IL44998A - Mercaptomethylpyridines and dioxino] c - 5, 4 [pyridines, discolphids and their N oxides - Google Patents

Mercaptomethylpyridines and dioxino] c - 5, 4 [pyridines, discolphids and their N oxides

Info

Publication number
IL44998A
IL44998A IL44998A IL4499874A IL44998A IL 44998 A IL44998 A IL 44998A IL 44998 A IL44998 A IL 44998A IL 4499874 A IL4499874 A IL 4499874A IL 44998 A IL44998 A IL 44998A
Authority
IL
Israel
Prior art keywords
methyl
compound
dioxino
hydroxy
pyridine
Prior art date
Application number
IL44998A
Other languages
English (en)
Hebrew (he)
Other versions
IL44998A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL44998A0 publication Critical patent/IL44998A0/xx
Publication of IL44998A publication Critical patent/IL44998A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL44998A 1973-06-15 1974-06-10 Mercaptomethylpyridines and dioxino] c - 5, 4 [pyridines, discolphids and their N oxides IL44998A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36877473A 1973-06-15 1973-06-15
US05/470,231 US3971797A (en) 1973-06-15 1974-05-16 S,S'-bis(pyridylmethyl)-carbonodithioates

Publications (2)

Publication Number Publication Date
IL44998A0 IL44998A0 (en) 1974-09-10
IL44998A true IL44998A (en) 1977-10-31

Family

ID=27004328

Family Applications (1)

Application Number Title Priority Date Filing Date
IL44998A IL44998A (en) 1973-06-15 1974-06-10 Mercaptomethylpyridines and dioxino] c - 5, 4 [pyridines, discolphids and their N oxides

Country Status (21)

Country Link
US (1) US3971797A (pl)
JP (3) JPS5032180A (pl)
AR (1) AR203749A1 (pl)
BG (1) BG24408A3 (pl)
CA (1) CA1037956A (pl)
CH (4) CH613951A5 (pl)
DD (1) DD113001A5 (pl)
DE (2) DE2428409C3 (pl)
DK (1) DK148595C (pl)
ES (1) ES427277A1 (pl)
FI (1) FI58775C (pl)
FR (2) FR2233056B1 (pl)
GB (2) GB1466386A (pl)
IE (1) IE39467B1 (pl)
IL (1) IL44998A (pl)
LU (1) LU70342A1 (pl)
NL (2) NL185841C (pl)
NO (1) NO144149C (pl)
PH (1) PH10366A (pl)
RO (2) RO70852A (pl)
SE (1) SE411346B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061759A (en) * 1975-05-19 1977-12-06 Merck & Co., Inc. Ethenyl and ethynyl mercaptoalkyl pyridines
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
GB2266887B (en) * 1992-05-15 1996-04-17 British Tech Group Substituted pyridines,their preparation and pharmaceutical use
EP0640072B1 (en) * 1992-05-15 2000-08-23 Btg International Limited Derivatives of pyridine as hydroxylase and lyase inhibitors
GB201718148D0 (en) * 2017-11-02 2017-12-20 Ipotts Ltd Hair cutting comb
GB2603007B (en) * 2021-01-26 2023-01-11 Pickuls Gizmo Ltd A hair cutting guide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3515726A (en) * 1968-10-16 1970-06-02 Olin Mathieson 2,2'-bis(pyridyl-n-oxide) dithiolcarbonates and trithiocarbonates

