FI58775C - Foerfarande foer framstaellning av vid terapi av ledgaongsreumatism anvaendbart 3,4alfa-di-0-isopropyliden-derivat av 2-metyl-3-hydroxi-4-hydroximetyl-5-merkaptometylpyridin-n-oxid - Google Patents

Foerfarande foer framstaellning av vid terapi av ledgaongsreumatism anvaendbart 3,4alfa-di-0-isopropyliden-derivat av 2-metyl-3-hydroxi-4-hydroximetyl-5-merkaptometylpyridin-n-oxid Download PDF

Info

Publication number
FI58775C
FI58775C FI1685/74A FI168574A FI58775C FI 58775 C FI58775 C FI 58775C FI 1685/74 A FI1685/74 A FI 1685/74A FI 168574 A FI168574 A FI 168574A FI 58775 C FI58775 C FI 58775C
Authority
FI
Finland
Prior art keywords
methyl
hydroxy
oxide
hydroxymethyl
derivative
Prior art date
Application number
FI1685/74A
Other languages
English (en)
Finnish (fi)
Other versions
FI168574A (pl
FI58775B (fi
Inventor
Tsung-Ying Shen
Dennis Michael Mulvey
Conrad Peter Dorn
Howard Jones
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI168574A publication Critical patent/FI168574A/fi
Application granted granted Critical
Publication of FI58775B publication Critical patent/FI58775B/fi
Publication of FI58775C publication Critical patent/FI58775C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI1685/74A 1973-06-15 1974-06-03 Foerfarande foer framstaellning av vid terapi av ledgaongsreumatism anvaendbart 3,4alfa-di-0-isopropyliden-derivat av 2-metyl-3-hydroxi-4-hydroximetyl-5-merkaptometylpyridin-n-oxid FI58775C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36877473A 1973-06-15 1973-06-15
US36877473 1973-06-15
US05/470,231 US3971797A (en) 1973-06-15 1974-05-16 S,S'-bis(pyridylmethyl)-carbonodithioates
US47023174 1974-05-16

Publications (3)

Publication Number Publication Date
FI168574A FI168574A (pl) 1974-12-16
FI58775B FI58775B (fi) 1980-12-31
FI58775C true FI58775C (fi) 1981-04-10

Family

ID=27004328

Family Applications (1)

Application Number Title Priority Date Filing Date
FI1685/74A FI58775C (fi) 1973-06-15 1974-06-03 Foerfarande foer framstaellning av vid terapi av ledgaongsreumatism anvaendbart 3,4alfa-di-0-isopropyliden-derivat av 2-metyl-3-hydroxi-4-hydroximetyl-5-merkaptometylpyridin-n-oxid

Country Status (21)

Country Link
US (1) US3971797A (pl)
JP (3) JPS5032180A (pl)
AR (1) AR203749A1 (pl)
BG (1) BG24408A3 (pl)
CA (1) CA1037956A (pl)
CH (4) CH613951A5 (pl)
DD (1) DD113001A5 (pl)
DE (2) DE2428409C3 (pl)
DK (1) DK148595C (pl)
ES (1) ES427277A1 (pl)
FI (1) FI58775C (pl)
FR (2) FR2233056B1 (pl)
GB (2) GB1466386A (pl)
IE (1) IE39467B1 (pl)
IL (1) IL44998A (pl)
LU (1) LU70342A1 (pl)
NL (2) NL185841C (pl)
NO (1) NO144149C (pl)
PH (1) PH10366A (pl)
RO (2) RO70852A (pl)
SE (1) SE411346B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061759A (en) * 1975-05-19 1977-12-06 Merck & Co., Inc. Ethenyl and ethynyl mercaptoalkyl pyridines
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
GB2266887B (en) * 1992-05-15 1996-04-17 British Tech Group Substituted pyridines,their preparation and pharmaceutical use
EP0640072B1 (en) * 1992-05-15 2000-08-23 Btg International Limited Derivatives of pyridine as hydroxylase and lyase inhibitors
GB201718148D0 (en) * 2017-11-02 2017-12-20 Ipotts Ltd Hair cutting comb
GB2603007B (en) * 2021-01-26 2023-01-11 Pickuls Gizmo Ltd A hair cutting guide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3515726A (en) * 1968-10-16 1970-06-02 Olin Mathieson 2,2'-bis(pyridyl-n-oxide) dithiolcarbonates and trithiocarbonates

