (da)
MY (1) MY8200176A (da)
NL (1) NL7713336A (da)
NZ (1) NZ185818A (da)
PL (2) PL110671B1 (da)
PT (2) PT67343B (da)
RO (2) RO74137A (da)
SE (2) SE435930B (da)
SU (2) SU843753A3 (da)
ZA (1) ZA777237B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU181874B (en) * 1977-08-08 1983-11-28 Lilly Co Eli Process for preparing amides of deacetyl-leurosine and deacetyl-leuroformine
US4357334A (en) * 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
US4362664A (en) * 1980-12-29 1982-12-07 Eli Lilly And Company Vinblastine oxazolidinedione disulfides and related compounds
EP0124502B1 (fr) * 1983-04-29 1991-06-12 OMNICHEM Société anonyme Nouveaux conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques contenant ces conjugués
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL265085A (da) * 1960-05-24
HU165986B (da) * 1973-02-16 1974-12-28
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
US4012390A (en) * 1974-10-16 1977-03-15 Eli Lilly And Company Vinblastinoic acid

Also Published As

Publication number Publication date
DK145001B (da) 1982-07-26
RO74137A (ro) 1981-08-30
DK541177A (da) 1978-06-07
PL202659A1 (pl) 1978-12-04
CH634076A5 (de) 1983-01-14
SE7713586L (sv) 1978-06-07
DK145001C (da) 1982-12-27
GB1590649A (en) 1981-06-03
ZA777237B (en) 1979-07-25
IL53506A0 (en) 1978-03-10
HK57281A (en) 1981-11-27
ATA868777A (de) 1980-08-15
SE436036B (sv) 1984-11-05
IE46105B1 (en) 1983-02-23
MY8200176A (en) 1982-12-31
SU843753A3 (ru) 1981-06-30
HU180725B (en) 1983-04-29
DE2753791C2 (da) 1990-08-02
ES464764A1 (es) 1979-01-01
DD134227A5 (de) 1979-02-14
DK144916B (da) 1982-07-05
AT361638B (de) 1981-03-25
AU513936B2 (en) 1981-01-15
CA1103664A (en) 1981-06-23
BG33436A3 (en) 1983-02-15
JPS625160B2 (da) 1987-02-03
DK144916C (da) 1982-12-06
GR67243B (da) 1981-06-25
IE46105L (en) 1978-06-06
DK541077A (da) 1978-06-07
CA1082180A (en) 1980-07-22
NZ185818A (en) 1979-12-11
CS195344B2 (en) 1980-01-31
BE861417A (fr) 1978-06-02
PT67342A (en) 1977-12-01
PT67343B (en) 1979-04-26
SU865127A3 (ru) 1981-09-15
RO75391A (ro) 1980-11-30
ATA868877A (de) 1979-05-15
SE435930B (sv) 1984-10-29
US4096148A (en) 1978-06-20
HU180724B (en) 1983-04-29
PT67342B (en) 1979-04-26
CH632516A5 (de) 1982-10-15
NL7713336A (nl) 1978-06-08
FR2372839A1 (fr) 1978-06-30
MX4326E (es) 1982-03-24
PL106522B1 (pl) 1979-12-31
JPS5371100A (en) 1978-06-24
DE2753791A1 (de) 1978-06-08
ES464765A1 (es) 1979-01-01
PT67343A (en) 1977-12-01
AR218467A1 (es) 1980-06-13
AU3123077A (en) 1979-06-14
FR2372839B1 (da) 1981-11-06
SE7713587L (sv) 1978-06-07
CS195343B2 (en) 1980-01-31
GR67244B (da) 1981-06-25
PL202660A1 (pl) 1978-08-28
PL110671B1 (en) 1980-07-31
DD134228A5 (de) 1979-02-14
AT353987B (de) 1979-12-10

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