Also Published As

Publication number Publication date
DE2428409C3 (de) 1979-08-09
FI58775C (fi) 1981-04-10
IE39467B1 (en) 1978-10-11
NL185841B (nl) 1990-03-01
RO71434A (ro) 1981-08-17
NO144149B (no) 1981-03-23
CH634302A5 (de) 1983-01-31
DD113001A5 (pl) 1975-05-12
JPS5387363A (en) 1978-08-01
NO742042L (pl) 1975-05-05
DK148595C (da) 1986-01-27
GB1466295A (en) 1977-03-02
AR203749A1 (es) 1975-10-15
NO144149C (no) 1981-07-01
NL7407618A (pl) 1974-12-17
FI168574A (pl) 1974-12-16
CH610305A5 (pl) 1979-04-12
LU70342A1 (pl) 1975-03-27
FR2233056A1 (pl) 1975-01-10
FR2233057A1 (pl) 1975-01-10
IE39467L (en) 1974-12-15
BG24408A3 (en) 1978-02-10
SE411346B (sv) 1979-12-17
JPS5032180A (pl) 1975-03-28
CH613951A5 (pl) 1979-10-31
DK303274A (pl) 1975-02-10
JPS5747189B2 (pl) 1982-10-07
DE2428409B2 (de) 1978-11-30
CA1037956A (en) 1978-09-05
US3971797A (en) 1976-07-27
DK148595B (da) 1985-08-12
ES427277A1 (es) 1976-09-16
FI58775B (fi) 1980-12-31
IL44998A0 (en) 1974-09-10
FR2233056B1 (pl) 1977-10-28
DE2428409A1 (de) 1975-01-09
NL7407616A (pl) 1974-12-17
SE7407296L (pl) 1974-12-16
GB1466386A (en) 1977-03-09
FR2233057B1 (pl) 1978-03-24
JPS5032181A (pl) 1975-03-28
CH618428A5 (pl) 1980-07-31
NL185841C (nl) 1990-08-01
PH10366A (en) 1977-01-18
DE2428294A1 (de) 1975-01-09
RO70852A (ro) 1981-08-17
AU7004174A (en) 1975-12-18

Similar Documents

Publication Publication Date Title
US4212976A (en) 3,4α-Di-O-derivatives of mercaptomethylpyridine and pyridylmethyldisulfide
IL44998A (en) Mercaptomethylpyridines and dioxino] c - 5, 4 [pyridines, discolphids and their N oxides
US5585390A (en) Alpha-amino acid compounds
EP0310109B1 (en) Novel aminoalkyl-substituted heterocyclic sulfur compounds
EP0282077A2 (en) Pyridyloxy derivatives
US4657916A (en) Quinoline-N-oxide derivative and pharmaceutical composition
EP0083222B1 (en) New quinolylacetic acid compounds and pharmaceutical compositions containing them
EP1618084A1 (en) Bioreductively activated stilbene prodrugs
KR860001583B1 (ko) 6-아닐리노-5,8-퀴녹살린 디온의 제조방법
US3875176A (en) 2-benzoyl -3-amino-pyridines
US4707473A (en) 4-monosubstituted and 4,6-disubstituted phenoxazines
US4057637A (en) 5-Mercaptopyridoxine esters
JPH0665668B2 (ja) フエニルピラジン誘導体および抗血栓剤
EP0547090B1 (en) Phenolic thioetheramides as 5-lipoxygenase inhibitors
US3501485A (en) Certain pyridinemethanol carbamate derivatives
US4847305A (en) Phenolic thioethers as inhibitors of 5-lipoxygenase
JPH0320264A (ja) ジェム置換チア複素環式カルボン酸およびその誘導体
IE851521L (en) Oxazinobenzothiazines and oxazinothienothiazines
JPH0782259A (ja) スクシンアミド酸誘導体及びそれを含有する糖尿病合併症治療剤
US3476748A (en) Substituted 6,7-dihydro-5-h-pyrimidino thiazines
Isenberg et al. Synthesis of 5-Carboxy-2′-deoxyuridine
EP0613463A1 (en) Derivatives of cyclic phenolic thioethers as inhibitors or stimulators of superoxide generation
KR790001259B1 (ko) 1-프탈라존 유도체의 제조법
US4217352A (en) Anti-inflammatory 4H-1,3-oxathiino(4,5-c)
US4803269A (en) 4-monosubstituted and 4,6-disubstituted N-(α-phenylethyl)phenoxazines