Also Published As

Publication number Publication date
DE2428409C3 (de) 1979-08-09
IE39467B1 (en) 1978-10-11
NL185841B (nl) 1990-03-01
RO71434A (ro) 1981-08-17
NO144149B (no) 1981-03-23
CH634302A5 (de) 1983-01-31
DD113001A5 (pl) 1975-05-12
JPS5387363A (en) 1978-08-01
NO742042L (pl) 1975-05-05
DK148595C (da) 1986-01-27
GB1466295A (en) 1977-03-02
AR203749A1 (es) 1975-10-15
NO144149C (no) 1981-07-01
NL7407618A (pl) 1974-12-17
FI168574A (pl) 1974-12-16
CH610305A5 (pl) 1979-04-12
LU70342A1 (pl) 1975-03-27
FR2233056A1 (pl) 1975-01-10
FR2233057A1 (pl) 1975-01-10
IE39467L (en) 1974-12-15
BG24408A3 (en) 1978-02-10
SE411346B (sv) 1979-12-17
IL44998A (en) 1977-10-31
JPS5032180A (pl) 1975-03-28
CH613951A5 (pl) 1979-10-31
DK303274A (pl) 1975-02-10
JPS5747189B2 (pl) 1982-10-07
DE2428409B2 (de) 1978-11-30
CA1037956A (en) 1978-09-05
US3971797A (en) 1976-07-27
DK148595B (da) 1985-08-12
ES427277A1 (es) 1976-09-16
FI58775B (fi) 1980-12-31
IL44998A0 (en) 1974-09-10
FR2233056B1 (pl) 1977-10-28
DE2428409A1 (de) 1975-01-09
NL7407616A (pl) 1974-12-17
SE7407296L (pl) 1974-12-16
GB1466386A (en) 1977-03-09
FR2233057B1 (pl) 1978-03-24
JPS5032181A (pl) 1975-03-28
CH618428A5 (pl) 1980-07-31
NL185841C (nl) 1990-08-01
PH10366A (en) 1977-01-18
DE2428294A1 (de) 1975-01-09
RO70852A (ro) 1981-08-17
AU7004174A (en) 1975-12-18

Similar Documents

Publication Publication Date Title
US5260291A (en) Tetrazine derivatives
US4212976A (en) 3,4α-Di-O-derivatives of mercaptomethylpyridine and pyridylmethyldisulfide
EP0149088A1 (de) Neue Pyridin-2-ether beziehungsweise Pyridin-2-thioether mit einem stickstoffhaltigen cycloaliphatischen Ring sowie deren Sulforide, Sulfone und Pyridin-N-oxide
DE69704255T2 (de) Aromatische Diselenide und Selenosulfide zur Verwendung als Antioxidans-Mittel
EP0127763A1 (de) Tricyclische Ether, Verfahren zu ihrer Herstellung, ihre Anwendung und sie enthaltende Arzneimittel
FI58775C (fi) Foerfarande foer framstaellning av vid terapi av ledgaongsreumatism anvaendbart 3,4alfa-di-0-isopropyliden-derivat av 2-metyl-3-hydroxi-4-hydroximetyl-5-merkaptometylpyridin-n-oxid
JPH09507070A (ja) 抗痙攣性プソイドフルクトピラノーススルファメート類
CH648824A5 (de) Bis(carboxamid)-derivate.
DE69132082T2 (de) Pyridin-Derivate, Verfahren zu deren Herstellung und Anwendung
US6160167A (en) Mercaptans and disulfides
EP1556376B1 (en) Large conductance calcium-activated k channel opener
EP0157098A1 (en) Xanthine derivatives, pharmaceuticals compositions containing them and a process for their preparation
DE2124103A1 (de) Nitroimidazolderivate
US4415495A (en) 5,6;8,9-Tetrahydro-7H-dibenz(d,f)azonines
GB2023579A (en) Methanimidamidyl cystamines
DE3587653T2 (de) Sparsomycinderivate.
DE2230620A1 (de) Cephalosporinester, deren Salze und Verfahren zu ihrer Herstellung
NO885576L (no) Trometaminsalt av 1-metyl-beta-okso-alfa-(fenyl-karbamoyl)-2-pyrrolpropionitril.
CA1162544A (en) Naphthyridine derivatives
DE60013607T2 (de) Bemzimidazolverbindungen und medikamente die diese enthalten
US4521606A (en) 5-Indolyl substituted aminoethanols
US4261999A (en) Thiazolothienopyridines and anti-viral compositions thereof
NO178400B (no) Analogifremgangsmåte til fremstilling av et terapeutisk aktivt pyridinkarboksimidamidderivat
US5185375A (en) Thioformamide derivatives
US4507304A (en) Use of 6-amino-5-pyrimidinecarbonitrile derivatives as cardiotonic agents